Steven Marwaha
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View article: A randomised controlled trial to evaluate the clinical and cost-effectiveness of Stimulant compared with Non-stimulant medication for adults with Attention-deficit/hyperactivity disorder and a history of Psychosis or biPolar disordER: SNAPPER
A randomised controlled trial to evaluate the clinical and cost-effectiveness of Stimulant compared with Non-stimulant medication for adults with Attention-deficit/hyperactivity disorder and a history of Psychosis or biPolar disordER: SNAPPER Open
View article: Nitrous oxide for the treatment of depression: a systematic review and meta-analysis
Nitrous oxide for the treatment of depression: a systematic review and meta-analysis Open
The funder had no role in study design, data collection, analysis, interpretation, or writing.
View article: Facilitators and Barriers to Recruitment and Engagement with a Randomised Controlled Trial in Mental Health Services: experiences of trial participants and intervention providers
Facilitators and Barriers to Recruitment and Engagement with a Randomised Controlled Trial in Mental Health Services: experiences of trial participants and intervention providers Open
Background Many randomised control trials struggle to recruit and retain participants. Few previous studies explore participants’ experiences of recruitment and engagement in trials in secondary mental health care contexts, and few include…
View article: Feasibility and acceptability of a workplace return to work intervention: a cluster randomised feasibility trial
Feasibility and acceptability of a workplace return to work intervention: a cluster randomised feasibility trial Open
Purpose Assess the feasibility, acceptability, and potential efficacy of PROWORK, a multicomponent, theory-driven intervention designed to support the return-to-work of workers on long-term sick leave due to mental health problems or comor…
View article: Underlying biological mechanisms of emotion dysregulation in bipolar disorder
Underlying biological mechanisms of emotion dysregulation in bipolar disorder Open
Difficulties with emotion regulation (ER) are a key feature of bipolar disorder (BD) contributing to poor psychosocial and functional outcomes. Abnormalities within emotion processing and regulation thus provide key targets for treatment s…
View article: Examining the needs, outcomes, and current treatment pathways of 2461 people with Treatment-Resistant Depression: A mixed-methods study
Examining the needs, outcomes, and current treatment pathways of 2461 people with Treatment-Resistant Depression: A mixed-methods study Open
Introduction Major Depressive Disorder (MDD) is a pervasive global health issue, contributing significantly to disability and impaired quality of life. A substantial proportion of individuals with MDD develop Treatment-Resistant Depression…
View article: Sleep debt in adolescence as a risk factor for depression in young adulthood
Sleep debt in adolescence as a risk factor for depression in young adulthood Open
Introduction Adolescence is a crucial stage, during which sleep undergoes significant maturation. Among the sleep changes that characterise adolescence, sleep debt is particularly relevant. Although existing evidence indicates that sleep d…
View article: Persistent shorter and longer sleep duration from infancy to childhood and its prospective association with chronic depression symptoms
Persistent shorter and longer sleep duration from infancy to childhood and its prospective association with chronic depression symptoms Open
Introduction Identifying early-life risk factors for chronic depression symptomology in young people, is essential to informing early targeted interventions. One highly prevalent symptom (and potential risk factor) in depression is sleep p…
View article: The impact of personality traits on the return of major depression: a case–control study
The impact of personality traits on the return of major depression: a case–control study Open
Background Major depression is a common, chronic, recurrent, debilitating disorder. Despite effective treatments, remission rates remain low, and many of those who do experience remission then relapse. Some personality traits are potential…
View article: Examining the needs, outcomes and current treatment pathways of 2461 people with treatment-resistant depression: mixed-methods study
Examining the needs, outcomes and current treatment pathways of 2461 people with treatment-resistant depression: mixed-methods study Open
Background A substantial subset of patients with major depressive disorder (MDD) experience treatment-resistant depression (TRD), typically defined as failure to respond to at least two sequential antidepressant trials at adequate dose and…
View article: ADHD symptom trajectories across childhood and early adolescence and risk for hypomanic symptoms in young adulthood
ADHD symptom trajectories across childhood and early adolescence and risk for hypomanic symptoms in young adulthood Open
Background There is increasing evidence that childhood Attention-Deficit Hyperactivity Disorder (ADHD) elevates the risk of later Bipolar Spectrum Disorder (BD). However, it remains unclear whether different trajectories of ADHD symptoms c…
View article: Adverse childhood experiences and their differential relationships with transdiagnostic mental health outcomes in young adults
Adverse childhood experiences and their differential relationships with transdiagnostic mental health outcomes in young adults Open
Adverse childhood experiences (ACEs) are associated with poor mental health outcomes, which are increasingly conceptualized from a transdiagnostic perspective. We examined the impact of ACEs on transdiagnostic mental health outcomes in you…
View article: Comorbid ADHD and schizophrenia and the use of psychostimulants: a scoping review protocol
Comorbid ADHD and schizophrenia and the use of psychostimulants: a scoping review protocol Open
Introduction Schizophrenia and attention deficit hyperactivity disorder (ADHD) are psychiatric disorders that have a profound impact on patients and healthcare systems globally. There is preliminary evidence suggesting a potential associat…
View article: Personality traits and change in depression status at 18 months: Findings from a British Psychiatric Morbidity Survey
Personality traits and change in depression status at 18 months: Findings from a British Psychiatric Morbidity Survey Open
The present study confirms previous findings and contributes evidence suggesting that personality dysfunctions worsen depression outcomes.
View article: Trajectories of Inflammation in Youth and Risk of Mental and Cardiometabolic Disorders in Adulthood
Trajectories of Inflammation in Youth and Risk of Mental and Cardiometabolic Disorders in Adulthood Open
Importance Research suggests that low-grade, nonresolving inflammation may predate adult mental and physical illness. However, evidence to date is largely cross-sectional or focuses on single disorder outcomes. Objectives To examine trajec…
View article: The relationship between childhood adversity and affective instability across psychiatric disorders: A meta‐analysis
The relationship between childhood adversity and affective instability across psychiatric disorders: A meta‐analysis Open
Introduction Affective instability represents an important, transdiagnostic biobehavioural dimension of mental ill health and clinical outcome. The causes of affective instability remain unclear. This systematic review and meta‐analysis ev…
View article: Collaborative care intervention for individuals with severe mental illness: the PARTNERS2 programme including complex intervention development and cluster RCT
Collaborative care intervention for individuals with severe mental illness: the PARTNERS2 programme including complex intervention development and cluster RCT Open
Background and aims Individuals living with severe mental illness such as schizophrenia and bipolar can have significant emotional, cognitive, physical and social challenges. Most people with severe mental illness in the United Kingdom do …
View article: Role of Inflammation in Short Sleep Duration Across Childhood and Psychosis in Young Adulthood
Role of Inflammation in Short Sleep Duration Across Childhood and Psychosis in Young Adulthood Open
Importance Short sleep duration over a prolonged period in childhood could have a detrimental impact on long-term mental health, including the development of psychosis. Further, potential underlying mechanisms of these associations remain …
View article: Shorter night‐time sleep duration and later sleep timing from infancy to adolescence
Shorter night‐time sleep duration and later sleep timing from infancy to adolescence Open
Background Here, we (a) examined the trajectories of night‐time sleep duration, bedtime and midpoint of night‐time sleep (MPS) from infancy to adolescence, and (b) explored perinatal risk factors for persistent poor sleep health. Methods T…
View article: Persistent Childhood Anxiety And Inflammation And Associations With Adult Mental And Cardiometabolic Health Disorders: Results From Two Longitudinal Cohort Studies.
Persistent Childhood Anxiety And Inflammation And Associations With Adult Mental And Cardiometabolic Health Disorders: Results From Two Longitudinal Cohort Studies. Open
View article: Affective instability and cannabis use during adolescence and risk for mental illnesses in early adulthood: a longitudinal birth cohort study
Affective instability and cannabis use during adolescence and risk for mental illnesses in early adulthood: a longitudinal birth cohort study Open
View article: Supporting employers and their employees with mental hEalth conditions to remain eNgaged and producTive at wORk (MENTOR): A feasibility randomised controlled trial
Supporting employers and their employees with mental hEalth conditions to remain eNgaged and producTive at wORk (MENTOR): A feasibility randomised controlled trial Open
View article: Cognitive Remediation in Bipolar (CRiB2): study protocol for a randomised controlled trial assessing efficacy and mechanisms of cognitive remediation therapy compared to treatment as usual
Cognitive Remediation in Bipolar (CRiB2): study protocol for a randomised controlled trial assessing efficacy and mechanisms of cognitive remediation therapy compared to treatment as usual Open
Background A substantial proportion of people with bipolar disorder (BD) experience persistent cognitive difficulties associated with impairments in psychosocial functioning and a poorer disorder course. Emerging evidence suggests that cog…
View article: Randomised controlled trial of the Community Navigator programme to reduce loneliness and depression for adults with treatment-resistant depression in secondary community mental health services: trial protocol
Randomised controlled trial of the Community Navigator programme to reduce loneliness and depression for adults with treatment-resistant depression in secondary community mental health services: trial protocol Open
Background New treatments are needed for people with treatment-resistant depression (TRD), who do not benefit from anti-depressants and many of whom do not recover fully with psychological treatments. The Community Navigator programme was …
View article: Using intervention mapping to develop evidence-based toolkits that support workers on long-term sick leave and their managers
Using intervention mapping to develop evidence-based toolkits that support workers on long-term sick leave and their managers Open
View article: Considerations for patient and public involvement and engagement in health research
Considerations for patient and public involvement and engagement in health research Open
View article: Digital Training Program for Line Managers (Managing Minds at Work): Protocol for a Feasibility Pilot Cluster Randomized Controlled Trial
Digital Training Program for Line Managers (Managing Minds at Work): Protocol for a Feasibility Pilot Cluster Randomized Controlled Trial Open
Background Mental health problems affect 1 in 6 workers annually and are one of the leading causes of sickness absence, with stress, anxiety, and depression being responsible for half of all working days lost in the United Kingdom. Primary…
View article: Rates and associations of relapse over 5 years of 2649 people with bipolar disorder: a retrospective UK cohort study
Rates and associations of relapse over 5 years of 2649 people with bipolar disorder: a retrospective UK cohort study Open
Background Evidence regarding the rate of relapse in people with bipolar disorder (BD), particularly from the UK, is lacking. This study aimed to evaluate the rate and associations of clinician-defined relapse over 5 years in a large sampl…
View article: A leaky umbrella has little value: evidence clearly indicates the serotonin system is implicated in depression
A leaky umbrella has little value: evidence clearly indicates the serotonin system is implicated in depression Open
View article: Treatments for major depression – Authors' reply
Treatments for major depression – Authors' reply Open