Steven C. Grambow
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View article: A Case Where It Is Better to have an Unstandardized measure of the Right Construct than a Standardized Measure of a Related One: Application to Coding Interviews Within a Course in SAS Programming
A Case Where It Is Better to have an Unstandardized measure of the Right Construct than a Standardized Measure of a Related One: Application to Coding Interviews Within a Course in SAS Programming Open
Interview-based examinations provide richer data than formats such as multiple choice and short answer, albeit at the cost of being less standardized. This describes administering a coding interview as the final examination in a class on S…
View article: Rationalizing the Mathematics Requirements for a Master of Biostatistics Program: A Case Study and Commentary
Rationalizing the Mathematics Requirements for a Master of Biostatistics Program: A Case Study and Commentary Open
Within a 2-year Master of Biostatistics program, we reconsidered the mathematics requirements for admission, and also the premise that the most distinguishing feature of a top candidate is deep exposure to mathematics. Our assessment took …
View article: The research equity and diversity initiative (READI): Changing the face of clinical research through community outreach and engagement
The research equity and diversity initiative (READI): Changing the face of clinical research through community outreach and engagement Open
Current evidence underscores a need to transform how we do clinical research, shifting from academic-driven priorities to co-led community partnership focused programs, accessible and relevant career pathway programs that expand opportunit…
View article: Integrating large language models in biostatistical workflows for clinical and translational research
Integrating large language models in biostatistical workflows for clinical and translational research Open
Introduction: Biostatisticians increasingly use large language models (LLMs) to enhance efficiency, yet practical guidance on responsible integration is limited. This study explores current LLM usage, challenges, and training needs to supp…
View article: Improving Statistical Literacy for Physician Scientists: Sampling Distributions
Improving Statistical Literacy for Physician Scientists: Sampling Distributions Open
This is the first in a multi-part series on teaching statistical inference to physician-scientists training to work as members of interdisciplinary scientific teams. This unique student audience has greater scientific sophistication than a…
View article: A Method for Teaching Biostatisticians to Write and Critique Specific Aims
A Method for Teaching Biostatisticians to Write and Critique Specific Aims Open
This article describes the design of a single instructional module on writing and critiquing the Specific Aims (SA) section of a grant proposal for a biomedical research study. It begins by discussing the goals and learning objectives for …
View article: Effective Scientific Presentations Across Formats: A Modern Guide for Science Trainees and Researchers
Effective Scientific Presentations Across Formats: A Modern Guide for Science Trainees and Researchers Open
This paper presents a comprehensive tutorial on delivering effective scientific presentations in the modern era, addressing a landscape altered by the COVID-19 pandemic. The shift to virtual and hybrid formats has fundamentally changed the…
View article: Rationalizing the Mathematics Requirements for a Master of Biostatistics Program: A Case Study and Commentary
Rationalizing the Mathematics Requirements for a Master of Biostatistics Program: A Case Study and Commentary Open
Within a 2-year Master of Biostatistics program, we reconsidered the mathematics requirements for admission, and also the premise that the most distinguishing feature of a top candidate is deep exposure to mathematics. Our assessment took …
View article: Biomedical Researchers Should be Taught Statistics Differently than Biostatisticians in Training: Illustration of a Module within a Clinical Research Seminar Course
Biomedical Researchers Should be Taught Statistics Differently than Biostatisticians in Training: Illustration of a Module within a Clinical Research Seminar Course Open
The predominant model for biomedical research is team science. Two critical members of the team are the clinical investigator and the biostatistician. Typically, the biostatistician performs statistical analyses and the clinical investigat…
View article: A Curriculum Review of Programming Courses in a Master of Biostatistics Program
A Curriculum Review of Programming Courses in a Master of Biostatistics Program Open
Computing is a core competency for collaborative biostatisticians, who work on interdisciplinary scientific teams in medicine and publich health. However, computing is a broad field that encompases many underlying pedagogical constructs an…
View article: Are Simulated Coding Interviews a Fair and Practical Examination Format for Non-professional Programmers Enrolled in a Master’s Degree Program in Biostatistics?
Are Simulated Coding Interviews a Fair and Practical Examination Format for Non-professional Programmers Enrolled in a Master’s Degree Program in Biostatistics? Open
This report describes an innovative and evidence-based approach to implementing coding interviews as an examination format for non-professional programmers: namely, students in a Master of Biostatistics program taking a course in the langu…
View article: Treatment Effect Estimates From Pilot Trials Are Unreliable
Treatment Effect Estimates From Pilot Trials Are Unreliable Open
Treatment effect estimates from pilot trials should not be used to make future development decisions regarding a novel therapy because of the high risk of misleading conclusions.
View article: Advancing workforce diversity by leveraging the Clinical and Translational Science Awards (CTSA) program
Advancing workforce diversity by leveraging the Clinical and Translational Science Awards (CTSA) program Open
Clinical trials continue to disproportionately underrepresent people of color. Increasing representation of diverse backgrounds among clinical research personnel has the potential to yield greater representation in clinical trials and more…
View article: Redesign of a First-Year Theory Course Sequence in Biostatistics
Redesign of a First-Year Theory Course Sequence in Biostatistics Open
This communication describes the process and results of a curriculum review of a first-year sequence of courses in statistical inference within a Master of Biostatistics program. Our primary aim was to develop an innovative course in stati…
View article: Experiential learning methods for biostatistics students: A model for embedding student interns in academic health centers
Experiential learning methods for biostatistics students: A model for embedding student interns in academic health centers Open
This manuscript describes an experiential learning program for future collaborative biostatisticians (CBs) developed within an academic medical program. The program is a collaborative effort between the Biostatistics, Epidemiology, and Res…
View article: A Visual Tool to Help Develop a Statistical Analysis Plan for Randomized Trials in Palliative Care
A Visual Tool to Help Develop a Statistical Analysis Plan for Randomized Trials in Palliative Care Open
View article: Administrative Considerations Pertaining to the Use of Creative Methods of Student Assessment: A Theoretically Grounded Reflection from a Master of Biostatistics Program
Administrative Considerations Pertaining to the Use of Creative Methods of Student Assessment: A Theoretically Grounded Reflection from a Master of Biostatistics Program Open
Student evaluation is a key consideration for educational program administrators because program success depends on students’ ability to demonstrate successful development of core competencies. Student evaluations must therefore be aligned…
View article: Preorientation Curriculum: An Approach for Preparing Students with Heterogenous Backgrounds for Training in a Master of Biostatistics Program
Preorientation Curriculum: An Approach for Preparing Students with Heterogenous Backgrounds for Training in a Master of Biostatistics Program Open
We describe an innovative preorientation curriculum (POC) for a Master of Biostatistics (MB) program. The goal of the POC is to fill critical skills gaps for students entering the MB program from heterogeneous backgrounds so they are prepa…
View article: A Course in Biology and Communication Skills for Master of Biostatistics Students
A Course in Biology and Communication Skills for Master of Biostatistics Students Open
We describe an innovative, semester-long course in biology and communication skills for master’s degree students in biostatistics. The primary goal of the course is to make the connection between biological science and statistics more expl…
View article: Predictors of variation in serum IGF1 and IGFBP3 levels in healthy African American and white men.
Predictors of variation in serum IGF1 and IGFBP3 levels in healthy African American and white men. Open
Background—Individual variation in circulating insulin-like growth factor-I (IGF1) and its major binding protein, insulin-like growth factor binding protein-3 (IGFBP3) have been etiologically linked to several chronic diseases, including s…
View article: Impact of lifestyle Intervention on branched‐chain amino acid catabolism and insulin sensitivity in adolescents with obesity
Impact of lifestyle Intervention on branched‐chain amino acid catabolism and insulin sensitivity in adolescents with obesity Open
Introduction Insulin resistance in adolescents with obesity associates with a sex‐dependent metabolic ‘signature’ comprising branched‐chain amino acids (BCAAs), glutamate and C3/C5 acylcarnitines (C3/C5), implicating altered flux through B…
View article: The Biomedical Research Pyramid: A Model for the Practice of Biostatistics
The Biomedical Research Pyramid: A Model for the Practice of Biostatistics Open
Biostatisticians apply statistical methods to solve problems in the biological sciences. Successful practioners of biostatistics have advanced technical knowledge, are skilled communicators, and can seamlesslessly integrate with interdisci…
View article: Quality of Nonmetastatic Colorectal Cancer Care in the Department of Veterans Affairs
Quality of Nonmetastatic Colorectal Cancer Care in the Department of Veterans Affairs Open
The Veterans Affairs (VA) healthcare system treats approximately 3% of patients with cancer in the United States each year. We measured the quality of nonmetastatic colorectal cancer (CRC) care in VA as indicated by concordance with Nation…
View article: Determinants of Medical System Delay in the Diagnosis of Colorectal Cancer Within the Veteran Affairs Health System
Determinants of Medical System Delay in the Diagnosis of Colorectal Cancer Within the Veteran Affairs Health System Open
The goals of this study were to evaluate determinants of the time in the medical system until a colorectal cancer diagnosis and to explore characteristics associated with stage at diagnosis.
View article: Early dissemination of bevacizumab for advanced colorectal cancer: a prospective cohort study
Early dissemination of bevacizumab for advanced colorectal cancer: a prospective cohort study Open
BackgroundWe describe early dissemination patterns for first-line bevacizumab given for metastatic colorectal cancer treatment.MethodsWe analyzed patient surveys and medical records for a population-based cohort with metastatic colorectal …
View article: Chemotherapy use and patient treatment preferences in advanced colorectal cancer: A prospective cohort study
Chemotherapy use and patient treatment preferences in advanced colorectal cancer: A prospective cohort study Open
Our objective was to determine how patient preferences guide the course of palliative chemotherapy for advanced colorectal cancer.
View article: Methods for training collaborative biostatisticians
Methods for training collaborative biostatisticians Open
The emphasis on team science in clinical and translational research increases the importance of collaborative biostatisticians (CBs) in healthcare. Adequate training and development of CBs ensure appropriate conduct of robust and meaningfu…
View article: Criteria for rapidly incorporating online instruction into traditionally in-person programs: a case study
Criteria for rapidly incorporating online instruction into traditionally in-person programs: a case study Open
Given the continuing uncertainty about the COCID-19 pandemic, we are planning for the possibility that, in the upcoming semester, some or all of the content of a Master of Biostatistics program will be delivered online. In order to help ma…
View article: Epidemiologic Trends in <i>Clostridioides difficile</i> Infections in a Regional Community Hospital Network
Epidemiologic Trends in <i>Clostridioides difficile</i> Infections in a Regional Community Hospital Network Open
The findings suggest that, despite the modest improvement in health care facility-associated CDI rates, a better understanding of community-acquired CDI incidence is needed for future infection prevention efforts.
View article: A New Stress Test for Knee Joint Cartilage
A New Stress Test for Knee Joint Cartilage Open