Steven Hébert
YOU?
Author Swipe
View article: Development of the EPO-Score – a multivariable tool to predict adverse outcome in infants with perinatal asphyxia undergoing therapeutic hypothermia – a retrospective study
Development of the EPO-Score – a multivariable tool to predict adverse outcome in infants with perinatal asphyxia undergoing therapeutic hypothermia – a retrospective study Open
Aim Early outcome prediction in neonates with perinatal asphyxia receiving therapeutic hypothermia (TH) remains difficult. Although several studies have explored prognostic markers and proposed scoring systems, none of these tools has been…
View article: A diverse landscape of FGFR alterations and co-mutations suggests potential therapeutic strategies in pediatric low-grade gliomas
A diverse landscape of FGFR alterations and co-mutations suggests potential therapeutic strategies in pediatric low-grade gliomas Open
Oncogenic alterations in fibroblast growth factor receptor (FGFR)-family proteins occur across cancers, including pediatric gliomas. Our genomic analysis of 11,635 gliomas across ages finds that 5.3% of all gliomas harbor FGFR alterations,…
View article: Figure S1-S10 from Targeting the Dependence on PIK3C3-mTORC1 Signaling in Dormancy-Prone Breast Cancer Cells Blunts Metastasis Initiation
Figure S1-S10 from Targeting the Dependence on PIK3C3-mTORC1 Signaling in Dormancy-Prone Breast Cancer Cells Blunts Metastasis Initiation Open
Supplementary Methods and Supplementary Figures
View article: Data from Targeting the Dependence on PIK3C3-mTORC1 Signaling in Dormancy-Prone Breast Cancer Cells Blunts Metastasis Initiation
Data from Targeting the Dependence on PIK3C3-mTORC1 Signaling in Dormancy-Prone Breast Cancer Cells Blunts Metastasis Initiation Open
Halting breast cancer metastatic relapse following primary tumor removal remains challenging due to a lack of specific vulnerabilities to target during the clinical dormancy phase. To identify such vulnerabilities, we conducted genome-wide…
View article: Supplementary Data from Targeting the Dependence on PIK3C3-mTORC1 Signaling in Dormancy-Prone Breast Cancer Cells Blunts Metastasis Initiation
Supplementary Data from Targeting the Dependence on PIK3C3-mTORC1 Signaling in Dormancy-Prone Breast Cancer Cells Blunts Metastasis Initiation Open
Tables S6-S8
View article: Supplementary Tables from Targeting the Dependence on PIK3C3-mTORC1 Signaling in Dormancy-Prone Breast Cancer Cells Blunts Metastasis Initiation
Supplementary Tables from Targeting the Dependence on PIK3C3-mTORC1 Signaling in Dormancy-Prone Breast Cancer Cells Blunts Metastasis Initiation Open
Tables S1-S5
View article: Targeting the Dependence on PIK3C3-mTORC1 Signaling in Dormancy-Prone Breast Cancer Cells Blunts Metastasis Initiation
Targeting the Dependence on PIK3C3-mTORC1 Signaling in Dormancy-Prone Breast Cancer Cells Blunts Metastasis Initiation Open
Halting breast cancer metastatic relapse following primary tumor removal remains challenging due to a lack of specific vulnerabilities to target during the clinical dormancy phase. To identify such vulnerabilities, we conducted genome-wide…
View article: Supplementary Table 4 from FOXR2 Targets LHX6<sup>+</sup>/DLX<sup>+</sup> Neural Lineages to Drive Central Nervous System Neuroblastoma
Supplementary Table 4 from FOXR2 Targets LHX6<sup>+</sup>/DLX<sup>+</sup> Neural Lineages to Drive Central Nervous System Neuroblastoma Open
Quality control metrics and processing parameters for single-cell data for patient tumors.
View article: Supplementary Table 10 from FOXR2 Targets LHX6<sup>+</sup>/DLX<sup>+</sup> Neural Lineages to Drive Central Nervous System Neuroblastoma
Supplementary Table 10 from FOXR2 Targets LHX6<sup>+</sup>/DLX<sup>+</sup> Neural Lineages to Drive Central Nervous System Neuroblastoma Open
ssGSEA enrichment of cell type specific gene signatures in bulk RNAseq tumors. For each sample, the highest scoring signature is shown.
View article: Supplementary Figure 4 from FOXR2 Targets LHX6<sup>+</sup>/DLX<sup>+</sup> Neural Lineages to Drive Central Nervous System Neuroblastoma
Supplementary Figure 4 from FOXR2 Targets LHX6<sup>+</sup>/DLX<sup>+</sup> Neural Lineages to Drive Central Nervous System Neuroblastoma Open
Bulk RNAseq projections by ssGSEA.
View article: Supplementary Table 5 from FOXR2 Targets LHX6<sup>+</sup>/DLX<sup>+</sup> Neural Lineages to Drive Central Nervous System Neuroblastoma
Supplementary Table 5 from FOXR2 Targets LHX6<sup>+</sup>/DLX<sup>+</sup> Neural Lineages to Drive Central Nervous System Neuroblastoma Open
Quality control metrics and processing parameters for single-cell data for murine models.
View article: Figure 6 from FOXR2 Targets LHX6<sup>+</sup>/DLX<sup>+</sup> Neural Lineages to Drive Central Nervous System Neuroblastoma
Figure 6 from FOXR2 Targets LHX6<sup>+</sup>/DLX<sup>+</sup> Neural Lineages to Drive Central Nervous System Neuroblastoma Open
Mouse models transcriptomically recapitulate human NB-FOXR2. A, Heatmap showing CNVs in Foxr2 p53LOF and Foxr2 alone models, computed with inferCNV. B, Top, Uniform Manifold Approximation and Projection (UMAP) joint representation of mouse…
View article: Supplementary Figure 1 from FOXR2 Targets LHX6<sup>+</sup>/DLX<sup>+</sup> Neural Lineages to Drive Central Nervous System Neuroblastoma
Supplementary Figure 1 from FOXR2 Targets LHX6<sup>+</sup>/DLX<sup>+</sup> Neural Lineages to Drive Central Nervous System Neuroblastoma Open
Quality control (QC) metrics and copy-number variation for scRNAseq datasets of NB-FOXR2 patient tumors.
View article: Supplementary Table 1 from FOXR2 Targets LHX6<sup>+</sup>/DLX<sup>+</sup> Neural Lineages to Drive Central Nervous System Neuroblastoma
Supplementary Table 1 from FOXR2 Targets LHX6<sup>+</sup>/DLX<sup>+</sup> Neural Lineages to Drive Central Nervous System Neuroblastoma Open
Analyses and materials related to murine IUE and orthotopic models.
View article: Supplementary Table 7 from FOXR2 Targets LHX6<sup>+</sup>/DLX<sup>+</sup> Neural Lineages to Drive Central Nervous System Neuroblastoma
Supplementary Table 7 from FOXR2 Targets LHX6<sup>+</sup>/DLX<sup>+</sup> Neural Lineages to Drive Central Nervous System Neuroblastoma Open
Reference dataset labels used for cell type annotation of mouse model single-cell datasets.
View article: Supplementary Table 3 from FOXR2 Targets LHX6<sup>+</sup>/DLX<sup>+</sup> Neural Lineages to Drive Central Nervous System Neuroblastoma
Supplementary Table 3 from FOXR2 Targets LHX6<sup>+</sup>/DLX<sup>+</sup> Neural Lineages to Drive Central Nervous System Neuroblastoma Open
Post-alignment quality control for bulk RNAseq data for pediatric brain tumors.
View article: Supplementary Figure 6 from FOXR2 Targets LHX6<sup>+</sup>/DLX<sup>+</sup> Neural Lineages to Drive Central Nervous System Neuroblastoma
Supplementary Figure 6 from FOXR2 Targets LHX6<sup>+</sup>/DLX<sup>+</sup> Neural Lineages to Drive Central Nervous System Neuroblastoma Open
Mouse models transcriptomically recapitulate human NB-FOXR2
View article: Figure 3 from FOXR2 Targets LHX6<sup>+</sup>/DLX<sup>+</sup> Neural Lineages to Drive Central Nervous System Neuroblastoma
Figure 3 from FOXR2 Targets LHX6<sup>+</sup>/DLX<sup>+</sup> Neural Lineages to Drive Central Nervous System Neuroblastoma Open
FOXR2 does not induce expression of MGE or EC-NB TFs. A, Bulk RNA-seq expression of telencephalon patterning TFs. Top and third rows, tumor samples from this study cohort. Second row, EC-NB samples (Gartlgruber and colleagues, ref. 21) sub…
View article: Supplementary Figure 3 from FOXR2 Targets LHX6<sup>+</sup>/DLX<sup>+</sup> Neural Lineages to Drive Central Nervous System Neuroblastoma
Supplementary Figure 3 from FOXR2 Targets LHX6<sup>+</sup>/DLX<sup>+</sup> Neural Lineages to Drive Central Nervous System Neuroblastoma Open
NB-FOXR2 express a transcription factor fingerprint of the medial ganglionic eminence.
View article: Figure 7 from FOXR2 Targets LHX6<sup>+</sup>/DLX<sup>+</sup> Neural Lineages to Drive Central Nervous System Neuroblastoma
Figure 7 from FOXR2 Targets LHX6<sup>+</sup>/DLX<sup>+</sup> Neural Lineages to Drive Central Nervous System Neuroblastoma Open
Foxr2 chromatin binding sites in Foxr2 p53LOF neurosphere show enrichment in ETS and glial pathways. A, Validation of FOXR2 overexpression and p53 downregulation in ex vivoFoxr2 p53LOF neurospheres by qRT-PCR. B, Validation of Nkx2-1, Lhx6…
View article: Figure 2 from FOXR2 Targets LHX6<sup>+</sup>/DLX<sup>+</sup> Neural Lineages to Drive Central Nervous System Neuroblastoma
Figure 2 from FOXR2 Targets LHX6<sup>+</sup>/DLX<sup>+</sup> Neural Lineages to Drive Central Nervous System Neuroblastoma Open
NB-FOXR2 expresses a TF fingerprint of the MGE. A, Expression of telencephalon-patterning TFs in the embryonal mouse brain. Top, stereo-seq in situ RNA expression of telencephalon-patterning TFs in E14 mouse (Chen and colleagues, ref. 75; …
View article: Supplementary Table 9 from FOXR2 Targets LHX6<sup>+</sup>/DLX<sup>+</sup> Neural Lineages to Drive Central Nervous System Neuroblastoma
Supplementary Table 9 from FOXR2 Targets LHX6<sup>+</sup>/DLX<sup>+</sup> Neural Lineages to Drive Central Nervous System Neuroblastoma Open
Cell type specific gene signatures derived from reference datasets, used for enrichment scoring.
View article: Figure 5 from FOXR2 Targets LHX6<sup>+</sup>/DLX<sup>+</sup> Neural Lineages to Drive Central Nervous System Neuroblastoma
Figure 5 from FOXR2 Targets LHX6<sup>+</sup>/DLX<sup>+</sup> Neural Lineages to Drive Central Nervous System Neuroblastoma Open
Foxr2 is oncogenic in the ventral telencephalon in mice. A, Schematic describing the IUE-based strategy to model FOXR2-driven brain tumors. PiggyBac and CRISPR vectors are delivered into neural stem cells in the GEs at E12.5. After birth, …
View article: Figure 4 from FOXR2 Targets LHX6<sup>+</sup>/DLX<sup>+</sup> Neural Lineages to Drive Central Nervous System Neuroblastoma
Figure 4 from FOXR2 Targets LHX6<sup>+</sup>/DLX<sup>+</sup> Neural Lineages to Drive Central Nervous System Neuroblastoma Open
NB-FOXR2 tumors transcriptionally resemble interneurons and OPC cells. A,t-Distributed stochastic neighbor embedding (t-SNE) of bulk RNA-seq profiles of pediatric brain tumors (left) and pediatric brain tumors with stage 4 high-risk EC-NBs…
View article: Supplementary Table 8 from FOXR2 Targets LHX6<sup>+</sup>/DLX<sup>+</sup> Neural Lineages to Drive Central Nervous System Neuroblastoma
Supplementary Table 8 from FOXR2 Targets LHX6<sup>+</sup>/DLX<sup>+</sup> Neural Lineages to Drive Central Nervous System Neuroblastoma Open
Quantification of expression and detection rate (Pct1) for transcription factors in the normal brain reference datasets.
View article: Supplementary Table 6 from FOXR2 Targets LHX6<sup>+</sup>/DLX<sup>+</sup> Neural Lineages to Drive Central Nervous System Neuroblastoma
Supplementary Table 6 from FOXR2 Targets LHX6<sup>+</sup>/DLX<sup>+</sup> Neural Lineages to Drive Central Nervous System Neuroblastoma Open
Summary of reference datasets for the normal brain and adrenal gland used in this study.
View article: Supplementary Table 2 from FOXR2 Targets LHX6<sup>+</sup>/DLX<sup>+</sup> Neural Lineages to Drive Central Nervous System Neuroblastoma
Supplementary Table 2 from FOXR2 Targets LHX6<sup>+</sup>/DLX<sup>+</sup> Neural Lineages to Drive Central Nervous System Neuroblastoma Open
Summary of patient samples included in this study, and profiling by RNAseq, scRNAseq, or scMultiome.
View article: Figure S5 from The Neurodevelopmental Protein POGZ Suppresses Metastasis in Triple-Negative Breast Cancer by Attenuating TGFβ Signaling
Figure S5 from The Neurodevelopmental Protein POGZ Suppresses Metastasis in Triple-Negative Breast Cancer by Attenuating TGFβ Signaling Open
Supplemental Figure 5 with legend