Steven L. Austin
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View article: Aromatic residues in mobile regions distal to the active site support the closed conformation of <i>E. coli</i> DXPS
Aromatic residues in mobile regions distal to the active site support the closed conformation of <i>E. coli</i> DXPS Open
The essential bacterial enzyme 1-deoxy-D-xylulose 5-phosphate synthase (DXPS) is absent in humans, making the enzyme an attractive antimicrobial target. Its product DXP sits at a metabolic branchpoint between the biosynthesis of pyridoxal …
View article: Identification of Protein Cryptic Sites via Conformational Dynamics Capturing and Water-Based Pocket Characterization in Molecular Dynamics Simulations
Identification of Protein Cryptic Sites via Conformational Dynamics Capturing and Water-Based Pocket Characterization in Molecular Dynamics Simulations Open
Employing molecular dynamics (MD) simulation to study the formation of novel protein cryptic sites has attracted increasing interest in the field of drug discovery. One specific challenge in this area is finding a viable method to accurate…
View article: CHARMM at 45: Enhancements in Accessibility, Functionality, and Speed
CHARMM at 45: Enhancements in Accessibility, Functionality, and Speed Open
Since its inception nearly a half century ago, CHARMM has been playing a central role in computational biochemistry and biophysics. Commensurate with the developments in experimental research and advances in computer hardware, the range of…
View article: Disruption of an Active Site Network Leads to Activation of C2α-Lactylthiamin Diphosphate on the Antibacterial Target 1-Deoxy-<scp>d</scp>-xylulose-5-phosphate Synthase
Disruption of an Active Site Network Leads to Activation of C2α-Lactylthiamin Diphosphate on the Antibacterial Target 1-Deoxy-<span>d</span>-xylulose-5-phosphate Synthase Open
The bacterial metabolic enzyme 1-deoxy-d-xylulose-5-phosphate synthase (DXPS) catalyzes the thiamin diphosphate (ThDP)-dependent formation of DXP from pyruvate and d-glyceraldehyde-3-phosphate (d-GAP). DXP is an essential bacteria-specific…
View article: "Into the mouth of the wolf": Guatemalan refugees prepare for repatriation
"Into the mouth of the wolf": Guatemalan refugees prepare for repatriation Open
This dissertation is based on one year of fieldwork, conducted in Chiapas, Mexico, and the departments of Quiche and Huehuetenango, Guatemala, from 1991 to 1992. The focus of the investigation is on explaining the attitudes of Guatemalan r…