Steven Dykstra
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View article: Longitudinal Changes in Multiple Cardiac Biomarkers in Transthyretin Amyloidosis Cardiomyopathy Patients Treated Vs Untreated with Tafamidis
Longitudinal Changes in Multiple Cardiac Biomarkers in Transthyretin Amyloidosis Cardiomyopathy Patients Treated Vs Untreated with Tafamidis Open
NTproBNP level, troponin-T level, and New York Heart Association functional class remain stable over 1 year in a real-world cohort of tafamidis-treated ATTR-CM patients. These results may help inform therapeutic monitoring strategies in cl…
View article: Incremental Value of Bi-Ventricular Ejection Fraction (BiVEF) Phenotyping for the Discrimination of Heart Failure Symptoms and Clinical Outcomes: A Cardiovascular Magnetic Resonance Study of 9,437 Patients
Incremental Value of Bi-Ventricular Ejection Fraction (BiVEF) Phenotyping for the Discrimination of Heart Failure Symptoms and Clinical Outcomes: A Cardiovascular Magnetic Resonance Study of 9,437 Patients Open
Background Left ventricular ejection fraction (LVEF) continues to be employed as the principle phenotypic marker for the classification, prognostication, and management of cardiovascular disease. However, expanding evidence identifies simi…
View article: An institutional framework to support ethical fair and equitable artificial intelligence augmented care
An institutional framework to support ethical fair and equitable artificial intelligence augmented care Open
View article: Association of CMR-derived left ventricular filling pressure with adverse outcomes in a cardiovascular disease referral population: findings from the CIROC registry
Association of CMR-derived left ventricular filling pressure with adverse outcomes in a cardiovascular disease referral population: findings from the CIROC registry Open
View article: Phenotypic clustering of hypertrophic cardiomyopathy using 3D cardiac shape models and associations with future adverse outcomes
Phenotypic clustering of hypertrophic cardiomyopathy using 3D cardiac shape models and associations with future adverse outcomes Open
View article: AI-based discrimination of cardiac amyloidosis from hypertrophic cardiomyopathy using cardiac MRI 3D shape phenomics
AI-based discrimination of cardiac amyloidosis from hypertrophic cardiomyopathy using cardiac MRI 3D shape phenomics Open
View article: Derivation of a risk score for prediction of future adverse outcomes in asymptomatic hypertrophic cardiomyopathy patients from the CIROC registry
Derivation of a risk score for prediction of future adverse outcomes in asymptomatic hypertrophic cardiomyopathy patients from the CIROC registry Open
View article: Unsupervised phenotypic clustering in dilated and hypokinetic non-dilated forms of Non-ischemic cardiomyopathy and associations with future clinical outcomes
Unsupervised phenotypic clustering in dilated and hypokinetic non-dilated forms of Non-ischemic cardiomyopathy and associations with future clinical outcomes Open
View article: Baseline Predictors of Adverse Outcomes for Transthyretin Amyloidosis Cardiomyopathy Patients Treated and Untreated with Tafamidis: A Canadian Referral Center Experience
Baseline Predictors of Adverse Outcomes for Transthyretin Amyloidosis Cardiomyopathy Patients Treated and Untreated with Tafamidis: A Canadian Referral Center Experience Open
Background: Tafamidis is a costly therapy that improves outcomes for patients with transthyretin amyloidosis cardiomyopathy (ATTR-CM), although significant knowledge gaps exist for predicting longer-term response to treatment. The purpose …
View article: Exploration of Geometric Deep Learning FBom 3D Cardiac Shape Models for the Classification of Cardiac Amyloid Sub-type FBom 2D Cine Cardiovascular Magnetic Resonance Imaging
Exploration of Geometric Deep Learning FBom 3D Cardiac Shape Models for the Classification of Cardiac Amyloid Sub-type FBom 2D Cine Cardiovascular Magnetic Resonance Imaging Open
View article: Comparison of Multi-chamber CMR Phenotype and Clinical Outcomes in ATTR versus AL Cardiac Amyloidosis
Comparison of Multi-chamber CMR Phenotype and Clinical Outcomes in ATTR versus AL Cardiac Amyloidosis Open
View article: Artificial Intelligence-based Classification of ATTR versus AL Cardiac Amyloidosis by Cine-based 3D Shape Phenomics
Artificial Intelligence-based Classification of ATTR versus AL Cardiac Amyloidosis by Cine-based 3D Shape Phenomics Open
View article: Prevalence, Associations, and Prognostic Relevance of Right Ventricular Dysfunction in Patients with Chronic Ischemic Cardiomyopathy Undergoing Cardiovascular Magnetic Resonance Imaging
Prevalence, Associations, and Prognostic Relevance of Right Ventricular Dysfunction in Patients with Chronic Ischemic Cardiomyopathy Undergoing Cardiovascular Magnetic Resonance Imaging Open
View article: Left Atrial 4D Flow Characteristics in Patients with Atrial Fibrillation: Comparison with Healthy Controls and Associations with Left Atrial Remodelling and Contractile Health
Left Atrial 4D Flow Characteristics in Patients with Atrial Fibrillation: Comparison with Healthy Controls and Associations with Left Atrial Remodelling and Contractile Health Open
View article: Automated Cloud-deployable Pipeline for 3D Cardiac Shape Phenomics FBom 2D Cine Cardiac Magnetic Resonance Imaging
Automated Cloud-deployable Pipeline for 3D Cardiac Shape Phenomics FBom 2D Cine Cardiac Magnetic Resonance Imaging Open
View article: Biventricular CMR Strain-based Phenotyping for the Prediction of Cardiovascular Outcomes in Cardiac Amyloidosis
Biventricular CMR Strain-based Phenotyping for the Prediction of Cardiovascular Outcomes in Cardiac Amyloidosis Open
View article: PATIENTS WITH NON-ISCHEMIC CARDIOMYOPATHY AND MID-WALL STRIAE HAVE SIMILAR OUTCOMES AS PATIENTS WITH ISCHEMIC CARDIOMYOPATHY: A PROPENSITY-MATCHED ANALYSIS
PATIENTS WITH NON-ISCHEMIC CARDIOMYOPATHY AND MID-WALL STRIAE HAVE SIMILAR OUTCOMES AS PATIENTS WITH ISCHEMIC CARDIOMYOPATHY: A PROPENSITY-MATCHED ANALYSIS Open
View article: Machine learning prediction of atrial fibrillation in cardiovascular patients using cardiac magnetic resonance and electronic health information
Machine learning prediction of atrial fibrillation in cardiovascular patients using cardiac magnetic resonance and electronic health information Open
Background Atrial fibrillation (AF) is a commonly encountered cardiac arrhythmia associated with morbidity and substantial healthcare costs. While patients with cardiovascular disease experience the greatest risk of new-onset AF, no risk m…
View article: Natural History of Myocardial Injury After COVID-19 Vaccine–Associated Myocarditis
Natural History of Myocardial Injury After COVID-19 Vaccine–Associated Myocarditis Open
View article: Influence of Sex-Based Differences in Cardiac Phenotype on Atrial Fibrillation Recurrence in Patients Undergoing Pulmonary Vein Isolation
Influence of Sex-Based Differences in Cardiac Phenotype on Atrial Fibrillation Recurrence in Patients Undergoing Pulmonary Vein Isolation Open
Background Pulmonary vein isolation (PVI) is a commonly engaged therapy for symptomatic atrial fibrillation (AF). Prior studies have documented elevated AF recurrence rates among females vs. males. Sex-specific mechanisms underlying this p…
View article: Machine Learning Patient-Specific Prediction of Heart Failure Hospitalization Using Cardiac MRI-Based Phenotype and Electronic Health Information
Machine Learning Patient-Specific Prediction of Heart Failure Hospitalization Using Cardiac MRI-Based Phenotype and Electronic Health Information Open
Background Heart failure (HF) hospitalization is a dominant contributor of morbidity and healthcare expenditures in patients with systolic HF. Cardiovascular magnetic resonance (CMR) imaging is increasingly employed for the evaluation of H…
View article: Mid-wall striae fibrosis predicts heart failure admission, composite heart failure events, and life-threatening arrhythmias in dilated cardiomyopathy
Mid-wall striae fibrosis predicts heart failure admission, composite heart failure events, and life-threatening arrhythmias in dilated cardiomyopathy Open
View article: Prevalence and predictors of right ventricular dysfunction in cancer patients treated with cardiotoxic chemotherapy – a prospective cardiovascular magnetic resonance study
Prevalence and predictors of right ventricular dysfunction in cancer patients treated with cardiotoxic chemotherapy – a prospective cardiovascular magnetic resonance study Open
Background Right ventricular (RV) function has an established incremental prognostic value in cardiomyopathy. Studies on cancer therapeutics-related cardiac dysfunction (CTRCD) primarily focused on the left ventricle (LV), with conflicting…
View article: Effect of Active Cancer on the Cardiac Phenotype: A Cardiac Magnetic Resonance Imaging‐Based Study of Myocardial Tissue Health and Deformation in Patients With Chemotherapy‐Naïve Cancer
Effect of Active Cancer on the Cardiac Phenotype: A Cardiac Magnetic Resonance Imaging‐Based Study of Myocardial Tissue Health and Deformation in Patients With Chemotherapy‐Naïve Cancer Open
Background The overlap between cancer and cardiovascular care continues to expand, with intersections emerging before, during, and following cancer therapies. To date, emphasis has been placed on how cancer therapeutics influence downstrea…
View article: Right ventricular insertion site fibrosis in a dilated cardiomyopathy referral population: phenotypic associations and value for the prediction of heart failure admission or death
Right ventricular insertion site fibrosis in a dilated cardiomyopathy referral population: phenotypic associations and value for the prediction of heart failure admission or death Open
View article: Right Ventricular Ejection Fraction for the Prediction of Major Adverse Cardiovascular and Heart Failure-Related Events
Right Ventricular Ejection Fraction for the Prediction of Major Adverse Cardiovascular and Heart Failure-Related Events Open
Background: There is increasing evidence that right ventricular ejection fraction (RVEF) may provide incremental value to left ventricular (LV) ejection fraction for the prediction of major adverse cardiovascular events. To date, generaliz…
View article: Neural-Network-Based Diagnosis Using 3-Dimensional Myocardial Architecture and Deformation: Demonstration for the Differentiation of Hypertrophic Cardiomyopathy
Neural-Network-Based Diagnosis Using 3-Dimensional Myocardial Architecture and Deformation: Demonstration for the Differentiation of Hypertrophic Cardiomyopathy Open
The diagnosis of cardiomyopathy states may benefit from machine-learning (ML) based approaches, particularly to distinguish those states with similar phenotypic characteristics. Three-dimensional myocardial deformation analysis (3D-MDA) ha…
View article: Identifying the value of RVEF for the prediction of major cardiovascular outcomes: a study of 7,131 patients undergoing cardiovascular magnetic resonance imaging
Identifying the value of RVEF for the prediction of major cardiovascular outcomes: a study of 7,131 patients undergoing cardiovascular magnetic resonance imaging Open
Background Right ventricular (RV) function remains poorly recognized for its value in predicting cardiovascular events at a population level. Cardiovascular Magnetic Resonance (CMR) imaging is the gold standard for RV assessment. Purpose T…
View article: Prognostic Value of Late Gadolinium Enhancement for the Prediction of Cardiovascular Outcomes in Dilated Cardiomyopathy
Prognostic Value of Late Gadolinium Enhancement for the Prediction of Cardiovascular Outcomes in Dilated Cardiomyopathy Open
Background: Dilated cardiomyopathy is associated with increased risk of major cardiovascular events. Late gadolinium enhancement (LGE) cardiac magnetic resonance imaging is a unique tissue-based marker that, in single-center studies, sugge…
View article: Scientific Minimalism and the Division of Moral Labor in Regulating Dual-Use Research
Scientific Minimalism and the Division of Moral Labor in Regulating Dual-Use Research Open
: In this paper I examine the merits of a “division ofmoral labor” regulatory system for dual-use research. I borrow anargument from Thomas Douglas against scientific isolationism toshow that researchers must be morally responsible for res…