Steven Lo
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View article: The CSAP Flap: Updated Anatomy, Surgical Technique, and Outcome of 71 Flaps
The CSAP Flap: Updated Anatomy, Surgical Technique, and Outcome of 71 Flaps Open
View article: “3D telemedicine outperforms 2D telemedicine: A randomized crossover trial in reconstructive plastic surgery”
“3D telemedicine outperforms 2D telemedicine: A randomized crossover trial in reconstructive plastic surgery” Open
One of the key barriers to adoption of Telemedicine remains patients’ preference for in-person consultations. To address this, an immersive 3D telemedicine system was co-developed with patients in order to improve the realism, quality and …
View article: Metabolic Reprogramming and GM-CSF Secretion in Areca Nut-Activated Fibroblast Drives Oral Precancer Progression
Metabolic Reprogramming and GM-CSF Secretion in Areca Nut-Activated Fibroblast Drives Oral Precancer Progression Open
Oral cancer, marked by a rising global incidence and dismal prognosis, is associated with areca nut use, particularly in South and Southeast Asia. Yet, its influence on the oral tissue microenvironment is not well elucidated. This research…
View article: Oncogenic role of fumarate hydratase in breast cancer: metabolic reprogramming and mechanistic insights
Oncogenic role of fumarate hydratase in breast cancer: metabolic reprogramming and mechanistic insights Open
View article: The role of the tumour microenvironment in lung cancer and its therapeutic implications
The role of the tumour microenvironment in lung cancer and its therapeutic implications Open
Lung cancer is the leading cause of cancer-related deaths globally, with tumour growth, invasion, and treatment response heavily influenced by the tumour microenvironment (TME). The TME promotes tumour progression by creating an immunosupp…
View article: NDUFS1 promotes malignant breast cancer behaviors through activation of mitochondrial metabolism and PROX1/c-Myc signaling
NDUFS1 promotes malignant breast cancer behaviors through activation of mitochondrial metabolism and PROX1/c-Myc signaling Open
Breast cancer is the most prevalent cancer among women. Previous studies demonstrated that adipose-derived stem cells (ADSCs) co-cultured with resistin promote malignant behaviors in breast cancer cells. This study explores the roles of AD…
View article: Areca nut-induced metabolic reprogramming and M2 differentiation promote OPMD malignant transformation
Areca nut-induced metabolic reprogramming and M2 differentiation promote OPMD malignant transformation Open
View article: Differential impact of cytoplasmic vs. nuclear RAD51 expression on breast cancer progression and patient prognosis
Differential impact of cytoplasmic vs. nuclear RAD51 expression on breast cancer progression and patient prognosis Open
RAD51 recombinase is one of the DNA damage repair proteins associated with breast cancer risk. Apart from its function to maintain genomic integrity within the cell nucleus, RAD51 localized to the cytoplasm has also been implicated in brea…
View article: Ghana 3D Telemedicine International MDT: A proof-of-concept study
Ghana 3D Telemedicine International MDT: A proof-of-concept study Open
This novel technology has the potential to enhance the delivery of overseas surgical visits to low-to-middle-income countries, by improving planning, informed discussion with patients, expert consensus on complex cases, and fostering engag…
View article: Tenosynovial giant cell tumor: a case report
Tenosynovial giant cell tumor: a case report Open
View article: Effect of differing flap reconstruction strategies in perineal closure following advanced pelvic oncological resection: a retrospective cohort study
Effect of differing flap reconstruction strategies in perineal closure following advanced pelvic oncological resection: a retrospective cohort study Open
Introduction: Advancing approaches to locally invasive pelvic malignancy creates a large tissue defect resulting in perineal wound complications, dehiscence, and perineal hernia. Use of reconstructive flaps such as vertical rectus abdominu…
View article: IL-1RA promotes oral squamous cell carcinoma malignancy through mitochondrial metabolism-mediated EGFR/JNK/SOX2 pathway
IL-1RA promotes oral squamous cell carcinoma malignancy through mitochondrial metabolism-mediated EGFR/JNK/SOX2 pathway Open
Background Interleukin-1 receptor antagonist (IL-1RA), a member of the IL-1 family, has diverse roles in cancer development. However, the role of IL-1RA in oral squamous cell carcinoma (OSCC), in particular the underlying mechanisms, remai…
View article: IL-1RA promotes oral squamous cell carcinoma malignancy through mitochondrial metabolism-mediated EGFR/JNK/SOX2 pathway
IL-1RA promotes oral squamous cell carcinoma malignancy through mitochondrial metabolism-mediated EGFR/JNK/SOX2 pathway Open
Background Interleukin-1 receptor antagonist (IL-1RA), a member of the IL-1 family, has diverse roles in cancer development. However, the role of IL-1RA in oral squamous cell carcinoma (OSCC), in particular the underlying mechanisms, remai…
View article: In search of the ideal periosteal flap for bone non-union: The chimeric fibula-periosteal flap
In search of the ideal periosteal flap for bone non-union: The chimeric fibula-periosteal flap Open
View article: Data from Extracellular Visfatin-Promoted Malignant Behavior in Breast Cancer Is Mediated Through c-Abl and STAT3 Activation
Data from Extracellular Visfatin-Promoted Malignant Behavior in Breast Cancer Is Mediated Through c-Abl and STAT3 Activation Open
Purpose: Visfatin is an adipocytokine involved in cellular metabolism, inflammation, and cancer. This study investigated the roles of extracellular visfatin in breast cancer, and explored underlying mechanisms in clinical and experi…
View article: Supplementary Figure 2 from Extracellular Visfatin-Promoted Malignant Behavior in Breast Cancer Is Mediated Through c-Abl and STAT3 Activation
Supplementary Figure 2 from Extracellular Visfatin-Promoted Malignant Behavior in Breast Cancer Is Mediated Through c-Abl and STAT3 Activation Open
Supplementary Figure 2. Association of disease-free survival with serum visfatin levels according to adjuvant treatment in breast cancer patients.
View article: Supplementary Figure 1 from Extracellular Visfatin-Promoted Malignant Behavior in Breast Cancer Is Mediated Through c-Abl and STAT3 Activation
Supplementary Figure 1 from Extracellular Visfatin-Promoted Malignant Behavior in Breast Cancer Is Mediated Through c-Abl and STAT3 Activation Open
Supplementary Figure 1. Association of overall survival with serum visfatin levels according to adjuvant treatment in breast cancer patients.
View article: Supplementary Figure 1 from Extracellular Visfatin-Promoted Malignant Behavior in Breast Cancer Is Mediated Through c-Abl and STAT3 Activation
Supplementary Figure 1 from Extracellular Visfatin-Promoted Malignant Behavior in Breast Cancer Is Mediated Through c-Abl and STAT3 Activation Open
Supplementary Figure 1. Association of overall survival with serum visfatin levels according to adjuvant treatment in breast cancer patients.
View article: supplemental figure legend from Extracellular Visfatin-Promoted Malignant Behavior in Breast Cancer Is Mediated Through c-Abl and STAT3 Activation
supplemental figure legend from Extracellular Visfatin-Promoted Malignant Behavior in Breast Cancer Is Mediated Through c-Abl and STAT3 Activation Open
supplemental figure legend
View article: Supplementary Figure 6 from Extracellular Visfatin-Promoted Malignant Behavior in Breast Cancer Is Mediated Through c-Abl and STAT3 Activation
Supplementary Figure 6 from Extracellular Visfatin-Promoted Malignant Behavior in Breast Cancer Is Mediated Through c-Abl and STAT3 Activation Open
Supplementary Figure 6. A, Comparison of serum visfatin levels according to molecular subtypes of breast cancer patients.
View article: Supplemental Tables from Extracellular Visfatin-Promoted Malignant Behavior in Breast Cancer Is Mediated Through c-Abl and STAT3 Activation
Supplemental Tables from Extracellular Visfatin-Promoted Malignant Behavior in Breast Cancer Is Mediated Through c-Abl and STAT3 Activation Open
Supplementary Table 1. Association between clinicopathological characteristics of breast cancer patients and disease-free survival Supplementary Table 2. Association of serum visfatin with disease recurrence after radiotherapy, chemotherap…
View article: Supplementary Figure 5 from Extracellular Visfatin-Promoted Malignant Behavior in Breast Cancer Is Mediated Through c-Abl and STAT3 Activation
Supplementary Figure 5 from Extracellular Visfatin-Promoted Malignant Behavior in Breast Cancer Is Mediated Through c-Abl and STAT3 Activation Open
Supplementary Figure 5. Body weight and blood test for orthotopic xenograft nude mice.
View article: Supplemental Tables from Extracellular Visfatin-Promoted Malignant Behavior in Breast Cancer Is Mediated Through c-Abl and STAT3 Activation
Supplemental Tables from Extracellular Visfatin-Promoted Malignant Behavior in Breast Cancer Is Mediated Through c-Abl and STAT3 Activation Open
Supplementary Table 1. Association between clinicopathological characteristics of breast cancer patients and disease-free survival Supplementary Table 2. Association of serum visfatin with disease recurrence after radiotherapy, chemotherap…
View article: Supplementary Figure 3 from Extracellular Visfatin-Promoted Malignant Behavior in Breast Cancer Is Mediated Through c-Abl and STAT3 Activation
Supplementary Figure 3 from Extracellular Visfatin-Promoted Malignant Behavior in Breast Cancer Is Mediated Through c-Abl and STAT3 Activation Open
Supplementary Figure 3. A-B, Effect of visfatin on cell viability and activation of c-Abl and STAT3 in SKBR-3 breast cancer cells.
View article: Supplementary Figure 6 from Extracellular Visfatin-Promoted Malignant Behavior in Breast Cancer Is Mediated Through c-Abl and STAT3 Activation
Supplementary Figure 6 from Extracellular Visfatin-Promoted Malignant Behavior in Breast Cancer Is Mediated Through c-Abl and STAT3 Activation Open
Supplementary Figure 6. A, Comparison of serum visfatin levels according to molecular subtypes of breast cancer patients.
View article: Supplementary Figure 4 from Extracellular Visfatin-Promoted Malignant Behavior in Breast Cancer Is Mediated Through c-Abl and STAT3 Activation
Supplementary Figure 4 from Extracellular Visfatin-Promoted Malignant Behavior in Breast Cancer Is Mediated Through c-Abl and STAT3 Activation Open
Supplementary Figure 4. A, Effect of visfatin on anoikis cell death.
View article: Supplementary Figure 5 from Extracellular Visfatin-Promoted Malignant Behavior in Breast Cancer Is Mediated Through c-Abl and STAT3 Activation
Supplementary Figure 5 from Extracellular Visfatin-Promoted Malignant Behavior in Breast Cancer Is Mediated Through c-Abl and STAT3 Activation Open
Supplementary Figure 5. Body weight and blood test for orthotopic xenograft nude mice.
View article: Data from Extracellular Visfatin-Promoted Malignant Behavior in Breast Cancer Is Mediated Through c-Abl and STAT3 Activation
Data from Extracellular Visfatin-Promoted Malignant Behavior in Breast Cancer Is Mediated Through c-Abl and STAT3 Activation Open
Purpose: Visfatin is an adipocytokine involved in cellular metabolism, inflammation, and cancer. This study investigated the roles of extracellular visfatin in breast cancer, and explored underlying mechanisms in clinical and experi…
View article: Supplementary Figure 3 from Extracellular Visfatin-Promoted Malignant Behavior in Breast Cancer Is Mediated Through c-Abl and STAT3 Activation
Supplementary Figure 3 from Extracellular Visfatin-Promoted Malignant Behavior in Breast Cancer Is Mediated Through c-Abl and STAT3 Activation Open
Supplementary Figure 3. A-B, Effect of visfatin on cell viability and activation of c-Abl and STAT3 in SKBR-3 breast cancer cells.
View article: Supplementary Figure 2 from Extracellular Visfatin-Promoted Malignant Behavior in Breast Cancer Is Mediated Through c-Abl and STAT3 Activation
Supplementary Figure 2 from Extracellular Visfatin-Promoted Malignant Behavior in Breast Cancer Is Mediated Through c-Abl and STAT3 Activation Open
Supplementary Figure 2. Association of disease-free survival with serum visfatin levels according to adjuvant treatment in breast cancer patients.