Steven E. Whitesall
YOU?
Author Swipe
View article: Myeloid interleukin-4 receptor α is essential in postmyocardial infarction healing by regulating inflammation and fibrotic remodeling
Myeloid interleukin-4 receptor α is essential in postmyocardial infarction healing by regulating inflammation and fibrotic remodeling Open
This study showed, for the first time, the role of endogenous IL4Rα signaling in myeloid cells during cardiac remodeling and the underlying mechanisms. We identified myeloid cells are the critical target cell types of IL4Rα signaling durin…
View article: Potential role of intermittent functioning of baroreflexes in the etiology of hypertension in spontaneously hypertensive rats
Potential role of intermittent functioning of baroreflexes in the etiology of hypertension in spontaneously hypertensive rats Open
The spontaneously hypertensive rat (SHR) is a genetic model of primary hypertension with an etiology that includes sympathetic overdrive. To elucidate the neurogenic mechanisms underlying the pathophysiology of this model, we analyzed the …
View article: Enhanced dimethylarginine degradation improves coronary flow reserve and exercise tolerance in Duchenne muscular dystrophy carrier mice
Enhanced dimethylarginine degradation improves coronary flow reserve and exercise tolerance in Duchenne muscular dystrophy carrier mice Open
Duchenne muscular dystrophy (DMD) carriers are at risk for cardiomyopathy. The nitric oxide synthase inhibitor asymmetric dimethylarginine (ADMA) is released from damaged muscle in DMD and impairs exercise performance. Transgenic expressio…
View article: Impaired Myocardial Energetics Causes Mechanical Dysfunction in Decompensated Failing Hearts
Impaired Myocardial Energetics Causes Mechanical Dysfunction in Decompensated Failing Hearts Open
Cardiac mechanical function is supported by ATP hydrolysis, which provides the chemical-free energy to drive the molecular processes underlying cardiac pumping. Physiological rates of myocardial ATP consumption require the heart to resynth…
View article: Continuous glucose monitoring reveals glycemic variability and hypoglycemia after vertical sleeve gastrectomy in rats
Continuous glucose monitoring reveals glycemic variability and hypoglycemia after vertical sleeve gastrectomy in rats Open
Rat bariatric surgery duplicates many features of human post-bariatric surgery hypoglycemia including postprandial hypoglycemia and glycemic variability, while blockade of GLP-1R signaling prevents hypoglycemia but not the variability.
View article: Computational analysis of continuous body temperature provides early discrimination of graft-versus-host disease in mice
Computational analysis of continuous body temperature provides early discrimination of graft-versus-host disease in mice Open
Key Points Unsupervised machine learning analysis of continuous body temperature data revealed early signals of aGVHD in allo-HCT mice. Continuous measurement of body temperature is promising for early prediction of aGVHD in human allo-HCT…
View article: Sap97 Expression is Important for Heart Rate Control in the Murine Sinus Node
Sap97 Expression is Important for Heart Rate Control in the Murine Sinus Node Open
View article: Differential impact of type-1 and type-2 diabetes on control of heart rate in mice
Differential impact of type-1 and type-2 diabetes on control of heart rate in mice Open
View article: Ambient Light Promotes Selective Subcellular Proteotoxicity after Endogenous and Exogenous Porphyrinogenic Stress
Ambient Light Promotes Selective Subcellular Proteotoxicity after Endogenous and Exogenous Porphyrinogenic Stress Open
View article: Packed Red Blood Cells Are an Abundant and Proximate Potential Source of Nitric Oxide Synthase Inhibition
Packed Red Blood Cells Are an Abundant and Proximate Potential Source of Nitric Oxide Synthase Inhibition Open
The compelling physiological ramifications are that regardless of storage age, 1) PRBCs can rapidly release pathologically relevant quantities of ADMA and LNMMA when incubated and 2) PRBCs have a protein-incorporated inhibitory methylargin…