Steven C. Zimmerman
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View article: Real-time Monitoring of the Reversible Capture and Release of CO2 on Anthraquinone and Riboflavin-Modified Graphitic Electrodes using ATR-SEIRAS
Real-time Monitoring of the Reversible Capture and Release of CO2 on Anthraquinone and Riboflavin-Modified Graphitic Electrodes using ATR-SEIRAS Open
Electrochemically mediated carbon capture (EMCC) offers a promising alternative to thermochemical carbon capture methods due to its higher energy efficiency and the ability to operate under standard conditions. Graphitic electrodes functio…
View article: Real-time monitoring of the reversible capture and release of CO <sub>2</sub> on anthraquinone and riboflavin-modified graphitic electrodes using ATR-SEIRAS
Real-time monitoring of the reversible capture and release of CO <sub>2</sub> on anthraquinone and riboflavin-modified graphitic electrodes using ATR-SEIRAS Open
In situ ATR-SEIRAS was used to monitor the real-time functionalization and reversible capture and release of CO 2 at the electrode/electrolyte interface from anthraquinone and 10-ethyl-3-methyl flavin derivative-modified graphitic electrod…
View article: Toward Polymeric Room Temperature Acid Generators
Toward Polymeric Room Temperature Acid Generators Open
Although a variety of acid‐generating molecules have been developed, the formation of toxic byproducts and the need for light‐activation or temperatures that may be incompatible with physiological conditions leave room for the optimization…
View article: Goals, challenges, and perspectives in chemical transformations within living systems
Goals, challenges, and perspectives in chemical transformations within living systems Open
Chemical transformations have been a central focus of chemistry for centuries, and the development of elegant catalytic systems working in live systems has recently distinguished them from traditional catalyst designs, enabling multifacete…
View article: Selective and Reversible Ligand Assembly on the DNA and RNA Repeat Sequences in Myotonic Dystrophy
Selective and Reversible Ligand Assembly on the DNA and RNA Repeat Sequences in Myotonic Dystrophy Open
Small molecule targeting of DNA and RNA sequences has come into focus as a therapeutic strategy for diseases such as myotonic dystrophy type 1 (DM1), a trinucleotide repeat disease characterized by RNA gain‐of‐function. Herein, we report a…
View article: A Novel Minor Groove Binder as a Potential Therapeutic Agent for Myotonic Dystrophy Type 1
A Novel Minor Groove Binder as a Potential Therapeutic Agent for Myotonic Dystrophy Type 1 Open
Myotonic dystrophy type 1 (DM1) is a multisystemic neuromuscular disorder that is inherited in an autosomal dominant manner. DM1 originates in a (CTG⋅CAG) repeat expansion in the 3’‐UTR of the dystrophia myotonic protein kinase ( DMPK ) ge…
View article: Versatile Target-Guided Screen for Discovering Bidirectional Transcription Inhibitors of a Trinucleotide Repeat Disease
Versatile Target-Guided Screen for Discovering Bidirectional Transcription Inhibitors of a Trinucleotide Repeat Disease Open
Myotonic dystrophy type 1 originates from d(CTG·CAG) repeats that undergo aberrant expansion during normal processing because the d(CTG) repeat forms stable hairpin structures. Bidirectional transcription of d(CTG·CAG) yields two RNA trans…
View article: CAG RNAs induce DNA damage and apoptosis by silencing <i>NUDT16</i> expression in polyglutamine degeneration
CAG RNAs induce DNA damage and apoptosis by silencing <i>NUDT16</i> expression in polyglutamine degeneration Open
Significance Small CAG (sCAG) RNAs are neurotoxic, but their role in polyglutamine degeneration remains to be fully elucidated. We observed that cellular expression of sCAGs is sufficient to induce neuronal DNA damage and discovered that t…
View article: End-of-life upcycling of robust polyurethanes using a room temperature, mechanism-based degradation
End-of-life upcycling of robust polyurethanes using a room temperature, mechanism-based degradation Open
A major challenge in developing recyclable polymeric materials is the inherent conflict between the properties required during and after its life span. In particular, materials must be strong and durable when in use, but undergo complete a…
View article: A polymeric approach toward resistance-resistant antimicrobial agent with dual-selective mechanisms of action
A polymeric approach toward resistance-resistant antimicrobial agent with dual-selective mechanisms of action Open
An oligoamidine with two bacteria-specific mechanisms of action showed broad-spectrum, resistance-resistant antimicrobial effect.
View article: Expanded DNA and RNA Trinucleotide Repeats in Myotonic Dystrophy Type 1 Select Their Own Multitarget, Sequence-Selective Inhibitors
Expanded DNA and RNA Trinucleotide Repeats in Myotonic Dystrophy Type 1 Select Their Own Multitarget, Sequence-Selective Inhibitors Open
There are few methods available for the rapid discovery of multitarget drugs. Herein, we describe the template-assisted, target-guided discovery of small molecules that recognize d(CTG) in the expanded d(CTG·CAG) sequence and its r(CUG) tr…
View article: A Bioorthogonal Small Molecule Selective Polymeric “Clickase”
A Bioorthogonal Small Molecule Selective Polymeric “Clickase” Open
Synthetic polymer scaffolds may serve as gatekeepers preventing the adhesion of biomacromolecules. Herein, we use gating to develop a copper-containing single-chain nanoparticle (SCNP) catalyst as an artificial "clickase" that operates sel…
View article: Structural Basis for Targeting T:T Mismatch with Triaminotriazine-Acridine Conjugate Induces a U-Shaped Head-to-Head Four-Way Junction in CTG Repeat DNA
Structural Basis for Targeting T:T Mismatch with Triaminotriazine-Acridine Conjugate Induces a U-Shaped Head-to-Head Four-Way Junction in CTG Repeat DNA Open
The potent DNA-binding compound triaminotriazine-acridine conjugate (Z1) functions by targeting T:T mismatches in CTG trinucleotide repeats that are responsible for causing neurological diseases such as myotonic dystrophy type 1, but its b…
View article: Intramolecularly Cross-Linked Polymers: From Structure to Function with Applications as Artificial Antibodies and Artificial Enzymes
Intramolecularly Cross-Linked Polymers: From Structure to Function with Applications as Artificial Antibodies and Artificial Enzymes Open
Cross-linking of polymers significantly alters their physical properties, greatly expanding their everyday utility. Indeed, the polymeric networks resulting from linkages between polymer chains are found in everyday materials from soft con…
View article: Single-Chain Nanoparticle Delivers a Partner Enzyme for Concurrent and Tandem Catalysis in Cells
Single-Chain Nanoparticle Delivers a Partner Enzyme for Concurrent and Tandem Catalysis in Cells Open
Combining synthetic chemistry and biocatalysis is a promising but underexplored approach to intracellular catalysis. We report a strategy to codeliver a single-chain nanoparticle (SCNP) catalyst and an exogenous enzyme into cells for perfo…
View article: Base-triggered self-amplifying degradable polyurethanes with the ability to translate local stimulation to continuous long-range degradation
Base-triggered self-amplifying degradable polyurethanes with the ability to translate local stimulation to continuous long-range degradation Open
A new type of base-triggered self-amplifying degradable polyurethane is reported that degrades under mild conditions, with the release of increasing amounts of amine product leading to self-amplified degradation.
View article: Independent control over size, valence, and elemental composition in the synthesis of DNA–nanoparticle conjugates
Independent control over size, valence, and elemental composition in the synthesis of DNA–nanoparticle conjugates Open
DNA–nanoparticle conjugates can be synthesized with independent control over size, valence and elemental composition using a template-based strategy.
View article: Structure of an RNA helix with pyrimidine mismatches and cross-strand stacking
Structure of an RNA helix with pyrimidine mismatches and cross-strand stacking Open
The structure of a 22-base-pair RNA helix with mismatched pyrimidine base pairs is reported. The helix contains two symmetry-related CUG sequences: a triplet-repeat motif implicated in myotonic dystrophy type 1. The CUG repeat contains a U…
View article: Intrinsically cell-penetrating multivalent and multitargeting ligands for myotonic dystrophy type 1
Intrinsically cell-penetrating multivalent and multitargeting ligands for myotonic dystrophy type 1 Open
Significance Multivalent ligands have tremendous potential as therapeutic agents; however, their efficacy is limited by delivery issues, poor cell permeability, and toxicity. We report here a strategy wherein multivalent ligands are design…
View article: Acid-Triggered, Acid-Generating, and Self-Amplifying Degradable Polymers
Acid-Triggered, Acid-Generating, and Self-Amplifying Degradable Polymers Open
We describe the 3-iodopropyl acetal moiety as a simple cleavable unit that undergoes acid catalyzed hydrolysis to liberate HI (p Ka ∼ -10) and acrolein stoichiometrically. Integrating this unit into linear and network polymers gives a clas…
View article: Engineering the Surface of Therapeutic “Living” Cells
Engineering the Surface of Therapeutic “Living” Cells Open
Biological cells are complex living machines that have garnered significant attention for their potential to serve as a new generation of therapeutic and delivery agents. Because of their secretion, differentiation, and homing activities, …
View article: Bottom-Up Strategy To Prepare Nanoparticles with a Single DNA Strand
Bottom-Up Strategy To Prepare Nanoparticles with a Single DNA Strand Open
We describe the preparation of cross-linked, polymeric organic nanoparticles (ONPs) with a single, covalently linked DNA strand. The structure and functionalities of the ONPs are controlled by the synthesis of their parent linear block cop…
View article: Patterning Three-Dimensional Hydrogel Microenvironments Using Hyperbranched Polyglycerols for Independent Control of Mesh Size and Stiffness
Patterning Three-Dimensional Hydrogel Microenvironments Using Hyperbranched Polyglycerols for Independent Control of Mesh Size and Stiffness Open
The extracellular matrix is an environment rich with structural, mechanical, and molecular signals that can impact cell biology. Traditional approaches in hydrogel biomaterial design often rely on modifying the concentration of cross-linki…
View article: Worm-Like Superparamagnetic Nanoparticle Clusters for Enhanced Adhesion and Magnetic Resonance Relaxivity
Worm-Like Superparamagnetic Nanoparticle Clusters for Enhanced Adhesion and Magnetic Resonance Relaxivity Open
Nanosized bioprobes that can highlight diseased tissue can be powerful diagnostic tools. However, a major unmet need is a tool with adequate adhesive properties and contrast-to-dose ratio. To this end, this study demonstrates that targeted…
View article: Supramolecular chemistry at the interface of biology, materials and medicine
Supramolecular chemistry at the interface of biology, materials and medicine Open
Keywords: biomimetic chemistry; host–guest chemistry; molecular recognition; molecular sensors