Steven H. Wright
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View article: Radiomic Feature Characteristics of Ovine Pulmonary Adenocarcinoma
Radiomic Feature Characteristics of Ovine Pulmonary Adenocarcinoma Open
Radiomic feature (RF) analysis of computed tomography (CT) images may aid the diagnosis and staging of ovine pulmonary adenocarcinoma (OPA). We assessed the RF characteristics of OPA tumours in JSRV-infected sheep compared to non-tumour lu…
View article: Spatial encoding and growth-related change of sheep lung radiomic features
Spatial encoding and growth-related change of sheep lung radiomic features Open
Introduction Different regions of the small ruminant lung exhibit variable susceptibility to specific lung pathologies. Such susceptibility may be reflected in regional lung radiomic features extracted from computed tomography (CT) images.…
View article: Tracking Ovine Pulmonary Adenocarcinoma Development Using an Experimental Jaagsiekte Sheep Retrovirus Infection Model
Tracking Ovine Pulmonary Adenocarcinoma Development Using an Experimental Jaagsiekte Sheep Retrovirus Infection Model Open
Ovine pulmonary adenocarcinoma (OPA) is an infectious, neoplastic lung disease of sheep that causes significant animal welfare and economic issues throughout the world. Understanding OPA pathogenesis is key to developing tools to control i…
View article: Mesothelial cell-derived antigen-presenting cancer-associated fibroblasts induce expansion of regulatory T cells in pancreatic cancer
Mesothelial cell-derived antigen-presenting cancer-associated fibroblasts induce expansion of regulatory T cells in pancreatic cancer Open
View article: Regional and organ-level responses to local lung irradiation in sheep
Regional and organ-level responses to local lung irradiation in sheep Open
Lung is a dose-limiting organ in radiotherapy. This may limit tumour control when effort is made in planning to limit the likelihood of radiation-induced lung injury (RILI). Understanding the factors that dictate susceptibility to radiatio…
View article: Targeting <scp>TGF</scp> βR2‐mutant tumors exposes vulnerabilities to stromal <scp>TGF</scp> β blockade in pancreatic cancer
Targeting <span>TGF</span> βR2‐mutant tumors exposes vulnerabilities to stromal <span>TGF</span> β blockade in pancreatic cancer Open
TGFβ is important during pancreatic ductal adenocarcinoma (PDA) progression. Canonical TGFβ signaling suppresses epithelial pancreatic cancer cell proliferation; as a result, inhibiting TGFβ has not been successful in PDA. In contrast, we …
View article: Nebulisation of synthetic lamellar lipids mitigates radiation-induced lung injury in a large animal model
Nebulisation of synthetic lamellar lipids mitigates radiation-induced lung injury in a large animal model Open
View article: Comparing microbiotas in the upper aerodigestive and lower respiratory tracts of lambs
Comparing microbiotas in the upper aerodigestive and lower respiratory tracts of lambs Open
In contrast to humans, we found that the lung microbiota of lambs is dissimilar to that of the upper aerodigestive tract, and we suggest that this may be related to physiological and anatomical differences between sheep and humans. Underst…
View article: Microbiota in Exhaled Breath Condensate and the Lung
Microbiota in Exhaled Breath Condensate and the Lung Open
The lung microbiota is commonly sampled using relatively invasive bronchoscopic procedures. Exhaled breath condensate (EBC) collection potentially offers a less invasive alternative for lung microbiota sampling. We compared lung microbiota…
View article: Additional file 2: of Comparing microbiotas in the upper aerodigestive and lower respiratory tracts of lambs
Additional file 2: of Comparing microbiotas in the upper aerodigestive and lower respiratory tracts of lambs Open
Dataset S2. Full list of bacterial OTUs and taxonomies. (XLSX 370Â kb)
View article: Additional file 1: of Comparing microbiotas in the upper aerodigestive and lower respiratory tracts of lambs
Additional file 1: of Comparing microbiotas in the upper aerodigestive and lower respiratory tracts of lambs Open
Dataset S1. Sample processing data for all samples. (XLSX 18Â kb)
View article: Variability of the Sheep Lung Microbiota
Variability of the Sheep Lung Microbiota Open
Sequencing technologies have recently facilitated the characterization of bacterial communities present in lungs during health and disease. However, there is currently a dearth of information concerning the variability of such data in heal…
View article: Lung Microbiota Changes Associated with Chronic Pseudomonas aeruginosa Lung Infection and the Impact of Intravenous Colistimethate Sodium
Lung Microbiota Changes Associated with Chronic Pseudomonas aeruginosa Lung Infection and the Impact of Intravenous Colistimethate Sodium Open
The proportional increase in Pseudomonadales relative to other Gram negative bacteria in the lungs of sheep treated with systemic CMS highlights the potential for such therapies to inadvertently select or create a niche for bacteria seedin…