Steven E. Kirberger
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View article: Genetically encoded discovery of perfluoroaryl macrocycles that bind to albumin and exhibit extended circulation in vivo
Genetically encoded discovery of perfluoroaryl macrocycles that bind to albumin and exhibit extended circulation in vivo Open
Peptide-based therapeutics have gained attention as promising therapeutic modalities, however, their prevalent drawback is poor circulation half-life in vivo. In this paper, we report the selection of albumin-binding macrocyclic peptides f…
View article: Design of Highly Fluorinated Peptides for Cell-based <sup>19</sup>F NMR
Design of Highly Fluorinated Peptides for Cell-based <sup>19</sup>F NMR Open
The design of imaging agents with high fluorine content is essential for overcoming the challenges associated with signal detection limits in 19F MRI-based molecular imaging. In addition to perfluorocarbon and fluorinated polymers, fluorin…
View article: Genetically-Encoded Discovery of Perfluoroaryl-Macrocycles that Bind to Albumin and Exhibit Extended Circulation in-vivo.
Genetically-Encoded Discovery of Perfluoroaryl-Macrocycles that Bind to Albumin and Exhibit Extended Circulation in-vivo. Open
In this paper, we report selection of albumin-binding macrocyclic peptides from genetically encoded libraries of peptides modified by perfluoroaryl-cysteine SNAr chemistry. Modification of phage-displayed libraries SXCXnC-phage,n = 3–5, wh…
View article: Genetically-Encoded Discovery of Perfluoroaryl-Macrocycles that Bind to Albumin and Exhibit Extended Circulation<i>in-vivo</i>
Genetically-Encoded Discovery of Perfluoroaryl-Macrocycles that Bind to Albumin and Exhibit Extended Circulation<i>in-vivo</i> Open
In this paper, we report selection of albumin-binding macrocyclic peptides from genetically encoded libraries of peptides modified by perfluoroaryl-cysteine S N Ar chemistry. Modification of phage-displayed libraries SXCX n C-phage, n =3–5…
View article: Correction to “Efficient Synthesis of 1,4-Thiazepanones and 1,4-Thiazepanes as 3D-Fragments for Screening Libraries”
Correction to “Efficient Synthesis of 1,4-Thiazepanones and 1,4-Thiazepanes as 3D-Fragments for Screening Libraries” Open
ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionCorrection to "Efficient Synthesis of 1,4-Thiazepanones and 1,4-Thiazepanes as 3D-Fragments for Screening Libraries"Anil K. PandeyAnil K. Pa…
View article: Efficient Synthesis of 1,4-Thiazepanones and 1,4-Thiazepanes as 3D Fragments for Screening Libraries
Efficient Synthesis of 1,4-Thiazepanones and 1,4-Thiazepanes as 3D Fragments for Screening Libraries Open
1,4-Thiazepanes and 1,4-thiazepanones represent seven-membered ring systems with highly 3D character and are currently underrepresented in fragment screening libraries. A nuclear magnetic resonance (NMR) fragment screen identified 1,4-acyl…
View article: Evaluating the Advantages of Using 3D-Enriched Fragments for Targeting BET Bromodomains
Evaluating the Advantages of Using 3D-Enriched Fragments for Targeting BET Bromodomains Open
Fragment-based ligand discovery has been successful in targeting diverse proteins. Despite drug-like molecules having more 3D character, traditional fragment libraries are largely composed of flat, aromatic fragments. The use of 3D-enriche…
View article: SAR by (Protein-Observed) <sup>19</sup>F NMR
SAR by (Protein-Observed) <sup>19</sup>F NMR Open
Inhibitor discovery for protein-protein interactions has proven difficult due to the large protein surface areas and dynamic interfaces involved. This is particularly the case when targeting transcription-factor-protein interactions. To ad…
View article: BPTF Maintains Chromatin Accessibility and the Self-Renewal Capacity of Mammary Gland Stem Cells
BPTF Maintains Chromatin Accessibility and the Self-Renewal Capacity of Mammary Gland Stem Cells Open
Chromatin remodeling is a key requirement for transcriptional control of cellular differentiation. However, the factors that alter chromatin architecture in mammary stem cells (MaSCs) are poorly understood. Here, we show that BPTF, the lar…
View article: Synthesis of Intrinsically Disordered Fluorinated Peptides for Modular Design of High‐Signal <sup>19</sup>F MRI Agents
Synthesis of Intrinsically Disordered Fluorinated Peptides for Modular Design of High‐Signal <sup>19</sup>F MRI Agents Open
19 F MRI is valuable for in vivo imaging due to the only trace amounts of fluorine in biological systems. Because of the low sensitivity of MRI however, designing new fluorochemicals remains a significant challenge for achieving sufficient…