Steven Grant
YOU?
Author Swipe
View article: Generation and preclinical assessment of depemokimab, an enhanced IL-5 antagonist monoclonal antibody
Generation and preclinical assessment of depemokimab, an enhanced IL-5 antagonist monoclonal antibody Open
This study describes the affinity maturation, molecular engineering, and preclinical assessment of depemokimab, an enhanced anti-interleukin-5 antagonist antibody. The molecular design objective for depemokimab was to generate a therapeuti…
View article: Supplementary Table S2 from Dual mTORC1/2 Inhibition Synergistically Enhances AML Cell Death in Combination with the BCL2 Antagonist Venetoclax
Supplementary Table S2 from Dual mTORC1/2 Inhibition Synergistically Enhances AML Cell Death in Combination with the BCL2 Antagonist Venetoclax Open
Clinical, molecular, and cytogenetic characteristics of patient samples (CD34+CD38-CD123+ population) exposed to ABT-199 ± INK-128
View article: Supplementary Figures S1-S14 from Dual mTORC1/2 Inhibition Synergistically Enhances AML Cell Death in Combination with the BCL2 Antagonist Venetoclax
Supplementary Figures S1-S14 from Dual mTORC1/2 Inhibition Synergistically Enhances AML Cell Death in Combination with the BCL2 Antagonist Venetoclax Open
Supplementary Figures S1-S14
View article: Supplementary Table S1 from Dual mTORC1/2 Inhibition Synergistically Enhances AML Cell Death in Combination with the BCL2 Antagonist Venetoclax
Supplementary Table S1 from Dual mTORC1/2 Inhibition Synergistically Enhances AML Cell Death in Combination with the BCL2 Antagonist Venetoclax Open
Clinical, molecular, and cytogenetic characteristics of patient samples (CD45dim SS low population) exposed to ABT-199 ± INK-128
View article: Hypochlorous Acid-Gated Hydrolysis of a Phosphinate Ester Dye in Living Cells
Hypochlorous Acid-Gated Hydrolysis of a Phosphinate Ester Dye in Living Cells Open
Theranostic fluorescent platforms are capable of the selective delivery of small molecules to target cells with simultaneous optical monitoring. Such technologies promise to significantly reduce off-target effects compared with cytotoxic c…
View article: Virtual Care Among Adults Facing Language Barriers
Virtual Care Among Adults Facing Language Barriers Open
Importance Patients with language barriers may experience difficulties accessing virtual care. Objectives To synthesize the literature on the association between language barriers and use of and satisfaction with virtual care among adult p…
View article: An international initiative to improve mental healthcare in Palestine through a tripartite collaboration
An international initiative to improve mental healthcare in Palestine through a tripartite collaboration Open
The number of people living in Palestine with mental disorders is significantly higher than the global average. Military occupation, violence and poverty contribute to collective trauma. International agencies have emphasised the need for …
View article: Src inhibition potentiates MCL-1 antagonist activity in acute myeloid leukemia
Src inhibition potentiates MCL-1 antagonist activity in acute myeloid leukemia Open
View article: Proteasome Inhibition Enhances Lysosome-mediated Targeted Protein Degradation
Proteasome Inhibition Enhances Lysosome-mediated Targeted Protein Degradation Open
Proteasome inhibitor drugs are currently used in the clinic to treat multiple myeloma and mantle cell lymphoma. These inhibitors cause accumulation of undegraded proteins, thus inducing proteotoxic stress and consequent cell death. However…
View article: A phase I study of MLN4924 and belinostat in relapsed/refractory acute myeloid leukemia or myelodysplastic syndrome
A phase I study of MLN4924 and belinostat in relapsed/refractory acute myeloid leukemia or myelodysplastic syndrome Open
View article: Toward a Deeper Understanding of Clonal Evolution in Acute Myeloid Leukemia: Translational and Clinical Impacts
Toward a Deeper Understanding of Clonal Evolution in Acute Myeloid Leukemia: Translational and Clinical Impacts Open
To understand disease biology of Acute Myeloid Leukemia requires an appreciation of initial clonal heterogeneity of the disease, as well as the selective pressures on these clones and the resulting change in cytomolecular profiles over tim…
View article: A Phase I Study of MLN4924 and Belinostat in Relapsed/Refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome
A Phase I Study of MLN4924 and Belinostat in Relapsed/Refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome Open
Purpose: Relapsed and/or refractory acute myeloid leukemia and high-risk myelodysplastic syndrome continue to have a poor prognosis with limited treatment options despite advancements in rational combination and targeted therapies. Belinos…
View article: #1. Acid ceramidase (ASAH1) is a key mediator of drug resistance in relapsed/refractory multiple myeloma
#1. Acid ceramidase (ASAH1) is a key mediator of drug resistance in relapsed/refractory multiple myeloma Open
View article: Azaphosphinate Dyes: A Low Molecular Weight Near‐Infrared Scaffold for Development of Photoacoustic or Fluorescence Imaging Probes
Azaphosphinate Dyes: A Low Molecular Weight Near‐Infrared Scaffold for Development of Photoacoustic or Fluorescence Imaging Probes Open
Near‐infrared (NIR) dyes are desirable for biological imaging applications including photoacoustic (PA) and fluorescence imaging. Nonetheless, current NIR dyes are often plagued by relatively large molecular weights, poor water solubility,…
View article: Single Atom Stabilization of Phosphinate Ester‐Containing Rhodamines Yields Cell Permeable Probes for Turn‐On Photoacoustic Imaging**
Single Atom Stabilization of Phosphinate Ester‐Containing Rhodamines Yields Cell Permeable Probes for Turn‐On Photoacoustic Imaging** Open
Photoacoustic imaging (PAI) is an emerging imaging technique that uses pulsed laser excitation with near‐infrared (NIR) light to elicit local temperature increases through non‐radiative relaxation events, ultimately leading to the producti…
View article: Secondary-Type Mutations in Acute Myeloid Leukemia: Updates from ELN 2022
Secondary-Type Mutations in Acute Myeloid Leukemia: Updates from ELN 2022 Open
The characterization of the molecular landscape and the advent of targeted therapies have defined a new era in the prognostication and treatment of acute myeloid leukemia. Recent revisions in the European LeukemiaNet 2022 guidelines have r…
View article: Venetoclax with Decitabine or Azacitidine in Relapsed or Refractory Acute Myeloid Leukemia
Venetoclax with Decitabine or Azacitidine in Relapsed or Refractory Acute Myeloid Leukemia Open
Relapsed or refractory acute myeloid leukemia (AML) is associated with poor outcomes and resistance to therapy. The addition of venetoclax, a BCL-2 antagonist, to lower-intensity therapies results in improved survival in the first-line set…
View article: Non-canonical role for the ataxia-telangiectasia-Rad3 pathway in STAT3 activation in human multiple myeloma cells
Non-canonical role for the ataxia-telangiectasia-Rad3 pathway in STAT3 activation in human multiple myeloma cells Open
View article: Supplementary Data from Chk1 Inhibition Potently Blocks STAT3 Tyrosine705 Phosphorylation, DNA-Binding Activity, and Activation of Downstream Targets in Human Multiple Myeloma Cells
Supplementary Data from Chk1 Inhibition Potently Blocks STAT3 Tyrosine705 Phosphorylation, DNA-Binding Activity, and Activation of Downstream Targets in Human Multiple Myeloma Cells Open
Supplementary Data from Chk1 Inhibition Potently Blocks STAT3 Tyrosine705 Phosphorylation, DNA-Binding Activity, and Activation of Downstream Targets in Human Multiple Myeloma Cells
View article: Supplementary Table 1, Figures 1 - 6 from The Novel Chk1 Inhibitor MK-8776 Sensitizes Human Leukemia Cells to HDAC Inhibitors by Targeting the Intra-S Checkpoint and DNA Replication and Repair
Supplementary Table 1, Figures 1 - 6 from The Novel Chk1 Inhibitor MK-8776 Sensitizes Human Leukemia Cells to HDAC Inhibitors by Targeting the Intra-S Checkpoint and DNA Replication and Repair Open
PDF file - 1275K, Supplemental Table 1. Synergism between MK-8776 and SBHA or vorinostat in various human leukemia cell lines. Supplemental Figure S1. SBHA or vorinostat significantly potentiates lethality of MK-8776 in leukemia cell lines…
View article: Supplementary Figure Legends 1-7 from Carfilzomib Interacts Synergistically with Histone Deacetylase Inhibitors in Mantle Cell Lymphoma Cells <i>In Vitro</i> and <i>In Vivo</i>
Supplementary Figure Legends 1-7 from Carfilzomib Interacts Synergistically with Histone Deacetylase Inhibitors in Mantle Cell Lymphoma Cells <i>In Vitro</i> and <i>In Vivo</i> Open
PDF file - 117K
View article: Data from Dinaciclib (SCH727965) Inhibits the Unfolded Protein Response through a CDK1- and 5-Dependent Mechanism
Data from Dinaciclib (SCH727965) Inhibits the Unfolded Protein Response through a CDK1- and 5-Dependent Mechanism Open
Evidence implicating dysregulation of the IRE1/XBP-1s arm of the unfolded protein response (UPR) in cancer pathogenesis (e.g., multiple myeloma) has prompted the development of IRE1 RNase inhibitors. Here, effects of cyclin-dependent kinas…
View article: Supplementary Figures 1-6 from Obatoclax Interacts Synergistically with the Irreversible Proteasome Inhibitor Carfilzomib in GC- and ABC-DLBCL Cells <i>In Vitro</i> and <i>In Vivo</i>
Supplementary Figures 1-6 from Obatoclax Interacts Synergistically with the Irreversible Proteasome Inhibitor Carfilzomib in GC- and ABC-DLBCL Cells <i>In Vitro</i> and <i>In Vivo</i> Open
PDF file - 402K, SFigure 1: Chemical structures of carfilzomib and obatoclax; SFigure 2: Co-treatment with carfilzomib and obatoclax synergistically induces cell death in SUDHL4 cells by Median Dose Effect analysis; SFigure 3: Combined tre…
View article: Supplementary Data from Chk1 Inhibition Potently Blocks STAT3 Tyrosine705 Phosphorylation, DNA-Binding Activity, and Activation of Downstream Targets in Human Multiple Myeloma Cells
Supplementary Data from Chk1 Inhibition Potently Blocks STAT3 Tyrosine705 Phosphorylation, DNA-Binding Activity, and Activation of Downstream Targets in Human Multiple Myeloma Cells Open
Supplementary Data from Chk1 Inhibition Potently Blocks STAT3 Tyrosine705 Phosphorylation, DNA-Binding Activity, and Activation of Downstream Targets in Human Multiple Myeloma Cells
View article: Supplementary Table S1 from Dual mTORC1/2 Inhibition Synergistically Enhances AML Cell Death in Combination with the BCL2 Antagonist Venetoclax
Supplementary Table S1 from Dual mTORC1/2 Inhibition Synergistically Enhances AML Cell Death in Combination with the BCL2 Antagonist Venetoclax Open
Clinical, molecular, and cytogenetic characteristics of patient samples (CD45dim SS low population) exposed to ABT-199 ± INK-128
View article: Supplementary Data from Chk1 Inhibition Potently Blocks STAT3 Tyrosine705 Phosphorylation, DNA-Binding Activity, and Activation of Downstream Targets in Human Multiple Myeloma Cells
Supplementary Data from Chk1 Inhibition Potently Blocks STAT3 Tyrosine705 Phosphorylation, DNA-Binding Activity, and Activation of Downstream Targets in Human Multiple Myeloma Cells Open
Supplementary Data from Chk1 Inhibition Potently Blocks STAT3 Tyrosine705 Phosphorylation, DNA-Binding Activity, and Activation of Downstream Targets in Human Multiple Myeloma Cells
View article: Supplementary Table 1, Figures 1 - 6 from The Novel Chk1 Inhibitor MK-8776 Sensitizes Human Leukemia Cells to HDAC Inhibitors by Targeting the Intra-S Checkpoint and DNA Replication and Repair
Supplementary Table 1, Figures 1 - 6 from The Novel Chk1 Inhibitor MK-8776 Sensitizes Human Leukemia Cells to HDAC Inhibitors by Targeting the Intra-S Checkpoint and DNA Replication and Repair Open
PDF file - 1275K, Supplemental Table 1. Synergism between MK-8776 and SBHA or vorinostat in various human leukemia cell lines. Supplemental Figure S1. SBHA or vorinostat significantly potentiates lethality of MK-8776 in leukemia cell lines…
View article: Supplementary Data from Chk1 Inhibition Potently Blocks STAT3 Tyrosine705 Phosphorylation, DNA-Binding Activity, and Activation of Downstream Targets in Human Multiple Myeloma Cells
Supplementary Data from Chk1 Inhibition Potently Blocks STAT3 Tyrosine705 Phosphorylation, DNA-Binding Activity, and Activation of Downstream Targets in Human Multiple Myeloma Cells Open
Supplementary Data from Chk1 Inhibition Potently Blocks STAT3 Tyrosine705 Phosphorylation, DNA-Binding Activity, and Activation of Downstream Targets in Human Multiple Myeloma Cells
View article: Supplementary Data from Chk1 Inhibition Potently Blocks STAT3 Tyrosine705 Phosphorylation, DNA-Binding Activity, and Activation of Downstream Targets in Human Multiple Myeloma Cells
Supplementary Data from Chk1 Inhibition Potently Blocks STAT3 Tyrosine705 Phosphorylation, DNA-Binding Activity, and Activation of Downstream Targets in Human Multiple Myeloma Cells Open
Supplementary Data from Chk1 Inhibition Potently Blocks STAT3 Tyrosine705 Phosphorylation, DNA-Binding Activity, and Activation of Downstream Targets in Human Multiple Myeloma Cells
View article: Data from Chk1 Inhibition Potently Blocks STAT3 Tyrosine705 Phosphorylation, DNA-Binding Activity, and Activation of Downstream Targets in Human Multiple Myeloma Cells
Data from Chk1 Inhibition Potently Blocks STAT3 Tyrosine705 Phosphorylation, DNA-Binding Activity, and Activation of Downstream Targets in Human Multiple Myeloma Cells Open
The relationship between the checkpoint kinase Chk1 and the STAT3 pathway was examined in multiple myeloma cells. Gene expression profiling of U266 cells exposed to low (nmol/L) Chk1 inhibitor [PF-477736 (PF)] concentrations revealed STAT3…