Steven E. Artandi
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View article: Mouse lemur cell atlas informs primate genes, physiology and disease
Mouse lemur cell atlas informs primate genes, physiology and disease Open
View article: Development and implementation of cancer clinical trial patient screening using an electronic medical record-integrated trial matching system
Development and implementation of cancer clinical trial patient screening using an electronic medical record-integrated trial matching system Open
Objectives Clinical trial enrolment is critical for the development and approval of novel cancer therapeutics, but patient identification and recruitment to clinical trials remains low and multiple trials accrue slowly or fail to meet accr…
View article: Clonal inactivation of TERT impairs stem cell competition
Clonal inactivation of TERT impairs stem cell competition Open
View article: Digital telomere measurement by long-read sequencing distinguishes healthy aging from disease
Digital telomere measurement by long-read sequencing distinguishes healthy aging from disease Open
View article: Targeted replacement of full-length CFTR in human airway stem cells by CRISPR-Cas9 for pan-mutation correction in the endogenous locus
Targeted replacement of full-length CFTR in human airway stem cells by CRISPR-Cas9 for pan-mutation correction in the endogenous locus Open
Cystic fibrosis (CF) is a monogenic disease caused by impaired production and/or function of the CF transmembrane conductance regulator (CFTR) protein. Although we have previously shown correction of the most common pathogenic mutation, th…
View article: Tert-expressing cells contribute to salivary gland homeostasis and tissue regeneration after radiation therapy
Tert-expressing cells contribute to salivary gland homeostasis and tissue regeneration after radiation therapy Open
Salivary gland homeostasis and regeneration after radiotherapy depend significantly on progenitor cells. However, the lineage of submandibular gland (SMG) progenitor cells remains less defined compared with other normal organs. Here, using…
View article: An organism-wide atlas of hormonal signaling based on the mouse lemur single-cell transcriptome
An organism-wide atlas of hormonal signaling based on the mouse lemur single-cell transcriptome Open
View article: Erratum. Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases: Workshop Proceedings. Diabetes 2023;72:433–448
Erratum. Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases: Workshop Proceedings. Diabetes 2023;72:433–448 Open
In the article cited above, the affiliations for authors Stephen J. Pandol and Maike Sander were inadvertently transposed. The correct affiliation for Stephen J. Pandol is Department of Gastroenterology, Cedars-Sinai Medical Center, Los An…
View article: Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases: Workshop Proceedings
Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases: Workshop Proceedings Open
The Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases workshop was a 1.5-day scientific conference at the National Institutes of Health (Bethesda, MD) that engaged clinical and basic science investigat…
View article: TRF2 rescues telomere attrition and prolongs cell survival in Duchenne muscular dystrophy cardiomyocytes derived from human iPSCs
TRF2 rescues telomere attrition and prolongs cell survival in Duchenne muscular dystrophy cardiomyocytes derived from human iPSCs Open
Duchenne muscular dystrophy (DMD) is a severe muscle wasting disease caused by the lack of dystrophin. Heart failure, driven by cardiomyocyte death, fibrosis, and the development of dilated cardiomyopathy, is the leading cause of death in …
View article: Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases
Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases Open
The “Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases” Workshop was a 1.5-day scientific conference at the National Institutes of Health (Bethesda, MD) that engaged clinical and basic science investig…
View article: TGS1 impacts snRNA 3′-end processing, ameliorates <i>survival motor neuron</i>-dependent neurological phenotypes <i>in vivo</i> and prevents neurodegeneration
TGS1 impacts snRNA 3′-end processing, ameliorates <i>survival motor neuron</i>-dependent neurological phenotypes <i>in vivo</i> and prevents neurodegeneration Open
Trimethylguanosine synthase 1 (TGS1) is a highly conserved enzyme that converts the 5′-monomethylguanosine cap of small nuclear RNAs (snRNAs) to a trimethylguanosine cap. Here, we show that loss of TGS1 in Caenorhabditis elegans, Drosophil…
View article: Tabula Microcebus: A transcriptomic cell atlas of mouse lemur, an emerging primate model organism
Tabula Microcebus: A transcriptomic cell atlas of mouse lemur, an emerging primate model organism Open
Mouse lemurs are the smallest, fastest reproducing, and among the most abundant primates, and an emerging model organism for primate biology, behavior, health and conservation. Although much has been learned about their physiology and thei…
View article: The S‐adenosylmethionine analog sinefungin inhibits the trimethylguanosine synthase TGS1 to promote telomerase activity and telomere lengthening
The S‐adenosylmethionine analog sinefungin inhibits the trimethylguanosine synthase TGS1 to promote telomerase activity and telomere lengthening Open
Mutations in many genes that control the expression, the function, or the stability of telomerase cause telomere biology disorders (TBDs), such as dyskeratosis congenita, pulmonary fibrosis, and aplastic anemia. Mutations in a subset of th…
View article: Systemic delivery of a targeted synthetic immunostimulant transforms the immune landscape for effective tumor regression
Systemic delivery of a targeted synthetic immunostimulant transforms the immune landscape for effective tumor regression Open
View article: 768 Systemic delivery of a tumor-targeted TLR9 agonist conjugate transforms the tumor immune landscape and induces tumor regression in mice
768 Systemic delivery of a tumor-targeted TLR9 agonist conjugate transforms the tumor immune landscape and induces tumor regression in mice Open
Background Tumor-localized delivery of Toll-like receptor (TLR) agonists is a promising strategy to promote immune activation within the tumor microenvironment (TME) to overcome tumor immunosuppression and induce anti-tumor immune response…
View article: Acinar cell clonal expansion in pancreas homeostasis and carcinogenesis
Acinar cell clonal expansion in pancreas homeostasis and carcinogenesis Open
View article: Tissue-specific telomere shortening and degenerative changes in a patient with TINF2 mutation and dyskeratosis congenita
Tissue-specific telomere shortening and degenerative changes in a patient with TINF2 mutation and dyskeratosis congenita Open
Dyskeratosis congenita is a disease of impaired tissue maintenance downstream of telomere dysfunction. Characteristically, patients present with the clinical triad of nail dystrophy, oral leukoplakia, and skin pigmentation defects, but the…
View article: Clonal inactivation of telomerase promotes accelerated stem cell differentiation
Clonal inactivation of telomerase promotes accelerated stem cell differentiation Open
Summary Telomerase is intimately associated with stem cells and upregulated in cancer, where it serves essential roles through its catalytic action in elongating telomeres, nucleoprotein caps that protect chromosome ends 1 . Overexpression…
View article: Analysis of RNA conformation in endogenously assembled RNPs by icSHAPE
Analysis of RNA conformation in endogenously assembled RNPs by icSHAPE Open
View article: Targeted replacement of full-length CFTR in human airway stem cells by CRISPR-Cas9 for pan-mutation correction in the endogenous locus
Targeted replacement of full-length CFTR in human airway stem cells by CRISPR-Cas9 for pan-mutation correction in the endogenous locus Open
View article: Targeted replacement of full-length CFTR in human airway stem cells by CRISPR/Cas9 for pan-mutation correction in the endogenous locus
Targeted replacement of full-length CFTR in human airway stem cells by CRISPR/Cas9 for pan-mutation correction in the endogenous locus Open
Cystic fibrosis (CF) is a monogenic disease caused by impaired production and/or function of the cystic fibrosis transmembrane conductance regulator (CFTR) protein. Although we have previously shown correction of the most common pathogenic…
View article: A novel DDB2 mutation causes defective recognition of UV-induced DNA damages and prevalent equine squamous cell carcinoma
A novel DDB2 mutation causes defective recognition of UV-induced DNA damages and prevalent equine squamous cell carcinoma Open
View article: Regulation of human telomerase in homeostasis and disease
Regulation of human telomerase in homeostasis and disease Open
View article: Loss of Human TGS1 Hypermethylase Promotes Increased Telomerase RNA and Telomere Elongation
Loss of Human TGS1 Hypermethylase Promotes Increased Telomerase RNA and Telomere Elongation Open
View article: Abstract 4521: Mutant Kras expression triggers clonal acinar cell expansion as an early step in pancreas cancer
Abstract 4521: Mutant Kras expression triggers clonal acinar cell expansion as an early step in pancreas cancer Open
Pancreatic ductal adenocarcinoma (PDA) is the third leading cause of cancer-related deaths in the United States with the lowest 5-year survival rate of any major cancer, in part due to late detection of the disease. Studies indicate that p…
View article: Disruption of Telomerase RNA Maturation Kinetics Precipitates Disease
Disruption of Telomerase RNA Maturation Kinetics Precipitates Disease Open
View article: HiChIRP: RNA-centric chromatin conformation
HiChIRP: RNA-centric chromatin conformation Open
View article: An Activity Switch in Human Telomerase Based on RNA Conformation and Shaped by TCAB1
An Activity Switch in Human Telomerase Based on RNA Conformation and Shaped by TCAB1 Open
View article: Distributed hepatocytes expressing telomerase repopulate the liver in homeostasis and injury
Distributed hepatocytes expressing telomerase repopulate the liver in homeostasis and injury Open