Steven C. Neier
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View article: Light‐Controllable Binary Switch Activation of CAR T Cells
Light‐Controllable Binary Switch Activation of CAR T Cells Open
Major challenges to chimeric antigen receptor (CAR) T cell therapies include uncontrolled immune activity, off‐tumor toxicities and tumor heterogeneity. To overcome these challenges, we engineered CARs directed against small molecules. By …
View article: Quantification of Protein Interaction Network Dynamics using Multiplexed Co-Immunoprecipitation
Quantification of Protein Interaction Network Dynamics using Multiplexed Co-Immunoprecipitation Open
Dynamic protein-protein interactions control cellular behavior, from motility to DNA replication to signal transduction. However, monitoring dynamic interactions among multiple proteins in a protein interaction network is technically diffi…
View article: The lncRNA SLNCR Recruits the Androgen Receptor to EGR1-Bound Genes in Melanoma and Inhibits Expression of Tumor Suppressor p21
The lncRNA SLNCR Recruits the Androgen Receptor to EGR1-Bound Genes in Melanoma and Inhibits Expression of Tumor Suppressor p21 Open
Melanoma is the deadliest form of skin cancer, affecting men more frequently and severely than women. Although recent studies suggest that differences in activity of the androgen receptor (AR) underlie the observed sex bias, little is know…
View article: The early proximal αβ TCR signalosome specifies thymic selection outcome through a quantitative protein interaction network
The early proximal αβ TCR signalosome specifies thymic selection outcome through a quantitative protein interaction network Open
Quantitative activity through the TCR-proximal protein network specifies thymic positive versus negative selection.
View article: DIPG-39. UNCOUPLING CAR T CELL RECOGNITION FROM TUMOR KILLING FOR DIPG THERAPY
DIPG-39. UNCOUPLING CAR T CELL RECOGNITION FROM TUMOR KILLING FOR DIPG THERAPY Open
INTRODUCTION: T cells play a central role in our immune system’s responses to infections. Recent promising clinical studies have shown that the immune system can be ‘engineered’ to recognize and kill tumor cells by binding to specific prot…
View article: Gene Expression Signatures Characterized by Longitudinal Stability and Interindividual Variability Delineate Baseline Phenotypic Groups with Distinct Responses to Immune Stimulation
Gene Expression Signatures Characterized by Longitudinal Stability and Interindividual Variability Delineate Baseline Phenotypic Groups with Distinct Responses to Immune Stimulation Open
Human immunity exhibits remarkable heterogeneity among individuals, which engenders variable responses to immune perturbations in human populations. Population studies reveal that, in addition to interindividual heterogeneity, systemic imm…
View article: Additional file 1: of Clustering the autisms using glutamate synapse protein interaction networks from cortical and hippocampal tissue of seven mouse models
Additional file 1: of Clustering the autisms using glutamate synapse protein interaction networks from cortical and hippocampal tissue of seven mouse models Open
Table S1. Sheet 1:Â Log2 fold change (log2FC) matrices from Nâ =â 4 experiments were averaged to generate a single mean log2FC matrix per genotype/tissue type. Cells highlighed in red are ANC-significant, numbers in bold case indicate a fo…
View article: Multiplex matrix network analysis of protein complexes in the human TCR signalosome
Multiplex matrix network analysis of protein complexes in the human TCR signalosome Open
A multiplex antibody-mediated capture technique reveals patient-specific protein complexes.