Steven J. Del Signore
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View article: Deployment of endocytic machinery to periactive zones of nerve terminals is independent of active zone assembly and evoked release
Deployment of endocytic machinery to periactive zones of nerve terminals is independent of active zone assembly and evoked release Open
In presynaptic nerve terminals, the endocytic apparatus rapidly restores synaptic vesicles after neurotransmitter release. Many endocytic proteins localize to the periactive zone, a loosely defined area adjacent to active zones. A prevaili…
View article: Deployment of endocytic machinery to periactive zones of nerve terminals is independent of active zone assembly and evoked release
Deployment of endocytic machinery to periactive zones of nerve terminals is independent of active zone assembly and evoked release Open
In presynaptic nerve terminals, the endocytic apparatus rapidly restores synaptic vesicles after neurotransmitter release. Many endocytic proteins localize to the periactive zone, a loosely defined area adjacent to active zones. A prevaili…
View article: Deployment of endocytic machinery to periactive zones of nerve terminals is independent of active zone assembly and evoked release
Deployment of endocytic machinery to periactive zones of nerve terminals is independent of active zone assembly and evoked release Open
In presynaptic nerve terminals, the endocytic apparatus rapidly restores synaptic vesicles after neurotransmitter release. Many endocytic proteins localize to the periactive zone, a loosely defined area adjacent to active zones. A prevaili…
View article: ESCRT disruption provides evidence against trans-synaptic signaling via extracellular vesicles
ESCRT disruption provides evidence against trans-synaptic signaling via extracellular vesicles Open
Extracellular vesicles (EVs) are released by many cell types, including neurons, carrying cargoes involved in signaling and disease. It is unclear whether EVs promote intercellular signaling or serve primarily to dispose of unwanted materi…
View article: ESCRT disruption provides evidence against signaling functions for synaptic exosomes
ESCRT disruption provides evidence against signaling functions for synaptic exosomes Open
Extracellular vesicles (EVs) are released by many cell types including neurons, carrying cargoes involved in signaling and disease. It is unclear whether EVs promote intercellular signaling or serve primarily to dispose of unwanted materia…
View article: An approach for quantitative mapping of synaptic periactive zone architecture and organization
An approach for quantitative mapping of synaptic periactive zone architecture and organization Open
At neuronal synapses, endocytic proteins concentrate near sites of vesicle release in a membrane domain called the periactive zone. A new method and conceptual framework were devised to quantify periactive zone architecture, and it was fou…
View article: Quantitative mapping of synaptic periactive zone architecture and organization
Quantitative mapping of synaptic periactive zone architecture and organization Open
1. Abstract Following exocytosis at active zones, synaptic vesicle membranes and membrane-bound proteins must be recycled. The endocytic machinery that drives this recycling accumulates in the periactive zone (PAZ), a region of the synapse…
View article: An autoinhibitory clamp of actin assembly constrains and directs synaptic endocytosis
An autoinhibitory clamp of actin assembly constrains and directs synaptic endocytosis Open
Synaptic membrane-remodeling events such as endocytosis require force-generating actin assembly. The endocytic machinery that regulates these actin and membrane dynamics localizes at high concentrations to large areas of the presynaptic me…
View article: Author response: An autoinhibitory clamp of actin assembly constrains and directs synaptic endocytosis
Author response: An autoinhibitory clamp of actin assembly constrains and directs synaptic endocytosis Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Synaptic membrane-remodeling …
View article: An autoinhibitory clamp of actin assembly constrains and directs synaptic endocytosis
An autoinhibitory clamp of actin assembly constrains and directs synaptic endocytosis Open
Synaptic membrane-remodeling events such as endocytosis require force-generating actin assembly. The endocytic machinery that regulates these actin and membrane dynamics localizes at high concentrations to large areas of the presynaptic me…
View article: The enemy of my enemy: PTEN and PLCXD collude to fight endosomal PtdIns(4,5)P2
The enemy of my enemy: PTEN and PLCXD collude to fight endosomal PtdIns(4,5)P2 Open
Loss of the phosphoinositide 5-phosphatase OCRL causes accumulation of PtdIns(4,5)P2 on membranes and, ultimately, Lowe syndrome. In this issue, Mondin et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201805155) discover that a surp…
View article: Active Probes for Imaging Membrane Dynamics of Live Cells with High Spatial and Temporal Resolution over Extended Time Scales and Areas
Active Probes for Imaging Membrane Dynamics of Live Cells with High Spatial and Temporal Resolution over Extended Time Scales and Areas Open
Despite the advancement of molecular imaging techniques, there is an unmet need for probes for direct imaging of membrane dynamics of live cells. Here we report a novel type of active (or enzyme responsive) probes to directly image membran…
View article: The WAVE Regulatory Complex and Branched F-Actin Counterbalance Contractile Force to Control Cell Shape and Packing in the Drosophila Eye
The WAVE Regulatory Complex and Branched F-Actin Counterbalance Contractile Force to Control Cell Shape and Packing in the Drosophila Eye Open
View article: Cellular Uptake of A Taurine-Modified, Ester Bond-Decorated D-Peptide Derivative via Dynamin-Based Endocytosis and Macropinocytosis
Cellular Uptake of A Taurine-Modified, Ester Bond-Decorated D-Peptide Derivative via Dynamin-Based Endocytosis and Macropinocytosis Open
Most of the peptides used for promoting cellular uptake bear positive charges. In our previous study, we reported an example of taurine (bearing negative charges in physiological conditions) promoting cellular uptake of D-peptides. Taurine…
View article: dOCRL maintains immune cell quiescence by regulating endosomal traffic
dOCRL maintains immune cell quiescence by regulating endosomal traffic Open
Lowe Syndrome is a developmental disorder characterized by eye, kidney, and neurological pathologies, and is caused by mutations in the phosphatidylinositol-5-phosphatase OCRL. OCRL plays diverse roles in endocytic and endolysosomal traffi…
View article: Drosophila comes of age as a model system for understanding the function of cytoskeletal proteins in cells, tissues, and organisms
Drosophila comes of age as a model system for understanding the function of cytoskeletal proteins in cells, tissues, and organisms Open
available in PMC 2016 June 30
View article: <i>Drosophila</i> comes of age as a model system for understanding the function of cytoskeletal proteins in cells, tissues, and organisms
<i>Drosophila</i> comes of age as a model system for understanding the function of cytoskeletal proteins in cells, tissues, and organisms Open
For the last 100 years, Drosophila melanogaster has been a powerhouse genetic system for understanding mechanisms of inheritance, development, and behavior in animals. In recent years, advances in imaging and genetic tools have led to Dros…