Steven A. Stacker
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View article: An endothelial cell competition assay for determinants of the response to targeted anti-angiogenics
An endothelial cell competition assay for determinants of the response to targeted anti-angiogenics Open
/SUMMARYAnti-angiogenics, inhibitors of pathological blood vessel growth, are an important class of targeted agent for the treatment of common cancers and ocular conditions. However, efficacy is compromised by the absence of biomarkers to …
View article: Targeting insulin-like growth factor 1 receptor restricts development and severity of secondary lymphedema in mice
Targeting insulin-like growth factor 1 receptor restricts development and severity of secondary lymphedema in mice Open
Secondary lymphedema is a debilitating chronic tissue swelling in a limb caused by inadequate interstitial fluid drainage due to dysfunctional lymphatic vessels. Pathological enlargement of small lymphatics contributes to lymphatic dysfunc…
View article: Radiation therapy attenuates lymphatic vessel repair by reducing VEGFR-3 signalling
Radiation therapy attenuates lymphatic vessel repair by reducing VEGFR-3 signalling Open
Introduction: Surgery and radiotherapy are key cancer treatments and the leading causes of damage to the lymphatics, a vascular network critical to fluid homeostasis and immunity. The clinical manifestation of this damage constitutes a dev…
View article: Data from CCL27/CCL28–CCR10 Chemokine Signaling Mediates Migration of Lymphatic Endothelial Cells
Data from CCL27/CCL28–CCR10 Chemokine Signaling Mediates Migration of Lymphatic Endothelial Cells Open
Metastasis via the lymphatic vasculature is an important step in cancer progression. The formation of new lymphatic vessels (lymphangiogenesis), or remodeling of existing lymphatics, is thought to facilitate the entry and transport of tumo…
View article: Supplementary Data from CCL27/CCL28–CCR10 Chemokine Signaling Mediates Migration of Lymphatic Endothelial Cells
Supplementary Data from CCL27/CCL28–CCR10 Chemokine Signaling Mediates Migration of Lymphatic Endothelial Cells Open
Supplementary Figures S1-S8 S1 Heat map of chemokines and receptors S2 Immunohistochemical staining of lymphatic vessels S3 Expression of VEGF-D and chemokines in cancer cell lines S4 Expression of genes in melanoma patient samples S5 Chem…
View article: Data from CCL27/CCL28–CCR10 Chemokine Signaling Mediates Migration of Lymphatic Endothelial Cells
Data from CCL27/CCL28–CCR10 Chemokine Signaling Mediates Migration of Lymphatic Endothelial Cells Open
Metastasis via the lymphatic vasculature is an important step in cancer progression. The formation of new lymphatic vessels (lymphangiogenesis), or remodeling of existing lymphatics, is thought to facilitate the entry and transport of tumo…
View article: Supplementary Data from CCL27/CCL28–CCR10 Chemokine Signaling Mediates Migration of Lymphatic Endothelial Cells
Supplementary Data from CCL27/CCL28–CCR10 Chemokine Signaling Mediates Migration of Lymphatic Endothelial Cells Open
Supplementary Figures S1-S8 S1 Heat map of chemokines and receptors S2 Immunohistochemical staining of lymphatic vessels S3 Expression of VEGF-D and chemokines in cancer cell lines S4 Expression of genes in melanoma patient samples S5 Chem…
View article: Supplementary Figure 2 from A Role for Bone Morphogenetic Protein-4 in Lymph Node Vascular Remodeling and Primary Tumor Growth
Supplementary Figure 2 from A Role for Bone Morphogenetic Protein-4 in Lymph Node Vascular Remodeling and Primary Tumor Growth Open
PDF file - 161K
View article: Supplementary Methods from A Role for Bone Morphogenetic Protein-4 in Lymph Node Vascular Remodeling and Primary Tumor Growth
Supplementary Methods from A Role for Bone Morphogenetic Protein-4 in Lymph Node Vascular Remodeling and Primary Tumor Growth Open
PDF file - 162K
View article: Data from A Role for Bone Morphogenetic Protein-4 in Lymph Node Vascular Remodeling and Primary Tumor Growth
Data from A Role for Bone Morphogenetic Protein-4 in Lymph Node Vascular Remodeling and Primary Tumor Growth Open
Lymph node metastasis, an early and prognostically important event in the progression of many human cancers, is associated with expression of VEGF-D. Changes to lymph node vasculature that occur during malignant progression may create a me…
View article: Supplementary Figure 4 from A Role for Bone Morphogenetic Protein-4 in Lymph Node Vascular Remodeling and Primary Tumor Growth
Supplementary Figure 4 from A Role for Bone Morphogenetic Protein-4 in Lymph Node Vascular Remodeling and Primary Tumor Growth Open
PDF file - 95K
View article: Supplementary Figure 3 from A Role for Bone Morphogenetic Protein-4 in Lymph Node Vascular Remodeling and Primary Tumor Growth
Supplementary Figure 3 from A Role for Bone Morphogenetic Protein-4 in Lymph Node Vascular Remodeling and Primary Tumor Growth Open
PDF file - 86K
View article: Supplementary Figure 2 from A Role for Bone Morphogenetic Protein-4 in Lymph Node Vascular Remodeling and Primary Tumor Growth
Supplementary Figure 2 from A Role for Bone Morphogenetic Protein-4 in Lymph Node Vascular Remodeling and Primary Tumor Growth Open
PDF file - 161K
View article: Data from A Role for Bone Morphogenetic Protein-4 in Lymph Node Vascular Remodeling and Primary Tumor Growth
Data from A Role for Bone Morphogenetic Protein-4 in Lymph Node Vascular Remodeling and Primary Tumor Growth Open
Lymph node metastasis, an early and prognostically important event in the progression of many human cancers, is associated with expression of VEGF-D. Changes to lymph node vasculature that occur during malignant progression may create a me…
View article: Supplementary Figure 6 from A Role for Bone Morphogenetic Protein-4 in Lymph Node Vascular Remodeling and Primary Tumor Growth
Supplementary Figure 6 from A Role for Bone Morphogenetic Protein-4 in Lymph Node Vascular Remodeling and Primary Tumor Growth Open
PDF file - 147K
View article: Supplementary Figure 5 from A Role for Bone Morphogenetic Protein-4 in Lymph Node Vascular Remodeling and Primary Tumor Growth
Supplementary Figure 5 from A Role for Bone Morphogenetic Protein-4 in Lymph Node Vascular Remodeling and Primary Tumor Growth Open
PDF file - 79K
View article: Supplementary Figure 5 from A Role for Bone Morphogenetic Protein-4 in Lymph Node Vascular Remodeling and Primary Tumor Growth
Supplementary Figure 5 from A Role for Bone Morphogenetic Protein-4 in Lymph Node Vascular Remodeling and Primary Tumor Growth Open
PDF file - 79K
View article: Supplementary Figure 1 from A Role for Bone Morphogenetic Protein-4 in Lymph Node Vascular Remodeling and Primary Tumor Growth
Supplementary Figure 1 from A Role for Bone Morphogenetic Protein-4 in Lymph Node Vascular Remodeling and Primary Tumor Growth Open
PDF file - 98K
View article: Supplementary Figure 6 from A Role for Bone Morphogenetic Protein-4 in Lymph Node Vascular Remodeling and Primary Tumor Growth
Supplementary Figure 6 from A Role for Bone Morphogenetic Protein-4 in Lymph Node Vascular Remodeling and Primary Tumor Growth Open
PDF file - 147K
View article: Supplementary Figure 4 from A Role for Bone Morphogenetic Protein-4 in Lymph Node Vascular Remodeling and Primary Tumor Growth
Supplementary Figure 4 from A Role for Bone Morphogenetic Protein-4 in Lymph Node Vascular Remodeling and Primary Tumor Growth Open
PDF file - 95K
View article: Supplementary Figure 1 from A Role for Bone Morphogenetic Protein-4 in Lymph Node Vascular Remodeling and Primary Tumor Growth
Supplementary Figure 1 from A Role for Bone Morphogenetic Protein-4 in Lymph Node Vascular Remodeling and Primary Tumor Growth Open
PDF file - 98K
View article: Supplementary Figure 3 from A Role for Bone Morphogenetic Protein-4 in Lymph Node Vascular Remodeling and Primary Tumor Growth
Supplementary Figure 3 from A Role for Bone Morphogenetic Protein-4 in Lymph Node Vascular Remodeling and Primary Tumor Growth Open
PDF file - 86K
View article: Supplementary Methods from A Role for Bone Morphogenetic Protein-4 in Lymph Node Vascular Remodeling and Primary Tumor Growth
Supplementary Methods from A Role for Bone Morphogenetic Protein-4 in Lymph Node Vascular Remodeling and Primary Tumor Growth Open
PDF file - 162K
View article: YBX1 integration of oncogenic PI3K/mTOR signalling regulates the fitness of malignant epithelial cells
YBX1 integration of oncogenic PI3K/mTOR signalling regulates the fitness of malignant epithelial cells Open
View article: Brain Vascular Microenvironments in Cancer Metastasis
Brain Vascular Microenvironments in Cancer Metastasis Open
Primary tumours, particularly from major solid organs, are able to disseminate into the blood and lymphatic system and spread to distant sites. These secondary metastases to other major organs are the most lethal aspect of cancer, accounti…
View article: The microRNA miR-132 is a key regulator of lymphatic vascular remodelling
The microRNA miR-132 is a key regulator of lymphatic vascular remodelling Open
Lymphangiogenesis (growth of new lymphatic vessels), and lymphatic remodelling more broadly, are important for disease progression in cancer, lymphedema and the pulmonary disease lymphangioleiomyomatosis. Multiple molecular pathways which …
View article: Three-dimensional CRISPR screening reveals epigenetic interaction with anti-angiogenic therapy
Three-dimensional CRISPR screening reveals epigenetic interaction with anti-angiogenic therapy Open
View article: <i>Pkd1</i> and <i>Wnt5a</i> genetically interact to control lymphatic vascular morphogenesis in mice
<i>Pkd1</i> and <i>Wnt5a</i> genetically interact to control lymphatic vascular morphogenesis in mice Open
Background Lymphatic vascular development is regulated by well‐characterized signaling and transcriptional pathways. These pathways regulate lymphatic endothelial cell (LEC) migration, motility, polarity, and morphogenesis. Canonical and n…
View article: <i>Pkd1</i>and<i>Wnt5a</i>genetically interact to control lymphatic vascular morphogenesis in mice
<i>Pkd1</i>and<i>Wnt5a</i>genetically interact to control lymphatic vascular morphogenesis in mice Open
Lymphatic vascular development is regulated by well-characterised signalling and transcriptional pathways. These pathways regulate lymphatic endothelial cell (LEC) migration, motility, polarity and and morphogenesis. Canonical and non-cano…
View article: Control of Gene Expression by Exosome-Derived Non-Coding RNAs in Cancer Angiogenesis and Lymphangiogenesis
Control of Gene Expression by Exosome-Derived Non-Coding RNAs in Cancer Angiogenesis and Lymphangiogenesis Open
Tumour angiogenesis and lymphangiogenesis are hallmarks of cancer and have been associated with tumour progression, tumour metastasis and poor patient prognosis. Many factors regulate angiogenesis and lymphangiogenesis in cancer including …