Steven Cepa
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View article: Supplementary Table S4 from Discovery and Characterization of Novel Nonsubstrate and Substrate NAMPT Inhibitors
Supplementary Table S4 from Discovery and Characterization of Novel Nonsubstrate and Substrate NAMPT Inhibitors Open
Structures and PC3 viability IC50 data for compounds in Figure 2.
View article: Supplementary Table S4 from Discovery and Characterization of Novel Nonsubstrate and Substrate NAMPT Inhibitors
Supplementary Table S4 from Discovery and Characterization of Novel Nonsubstrate and Substrate NAMPT Inhibitors Open
Structures and PC3 viability IC50 data for compounds in Figure 2.
View article: Wilsbacher et. al. supplement from Discovery and Characterization of Novel Nonsubstrate and Substrate NAMPT Inhibitors
Wilsbacher et. al. supplement from Discovery and Characterization of Novel Nonsubstrate and Substrate NAMPT Inhibitors Open
Supplementary methods, tables S1-S3, and supplementary figures 1-7
View article: Wilsbacher et. al. supplement from Discovery and Characterization of Novel Nonsubstrate and Substrate NAMPT Inhibitors
Wilsbacher et. al. supplement from Discovery and Characterization of Novel Nonsubstrate and Substrate NAMPT Inhibitors Open
Supplementary methods, tables S1-S3, and supplementary figures 1-7
View article: Data from Discovery and Characterization of Novel Nonsubstrate and Substrate NAMPT Inhibitors
Data from Discovery and Characterization of Novel Nonsubstrate and Substrate NAMPT Inhibitors Open
Cancer cells are highly reliant on NAD+-dependent processes, including glucose metabolism, calcium signaling, DNA repair, and regulation of gene expression. Nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzym…
View article: Data from Discovery and Characterization of Novel Nonsubstrate and Substrate NAMPT Inhibitors
Data from Discovery and Characterization of Novel Nonsubstrate and Substrate NAMPT Inhibitors Open
Cancer cells are highly reliant on NAD+-dependent processes, including glucose metabolism, calcium signaling, DNA repair, and regulation of gene expression. Nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzym…
View article: Novel Modes of Inhibition of Wild-Type Isocitrate Dehydrogenase 1 (IDH1): Direct Covalent Modification of His315
Novel Modes of Inhibition of Wild-Type Isocitrate Dehydrogenase 1 (IDH1): Direct Covalent Modification of His315 Open
IDH1 plays a critical role in a number of metabolic processes and serves as a key source of cytosolic NADPH under conditions of cellular stress. However, few inhibitors of wild-type IDH1 have been reported. Here we present the discovery an…
View article: Discovery and Characterization of Novel Nonsubstrate and Substrate NAMPT Inhibitors
Discovery and Characterization of Novel Nonsubstrate and Substrate NAMPT Inhibitors Open
Cancer cells are highly reliant on NAD+-dependent processes, including glucose metabolism, calcium signaling, DNA repair, and regulation of gene expression. Nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme for NAD+ …