Explanipedia

Remote Preconditioning Provides Protection Against Retinal Cell Death From Retinal Detachment Open

Bruna Miglioranza Scavuzzi, Sumathi Shanmugam, Meng-Ling Yang, Jingyu Yao, Heather Hager , et al. · 2025

RD in one eye produces a transient remote preconditioning effect that protects the fellow retina against retinal cell death following subsequent RD.

Diabetes Renders Photoreceptors Susceptible to Retinal Ischemia-Reperfusion Injury Open

David A. Antonetti, Cheng‐mao Lin, Sumathi Shanmugam, Heather Hager, Manjing Cao , et al. · 2024

Diabetes caused PR to become highly susceptible to IR injury. The ability of phlorizin pretreatment to block outer retinal thinning after IR suggests that the effects of diabetes on PR are readily reversible.

ER Stress and Mitochondrial Perturbations Regulate Cell Death in Retinal Detachment: Exploring the Role of HIF1α Open

Bhavneet Kaur, Bruna Miglioranza Scavuzzi, Meng-Ling Yang, Jingyu Yao, Lin Jia , et al. · 2024

RD results in the activation of ERS, mitophagy, mitochondrial dysfunction, and accumulation of polyubiquitinated proteins. Results suggest a role for HIF1α in activation of the mitophagy pathway after RD, which may serve to protect the PR …

The mouse retinal pigment epithelium mounts an innate immune defense response following retinal detachment Open

Steven F. Abcouwer, Bruna Miglioranza Scavuzzi, Phillip E. Kish, Dejuan Kong, Sumathi Shanmugam , et al. · 2024

A simplified protocol to induce hypoxia in a standard incubator: A focus on retinal cells Open

Bhavneet Kaur, Bruna Miglioranza Scavuzzi, Steven F. Abcouwer, David N. Zacks · 2023

Delineating effects of angiopoietin-2 inhibition on vascular permeability and inflammation in models of retinal neovascularization and ischemia/reperfusion Open

Jérémie Canonica, Richard Foxton, Marina Garcia Garrido, Cheng‐mao Lin, Sabine Uhles , et al. · 2023

Introduction Clinical trials demonstrated that co-targeting angiopoietin-2 (Ang-2) and vascular endothelial growth factor (VEGF-A) with faricimab controls anatomic outcomes and maintains vision improvements, with strong durability, through…

A Simplified Protocol to Induce Hypoxia in a Standard Incubator: A Focus on Retinal Cells Open

Bhavneet Kaur, Bruna Miglioranza Scavuzzi, Steven F. Abcouwer, David N. Zacks · 2023

Hypoxia-Inducible Factor-1α in Rods Is Neuroprotective Following Retinal Detachment Open

Bing X. Ross, Lin Jia, Dejuan Kong, Tiantian Wang, Jingyu Yao , et al. · 2022

Rod-derived HIF-1α plays a key role in the PR response to RD, mediating the transcriptional activity of a battery of genes to promote PR cell survival.

mTORC1 regulates high levels of protein synthesis in retinal ganglion cells of adult mice Open

Patrice E. Fort, Mandy K. Losiewicz, Lynda Elghazi, Dejuan Kong, Corentin Cras‐Méneur , et al. · 2022

Inflammatory resolution and vascular barrier restoration after retinal ischemia reperfusion injury Open

Steven F. Abcouwer, Sumathi Shanmugam, Arivalagan Muthusamy, Cheng‐mao Lin, Dejuan Kong , et al. · 2021

Diminished retinal complex lipid synthesis and impaired fatty acid β-oxidation associated with human diabetic retinopathy Open

Patrice E. Fort, Thekkelnaycke M. Rajendiran, Tanu Soni, Jaeman Byun, Yang Shan , et al. · 2021

BACKGROUNDThis study systematically investigated circulating and retinal tissue lipid determinants of human diabetic retinopathy (DR) to identify underlying lipid alterations associated with severity of DR.METHODSRetinal tissues were retri…

Conditional Knock out of High-Mobility Group Box 1 (HMGB1) in Rods Reduces Autophagy Activation after Retinal Detachment Open

Bing X. Ross, Lin Jia, Dejuan Kong, Tiantian Wang, Heather Hager , et al. · 2021

After retinal detachment (RD), the induction of autophagy protects photoreceptors (PR) from apoptotic cell death. The cytoplasmic high-mobility group box 1 (HMGB1) promotes autophagy. We previously demonstrated that the deletion of HMGB1 f…

Inactivation of Mechanistic Target of Rapamycin Complex 1 Results in Loss of Retinal Ganglion cells Open

Dejuan Kong, Lynda Elghazi, Heather Hager, Mandy K. Losiewicz, Sumathi Shanmugam , et al. · 2021

Inflammatory Resolution and Vascular Barrier Restoration after Retinal Ischemia Reperfusion Injury Open

Steven F. Abcouwer, Sumathi Shanmugam, Arivalagan Muthusamy, Cheng‐mao Lin, Dejuan Kong , et al. · 2021

Several retinal pathologies exhibit both inflammation and breakdown of the inner blood-retinal barrier (iBRB) resulting in vascular permeability, suggesting that treatments that trigger resolution of inflammation may also promote iBRB rest…

Differential effects of minocycline on microvascular complications in murine models of type 1 and type 2 diabetes Open

Stéphanie Eid, Phillipe D. O’Brien, Lucy M. Hinder, John M. Hayes, Faye E. Mendelson , et al. · 2021

Diabetes is a global healthcare problem associated with enormous healthcare and personal costs. Despite glucose lowering agents that control glycaemia, both type 1 (T1D) and type (T2D) diabetes patients often develop microvascular complica…

Differential Effects of Empagliflozin on Microvascular Complications in Murine Models of Type 1 and Type 2 Diabetes Open

Stéphanie Eid, Phillipe D. O’Brien, Lucy M. Hinder, John M. Hayes, Faye E. Mendelson , et al. · 2020

Microvascular complications account for the significant morbidity associated with diabetes. Despite tight glycemic control, disease risk remains especially in type 2 diabetes (T2D) patients and no therapy fully prevents nerve, retinal, or …

mTORC1 and mTORC2 expression in inner retinal neurons and glial cells Open

Mandy K. Losiewicz, Lynda Elghazi, Diane C. Fingar, Raju V. S. Rajala, Stephen I. Lentz , et al. · 2020

mTORC1 is needed for maintenance of retinal microglia numbers and dendritic arbors but is not necessary for their proliferation in response to retinal injury Open

Steven F. Abcouwer, Sumathi Shanmugam, Heather Hager, Dejuan Kong, David A. Antonetti · 2020

All-<i>trans</i>-Retinaldehyde Contributes to Retinal Vascular Permeability in Ischemia Reperfusion Open

Alyssa Dreffs, Cheng‐mao Lin, Xuwen Liu, Sumathi Shanmugam, Steven F. Abcouwer , et al. · 2020

Outer retinal pathology may contribute to vascular permeability by release of atRAL, which can act directly on vascular endothelial cells to alter barrier properties and induce cell death. These studies may have implications for a variety …

Loss of High-Mobility Group Box 1 (HMGB1) Protein in Rods Accelerates Rod Photoreceptor Degeneration After Retinal Detachment Open

Bing X. Ross, Joanne Choi, Jingyu Yao, Heather Hager, Steven F. Abcouwer , et al. · 2020

Increased HMGB1 expression in stressed rods may represent an intrinsic mechanism regulating their survival after RD.

New insights into the mechanisms of diabetic complications: role of lipids and lipid metabolism Open

Stéphanie Eid, Kelli M. Sas, Steven F. Abcouwer, Eva L. Feldman, Thomas W. Gardner , et al. · 2019

Roles of Mechanistic Target of Rapamycin Complexes in Retinal Development and Visual Function Open

Dejuan Kong, Heather Hager, Sumathi Shanmugam, Lynda Elghazi, Patrice E. Fort , et al. · 2019

Effects of diabetes on retinal protein lysine malonylation Open

Steven F. Abcouwer, Sumathi Shanmugam, Heather Hager, Cheng‐mao Lin, Thomas W. Gardner , et al. · 2019

Knockout of the Toll-like Receptors (TLR) 2 and 4 Affects the Recruitment of Microglia/Macrophages to the Stressed Photoreceptor Cells in Response to Retinal Detachment Open

Joanne Choi, Bing X. Ross, Jingyu Yao, Lin Jia, Steven F. Abcouwer , et al. · 2019

Journal of Clinical & Cellular Immunology Open

Steven F. Abcouwer · 2019

Diabetic retinopathy (DR) is a sight-threatening complication of both type-1 and type-2 diabetes. The recent success of treatments inhibiting the function of vascular endothelial growth factor (VEGF) demonstrates that specific targeting of…

Mitochondrial uncoupling has no effect on microvascular complications in type 2 diabetes Open

Lucy M. Hinder, Kelli M. Sas, Phillipe D. O’Brien, Carey Backus, Pradeep Kayampilly , et al. · 2019

Inhibition of Atypical Protein Kinase C Reduces Inflammation-Induced Retinal Vascular Permeability Open

Cheng‐mao Lin, Paul M. Titchenell, Jason M. Keil, Adolfo García‐Ocaña, Mark Bolinger , et al. · 2018

Vitreous Cytokine Expression and a Murine Model Suggest a Key Role of Microglia in the Inflammatory Response to Retinal Detachment Open

Lee Kiang, Bing X. Ross, Jingyu Yao, Sumathi Shanmugam, Chris Andrews , et al. · 2018

The findings suggest that an inflammatory response involving microglia is a component of the reaction to retinal detachment that may impact visual acuity after surgical repair and that mouse experimental RD can serve as a model to study th…

Trapping all trans retinal is protective to vascular damage in ischemia reperfusion Open

David A. Antonetti, Cheng‐mao Lin, Timothy S. Kern, Steven F. Abcouwer · 2018

Conditional knockout of mTORC1 in retina blocks developmental formation of the astrocyte network and retinal vasculature Open

Steven F. Abcouwer, Dejuan Kong, Lynda Elghazi-Cras, Patrice E. Fort, Thomas W. Gardner · 2018

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