Steven G. Kohama
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View article: Age-related severity of nontuberculous mycobacterial lung disease is mediated by aberrant macrophage responses and lung microbial dysbiosis
Age-related severity of nontuberculous mycobacterial lung disease is mediated by aberrant macrophage responses and lung microbial dysbiosis Open
These data reveal that nontuberculous mycobacterial pulmonary disease severity in the aged animals is driven by dysregulated inflammatory responses and dysbiosis of the lung microbiome.
View article: Patterns of transcriptomic aging in the hippocampus of rhesus macaques highlight midlife transitions
Patterns of transcriptomic aging in the hippocampus of rhesus macaques highlight midlife transitions Open
Patterns of brain aging are generally conserved among primates; however, there is marked variation in the observed rate among individuals, species, and brain regions. The hippocampus is a region particularly susceptible to the aging proces…
View article: α-klotho as a biomarker of amyloid β levels in the cerebrospinal fluid
α-klotho as a biomarker of amyloid β levels in the cerebrospinal fluid Open
Introduction CSF α -klotho levels might affect Aβ40, Aβ42, and the Aβ42/40 ratio in the cerebrospinal fluid (CSF). Methods CSF α -klotho was assayed in ovariectomized rhesus macaques (NHPs) maintained on a Western-style diet (WSD) to asses…
View article: Age-related differences in cerebral morphology and microstructure in rhesus macaques
Age-related differences in cerebral morphology and microstructure in rhesus macaques Open
The rhesus macaque presents a promising model for translational research into human brain aging due to this species' long lifespan and close phylogenic relationship. We conducted a cross-sectional study identifying microstructural and morp…
View article: Pituitary gonadotropin‐releasing hormone <scp>II</scp> as a possible mediator of positive estrogen feedback
Pituitary gonadotropin‐releasing hormone <span>II</span> as a possible mediator of positive estrogen feedback Open
It has previously been shown that rhesus macaques express two forms of gonadotropin‐releasing hormone ( GNRH1 and GNRH2 ) in the hypothalamus and that both forms can stimulate the release of luteinizing hormone (LH) in vivo. However, while…
View article: Immunological and microbial shifts in the aging rhesus macaque lung during nontuberculous mycobacterial infection
Immunological and microbial shifts in the aging rhesus macaque lung during nontuberculous mycobacterial infection Open
Nontuberculous mycobacteria (NTM) are environmentally ubiquitous organisms that predominately cause NTM pulmonary disease (NTMPD) in individuals over the age of 65. The incidence of NTMPD has increased in the U.S., exceeding that of Mycoba…
View article: Modulation of neural gene networks by estradiol in old rhesus macaque females
Modulation of neural gene networks by estradiol in old rhesus macaque females Open
The postmenopausal decrease in circulating estradiol (E2) levels has been shown to contribute to several adverse physiological and psychiatric effects. To elucidate the molecular effects of E2 on the brain, we examined differential gene ex…
View article: Age-related increase in the expression of 11β-hydroxysteroid dehydrogenase type 1 in the hippocampus of male rhesus macaques
Age-related increase in the expression of 11β-hydroxysteroid dehydrogenase type 1 in the hippocampus of male rhesus macaques Open
Introduction The hippocampus is especially susceptible to age-associated neuronal pathologies, and there is concern that the age-associated rise in cortisol secretion from the adrenal gland may contribute to their etiology. Furthermore, be…
View article: Effect of hormone replacement therapy on amyloid beta (Aβ) plaque density in the rhesus macaque amygdala
Effect of hormone replacement therapy on amyloid beta (Aβ) plaque density in the rhesus macaque amygdala Open
Background Amyloid beta (Aβ) plaque density was examined in the amygdala of rhesus macaques, to elucidate the influence of age, diet and hormonal environment. Methods Luminex technology was used to measure cerebrospinal fluid (CSF) concent…
View article: Pathological Markers of Alzheimer’s Disease and Related Dementia in the Rhesus Macaque Amygdala
Pathological Markers of Alzheimer’s Disease and Related Dementia in the Rhesus Macaque Amygdala Open
Rhesus macaques develop amyloid-β (Aβ) plaques during old age, but it is unclear how extensively they express other pathological hallmarks of dementia. Here we used immunohistochemistry to examine expression of phosphorylated tau (pTau) pr…
View article: Modulation of neural gene networks by estradiol in old rhesus macaque females
Modulation of neural gene networks by estradiol in old rhesus macaque females Open
The postmenopausal decrease in circulating estradiol (E2) levels has been shown to contribute to several adverse physiological and psychiatric effects. To elucidate the molecular effects of E2 on the brain, we examined differential gene ex…
View article: Brain volumetrics across the lifespan of the rhesus macaque
Brain volumetrics across the lifespan of the rhesus macaque Open
View article: A class of anti-inflammatory lipids decrease with aging in the central nervous system
A class of anti-inflammatory lipids decrease with aging in the central nervous system Open
View article: A macaque clonal hematopoiesis model demonstrates expansion of TET2-disrupted clones and utility for testing interventions
A macaque clonal hematopoiesis model demonstrates expansion of TET2-disrupted clones and utility for testing interventions Open
Individuals with age-related clonal hematopoiesis (CH) are at greater risk for hematologic malignancies and cardiovascular diseases. However, predictive preclinical animal models to recapitulate the spectrum of human CH are lacking. Throug…
View article: Functional, transcriptional, and microbial shifts associated with healthy pulmonary aging in rhesus macaques
Functional, transcriptional, and microbial shifts associated with healthy pulmonary aging in rhesus macaques Open
View article: Functional, transcriptional, and microbial shifts associated with healthy pulmonary aging: insights from rhesus macaques
Functional, transcriptional, and microbial shifts associated with healthy pulmonary aging: insights from rhesus macaques Open
Older individuals are at increased risk of developing severe respiratory infections due to age-related changes in the immunological, microbial, and functional landscape of the lung. However, our understanding of the impact of age on the re…
View article: Effects of estradiol supplementation on the brain transcriptome of old rhesus macaques maintained on an obesogenic diet
Effects of estradiol supplementation on the brain transcriptome of old rhesus macaques maintained on an obesogenic diet Open
View article: MRI characteristics of Japanese macaque encephalomyelitis: Comparison to human diseases
MRI characteristics of Japanese macaque encephalomyelitis: Comparison to human diseases Open
Background and Purpose To describe MRI findings in Japanese macaque encephalomyelitis (JME) with emphasis on lesion characteristics, lesion evolution, normal‐appearing brain tissue, and similarities to human demyelinating disease. Methods …
View article: Myelin‐specific T cells in animals with Japanese macaque encephalomyelitis
Myelin‐specific T cells in animals with Japanese macaque encephalomyelitis Open
Objective To determine whether animals with Japanese macaque encephalomyelitis (JME), a spontaneous demyelinating disease similar to multiple sclerosis (MS), harbor myelin‐specific T cells in their central nervous system (CNS) and peripher…
View article: Lack of effect of short-term DHEA supplementation on the perimenopausal ovary†
Lack of effect of short-term DHEA supplementation on the perimenopausal ovary† Open
Dehydroepiandrosterone (DHEA) hormonal supplementation can improve oocyte quality in women with diminished ovarian function. However, it is unclear whether DHEA supplementation can also enhance ovarian function during the perimenopause (i.…
View article: Longitudinal Effects of Immediate and Delayed Estradiol on Cognitive Performance in a Spatial Maze and Hippocampal Volume in Menopausal Macaques Under an Obesogenic Diet
Longitudinal Effects of Immediate and Delayed Estradiol on Cognitive Performance in a Spatial Maze and Hippocampal Volume in Menopausal Macaques Under an Obesogenic Diet Open
The consumption of a diet high in fat and refined sugars has several health risks, including the development of cognitive decline and neurodegeneration. For women, menopause carries additional health risks that may interact with a high-fat…
View article: Regional Molecular Mapping of Primate Synapses during Normal Healthy Aging
Regional Molecular Mapping of Primate Synapses during Normal Healthy Aging Open
Normal mammalian brain aging is characterized by the selective loss of discrete populations of dendritic spines and synapses, particularly affecting neuroanatomical regions such as the hippocampus. Although previous investigations have qua…
View article: SAT-LB042 Effect of Dehydroepiandrosterone on the Perimenopausal Ovary
SAT-LB042 Effect of Dehydroepiandrosterone on the Perimenopausal Ovary Open
Dehydroepiandrosterone (DHEA) supplementation can improve oocyte quality in women with diminished ovarian function(1-2). However, it is unclear if similar beneficial effects of DHEA supplementation can be obtained during the perimenopause,…
View article: Preconditioning in the Rhesus Macaque Induces a Proteomic Signature Following Cerebral Ischemia that Is Associated with Neuroprotection
Preconditioning in the Rhesus Macaque Induces a Proteomic Signature Following Cerebral Ischemia that Is Associated with Neuroprotection Open
View article: Discovery of a CLN7 model of Batten disease in non-human primates
Discovery of a CLN7 model of Batten disease in non-human primates Open
View article: Gene expression profiling of the SCN in young and old rhesus macaques
Gene expression profiling of the SCN in young and old rhesus macaques Open
In mammals, the suprachiasmatic nucleus (SCN) is the location of a master circadian pacemaker. It receives photic signals from the environment via the retinal hypothalamic tract, which play a key role in synchronizing the body’s endogenous…
View article: DNA-PK Promotes the Mitochondrial, Metabolic, and Physical Decline that Occurs During Aging
DNA-PK Promotes the Mitochondrial, Metabolic, and Physical Decline that Occurs During Aging Open
View article: Effects of obesogenic diet and estradiol on dorsal raphe gene expression in old female macaques
Effects of obesogenic diet and estradiol on dorsal raphe gene expression in old female macaques Open
The beneficial effects of bioidentical ovarian steroid hormone therapy (HT) during the perimenopause are gaining recognition. However, the positive effects of estrogen (E) plus or minus progesterone (P) administration to ovariectomized (Ov…
View article: Age-associated gene expression changes in the arcuate nucleus of male rhesus macaques
Age-associated gene expression changes in the arcuate nucleus of male rhesus macaques Open
The hypothalamic arcuate nucleus (ARC) represents a major component of the neuroendocrine reproductive axis and plays an important role in controlling the onset of puberty as well as age-associated reproductive senescence. Although signifi…
View article: DNA-PK Promotes the Mitochondrial, Metabolic, and Physical Decline that Occurs During Aging
DNA-PK Promotes the Mitochondrial, Metabolic, and Physical Decline that Occurs During Aging Open