Steven J. Eppell
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View article: Doxycycline Release From Cyclodextrin Oligomer-Containing Collagen Gels
Doxycycline Release From Cyclodextrin Oligomer-Containing Collagen Gels Open
Dental implants commonly suffer from chronic peri-implantitis arising from infection and inflammation at the abutment/gingiva interface, primarily because they fail to replicate the collagen-rich soft tissue interface between natural teeth…
View article: Three-dimensional tissue platform co-laid with native collagen fibers and cells for phenotypic screening of stem cell interactions
Three-dimensional tissue platform co-laid with native collagen fibers and cells for phenotypic screening of stem cell interactions Open
Phenotypic screening of cell-cell and cell-matrix interactions is critical yet challenging for drug discovery and disease modeling. In this study, a scalable 3D tissue platform was developed by co-laying extracted natural insoluble collage…
View article: Collagen fibrils from both positional and energy-storing tendons exhibit increased amounts of denatured collagen when stretched beyond the yield point
Collagen fibrils from both positional and energy-storing tendons exhibit increased amounts of denatured collagen when stretched beyond the yield point Open
View article: Platelet-mimicking procoagulant nanoparticles augment hemostasis in animal models of bleeding
Platelet-mimicking procoagulant nanoparticles augment hemostasis in animal models of bleeding Open
Treatment of bleeding disorders using transfusion of donor-derived platelets faces logistical challenges due to their limited availability, high risk of contamination, and short (5 to 7 days) shelf life. These challenges could be potential…
View article: Mandible Biomechanics and Continuously Erupting Teeth: A New Defect Model for Studying Load-Bearing Biomaterials
Mandible Biomechanics and Continuously Erupting Teeth: A New Defect Model for Studying Load-Bearing Biomaterials Open
Animals with elodont dentition and unfused mandible symphyses are hypothesized to have symmetric incisor morphology. Since these animals maintain their teeth by gnawing, they may provide physiologic feedback on mechanical function when uni…
View article: Effect of Neutrophil Adhesion on the Mechanical Properties of Lung Microvascular Endothelial Cells
Effect of Neutrophil Adhesion on the Mechanical Properties of Lung Microvascular Endothelial Cells Open
Neutrophil adhesion to pulmonary microvascular endothelial cells (ECs) initiates intracellular signaling, resulting in remodeling of F-actin cytoskeletal structure of ECs. The present study determined the mechanical properties of ECs and t…
View article: A complementary energy approach accommodates scale differences in soft tissues
A complementary energy approach accommodates scale differences in soft tissues Open
View article: Euler–Bernoulli theory accurately predicts atomic force microscope cantilever shape during non-equilibrium snap-to-contact motion
Euler–Bernoulli theory accurately predicts atomic force microscope cantilever shape during non-equilibrium snap-to-contact motion Open
We prove that the Euler-Bernoulli elastic beam theory can be reliably used to describe the dynamics of an atomic force microscope cantilever during the far from equilibrium snap-to-contact event. In conventional atomic force microscope ope…
View article: Minor Review: An Overview of a Synthetic Nanophase Bone Substitute
Minor Review: An Overview of a Synthetic Nanophase Bone Substitute Open
Material is reviewed that consists of reconstituted collagen fibril gel mineralized in a manner that produces biomimetically sized nanoapatites intimately associated with the fibrils. This gel is formed into usable shapes with a modulus an…
View article: Issue Information
Issue Information Open
Part B: Applied Biomaterials is a highly interdisciplinary peer-reviewed journal serving the needs of biomaterials professionals who design, develop, produce and apply biomaterials and medical devices.It has the common focus of biomaterial…
View article: Unexplored territory in the AFM force curve contains nanomechanics information
Unexplored territory in the AFM force curve contains nanomechanics information Open
We demonstrate the existence of a previously unknown damped oscillating signal just after the point when an atomic force microscope tip hits a sample surface. This oscillating signal is below the noise in a single force-displacement measur…
View article: Method to extract minimally damaged collagen fibrils from tendon
Method to extract minimally damaged collagen fibrils from tendon Open
A new method is presented to extract collagen fibrils from mammalian tendon tissue. Mammalian tendons are treated with a trypsin-based extraction medium and gently separated with tweezers in an aqueous solution. Collagen fibrils rele…
View article: Accuracy of AFM force distance curves via direct solution of the Euler-Bernoulli equation
Accuracy of AFM force distance curves via direct solution of the Euler-Bernoulli equation Open
In an effort to improve the accuracy of force-separation curves obtained from atomic force microscope data, we compare force-separation curves computed using two methods to solve the Euler-Bernoulli equation. A recently introduced method u…
View article: Tension tests on mammalian collagen fibrils
Tension tests on mammalian collagen fibrils Open
A brief overview of isolated collagen fibril mechanics testing is followed by presentation of the first results testing fibrils isolated from load-bearing mammalian tendons using a microelectromechanical systems platform. The in vitro modu…