Steven Lehrer
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View article: Comparative Analysis of CHEK1, Extrachromosomal DNA Dynamics, and 1p/19q Status in Lower-Grade and High-Grade Glioma
Comparative Analysis of CHEK1, Extrachromosomal DNA Dynamics, and 1p/19q Status in Lower-Grade and High-Grade Glioma Open
Background Extrachromosomal DNA (ecDNA) drives rapid tumor evolution, genomic instability, and therapy resistance in gliomas by amplifying oncogenes and generating intratumoral heterogeneity. These genomic alterations induce replication–tr…
View article: Multi-Layered Dysregulation of NRCAM in Gliomas: Insights from TCGA Copy Number and Epigenetic Analyses
Multi-Layered Dysregulation of NRCAM in Gliomas: Insights from TCGA Copy Number and Epigenetic Analyses Open
Background NRCAM, a neuronal cell adhesion molecule, has been implicated in glioma biology through splicing alterations reported by prior studies. However, the relative contributions of genomic and epigenetic mechanisms to NRCAM dysregulat…
View article: Growth Differentiation Factor 15 Connects Stress and Ageing in a UK Biobank Cohort
Growth Differentiation Factor 15 Connects Stress and Ageing in a UK Biobank Cohort Open
Background The brain–body energy-conservation model proposes that signals from metabolically active senescent cells, including growth differentiation factor 15 (GDF15), prompt the brain to downregulate systemic energy expenditure, leading …
View article: Glatiramer Acetate Reduces Risk of Cardiovascular Disease and Myocardial Infarction
Glatiramer Acetate Reduces Risk of Cardiovascular Disease and Myocardial Infarction Open
Despite rare adverse cardiovascular side-effects and given its established safety profile, GA shows promise as a novel treatment option for heart disease. Further studies could lead to an important new use of GA especially in patients who …
View article: PROX1 expression is significantly associated with ERG expression and the TMPRSS2-ERG fusion gene in prostate cancer
PROX1 expression is significantly associated with ERG expression and the TMPRSS2-ERG fusion gene in prostate cancer Open
Background: Lineage plasticity enables prostate cancer cells to bypass androgen receptor (AR) dependence, contributing to metastasis, treatment resistance, and lethality. The developmental transcription factor PROX1 was recently identified…
View article: Structure-Guided Docking of Benzene-1,3-disulfonic Acid to the ApoE-HSPG Binding Site at Arginine 146 as a Christchurch-Mimetic Therapeutic Strategy for Alzheimer’s Disease
Structure-Guided Docking of Benzene-1,3-disulfonic Acid to the ApoE-HSPG Binding Site at Arginine 146 as a Christchurch-Mimetic Therapeutic Strategy for Alzheimer’s Disease Open
Background: The APOΕ3 Christchurch (APOΕ3Ch) variant, characterized by an R136S substitution, confers protection against Alzheimer’s disease (AD) by reducing Apolipoprotein E (ApoE) binding to heparan sulfate proteoglycans (HSPGs), thereby…
View article: Interaction Between HAQ-STING Mutation and COPA: Protection Against COPA Syndrome
Interaction Between HAQ-STING Mutation and COPA: Protection Against COPA Syndrome Open
This study provides novel structural insights into the protective role of HAQ-STING in COPA syndrome. The conformational shift induced by HAQ-STING may modulate immune signaling, preventing disease manifestation. A potential binding channe…
View article: Structure-Based Design of Apogossypol-Derived Ligands Targeting the PELO–HBS1L Interface for Cancer Therapy
Structure-Based Design of Apogossypol-Derived Ligands Targeting the PELO–HBS1L Interface for Cancer Therapy Open
Background The PELO–HBS1L complex is a critical mediator of ribosome-associated quality control, responsible for resolving stalled ribosomes and maintaining translational fidelity. Recent CRISPR-based synthetic lethality screens have ident…
View article: The HAQ STING mutation interacts with COPA causing allosteric structural rearrangements in COPA that may protect against COPA disease
The HAQ STING mutation interacts with COPA causing allosteric structural rearrangements in COPA that may protect against COPA disease Open
Background COPA disease is a rare autoinflammatory disorder caused by mutations in the COPA gene, leading to immune dysregulation and inflammatory pathology. The HAQ STING allele has been identified as a protective factor against disease m…
View article: Docking and Molecular Dynamic Simulation of ApoE isoforms to Trem2
Docking and Molecular Dynamic Simulation of ApoE isoforms to Trem2 Open
Background: Alzheimer’s disease (AD) is a progressive neurodegenerative disorder with limited therapeutic options. The interaction between Triggering Receptor Expressed on Myeloid Cells 2 (TREM2), a critical microglial receptor, and Apolip…
View article: SNP rs7549881, near SGIP1 at 1p31.3, is significantly associated with digestive disorders and Parkinsonism in women
SNP rs7549881, near SGIP1 at 1p31.3, is significantly associated with digestive disorders and Parkinsonism in women Open
SNP rs7549881 is associated with PD in females and with gastrointestinal disorders across both sexes. These findings reinforce the role of SGIP1 in synaptic endocytosis and suggest its contribution to gut-brain axis dysfunction in PD.
View article: The rs11150601 intron variant of SETD1A is associated with female schizophrenia in the UK Biobank cohort
The rs11150601 intron variant of SETD1A is associated with female schizophrenia in the UK Biobank cohort Open
Background Schizophrenia is a complex psychiatric disorder with an estimated heritability of 80%. SETD1A, a gene encoding a histone methyltransferase critical for transcriptional regulation, has been identified as a significant risk factor…
View article: Klebsiella pneumoniae infection increases risk of Alzheimer’s Disease in the UK Biobank cohort
Klebsiella pneumoniae infection increases risk of Alzheimer’s Disease in the UK Biobank cohort Open
Background Infections, including bacterial pathogens, have been implicated in Alzheimer’s disease (AD) risk. Klebsiella pneumoniae (K. pneumoniae) is a common hospital-acquired pathogen associated with significant inflammation, which may c…
View article: SNP rs7549881, near SGIP1 at 1p31.3, is significantly associated with digestive disorders and Parkinsonism in women
SNP rs7549881, near SGIP1 at 1p31.3, is significantly associated with digestive disorders and Parkinsonism in women Open
Background A recent study identified a mutation in the SH3GL Interacting Endocytic Adaptor 1 (SGIP1) gene, located at 1p31.3, linked to early-onset Parkinsonism in 2 sisters in an Arab family with a history of young-onset Parkinson symptom…
View article: The paired immunoglobulin-like type 2 receptor alpha (PILRA) gene polymorphism rs1859788 reduces risk of Alzheimer’s Disease in men homozygous for the ApoE ε4 allele
The paired immunoglobulin-like type 2 receptor alpha (PILRA) gene polymorphism rs1859788 reduces risk of Alzheimer’s Disease in men homozygous for the ApoE ε4 allele Open
Background The APOE gene has long been associated with Alzheimer Disease (AD) risk. Emerging research indicates that other genetic loci, including the paired immunoglobulin-like type 2 receptor alpha (PILRA) gene, may play a crucial role. …
View article: Tall women with breast cancer have poorer survival than short women
Tall women with breast cancer have poorer survival than short women Open
Background Tall women are more likely to develop breast cancer (BC). High Mobility Group AT-Hook 1(HMGA1), an oncofetal protein, plays a role in the progression of breast cancer. Non-coding sequences proximal to HMGA1 contain variants asso…
View article: Salbutamol, a Short Acting Beta-2 Agonist, Reduces Risk and Improves Prognosis of Prostate Cancer
Salbutamol, a Short Acting Beta-2 Agonist, Reduces Risk and Improves Prognosis of Prostate Cancer Open
Objectives: Beta-blockers, a class of drugs commonly used to manage blood pressure, have been the subject of research regarding their relationship to prostate cancer (PC) risk, prognosis, and treatment. Beta-blockers reduce risk and improv…
View article: Insulin and Metformin are Associated With Reduced Risk of Amyotrophic Lateral Sclerosis
Insulin and Metformin are Associated With Reduced Risk of Amyotrophic Lateral Sclerosis Open
Background Type 2 diabetes (T2D), but not type 1, protected against amyotrophic lateral sclerosis (ALS). In T2D serum insulin is normal or elevated in the early stages. Type 1 diabetes, characterized by a total lack of insulin, is associat…
View article: Verapamil is associated with reduced risk of Alzheimer’s Disease
Verapamil is associated with reduced risk of Alzheimer’s Disease Open
Background: Alzheimer’s Disease (AD) is a neurodegenerative disorder characterized by cognitive decline and memory loss. Recent research suggests that disruptions in calcium (Ca²⁺) homeostasis play a crucial role in the pathogenesis of AD.…
View article: Long-lasting cigarette smoking alterations in immune function occur in cannabis smokers, possibly rendering them vulnerable to smoking-related tumors in later life
Long-lasting cigarette smoking alterations in immune function occur in cannabis smokers, possibly rendering them vulnerable to smoking-related tumors in later life Open
Background Active cigarette smoking leads to increased CXCL5 production. CXCL5 mediates the immune response by attracting immune cells to areas of inflammation. Elevated CXCL5 levels are associated with various inflammatory diseases and tu…
View article: Salbutamol, a short acting beta-2 agonist, reduces risk and improves prognosis of prostate cancer
Salbutamol, a short acting beta-2 agonist, reduces risk and improves prognosis of prostate cancer Open
Background Beta-blockers, a class of drugs commonly used to manage blood pressure, have been the subject of research regarding their relationship to prostate cancer risk, prognosis, and treatment. Beta blockers reduce risk and improve prog…
View article: Insulin and metformin are associated with reduced risk of amyotrophic lateral sclerosis
Insulin and metformin are associated with reduced risk of amyotrophic lateral sclerosis Open
Background Type 2 diabetes (T2D), but not type 1, protected against ALS. In T2D serum insulin is normal or elevated in the early stages. Type 1 diabetes, characterized by a total lack of insulin, is associated with increased risk of ALS. T…
View article: RPTOR Is an Alzheimer’s Disease Susceptibility Gene Associated with the Risk Factors Body Mass Index and Infectious Encephalitis
RPTOR Is an Alzheimer’s Disease Susceptibility Gene Associated with the Risk Factors Body Mass Index and Infectious Encephalitis Open
Background: In comparison to persons who did not have viral encephalitis, people with viral encephalitis had a later-life risk of Alzheimer’s disease (AD) that was 31 times higher. In a previous study, we were able to confirm the associati…
View article: Amlodipine increases risk of primary open-angle glaucoma
Amlodipine increases risk of primary open-angle glaucoma Open
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View article: Effect of Glucosamine on Intraocular Pressure and Risk of Developing Glaucoma
Effect of Glucosamine on Intraocular Pressure and Risk of Developing Glaucoma Open
Précis: Glucosamine supplementation is common but can be associated with increased intraocular pressure (IOP) and could contribute to the pathogenesis of glaucoma. It may be prudent for ophthalmologists to elicit any history of glucosamine…
View article: RPTOR is an Alzheimer’s Disease susceptibility gene associated with Alzheimer’s Disease risk factors BMI and infectious encephalitis
RPTOR is an Alzheimer’s Disease susceptibility gene associated with Alzheimer’s Disease risk factors BMI and infectious encephalitis Open
Background: In comparison to persons who did not have viral encephalitis, people with viral encephalitis had a later-life risk of Alzheimer's disease (AD) that was 31 times higher. In a previous study, we were able to confirm the associati…
View article: Chromosome 1p deletion in colorectal cancer and lower grade glioma: possible relationship with the enteric nervous system
Chromosome 1p deletion in colorectal cancer and lower grade glioma: possible relationship with the enteric nervous system Open
Background Enteric neurons and enteric glial cells are a part of the enteric nervous system, which is sometimes referred to as the “second brain” of the body. This complex network of neurons controls various functions of the gastrointestin…
View article: Retinal thickness and antidepressants
Retinal thickness and antidepressants Open
Background Depression is associated with synaptic pruning in the brain. Antidepressants reverse this process. Synaptic pruning can be inferred by measuring retinal thickness with ocular coherence tomography (OCT). With data from UK Biobank…