Explanipedia

High-fidelity measurement of pulse arrival time in critically ill children using standard bedside monitoring equipment Open

Ian Ruffolo, Asad Siddiqui, Binh Nguyen, William G Dixon, Azadeh Assadi , et al. · 2025

Objective . Pulse arrival time (PAT) is known to be correlated with blood pressure. Although PAT can be measured using electrocardiography (ECG), photoplethysmography (PPG), and other signals commonly available in clinical settings, recent…

Investigation of a Novel Noninvasive Risk Analytics Algorithm With Laboratory Central Venous Oxygen Saturation Measurements in Critically Ill Pediatric Patients Open

Sarah A. Teele, Avihu Z. Gazit, Craig Futterman, William La Cava, David S. Cooper , et al. · 2025

BACKGROUND: Accurate assessment of oxygen delivery relative to oxygen demand is crucial in the care of a critically ill patient. The central venous oxygen saturation (Sv o 2 ) enables an estimate of cardiac output yet obtaining these clini…

Quality and Safety Initiatives in a Pediatric and Congenital Heart Surgery Program in a Low- and Middle-Income Country: The Impact of International Collaboration Open

Leonardo Augusto Miana, Valdano Manuel, Desiree Machado, Bistra Zheleva, Andreas Tsakistos , et al. · 2025

The introduction of Q&S initiatives led to marked improvements in PCHS outcomes, even amid growing case complexity and acuity. These findings highlight the value of structured protocols and sustained Q&S efforts and underscore the transfor…

Unstable right ventricular hypertension in pulmonary atresia and intact ventricular septum: a case report Open

Joshua D Griesman, David J. Barron, Steven M. Schwartz · 2024

Arterial oxygen saturation in single ventricle patients is dependent on systemic cardiac output. Here, we describe a case of a newborn with single ventricle physiology and an unusual mechanism to explain poor cardiac output and cyanosis. T…

Joint effects of intensity and duration of cigarette smoking on the risk of head and neck cancer: A bivariate spline model approach Open

G. Di Credico, Valeria Edefonti, Jerry Polesel, Francesco Pauli, Nicola Torelli , et al. · 2024

Alcohol drinking and head and neck cancer risk: the joint effect of intensity and duration Open

G. Di Credico, Jerry Polesel, Luigino Dal Maso, Francesco Pauli, Nicola Torelli , et al. · 2024

Background: Alcohol is a well-established risk factor for head and neck cancer (HNC). This study aims to explore the effect of alcohol intensity and duration, as joint continuous exposures, on HNC risk. Methods: Data from 26 case-control s…

Age at start of using tobacco on the risk of head and neck cancer: Pooled analysis in the International Head and Neck Cancer Epidemiology Consortium (INHANCE) Open

Chih-Ping Chang, S.C. Chang, Shih‐Chang Chuang, J. Berthiller, G. Ferro , et al. · 2024

Background: Tobacco use is a well-established risk factor for head and neck cancer (HNC). However, less is known about the potential impact of exposure to tobacco at an early age on HNC risk. Methods: We analyzed individual-level data on e…

Sequence variants and the risk of head and neck cancer: Pooled analysis in the INHANCE consortium Open

Shih‐Chang Chuang, Antonio Agudo, Wolfgang Ahrens, Devasena Anantharaman, Simone Benhamou , et al. · 2024

Previous molecular epidemiological studies on head and neck cancer have examined various single nucleotide polymorphisms (SNPs), but there are very few documented associations. In the International head and neck cancer epidemiology (INHANC…

Risk Prediction Models for Head and Neck Cancer in the US Population from the INHANCE Consortium Open

Y.-C.A. Lee, Mohammed H. Al-Temimi, Ying Jing, J. Muscat, A.F. Olshan , et al. · 2024

Head and neck cancer (HNC) risk prediction models based on risk factor profiles have not yet been developed. We took advantage of the large database of the International Head and Neck Cancer Epidemiology (INHANCE) Consortium, including 14 …

Racial differences in the relationship between tobacco, alcohol, and the risk of head and neck cancer: pooled analysis of US studies in the INHANCE Consortium Open

Kristin J. Voltzke, Y.-C.A. Lee, Zuo‐Feng Zhang, José P. Zevallos, Yu Gao , et al. · 2024

Longitudinal Follow-Up of Children With HLHS and Association Between Norwood Shunt Type and Long-Term Outcomes: The SVR III Study Open

Caren S. Goldberg, Felicia Trachtenberg, J. William Gaynor, William T. Mahle, Chitra Ravishankar , et al. · 2023

OBJECTIVE: In the SVR trial (Single Ventricle Reconstruction), newborns with hypoplastic left heart syndrome were randomly assigned to receive a modified Blalock-Taussig-Thomas shunt (mBTTS) or a right ventricle-to-pulmonary artery shunt (…

Who is a lost wilderness tourist? Open

Steven M. Schwartz · 2023

This article proposes a working definition for the term ‘lost wilderness tourist’ and uses this definition to examine lost wilderness tourist events through the lenses of tourism literature, lost person behaviour literature, search and res…

Milrinone therapeutic drug monitoring to reduce low cardiac output syndrome in pediatric patients Open

Katherine Taylor, Carolyne Pehora, David Faraoni, Susan Ferri, David Colantonio , et al. · 2023

Methods to Enhance Causal Inference for Assessing Impact of Clinical Informatics Platform Implementation Open

Michael Gaies, Mary K. Olive, Gabe E. Owens, John R. Charpie, Wenying Zhang , et al. · 2023

Background: Hospitals are increasingly likely to implement clinical informatics tools to improve quality of care, necessitating rigorous approaches to evaluate effectiveness. We leveraged a multi-institutional data repository and applied c…

Analyzing Continuous Physiologic Data to Find Hemodynamic Signatures Associated With New Brain Injury After Congenital Heart Surgery Open

Jessica Nicoll, Jonathan Somer, Danny Eytan, Vann Chau, Davide Marini , et al. · 2022

IMPORTANCE: Continuous data capture technology is becoming more common. Establishing analytic approaches for continuous data could aid in understanding the relationship between physiology and clinical outcomes. OBJECTIVES: Our objective wa…

The Promise of Small Data for Telemedicine in Chronic Condition Management: A Real-World Case Series Open

Steven M. Schwartz, Brigid Byrd, Helen Dempster, Tim Payne · 2021

Connected care is defined as the “real-time, electronic communication between a patient and a provider, including telehealth, remote patient monitoring, and secure email communication between clinicians and their patients” (Alliance of Con…

To the remark of F. K. Kessel "Chloroform anesthesia or toxicosis from a biochemical point of view" Open

M. A. Nimtsovitskaya, Steven M. Schwartz · 2021

In our work on the study of biochemical changes in blood during chloroform and ether anesthesia, it is indicated that the lipolytic enzyme gives a significant increase in the days following chloroform anesthesia. As you can see from the ta…

Impact of Major Residual Lesions on Outcomes After Surgery for Congenital Heart Disease Open

Meena Nathan, Jami C. Levine, Maria I. Van Rompay, Linda M. Lambert, Felicia Trachtenberg , et al. · 2021

Digital Twins and the Emerging Science of Self: Implications for Digital Health Experience Design and “Small” Data Open

Steven M. Schwartz, Kevin Wildenhaus, Amy Bucher, Brigid Byrd · 2020

The technology currently available for quantifying various biometric, behavioral, emotional, cognitive, and psychological aspects of daily life has become increasingly diverse, accurate, and accessible as a result of ongoing and continuous…

Improvement in Pediatric Cardiac Surgical Outcomes Through Interhospital Collaboration Open

Michael Gaies, Sara K. Pasquali, Mousumi Banerjee, Justin B. Dimick, John D. Birkmeyer , et al. · 2019

The Pediatric Heart Network Residual Lesion Score Study: Design and objectives Open

Meena Nathan, Felicia Trachtenberg, Maria I. Van Rompay, J. William Gaynor, Kirk R. Kanter , et al. · 2019

Commentary: Why the Y-graft? Open

Steven M. Schwartz · 2019

Extracorporeal Membrane Oxygenation (ECMO) Support in Special Patient Populations—The Bidirectional Glenn and Fontan Circulations Open

Matthew Bacon, Seth Gray, Steven M. Schwartz, David S. Cooper · 2018

Extracorporeal membrane oxygenation (ECMO) is a support modality used within the pediatric cardiac ICU population as a bridge to recovery or decision in the setting of acute myocardial decompensation, support for combined cardiopulmonary f…

A randomized clinical trial of age and genotype‐guided tacrolimus dosing after pediatric solid organ transplantation Open

Sandar Min, Tanya Papaz, Myriam Lafrenière‐Roula, Nadya Nalli, Hartmut Grasemann , et al. · 2018

Background Tacrolimus pharmacokinetics are influenced by age and CYP 3A5 genotype with CYP 3A5 expressors ( CYP 3A5*1/*1 or *1/*3 ) being fast metabolizers. However, the benefit of genotype‐guided dosing in pediatric solid organ transplant…

Consensus Recommendations for RBC Transfusion Practice in Critically Ill Children From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative Open

Stacey L. Valentine, Melania M. Bembea, Jennifer A. Muszynski, Jill M. Cholette, Allan Doctor , et al. · 2018

Objectives: To date, there are no published guidelines to direct RBC transfusion decision-making specifically for critically ill children. We present the recommendations from the Pediatric Critical Care Transfusion and Anemia Expertise Ini…

Recommendations on RBC Transfusion in Infants and Children With Acquired and Congenital Heart Disease From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative Open

Jill M. Cholette, Ariane Willems, Stacey L. Valentine, Scot T. Bateman, Steven M. Schwartz · 2018

Objectives: To present the recommendations and supporting literature for RBC transfusions in critically ill children with acquired and congenital heart disease developed by the Pediatric Critical Care Transfusion and Anemia Expertise Initi…

Variation in care for infants undergoing the Stage II palliation for hypoplastic left heart syndrome Open

Aaron Eckhauser, Sara K. Pasquali, Chitra Ravishankar, Linda M. Lambert, Jane W. Newburger , et al. · 2018

Background The Single Ventricle Reconstruction trial randomised neonates with hypoplastic left heart syndrome to a systemic-to-pulmonary-artery shunt strategy. Patients received care according to usual institutional practice. We analysed p…

Neurologic outcomes in pediatric cardiac arrest survivors enrolled in the THAPCA trials Open

Rebecca Ichord, Faye S. Silverstein, Beth S. Slomine, Russell Telford, James R. Christensen , et al. · 2018

The PRCA provides a robust method for depicting neurologic outcomes after acute encephalopathy caused by CA in children. It provides a global semiquantitative rating of neurologic impairment and domain-specific impairment. The strong corre…

Should magnesium be routine for arrhythmia prevention? Open

Steven M. Schwartz · 2018

The global burden of paediatric heart disease Open

Ndidiamaka Musa, Vibeke E. Hjortdal, Bistra Zheleva, Indah Kartika Murni, Shunji Sano , et al. · 2017

An estimated 15 million children die or are crippled annually by treatable or preventable heart disease in low- and middle-income countries. Global efforts to reduce under-5 mortality have focused on reducing death from communicable diseas…

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