Steven E. Kahn
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View article: Semaglutide and Hospitalizations in Patients With Obesity and Established Cardiovascular Disease
Semaglutide and Hospitalizations in Patients With Obesity and Established Cardiovascular Disease Open
Importance The primary analysis of the SELECT randomized clinical trial suggests that semaglutide reduced the rates of cardiovascular (CV) death, myocardial infarction, and stroke in patients with established CV disease (CVD) and overweigh…
View article: Cardiovascular Outcomes with Tirzepatide versus Dulaglutide in Type 2 Diabetes
Cardiovascular Outcomes with Tirzepatide versus Dulaglutide in Type 2 Diabetes Open
Among patients with type 2 diabetes and atherosclerotic cardiovascular disease, tirzepatide was noninferior to dulaglutide with respect to a composite of death from cardiovascular causes, myocardial infarction, or stroke. (Funded by Eli Li…
View article: Neuronal extracellular vesicle biomarkers of dysregulated insulin signaling and Alzheimer’s disease are strongly associated in prediabetes and type 2 diabetes
Neuronal extracellular vesicle biomarkers of dysregulated insulin signaling and Alzheimer’s disease are strongly associated in prediabetes and type 2 diabetes Open
Background Dysregulated insulin signaling in the IRS‐1/Akt/mTOR pathway underlies insulin resistance in prediabetes (PreD) and type 2 diabetes (T2D) and may contribute to the pathogenesis of Alzheimer’s disease and related dementias (AD/AD…
View article: Common genetic variants near <i>SLC2A2</i> and glycemic response to glimepiride in the GRADE comparative effectiveness clinical trial
Common genetic variants near <i>SLC2A2</i> and glycemic response to glimepiride in the GRADE comparative effectiveness clinical trial Open
Optimizing second-line therapy for type 2 diabetes is challenging due to interindividual variability in response. We conducted a pharmacogenomic genome-wide association study (GWAS) in the Glycemia Reduction Approaches in Type 2 Diabetes: …
View article: Impact of Parental or First-Degree Family History of Diabetes on Diabetes Incidence and Progression During Long-term Follow-up in the Diabetes Prevention Program Outcomes Study
Impact of Parental or First-Degree Family History of Diabetes on Diabetes Incidence and Progression During Long-term Follow-up in the Diabetes Prevention Program Outcomes Study Open
OBJECTIVE To determine the effects of first-degree family history of diabetes on diabetes incidence in Diabetes Prevention Program (DPP) and Diabetes Prevention Program Outcomes Study (DPPOS) participants. RESEARCH DESIGN AND METHODS In th…
View article: <b>Impact of Parental or First-Degree Family History of Diabetes on Diabetes Incidence and Progression during Long-term Follow-up in the Diabetes Prevention Program Outcomes Study</b>
<b>Impact of Parental or First-Degree Family History of Diabetes on Diabetes Incidence and Progression during Long-term Follow-up in the Diabetes Prevention Program Outcomes Study</b> Open
OBJECTIVETo determine the effects of first-degree family history of diabetes on diabetes incidence in Diabetes Prevention Program (DPP)/DPP Outcomes Study (DPPOS) participants.RESEARCH DESIGN AND METHODSThe DPP randomized adults with predi…
View article: <b>Impact of Parental or First-Degree Family History of Diabetes on Diabetes Incidence and Progression during Long-term Follow-up in the Diabetes Prevention Program Outcomes Study</b>
<b>Impact of Parental or First-Degree Family History of Diabetes on Diabetes Incidence and Progression during Long-term Follow-up in the Diabetes Prevention Program Outcomes Study</b> Open
OBJECTIVETo determine the effects of first-degree family history of diabetes on diabetes incidence in Diabetes Prevention Program (DPP)/DPP Outcomes Study (DPPOS) participants.RESEARCH DESIGN AND METHODSThe DPP randomized adults with predi…
View article: Analysis of long-term follow-up of a randomized clinical trial with departures from assigned treatments: Estimation of metformin effects on diabetes and its complications in the Diabetes Prevention Program Outcomes Study
Analysis of long-term follow-up of a randomized clinical trial with departures from assigned treatments: Estimation of metformin effects on diabetes and its complications in the Diabetes Prevention Program Outcomes Study Open
The Diabetes Prevention Program (DPP) was a 3-year randomized clinical trial evaluating lifestyle and metformin interventions compared with placebo for diabetes prevention in high-risk adults. Both interventions significantly reduced diabe…
View article: Analysis of long-term follow-up of a randomized clinical trial with departures from assigned treatments: Estimation of metformin effects on diabetes and its complications in the Diabetes Prevention Program Outcomes Study
Analysis of long-term follow-up of a randomized clinical trial with departures from assigned treatments: Estimation of metformin effects on diabetes and its complications in the Diabetes Prevention Program Outcomes Study Open
The Diabetes Prevention Program (DPP) was a 3-year randomized clinical trial evaluating lifestyle and metformin interventions compared with placebo for diabetes prevention in high-risk adults. Both interventions significantly reduced diabe…
View article: Analysis of Long-term Follow-up of a Randomized Clinical Trial With Departures From Assigned Treatments: Estimation of Metformin Effects on Diabetes and Its Complications in the Diabetes Prevention Program Outcomes Study
Analysis of Long-term Follow-up of a Randomized Clinical Trial With Departures From Assigned Treatments: Estimation of Metformin Effects on Diabetes and Its Complications in the Diabetes Prevention Program Outcomes Study Open
The Diabetes Prevention Program (DPP) was a 3-year randomized clinical trial (RCT) with evaluation of lifestyle and metformin interventions compared with placebo for diabetes prevention in high-risk adults. Both interventions significantly…
View article: Effect of obesity on the acute response to SARS-CoV-2 infection and development of post-acute sequelae of COVID-19 (PASC) in nonhuman primates
Effect of obesity on the acute response to SARS-CoV-2 infection and development of post-acute sequelae of COVID-19 (PASC) in nonhuman primates Open
Long-term adverse consequences of SARS-CoV-2 infection, termed “long COVID” or post-acute sequelae of COVID (PASC), are a major component of overall COVID-19 disease burden. Prior obesity and metabolic disease increase the severity of acut…
View article: Predictors of Initial and Sustained Glycemic and Weight Response to Tirzepatide: A Post Hoc Analysis of SURPASS-4
Predictors of Initial and Sustained Glycemic and Weight Response to Tirzepatide: A Post Hoc Analysis of SURPASS-4 Open
This post hoc analysis assessed sustainability of lowered glycated hemoglobin (HbA1c) and weight with tirzepatide in people with type 2 diabetes and increased cardiovascular risk. Participants achieving HbA1c ≤48 mmol/mol (6.5%) or weight …
View article: <b>Predictors of initial and sustained glycemic and weight response to tirzepatide: a post hoc analysis of SURPASS-4</b>
<b>Predictors of initial and sustained glycemic and weight response to tirzepatide: a post hoc analysis of SURPASS-4</b> Open
This post hoc analysis assessed sustainability of lowered HbA1c and weight with tirzepatide in people with type 2 diabetes and increased cardiovascular risk. Participants achieving HbA1c ≤48 mmol/mol (6.5%) or weight loss ≥10% at 52 weeks …
View article: <b>Predictors of initial and sustained glycemic and weight response to tirzepatide: a post hoc analysis of SURPASS-4</b>
<b>Predictors of initial and sustained glycemic and weight response to tirzepatide: a post hoc analysis of SURPASS-4</b> Open
This post hoc analysis assessed sustainability of lowered HbA1c and weight with tirzepatide in people with type 2 diabetes and increased cardiovascular risk. Participants achieving HbA1c ≤48 mmol/mol (6.5%) or weight loss ≥10% at 52 weeks …
View article: Inadequately controlled type 2 diabetes and hypercortisolism: improved glycemia with mifepristone treatment
Inadequately controlled type 2 diabetes and hypercortisolism: improved glycemia with mifepristone treatment Open
Objective: In many individuals, type 2 diabetes (T2D) remains poorly controlled despite taking multiple glucose-lowering therapies. Several studies have demonstrated that endogenous hypercortisolism is prevalent among these individuals. We…
View article: Inadequately controlled type 2 diabetes and hypercortisolism: improved glycemia with mifepristone treatment
Inadequately controlled type 2 diabetes and hypercortisolism: improved glycemia with mifepristone treatment Open
Objective: In many individuals, type 2 diabetes (T2D) remains poorly controlled despite taking multiple glucose-lowering therapies. Several studies have demonstrated that endogenous hypercortisolism is prevalent among these individuals. We…
View article: Inadequately Controlled Type 2 Diabetes and Hypercortisolism: Improved Glycemia With Mifepristone Treatment
Inadequately Controlled Type 2 Diabetes and Hypercortisolism: Improved Glycemia With Mifepristone Treatment Open
OBJECTIVE In many individuals, type 2 diabetes (T2D) remains poorly controlled despite taking multiple glucose-lowering therapies. Several studies have demonstrated that endogenous hypercortisolism is prevalent among these individuals. We …
View article: Youth-Onset Type 2 Diabetes: What We’ve Learned From Key Youth-Onset Type 2 Diabetes Studies, What We Still Don’t Know, and Why It Is Important
Youth-Onset Type 2 Diabetes: What We’ve Learned From Key Youth-Onset Type 2 Diabetes Studies, What We Still Don’t Know, and Why It Is Important Open
In this review, we describe the epidemiology, pathophysiology, pediatric-specific treatment response data, morbidity, and mortality of youth-onset type 2 diabetes. In recognition of the National Institute of Diabetes and Digestive and Kidn…
View article: The Normal 93: Linking the β-Cell and Insulin Sensitivity: Revisiting a 1993 <i>Diabetes</i> Classic by Kahn et al.
The Normal 93: Linking the β-Cell and Insulin Sensitivity: Revisiting a 1993 <i>Diabetes</i> Classic by Kahn et al. Open
In this month’s Classics in Diabetes featured article, published in Diabetes in 1993, the description by Kahn et al. of the relationship between insulin secretion and insulin sensitivity in 93 healthy adults without diabetes provided a mod…
View article: Prevalence of Hypercortisolism in Difficult-to-Control Type 2 Diabetes
Prevalence of Hypercortisolism in Difficult-to-Control Type 2 Diabetes Open
OBJECTIVE Despite the use of multiple glucose-lowering medications, glycemic targets are not met in a significant fraction of people with type 2 diabetes. In this prospective, observational study we assessed the prevalence of hypercortisol…
View article: Prevalence of Hypercortisolism in Difficult-to-Control Type 2 Diabetes
Prevalence of Hypercortisolism in Difficult-to-Control Type 2 Diabetes Open
Objective: Despite the use of multiple glucose-lowering medications, a significant fraction of individuals with type 2 diabetes (T2D) do not meet glycemic targets. This prospective, observational study assessed the prevalence of hypercorti…
View article: Prevalence of Hypercortisolism in Difficult-to-Control Type 2 Diabetes
Prevalence of Hypercortisolism in Difficult-to-Control Type 2 Diabetes Open
Objective: Despite the use of multiple glucose-lowering medications, a significant fraction of individuals with type 2 diabetes (T2D) do not meet glycemic targets. This prospective, observational study assessed the prevalence of hypercorti…
View article: Effect of obesity on the acute response to SARS-CoV-2 infection and development of post-acute sequelae of COVID-19 (PASC) in nonhuman primates
Effect of obesity on the acute response to SARS-CoV-2 infection and development of post-acute sequelae of COVID-19 (PASC) in nonhuman primates Open
Long-term adverse consequences of SARS-CoV-2 infection, termed “long COVID” or post-acute sequelae of COVID (PASC), are a major component of overall COVID-19 disease burden. Prior obesity and metabolic disease increase the severity of acut…