Steven Dower
YOU?
Author Swipe
View article: A mechanistic model of in vitro plasma activation to evaluate therapeutic kallikrein-kinin system inhibitors
A mechanistic model of in vitro plasma activation to evaluate therapeutic kallikrein-kinin system inhibitors Open
Background The kallikrein-kinin system (KKS) is a complex biochemical pathway that plays a crucial role in regulating several physiological processes, including inflammation, coagulation, and blood pressure. Dysregulation of the KKS has be…
View article: The endosomal system of primary human vascular endothelial cells and albumin–FcRn trafficking
The endosomal system of primary human vascular endothelial cells and albumin–FcRn trafficking Open
Human serum albumin (HSA) has a long circulatory half-life owing, in part, to interaction with the neonatal Fc receptor (FcRn or FCGRT) in acidic endosomes and recycling of internalised albumin. Vascular endothelial and innate immune cells…
View article: FVIII half-life extension by coadministration of a D′D3 albumin fusion protein in mice, rabbits, rats, and monkeys
FVIII half-life extension by coadministration of a D′D3 albumin fusion protein in mice, rabbits, rats, and monkeys Open
A novel mechanism for extending the circulatory half-life of coagulation factor VIII (FVIII) has been established and evaluated preclinically. The FVIII binding domain of von Willebrand factor (D′D3) fused to human albumin (rD′D3-FP) dose …
View article: FcRn mediates fast recycling of endocytosed albumin and IgG from early macropinosomes in primary macrophages
FcRn mediates fast recycling of endocytosed albumin and IgG from early macropinosomes in primary macrophages Open
The neonatal Fc receptor (FcRn) rescues albumin and IgG from degradation following endocytosis and thereby extends the half-life of these plasma proteins. However, the pathways for the uptake of these soluble FcRn ligands, and the recyclin…
View article: Half-life–extended recombinant coagulation factor IX–albumin fusion protein is recycled via the FcRn-mediated pathway
Half-life–extended recombinant coagulation factor IX–albumin fusion protein is recycled via the FcRn-mediated pathway Open
The neonatal Fc receptor (FcRn) has a pivotal role in albumin and IgG homeostasis. Internalized IgG captured by FcRn under acidic endosomal conditions is recycled to the cell surface where exocytosis and a shift to neutral pH promote extra…