Steven A. Goldstein
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View article: Two-pore domain potassium channels (K<sub>2P</sub>) in GtoPdb v.2025.4
Two-pore domain potassium channels (K<sub>2P</sub>) in GtoPdb v.2025.4 Open
The 4TM family of K channels mediate many of the background potassium currents observed in native cells. They are open across the physiological voltage-range and are regulated by a wide array of neurotransmitters and biochemical mediators.…
View article: C6 peptide blockade of Hv1 channels inhibits neutrophil migration into the lungs to suppress Pseudomonas aeruginosa-induced acute lung injury
C6 peptide blockade of Hv1 channels inhibits neutrophil migration into the lungs to suppress Pseudomonas aeruginosa-induced acute lung injury Open
View article: Amyloid precursor protein and C99 are subunits in human microglial Hv1 channels that enhance current and inflammatory mediator release
Amyloid precursor protein and C99 are subunits in human microglial Hv1 channels that enhance current and inflammatory mediator release Open
In Alzheimer’s disease (AD), hyperactivated microglia produce inflammatory mediators that contribute to neuroinflammation and neuronal damage. Amyloid precursor protein (APP), a transmembrane protein expressed in many cell types, including…
View article: HOPPR Medical-Grade Platform for Medical Imaging AI
HOPPR Medical-Grade Platform for Medical Imaging AI Open
Technological advances in artificial intelligence (AI) have enabled the development of large vision language models (LVLMs) that are trained on millions of paired image and text samples. Subsequent research efforts have demonstrated great …
View article: The molecular basis of pH sensing by the human fungal pathogen Candida albicans TOK potassium channel
The molecular basis of pH sensing by the human fungal pathogen Candida albicans TOK potassium channel Open
Two-pore domain, outwardly rectifying potassium (TOK) channels are exclusively expressed in fungi. Human fungal pathogen TOK channels are potential antifungal targets, but TOK channel modulation in general is poorly understood. Here, we di…
View article: Selective block of human Kv1.1 channels and an epilepsy‐associated gain‐of‐function mutation by <scp>AETX‐K</scp> peptide
Selective block of human Kv1.1 channels and an epilepsy‐associated gain‐of‐function mutation by <span>AETX‐K</span> peptide Open
Dysfunction of the human voltage‐gated K + channel Kv1.1 has been associated with epilepsy, multiple sclerosis, episodic ataxia, myokymia, and cardiorespiratory dysregulation. We report here that AETX‐K, a sea anemone type I (SAK1) peptide…
View article: The Concise Guide to PHARMACOLOGY 2023/24: Ion channels
The Concise Guide to PHARMACOLOGY 2023/24: Ion channels Open
The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and over 6000…
View article: Two-Pore-Domain Potassium Channels
Two-Pore-Domain Potassium Channels Open
Physiologists have appreciated the importance of background (or leak) K+ currents in determining the cellular resting membrane potential (VM) from the early 1900s. Since then, the activity of background K+ fluxes have been shown to regulat…
View article: Two-pore domain potassium channels (K<sub>2P</sub>) in GtoPdb v.2023.1
Two-pore domain potassium channels (K<sub>2P</sub>) in GtoPdb v.2023.1 Open
The 4TM family of K channels mediate many of the background potassium currents observed in native cells. They are open across the physiological voltage-range and are regulated by a wide array of neurotransmitters and biochemical mediators.…
View article: SUMOylation of NaV1.2 channels regulates the velocity of backpropagating action potentials in cortical pyramidal neurons
SUMOylation of NaV1.2 channels regulates the velocity of backpropagating action potentials in cortical pyramidal neurons Open
Voltage-gated sodium channels located in axon initial segments (AIS) trigger action potentials (AP) and play pivotal roles in the excitability of cortical pyramidal neurons. The differential electrophysiological properties and distribution…
View article: Author response: SUMOylation of NaV1.2 channels regulates the velocity of backpropagating action potentials in cortical pyramidal neurons
Author response: SUMOylation of NaV1.2 channels regulates the velocity of backpropagating action potentials in cortical pyramidal neurons Open
Article Figures and data Abstract Editor's evaluation Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Voltage-gated sodium c…
View article: Protection from acute lung injury by a peptide designed to inhibit the voltage-gated proton channel
Protection from acute lung injury by a peptide designed to inhibit the voltage-gated proton channel Open
View article: Molecular determinants of inhibition of the human proton channel hHv1 by the designer peptide C6 and a bivalent derivative
Molecular determinants of inhibition of the human proton channel hHv1 by the designer peptide C6 and a bivalent derivative Open
Significance We designed C6 peptide to address the absence of specific inhibitors of human voltage-gated proton channels (hHv1). Two C6 bind to the two hHv1 voltage sensors at the resting state, inhibiting activation on depolarization. Her…
View article: THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Ion channels
THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Ion channels Open
The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasi…
View article: Two-pore domain potassium channels (K<sub>2P</sub>) in GtoPdb v.2021.3
Two-pore domain potassium channels (K<sub>2P</sub>) in GtoPdb v.2021.3 Open
The 4TM family of K channels mediate many of the background potassium currents observed in native cells. They are open across the physiological voltage-range and are regulated by a wide array of neurotransmitters and biochemical mediators.…
View article: Two P domain potassium channels in GtoPdb v.2021.2
Two P domain potassium channels in GtoPdb v.2021.2 Open
The 4TM family of K channels mediate many of the background potassium currents observed in native cells. They are open across the physiological voltage-range and are regulated by a wide array of neurotransmitters and biochemical mediators.…
View article: Direct activation of the proton channel by albumin leads to human sperm capacitation and sustained release of inflammatory mediators by neutrophils
Direct activation of the proton channel by albumin leads to human sperm capacitation and sustained release of inflammatory mediators by neutrophils Open
View article: Deep Learning–Based Automated Echocardiographic Quantification of Left Ventricular Ejection Fraction: A Point-of-Care Solution
Deep Learning–Based Automated Echocardiographic Quantification of Left Ventricular Ejection Fraction: A Point-of-Care Solution Open
Background: We have recently tested an automated machine-learning algorithm that quantifies left ventricular (LV) ejection fraction (EF) from guidelines-recommended apical views. However, in the point-of-care (POC) setting, apical 2-chambe…
View article: Utility of a Deep-Learning Algorithm to Guide Novices to Acquire Echocardiograms for Limited Diagnostic Use
Utility of a Deep-Learning Algorithm to Guide Novices to Acquire Echocardiograms for Limited Diagnostic Use Open
This DL algorithm allows novices without experience in ultrasonography to obtain diagnostic transthoracic echocardiographic studies for evaluation of left ventricular size and function, right ventricular size, and presence of a nontrivial …
View article: Tethered peptide toxins for ion channels
Tethered peptide toxins for ion channels Open
In this method paper, we describe protocols for using membrane-tethered peptide toxins (T-toxins) to study the structure/function and biophysics of toxin-channel interactions with two-electrode voltage clamp (TEVC). Here, we show how T-tox…
View article: Mitral inflow obstruction by a descending thoracic aortic aneurysm
Mitral inflow obstruction by a descending thoracic aortic aneurysm Open
View article: Controversy of physiological vs. pharmacological effects of BMP signaling: Constitutive activation of BMP type IA receptor-dependent signaling in osteoblast lineage enhances bone formation and resorption, not affecting net bone mass
Controversy of physiological vs. pharmacological effects of BMP signaling: Constitutive activation of BMP type IA receptor-dependent signaling in osteoblast lineage enhances bone formation and resorption, not affecting net bone mass Open
View article: TOK channels use the two gates in classical K <sup>+</sup> channels to achieve outward rectification
TOK channels use the two gates in classical K <sup>+</sup> channels to achieve outward rectification Open
TOKs are outwardly rectifying K + channels in fungi with two pore‐loops and eight transmembrane spans. Here, we describe the TOKs from four pathogens that cause the majority of life‐threatening fungal infections in humans. These TOKs pass …
View article: Loss of BMP signaling mediated by BMPR1A in osteoblasts leads to differential bone phenotypes in mice depending on anatomical location of the bones
Loss of BMP signaling mediated by BMPR1A in osteoblasts leads to differential bone phenotypes in mice depending on anatomical location of the bones Open
View article: Evaluation of global gene expression in regenerate tissues during Masquelet treatment
Evaluation of global gene expression in regenerate tissues during Masquelet treatment Open
The Masquelet induced‐membrane (IM) technique is indicated for large segmental bone defects. Attributes of the IM and local milieu that contribute to graft‐to‐bone union are unknown. Using a rat model, we compared global gene expression pr…
View article: Tethered peptide neurotoxins display two blocking mechanisms in the K <sup>+</sup> channel pore as do their untethered analogs
Tethered peptide neurotoxins display two blocking mechanisms in the K <sup>+</sup> channel pore as do their untethered analogs Open
Hijacking the cell machinery to tether neurotoxins near their surface receptors (zombie scans) reveals sites of interaction.
View article: Hypoxia Produces Pro-arrhythmic Late Sodium Current in Cardiac Myocytes by SUMOylation of NaV1.5 Channels
Hypoxia Produces Pro-arrhythmic Late Sodium Current in Cardiac Myocytes by SUMOylation of NaV1.5 Channels Open
View article: Tethered Peptide Neurotoxins Facilitate Biophysical Study and Reveal Two Voltage-dependent Blocking Mechanisms for SAK1 Toxins in the K+ Channel Pore
Tethered Peptide Neurotoxins Facilitate Biophysical Study and Reveal Two Voltage-dependent Blocking Mechanisms for SAK1 Toxins in the K+ Channel Pore Open
View article: Two P domain potassium channels (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database
Two P domain potassium channels (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database Open
The 4TM family of K channels mediate many of the background potassium currents observed in native cells. They are open across the physiological voltage-range and are regulated by a wide array of neurotransmitters and biochemical mediators.…
View article: Developing a Knowledge Management Process Map for Stockpile Stewardship at the Nevada National Security Site
Developing a Knowledge Management Process Map for Stockpile Stewardship at the Nevada National Security Site Open