Explanipedia

Fluoride-related changes in the fetal cord blood proteome; a pilot study Open

Sami T. Tuomivaara, Susan J. Fisher, Steven C. Hall, Dana E. Goin, Aras N. Mattis , et al. · 2024

High rates of placental inflammation among samples collected by the Multi-Omics for Mothers and Infants consortium Open

Joshua F. Robinson, Sayan Das, Waqasuddin Khan, Rasheda Khanam, Joan T. Price , et al. · 2024

Fluoride-related changes in the fetal cord blood proteome; a pilot study Open

Sami T. Tuomivaara, Dana E. Goin, Susan J. Fisher, Steven C. Hall, Aras N. Mattis , et al. · 2024

Background: Fluoride exposure during pregnancy has been associated with various effects on offspring, including changes in behavior and IQ. To provide clues to possible mechanisms by which fluoride affects human fetal development, we comp…

Utility of long-read sequencing for All of Us Open

Medhat Mahmoud, Yongqing Huang, Kiran Garimella, Peter A. Audano, Wei Wan , et al. · 2024

The All of Us (AoU) initiative aims to sequence the genomes of over one million Americans from diverse ethnic backgrounds to improve personalized medical care. In a recent technical pilot, we compare the performance of traditional short-re…

Utility of long-read sequencing for All of Us Open

Medhat Mahmoud, Yongqing Huang, Kiran Garimella, Peter A. Audano, Wei Wan , et al. · 2023

The All of Us (AoU) initiative aims to sequence the genomes of over one million Americans from diverse ethnic backgrounds to improve personalized medical care. In a recent technical pilot, we compared the performance of traditional short-r…

Multifunctionality of Prostatic Acid Phosphatase in Prostate Cancer Pathogenesis Open

Evgenia Alpert, Armin Akhavan, Arie Gruzman, William J. Hansen, Joshua Lehrer- Graiwer , et al. · 2021

The role of human prostatic acid phosphatase (PAcP, P15309|PPAP_HUMAN) in prostate cancer was investigated using a new proteomic tool termed signal sequence swapping (replacement of domains from the native cleaved amino terminal signal seq…

Multifunctionality of prostatic acid phosphatase in prostate cancer pathogenesis Open

Evgenia Alpert, Armin Akhavan, Arie Gruzman, William J. Hansen, Joshua Lehrer‐Graiwer , et al. · 2021

The role of human prostatic acid phosphatase (PAcP, P15309|PPAP_HUMAN) in prostate cancer was investigated using a new proteomics tool termed signal sequence swapping (replacement of domains from the native cleaved amino terminal signal se…

RNA profiling of laser microdissected human trophoblast subtypes at mid-gestation reveals a role for cannabinoid signaling in invasion Open

Matthew Gormley, Oliver Oliverio, Mirhan Kapidzic, Katherine Ona, Steven C. Hall , et al. · 2021

Human placental architecture is complex. Its surface epithelium, specialized for transport, forms by fusion of cytotrophoblast progenitors into multinucleated syncytiotrophoblasts. Near the uterine surface, these progenitors assume a diffe…

Recent Evidence for Multifactorial Biofilm Regulation by Heme Sensor Proteins NosP and H-NOX Open

Jiayuan Fu, Steven C. Hall, Elizabeth M. Boon · 2021

Heme is involved in signal transduction by either acting as a cofactor of heme-based gas/redox sensors or binding reversely to heme-responsive proteins. Bacteria respond to low concentrations of nitric oxide (NO) to modulate group behavior…

STopTox: An In-Silico Alternative to Animal Testing for Acute Systemic and TOPical TOXicity Open

Joyce Villa Verde Bastos Borba, Vinícius M. Alves, Rodolpho C. Braga, Daniel Korn, Kirsten E. Overdahl , et al. · 2020

Since 2009, animal testing for cosmetic products has been prohibited in Europe, and in 2016, US EPA announced their intent to modernize the so-called "6-pack" of acute toxicity tests (acute oral toxicity, acute dermal toxicity, acute inhal…

STopTox: An In-Silico Alternative to Animal Testing for Acute Systemic and TOPical TOXicity Open

Joyce Villa Verde Bastos Borba, Vinícius M. Alves, Rodolpho C. Braga, Daniel Korn, Kirsten E. Overdahl , et al. · 2020

Since 2009, animal testing for cosmetic products has been prohibited in Europe, and in 2016, US EPA announced their intent to modernize the so-called "6-pack" of acute toxicity tests (acute oral toxicity, acute dermal toxicity, acute inhal…

Multi-site assessment of the precision and reproducibility of multiple reaction monitoring–based measurements of proteins in plasma Open

Terri A. Addona, Susan E. Abbatiello, Birgit Schilling, Steven J. Skates, D R Mani , et al. · 2020

Verification of candidate biomarkers relies upon specific, quantitative assays optimized for selective detection of target proteins, and is increasingly viewed as a critical step in the discovery pipeline that bridges unbiased biomarker di…

Distressed Firms and Dividend Reductions Open

Steven C. Hall, Vipin Agrawal, Pushpa Agrawal · 2019

We are interested in the effects of dividend reduction decisions on the firms that make them. We compare financial ratios of distressed dividend-reducing firms to distressed firms that did not reduce dividends, of nondistressed dividend-re…

Discovery of internalizing antibodies to basal breast cancer cells Open

Yu Zhou, Hao Zou, Christina Yau, Zhao Lequn, Steven C. Hall , et al. · 2017

We present a strategy to discover recombinant monoclonal antibodies (mAbs) to specific cancers and demonstrate this approach using basal subtype breast cancers. A phage antibody library was depleted of antibodies to common cell surface mol…

Development of Glatopa® (Glatiramer Acetate): The First FDA-Approved Generic Disease-Modifying Therapy for Relapsing Forms of Multiple Sclerosis Open

Christine Bell, James Anderson, Tanmoy Ganguly, James L. Prescott, Ishan Capila , et al. · 2017

The multiple sclerosis (MS) treatment landscape in the United States has changed dramatically over the past decade. While many disease-modifying therapies (DMTs) have been approved by the US Food and Drug Administration (FDA) for the treat…

Alterations in the Salivary Proteome and <i>N</i>-Glycome of Sjögren’s Syndrome Patients Open

Steven C. Hall, Maria E. Hassis, Katherine Williams, Matthew E. Albertolle, Akraporn Prakobphol , et al. · 2017

We used isobaric mass tagging (iTRAQ) and lectin affinity capture mass spectrometry (MS)-based workflows for global analyses of parotid saliva (PS) and whole saliva (WS) samples obtained from patients diagnosed with primary Sjögren's Syndr…

Quantitative Tagless Copurification: A Method to Validate and Identify Protein-Protein Interactions Open

Maxim Shatsky, Ming Dong, Haichuan Liu, Lee Lisheng Yang, Megan Choi , et al. · 2016

Report from the "What is Publishing?" (2) Workgroup Open

Melanie Dolechek, Sharon E. Farb, Steven C. Hall, Harriette Hemmasi, John R. Inglis , et al. · 2016

OSI2016 Workgroup QuestionWhat do we mean by publishing in today’s world? What should be the goals of scholarly publishing? What are the ideals to which scholarly publishing should aspire? What roles might scholarly publishers have in the …

Bacterial Interactomes: Interacting Protein Partners Share Similar Function and Are Validated in Independent Assays More Frequently Than Previously Reported Open

Maxim Shatsky, Simon Allen, B. Gold, Nancy L. Liu, Thomas R. Juba , et al. · 2016

Mass spectrometry-based analyses showing the effects of secretor and blood group status on salivary N-glycosylation Open

Matthew E. Albertolle, Maria E. Hassis, Connie Ng, Severino Cuison, Katherine Williams , et al. · 2015

Together, the results suggested a molecular basis for inter-individual variations in salivary protein glycosylation with functional implications for oral health.

Large-Scale Interlaboratory Study to Develop, Analytically Validate and Apply Highly Multiplexed, Quantitative Peptide Assays to Measure Cancer-Relevant Proteins in Plasma Open

Susan E. Abbatiello, Birgit Schilling, D.R. Mani, Lisa J. Zimmerman, Steven C. Hall , et al. · 2015

There is an increasing need in biology and clinical medicine to robustly and reliably measure tens to hundreds of peptides and proteins in clinical and biological samples with high sensitivity, specificity, reproducibility, and repeatabili…

MOESM2 of Mass spectrometry-based analyses showing the effects of secretor and blood group status on salivary N-glycosylation Open

Matthew E. Albertolle, Maria E. Hassis, Connie Ng, Severino Cuison, Katherine Williams , et al. · 2015

Additional file 2: Table S2. Protein Identifications and Associated N-glycosites.

MOESM7 of Mass spectrometry-based analyses showing the effects of secretor and blood group status on salivary N-glycosylation Open

Matthew E. Albertolle, Maria E. Hassis, Connie Ng, Severino Cuison, Katherine Williams , et al. · 2015

Additional file 7: Table S2. PNGase F-Released N-Glycans Detected by MALDI Ion Mobility MS.

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