Steven H. Bennett
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View article: Quinol–Enedione Rearrangement
Quinol–Enedione Rearrangement Open
The quinol-enedione rearrangement enables the synthesis of 2-cyclohexene-1,4-diones from readily available para-quinol substrates. Building on sporadic early reports of this transformation, we have optimized the reaction conditions …
View article: Difluorinated thromboxane A<sub>2</sub> reveals crosstalk between platelet activatory and inhibitory pathways by targeting both the TP and IP receptors
Difluorinated thromboxane A<sub>2</sub> reveals crosstalk between platelet activatory and inhibitory pathways by targeting both the TP and IP receptors Open
Background and Purpose Thromboxane A 2 (TXA 2 ) is a prostanoid produced during platelet activaton, important in enhancing platelet reactivity by activation of TP receptors. However, due to the short half‐life, studying TXA 2 signalling is…
View article: Stereoretentive enantioconvergent reactions
Stereoretentive enantioconvergent reactions Open
Enantioconvergent reactions are pre-eminent in contemporary asymmetric synthesis as they convert both enantiomers of a racemic starting material into a single enantioenriched product, thus avoiding the maximum 50% yield associated with res…
View article: De Novo Synthesis of Dihydrobenzofurans and Indolines and Its Application to a Modular, Asymmetric Synthesis of Beraprost
De Novo Synthesis of Dihydrobenzofurans and Indolines and Its Application to a Modular, Asymmetric Synthesis of Beraprost Open
Dihydrobenzofurans and indolines are important constituents of pharmaceuticals. Herein, we describe a novel strategy for their construction in which the aromatic ring is created de novo through an inverse-electron demand Diels-Alder…
View article: Stereoretentive enantioconvergent reactions
Stereoretentive enantioconvergent reactions Open
The stereoselective synthesis of chiral molecules in enantioenriched form – i.e., asymmetric synthesis – underpins many fields of pure and applied science. Enantioconvergent reactions are preeminent in contemporary asymmetric synthesis as …
View article: Organocatalytic Dimerization of Succinaldehyde
Organocatalytic Dimerization of Succinaldehyde Open
View article: CCDC 2003275: Experimental Crystal Structure Determination
CCDC 2003275: Experimental Crystal Structure Determination Open
View article: CCDC 2003277: Experimental Crystal Structure Determination
CCDC 2003277: Experimental Crystal Structure Determination Open
View article: CCDC 2003276: Experimental Crystal Structure Determination
CCDC 2003276: Experimental Crystal Structure Determination Open
View article: CCDC 2003273: Experimental Crystal Structure Determination
CCDC 2003273: Experimental Crystal Structure Determination Open
View article: CCDC 2003274: Experimental Crystal Structure Determination
CCDC 2003274: Experimental Crystal Structure Determination Open
View article: Difunctionalization of C–C σ-Bonds Enabled by the Reaction of Bicyclo[1.1.0]butyl Boronate Complexes with Electrophiles: Reaction Development, Scope, and Stereochemical Origins
Difunctionalization of C–C σ-Bonds Enabled by the Reaction of Bicyclo[1.1.0]butyl Boronate Complexes with Electrophiles: Reaction Development, Scope, and Stereochemical Origins Open
Difunctionalization reactions of C-C σ bonds have the potential to streamline access to molecules that would otherwise be difficult to prepare. However, the development of such reactions is challenging because C-C σ bonds are typically unr…
View article: Prostaglandin Total Synthesis Enabled by the Organocatalytic Dimerization of Succinaldehyde
Prostaglandin Total Synthesis Enabled by the Organocatalytic Dimerization of Succinaldehyde Open
Prostaglandins have been attractive targets in total synthesis for over 50 years, resulting in the development of new synthetic strategies and methodologies that have served the broader chemical community. However, these molecules are not …
View article: Synthesis, Stability, and Biological Studies of Fluorinated Analogues of Thromboxane A<sub>2</sub>
Synthesis, Stability, and Biological Studies of Fluorinated Analogues of Thromboxane A<sub>2</sub> Open
Platelet activation results in the generation of thromboxane A2 (TxA2), which promotes thrombus formation by further amplifying platelet function, as well as causing vasoconstriction. Due to its role in thrombus forma…