Steven J. Hancock
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View article: An mRNA vaccine encoding five conserved Group A Streptococcus antigens
An mRNA vaccine encoding five conserved Group A Streptococcus antigens Open
View article: <i>Klebsiella pneumoniae</i> remodels its Kdo<sub>2</sub>-lipid A in a TLR4-dependent manner to adapt to the macrophage intracellular environment
<i>Klebsiella pneumoniae</i> remodels its Kdo<sub>2</sub>-lipid A in a TLR4-dependent manner to adapt to the macrophage intracellular environment Open
SUMMARY Pathogen adaptations to the intracellular macrophage environment remain poorly understood. We performed a high-resolution structural analysis of the lipid A purified from intracellular Klebsiella pneumoniae (KP). In both mouse and …
View article: Author response: High-risk Escherichia coli clones that cause neonatal meningitis and association with recrudescent infection
Author response: High-risk Escherichia coli clones that cause neonatal meningitis and association with recrudescent infection Open
Full text Figures and data Peer review Side by side Abstract eLife assessment Introduction Results Discussion Methods Data availability References Article and author information Metrics Abstract Neonatal meningitis is a devastating disease…
View article: High-risk Escherichia coli clones that cause neonatal meningitis and association with recrudescent infection
High-risk Escherichia coli clones that cause neonatal meningitis and association with recrudescent infection Open
Neonatal meningitis is a devastating disease associated with high mortality and neurological sequelae. Escherichia coli is the second most common cause of neonatal meningitis in full-term infants (herein NMEC) and the most common cause of …
View article: Author Response: High-risk Escherichia coli clones that cause neonatal meningitis and association with recrudescent infection
Author Response: High-risk Escherichia coli clones that cause neonatal meningitis and association with recrudescent infection Open
Neonatal meningitis is a devastating disease associated with high mortality and neurological sequelae. Escherichia coli is the second most common cause of neonatal meningitis in full-term infants (herein NMEC) and the most common cause of …
View article: High-risk Escherichia coli clones that cause neonatal meningitis and association with recrudescent infection
High-risk Escherichia coli clones that cause neonatal meningitis and association with recrudescent infection Open
Neonatal meningitis is a devastating disease associated with high mortality and neurological sequelae. Escherichia coli is the second most common cause of neonatal meningitis in full-term infants (herein NMEC) and the most common cause of …
View article: A convergent evolutionary pathway attenuating cellulose production drives enhanced virulence of some bacteria
A convergent evolutionary pathway attenuating cellulose production drives enhanced virulence of some bacteria Open
View article: Reviewer #2 (Public Review): High-risk Escherichia coli clones that cause neonatal meningitis and association with recrudescent infection
Reviewer #2 (Public Review): High-risk Escherichia coli clones that cause neonatal meningitis and association with recrudescent infection Open
Neonatal meningitis is a devasting disease associated with high mortality and neurological sequelae. Escherichia coli is the second most common cause of neonatal meningitis (herein NMEC) and the most common cause of meningitis in preterm n…
View article: High-risk Escherichia coli clones that cause neonatal meningitis and association with recrudescent infection
High-risk Escherichia coli clones that cause neonatal meningitis and association with recrudescent infection Open
Neonatal meningitis is a devastating disease associated with high mortality and neurological sequelae. Escherichia coli is the second most common cause of neonatal meningitis in full-term infants (herein NMEC) and the most common cause of …
View article: Author Response: High-risk Escherichia coli clones that cause neonatal meningitis and association with recrudescent infection
Author Response: High-risk Escherichia coli clones that cause neonatal meningitis and association with recrudescent infection Open
Neonatal meningitis is a devasting disease associated with high mortality and neurological sequelae. Escherichia coli is the second most common cause of neonatal meningitis (herein NMEC) and the most common cause of meningitis in preterm n…
View article: High-risk Escherichia coli clones that cause neonatal meningitis and association with recrudescent infection
High-risk Escherichia coli clones that cause neonatal meningitis and association with recrudescent infection Open
Neonatal meningitis is a devasting disease associated with high mortality and neurological sequelae. Escherichia coli is the second most common cause of neonatal meningitis (herein NMEC) and the most common cause of meningitis in preterm n…
View article: High-risk <i>Escherichia coli</i> clones that cause neonatal meningitis and association with recrudescent infection
High-risk <i>Escherichia coli</i> clones that cause neonatal meningitis and association with recrudescent infection Open
Neonatal meningitis is a devastating disease associated with high mortality and neurological sequelae. Escherichia coli is the second most common cause of neonatal meningitis in full-term infants (herein NMEC) and the most common cause of …
View article: Type I interferons drive MAIT cell functions against bacterial pneumonia
Type I interferons drive MAIT cell functions against bacterial pneumonia Open
Mucosal-associated invariant T (MAIT) cells are abundant in the lung and contribute to host defense against infections. During bacterial infections, MAIT cell activation has been proposed to require T cell receptor (TCR)–mediated recogniti…
View article: Genetic basis of I-complex plasmid stability and conjugation
Genetic basis of I-complex plasmid stability and conjugation Open
Plasmids are major drivers of increasing antibiotic resistance, necessitating an urgent need to understand their biology. Here we describe a detailed dissection of the molecular components controlling the genetics of I-complex plasmids, a …
View article: Integrative omics identifies conserved and pathogen-specific responses of sepsis-causing bacteria
Integrative omics identifies conserved and pathogen-specific responses of sepsis-causing bacteria Open
Even in the setting of optimal resuscitation in high-income countries severe sepsis and septic shock have a mortality of 20–40%, with antibiotic resistance dramatically increasing this mortality risk. To develop a reference dataset enablin…
View article: Modelling the Gastrointestinal Carriage of Klebsiella pneumoniae Infections
Modelling the Gastrointestinal Carriage of Klebsiella pneumoniae Infections Open
Klebsiella pneumoniae is one of the pathogens that is sweeping the world in the antibiotic resistance pandemic. Klebsiella colonizes the nasopharynx and the gut of healthy subjects in an asymptomatic manner, making gut colonization a requi…
View article: Modelling the gastrointestinal carriage of <i>Klebsiella pneumoniae</i> infections
Modelling the gastrointestinal carriage of <i>Klebsiella pneumoniae</i> infections Open
Klebsiella pneumoniae is a leading cause of nosocomial and community acquired infections, making K. pneumoniae the second pathogen associated with the most deaths attributed to any antibiotic resistant infection. K. pneumoniae colonises th…
View article: Cyclic ADP ribose isomers: Production, chemical structures, and immune signaling
Cyclic ADP ribose isomers: Production, chemical structures, and immune signaling Open
Cyclic adenosine diphosphate (ADP)–ribose (cADPR) isomers are signaling molecules produced by bacterial and plant Toll/interleukin-1 receptor (TIR) domains via nicotinamide adenine dinucleotide (oxidized form) (NAD + ) hydrolysis. We show …
View article: Ucl fimbriae regulation and glycan receptor specificity contribute to gut colonisation by extra-intestinal pathogenic Escherichia coli
Ucl fimbriae regulation and glycan receptor specificity contribute to gut colonisation by extra-intestinal pathogenic Escherichia coli Open
Extra-intestinal pathogenic Escherichia coli (ExPEC) belong to a critical priority group of antibiotic resistant pathogens. ExPEC establish gut reservoirs that seed infection of the urinary tract and bloodstream, but the mechanisms of gut …
View article: Chemical structures of cyclic ADP ribose (cADPR) isomers and the molecular basis of their production and signaling
Chemical structures of cyclic ADP ribose (cADPR) isomers and the molecular basis of their production and signaling Open
Cyclic ADP ribose (cADPR) isomers are important signaling molecules produced by bacterial and plant Toll/interleukin-1 receptor (TIR) domains via NAD + hydrolysis, yet their chemical structures are unknown. We show that v-cADPR (2’cADPR) a…
View article: Variation of Antigen 43 self-association modulates bacterial compacting within aggregates and biofilms
Variation of Antigen 43 self-association modulates bacterial compacting within aggregates and biofilms Open
View article: Differential Afa/Dr Fimbriae Expression in the Multidrug-Resistant Escherichia coli ST131 Clone
Differential Afa/Dr Fimbriae Expression in the Multidrug-Resistant Escherichia coli ST131 Clone Open
E. coli ST131 is the most common antibiotic resistant UPEC clone associated with human urinary tract and bloodstream infections. Understanding the features of ST131 that have driven its global dissemination remains a critical priority if w…
View article: Multispecies Outbreak of Verona Integron-Encoded Metallo-ß-Lactamase-Producing Multidrug-Resistant Bacteria Driven by a Promiscuous Incompatibility Group A/C2 Plasmid
Multispecies Outbreak of Verona Integron-Encoded Metallo-ß-Lactamase-Producing Multidrug-Resistant Bacteria Driven by a Promiscuous Incompatibility Group A/C2 Plasmid Open
Background Antibiotic resistance is often spread through bacterial populations via conjugative plasmids. However, plasmid transfer is not well recognized in clinical settings because of technical limitations, and health care–associated inf…
View article: Genomic characterisation and context of the <i>bla</i><sub>NDM-1</sub> carbapenemase in <i>Escherichia coli</i> ST101
Genomic characterisation and context of the <i>bla</i><sub>NDM-1</sub> carbapenemase in <i>Escherichia coli</i> ST101 Open
Carbapenems are last-resort antibiotics; however, the spread of plasmid-encoded carbapenemases such as the New Delhi metallo-β-lactamase 1 (NDM-1) challenges their effectiveness. The rise of NDM-1 has coincided with the emergence of extens…
View article: Bioinformatic and Molecular Analysis of Inverse Autotransporters from Escherichia coli
Bioinformatic and Molecular Analysis of Inverse Autotransporters from Escherichia coli Open
Escherichia coli is one of the most prevalent facultative anaerobes of the human gut. E. coli normally exists as a harmless commensal but can also cause disease following the acquisition of genes that enhance its pathogenicity. Adhesion is…
View article: Copper Ions and Coordination Complexes as Novel Carbapenem Adjuvants
Copper Ions and Coordination Complexes as Novel Carbapenem Adjuvants Open
Carbapenem-resistant Enterobacteriaceae are urgent threats to global human health. These organisms produce β-lactamases with carbapenemase activity, such as the metallo-β-lactamase NDM-1, which is notable due to its association with mobile…
View article: Identification of IncA/C Plasmid Replication and Maintenance Genes and Development of a Plasmid Multilocus Sequence Typing Scheme
Identification of IncA/C Plasmid Replication and Maintenance Genes and Development of a Plasmid Multilocus Sequence Typing Scheme Open
Plasmids of incompatibility group A/C (IncA/C) are becoming increasingly prevalent within pathogenic Enterobacteriaceae . They are associated with the dissemination of multiple clinically relevant resistance genes, including bla CMY and bl…
View article: Molecular Characterization of a Multidrug Resistance IncF Plasmid from the Globally Disseminated Escherichia coli ST131 Clone
Molecular Characterization of a Multidrug Resistance IncF Plasmid from the Globally Disseminated Escherichia coli ST131 Clone Open
Escherichia coli sequence type 131 (E. coli ST131) is a recently emerged and globally disseminated multidrug resistant clone associated with urinary tract and bloodstream infections. Plasmids represent a major vehicle for the carriage of a…