Steven J. Czinn
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View article: Updated joint ESPGHAN/NASPGHAN guidelines for management of <i>Helicobacter pylori</i> infection in children and adolescents (2023)
Updated joint ESPGHAN/NASPGHAN guidelines for management of <i>Helicobacter pylori</i> infection in children and adolescents (2023) Open
Background Evolving epidemiological data and increasing antibiotic resistance mandate an update of the European and North American Societies of Pediatric Gastroenterology, Hepatology and Nutrition guidelines. Methods Certainty of evidence …
View article: The TNF-Alpha Inducing Protein is Associated With Gastric Inflammation and Hyperplasia in a Murine Model of Helicobacter pylori Infection
The TNF-Alpha Inducing Protein is Associated With Gastric Inflammation and Hyperplasia in a Murine Model of Helicobacter pylori Infection Open
Helicobacter pylori ( H. pylori ) is a Gram-negative bacterium that colonizes the human stomach leading to the development of chronic gastritis, peptic ulcers and gastric adenocarcinoma. A combination of host, environment and bacterial vir…
View article: Impact of Andrographolide and Melatonin Combinatorial Drug Therapy on Metastatic Colon Cancer Cells and Organoids
Impact of Andrographolide and Melatonin Combinatorial Drug Therapy on Metastatic Colon Cancer Cells and Organoids Open
Background: The death rate (the number of deaths per 100 000 people per year) of colorectal cancer (CRC) has been dropping since 1980 due to increased screening, lifestyle-related risk factors, and improved treatment options; however, CRC …
View article: Crosstalk between endoplasmic reticulum stress and anti-viral activities: A novel therapeutic target for COVID-19
Crosstalk between endoplasmic reticulum stress and anti-viral activities: A novel therapeutic target for COVID-19 Open
View article: Toward the elimination of bias in Pediatric Research
Toward the elimination of bias in Pediatric Research Open
View article: Identification of Cross Talk between FoxM1 and RASSF1A as a Therapeutic Target of Colon Cancer
Identification of Cross Talk between FoxM1 and RASSF1A as a Therapeutic Target of Colon Cancer Open
Metastatic colorectal cancer (mCRC) is characterized by the expression of cellular oncogenes, the loss of tumor suppressor gene function. Therefore, identifying integrated signaling between onco-suppressor genes may facilitate the developm…
View article: Upregulation of RASSF1A in Colon Cancer by Suppression of Angiogenesis Signaling and Akt Activation
Upregulation of RASSF1A in Colon Cancer by Suppression of Angiogenesis Signaling and Akt Activation Open
Background/Aims: Silencing of tumor suppressor genes (TSGs) and promotion of angiogenesis are associated with tumor development and metastasis. However, little is known if angiogenic molecules directly control TSGs and vice versa. Methods:…
View article: Supplementary Material for: Upregulation of RASSF1A in Colon Cancer by Suppression of Angiogenesis Signaling and Akt Activation
Supplementary Material for: Upregulation of RASSF1A in Colon Cancer by Suppression of Angiogenesis Signaling and Akt Activation Open
Background/Aims: Silencing of tumor suppressor genes (TSGs) and promotion of angiogenesis are associated with tumor development and metastasis. However, little is known if angiogenic molecules directly control TSGs and vice v…
View article: Increased reactive oxygen species levels cause ER stress and cytotoxicity in andrographolide treated colon cancer cells
Increased reactive oxygen species levels cause ER stress and cytotoxicity in andrographolide treated colon cancer cells Open
Chemotherapy continues to play an essential role in the management of many cancers including colon cancer, the third leading cause of death due to cancer in the United States. Many naturally occurring plant compounds have been demonstrated…
View article: Antibiotic Resistance of &lt;i&gt;Helicobacter pylori&lt;/i&gt; and Eradication Rate in Japanese Pediatric Patients
Antibiotic Resistance of <i>Helicobacter pylori</i> and Eradication Rate in Japanese Pediatric Patients Open
Helicobacter pylori (H. pylori) eradication rates achieved with a proton pump inhibitor (PPI), amoxicillin and clarithromycin have recently decreased to about 75% because of the increase in clarithromycin resistance in Japan. In the presen…
View article: A Retrospective Analysis of Three Non-Invasive Tests for Initial Diagnosis of &lt;i&gt;Helicobacter pylori&lt;/i&gt; Infection in Children
A Retrospective Analysis of Three Non-Invasive Tests for Initial Diagnosis of <i>Helicobacter pylori</i> Infection in Children Open
Proper diagnosis in the pediatric population is required to eradicate Helicobacter pylori (H. pylori) and prevent gastric cancer. Our aim was to assess the performance of non-invasive tests to diagnose H. pylori infection in pediatric pati…
View article: Identification of Helicobacter pylori and the evolution of an efficacious childhood vaccine to protect against gastritis and peptic ulcer disease
Identification of Helicobacter pylori and the evolution of an efficacious childhood vaccine to protect against gastritis and peptic ulcer disease Open
View article: Endoplasmic reticulum stress and IRE-1 signaling cause apoptosis in colon cancer cells in response to andrographolide treatment
Endoplasmic reticulum stress and IRE-1 signaling cause apoptosis in colon cancer cells in response to andrographolide treatment Open
The plant metabolite andrographolide induces cell cycle arrest and apoptosis in cancer cells. The mechanism(s) by which andrographolide induces apoptosis however, have not been elucidated. The present study was performed to determine the m…
View article: Early Molecular Events in Murine Gastric Epithelial Cells Mediated by <i>Helicobacter pylori</i> CagA
Early Molecular Events in Murine Gastric Epithelial Cells Mediated by <i>Helicobacter pylori</i> CagA Open
Background Murine models of Helicobacter pylori infection are used to study host–pathogen interactions, but lack of severe gastritis in this model has limited its usefulness in studying pathogenesis. We compared the murine gastric epitheli…
View article: Mucosal-Associated Invariant T Cells in the Human Gastric Mucosa and Blood: Role in Helicobacter pylori Infection
Mucosal-Associated Invariant T Cells in the Human Gastric Mucosa and Blood: Role in Helicobacter pylori Infection Open
Mucosal-associated invariant T (MAIT) cells represent a class of antimicrobial innate-like T cells that have been characterized in human blood, liver, lungs, and intestine. Here, we investigated, for the first time, the presence of MAIT ce…
View article: Gastric LTi cells promote lymphoid follicle formation but are limited by IRAK-M and do not alter microbial growth
Gastric LTi cells promote lymphoid follicle formation but are limited by IRAK-M and do not alter microbial growth Open