Steven H. DeVries
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View article: Heterochronic transcription factor expression drives cone-dominant retina development in 13-lined ground squirrels
Heterochronic transcription factor expression drives cone-dominant retina development in 13-lined ground squirrels Open
Evolutionary adaptation to diurnal vision in ground squirrels has led to the development of a cone-dominant retina, in stark contrast to the rod-dominant retinas of most mammals. The molecular mechanisms driving this shift remain largely u…
View article: Heterochronic transcription factor expression drives cone-dominant retina development in 13-lined ground squirrels
Heterochronic transcription factor expression drives cone-dominant retina development in 13-lined ground squirrels Open
Evolutionary adaptation to diurnal vision in ground squirrels has led to the development of a cone-dominant retina, in stark contrast to the rod-dominant retinas of most mammals. The molecular mechanisms driving this shift remain largely u…
View article: Author response: A non-conducting role of the Cav1.4 Ca2+ channel drives homeostatic plasticity at the cone photoreceptor synapse
Author response: A non-conducting role of the Cav1.4 Ca2+ channel drives homeostatic plasticity at the cone photoreceptor synapse Open
View article: A non-conducting role of the Cav1.4 Ca2+ channel drives homeostatic plasticity at the cone photoreceptor synapse
A non-conducting role of the Cav1.4 Ca2+ channel drives homeostatic plasticity at the cone photoreceptor synapse Open
In congenital stationary night blindness, type 2 (CSNB2)—a disorder involving the Ca v 1.4 (L-type) Ca 2+ channel—visual impairment is mild considering that Ca v 1.4 mediates synaptic release from rod and cone photoreceptors. Here, we addr…
View article: Author response: A non-conducting role of the Cav1.4 Ca2+ channel drives homeostatic plasticity at the cone photoreceptor synapse
Author response: A non-conducting role of the Cav1.4 Ca2+ channel drives homeostatic plasticity at the cone photoreceptor synapse Open
View article: A non-conducting role of the Cav1.4 Ca2+ channel drives homeostatic plasticity at the cone photoreceptor synapse
A non-conducting role of the Cav1.4 Ca2+ channel drives homeostatic plasticity at the cone photoreceptor synapse Open
In congenital stationary night blindness type 2 (CSNB2)—a disorder involving the Cav1.4 (L-type) Ca2+ channel—visual impairment is mild considering that Cav1.4 mediates synaptic release from rod and cone photoreceptors. Here, we addressed …
View article: A non-conducting role of the Cav1.4 Ca2+ channel drives homeostatic plasticity at the cone photoreceptor synapse
A non-conducting role of the Cav1.4 Ca2+ channel drives homeostatic plasticity at the cone photoreceptor synapse Open
In congenital stationary night blindness type 2 (CSNB2)—a disorder involving the Cav1.4 (L-type) Ca2+ channel—visual impairment is mild considering that Cav1.4 mediates synaptic release from rod and cone photoreceptors. Here, we addressed …
View article: Author response: A non-conducting role of the Cav1.4 Ca2+ channel drives homeostatic plasticity at the cone photoreceptor synapse
Author response: A non-conducting role of the Cav1.4 Ca2+ channel drives homeostatic plasticity at the cone photoreceptor synapse Open
In congenital stationary night blindness type 2 (CSNB2)—a disorder involving the Cav1.4 (L-type) Ca2+ channel—visual impairment is mild considering that Cav1.4 mediates synaptic release from rod and cone photoreceptors. Here, we addressed …
View article: Author Correction: Mechanisms of simultaneous linear and nonlinear computations at the mammalian cone photoreceptor synapse
Author Correction: Mechanisms of simultaneous linear and nonlinear computations at the mammalian cone photoreceptor synapse Open
View article: Reviewer #3 (Public Review): A non-conducting role of the Cav1.4 Ca2+ channel drives homeostatic plasticity at the cone photoreceptor synapse
Reviewer #3 (Public Review): A non-conducting role of the Cav1.4 Ca2+ channel drives homeostatic plasticity at the cone photoreceptor synapse Open
In congenital stationary night blindness type 2 (CSNB2)—a disorder involving dysfunction of the Cav1.4 Ca2+ channel—visual impairment is relatively mild considering that Cav1.4 mediates synaptic transmission by rod and cone photoreceptors.…
View article: Reviewer #2 (Public Review): A non-conducting role of the Cav1.4 Ca2+ channel drives homeostatic plasticity at the cone photoreceptor synapse
Reviewer #2 (Public Review): A non-conducting role of the Cav1.4 Ca2+ channel drives homeostatic plasticity at the cone photoreceptor synapse Open
In congenital stationary night blindness type 2 (CSNB2)—a disorder involving dysfunction of the Cav1.4 Ca2+ channel—visual impairment is relatively mild considering that Cav1.4 mediates synaptic transmission by rod and cone photoreceptors.…
View article: A non-conducting role of the Cav1.4 Ca2+ channel drives homeostatic plasticity at the cone photoreceptor synapse
A non-conducting role of the Cav1.4 Ca2+ channel drives homeostatic plasticity at the cone photoreceptor synapse Open
In congenital stationary night blindness, type 2 (CSNB2)—a disorder involving the Ca v 1.4 (L-type) Ca 2+ channel—visual impairment is mild considering that Ca v 1.4 mediates synaptic release from rod and cone photoreceptors. Here, we addr…
View article: Reviewer #4 (Public Review): A non-conducting role of the Cav1.4 Ca2+ channel drives homeostatic plasticity at the cone photoreceptor synapse
Reviewer #4 (Public Review): A non-conducting role of the Cav1.4 Ca2+ channel drives homeostatic plasticity at the cone photoreceptor synapse Open
In congenital stationary night blindness type 2 (CSNB2)—a disorder involving dysfunction of the Cav1.4 Ca2+ channel—visual impairment is relatively mild considering that Cav1.4 mediates synaptic transmission by rod and cone photoreceptors.…
View article: A non-conducting role of the Cav1.4 Ca2+ channel drives homeostatic plasticity at the cone photoreceptor synapse
A non-conducting role of the Cav1.4 Ca2+ channel drives homeostatic plasticity at the cone photoreceptor synapse Open
In congenital stationary night blindness type 2 (CSNB2)—a disorder involving dysfunction of the Cav1.4 Ca2+ channel—visual impairment is relatively mild considering that Cav1.4 mediates synaptic transmission by rod and cone photoreceptors.…
View article: Author Response: A non-conducting role of the Cav1.4 Ca2+ channel drives homeostatic plasticity at the cone photoreceptor synapse
Author Response: A non-conducting role of the Cav1.4 Ca2+ channel drives homeostatic plasticity at the cone photoreceptor synapse Open
In congenital stationary night blindness type 2 (CSNB2)—a disorder involving dysfunction of the Cav1.4 Ca2+ channel—visual impairment is relatively mild considering that Cav1.4 mediates synaptic transmission by rod and cone photoreceptors.…
View article: A non-conducting role of the Ca <sub>v</sub> 1.4 Ca <sup>2+</sup> channel drives homeostatic plasticity at the cone photoreceptor synapse
A non-conducting role of the Ca <sub>v</sub> 1.4 Ca <sup>2+</sup> channel drives homeostatic plasticity at the cone photoreceptor synapse Open
In congenital stationary night blindness type 2 (CSNB2), a disorder involving the Cav1.4 (L-type) Ca2+ channel, visual impairment is mild considering that Cav1.4 mediates synaptic release from rod and cone photoreceptors. Here, we addresse…
View article: Modular interneuron circuits control motion sensitivity in the mouse retina
Modular interneuron circuits control motion sensitivity in the mouse retina Open
View article: A sign-inverted receptive field of inhibitory interneurons provides a pathway for ON-OFF interactions in the retina
A sign-inverted receptive field of inhibitory interneurons provides a pathway for ON-OFF interactions in the retina Open
A fundamental organizing plan of the retina is that visual information is divided into ON and OFF streams that are processed in separate layers. This functional dichotomy originates in the ON and OFF bipolar cells, which then make excitato…
View article: Mechanisms of simultaneous linear and nonlinear computations at the mammalian cone photoreceptor synapse
Mechanisms of simultaneous linear and nonlinear computations at the mammalian cone photoreceptor synapse Open
View article: Design of the mammalian cone photoreceptor to Off bipolar cell synapse
Design of the mammalian cone photoreceptor to Off bipolar cell synapse Open
Graded synapses in sensory systems reliably transmit small signals in the presence of continuous quantal noise. To understand how signaling is optimized during graded transmission, we counted the number of vesicles released by a mammalian …
View article: Quantification of Adeno-Associated Virus with Safe Nucleic Acid Dyes
Quantification of Adeno-Associated Virus with Safe Nucleic Acid Dyes Open
Adeno-associated virus (AAV) is the most commonly used viral vector for both biological and gene therapeutic applications. Although many methods have been developed to measure quantity attributes of AAV, they are often technically challeng…
View article: Quantification of Adeno-Associated Virus with Safe Nucleic Acid Dyes
Quantification of Adeno-Associated Virus with Safe Nucleic Acid Dyes Open
Adeno-associated virus (AAV) is the most commonly used viral vector for both biological and gene therapeutic applications 1 . Although many methods have been developed to measure quantity attributes of AAV, they are often technically chall…
View article: Temporal filtering of light responses at cone to Off bipolar cell synapses in the ground squirrel retina
Temporal filtering of light responses at cone to Off bipolar cell synapses in the ground squirrel retina Open
View article: Intersectional Strategies for Targeting Amacrine and Ganglion Cell Types in the Mouse Retina
Intersectional Strategies for Targeting Amacrine and Ganglion Cell Types in the Mouse Retina Open
The mammalian retina harbors over 100 different cell types. To understand how retinal circuits work, it is essential to systematically access each type. A widely used approach for achieving targeted transgene expression exploits promoter-d…
View article: The challenge of transplantation: The intricate structure and function of the cone photoreceptor synapse
The challenge of transplantation: The intricate structure and function of the cone photoreceptor synapse Open
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View article: Intersectional strategies for targeting amacrine and ganglion cell types in the mouse retina
Intersectional strategies for targeting amacrine and ganglion cell types in the mouse retina Open
View article: Light acts directly on S-cone terminals to regulate transmitter release
Light acts directly on S-cone terminals to regulate transmitter release Open
View article: Mechanism of High-Frequency Signaling at a Depressing Ribbon Synapse
Mechanism of High-Frequency Signaling at a Depressing Ribbon Synapse Open
View article: Healthy and diseased corticospinal motor neurons are selectively transduced upon direct AAV2-2 injection into the motor cortex
Healthy and diseased corticospinal motor neurons are selectively transduced upon direct AAV2-2 injection into the motor cortex Open
Direct gene delivery to the neurons of interest, without affecting other neuron populations in the cerebral cortex, represent a challenge owing to the heterogeneity and cellular complexity of the brain. Genetic modulation of corticospinal …
View article: An Amacrine Cell Circuit for Signaling Steady Illumination in the Retina
An Amacrine Cell Circuit for Signaling Steady Illumination in the Retina Open
Decades of research have focused on the circuit connectivity between retinal neurons, but only a handful of amacrine cells have been described functionally and placed in the context of a specific retinal circuit. Here, we identify a circui…