Steven E. Mather
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View article: The pH-sensitive translocation of V-ATPase in the small airway of cystic fibrosis pigs
The pH-sensitive translocation of V-ATPase in the small airway of cystic fibrosis pigs Open
In this study, we describe that vacuolar-type H + ATPase (V-ATPase) internalizes when the airway surface liquid (ASL) pH in pig small airways is less than 7.10. Furthermore, we found that V-ATPase is not localized to the apical membrane in…
View article: WNK Inhibition Increases Surface Liquid pH and Host Defense in Cystic Fibrosis Airway Epithelia
WNK Inhibition Increases Surface Liquid pH and Host Defense in Cystic Fibrosis Airway Epithelia Open
In cystic fibrosis (CF), reduced HCO3- secretion acidifies the airway surface liquid (ASL), and the acidic pH disrupts host defenses. Thus, understanding the control of ASL pH (pHASL) in CF may help identify novel targets and facilitate th…
View article: Transduction of Pig Small Airway Epithelial Cells and Distal Lung Progenitor Cells by AAV4
Transduction of Pig Small Airway Epithelial Cells and Distal Lung Progenitor Cells by AAV4 Open
Cystic fibrosis (CF) is caused by genetic mutations of the CF transmembrane conductance regulator (CFTR), leading to disrupted transport of Cl− and bicarbonate and CF lung disease featuring bacterial colonization and chronic infection in c…
View article: V-Type ATPase Mediates Airway Surface Liquid Acidification in Pig Small Airway Epithelial Cells
V-Type ATPase Mediates Airway Surface Liquid Acidification in Pig Small Airway Epithelial Cells Open
In a newborn pig cystic fibrosis (CF) model, the ability of gland-containing airways to fight infection was affected by at least two major host-defense defects: impaired mucociliary transport and a lower airway surface liquid (ASL) pH. In …
View article: Topography-dependent gene expression and function of common cell archetypes in large and small porcine airways
Topography-dependent gene expression and function of common cell archetypes in large and small porcine airways Open
Summary The small airways of humans are affected early in several lung diseases. However, because they are relatively inaccessible, little is known about the epithelial cells that line these airways. We performed a single cell RNA-seq cens…
View article: Lack of airway submucosal glands impairs respiratory host defenses
Lack of airway submucosal glands impairs respiratory host defenses Open
Submucosal glands (SMGs) are a prominent structure that lines human cartilaginous airways. Although it has been assumed that SMGs contribute to respiratory defense, that hypothesis has gone without a direct test. Therefore, we studied pigs…