Steven Meng
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View article: Effects of topical sodium bicarbonate emulsion on exercise exhaustion and training effects following high-intensity interval training in high-level soccer players
Effects of topical sodium bicarbonate emulsion on exercise exhaustion and training effects following high-intensity interval training in high-level soccer players Open
Background and Goal: High-level football players’ competitive performance and training efficacy are significantly impacted by sports weariness. Verifying the possible use of external sodium bicarbonate lotion in professional sports and inv…
View article: Lung ultrasound volume sweep imaging for respiratory illness: a new horizon in expanding imaging access
Lung ultrasound volume sweep imaging for respiratory illness: a new horizon in expanding imaging access Open
Background Respiratory illness is a leading cause of morbidity in adults and the number one cause of mortality in children, yet billions of people lack access to medical imaging to assist in its diagnosis. Although ultrasound is highly sen…
View article: Fibroblast Growth Factor 21 Protects Photoreceptor Function in Type 1 Diabetic Mice
Fibroblast Growth Factor 21 Protects Photoreceptor Function in Type 1 Diabetic Mice Open
Retinal neuronal abnormalities occur before vascular changes in diabetic retinopathy. Accumulating experimental evidence suggests that neurons control vascular pathology in diabetic and other neovascular retinal diseases. Therefore, normal…
View article: Photoreceptor glucose metabolism determines normal retinal vascular growth
Photoreceptor glucose metabolism determines normal retinal vascular growth Open
The neural cells and factors determining normal vascular growth are not well defined even though vision-threatening neovessel growth, a major cause of blindness in retinopathy of prematurity (ROP) (and diabetic retinopathy), is driven by d…
View article: Adiponectin Mediates Dietary Omega-3 Long-Chain Polyunsaturated Fatty Acid Protection Against Choroidal Neovascularization in Mice
Adiponectin Mediates Dietary Omega-3 Long-Chain Polyunsaturated Fatty Acid Protection Against Choroidal Neovascularization in Mice Open
APN in part mediated ω3-LCPUFA inhibition of neovascularization in two mouse models of AMD. Modulating the APN pathway in conjunction with a ω3-LCPUFA-enriched-diet may augment the beneficial effects of ω3-LCPUFA in AMD patients.
View article: RORα modulates semaphorin 3E transcription and neurovascular interaction in pathological retinal angiogenesis
RORα modulates semaphorin 3E transcription and neurovascular interaction in pathological retinal angiogenesis Open
Pathological proliferation of retinal blood vessels commonly causes vision impairment in proliferative retinopathies, including retinopathy of prematurity. Dysregulated crosstalk between the vasculature and retinal neurons is increasingly …
View article: Inflammatory signals from photoreceptor modulate pathological retinal angiogenesis via c-Fos
Inflammatory signals from photoreceptor modulate pathological retinal angiogenesis via c-Fos Open
Pathological neovessels growing into the normally avascular photoreceptors cause vision loss in many eye diseases, such as age-related macular degeneration and macular telangiectasia. Ocular neovascularization is strongly associated with i…
View article: Sema3f Protects Against Subretinal Neovascularization In Vivo
Sema3f Protects Against Subretinal Neovascularization In Vivo Open
Pathological neovascularization of the outer retina is the hallmark of neovascular age-related macular degeneration (nAMD). Building on our previous observations that semaphorin 3F (Sema3f) is expressed in the outer retina and demonstrates…
View article: Lutein facilitates physiological revascularization in a mouse model of retinopathy of prematurity
Lutein facilitates physiological revascularization in a mouse model of retinopathy of prematurity Open
Background Retinopathy of prematurity is one of the leading causes of childhood blindness worldwide, with vessel growth cessation and vessel loss in phase I followed by neovascularization in phase II. Ischaemia contributes to its pathogene…
View article: Fenofibrate Inhibits Cytochrome P450 Epoxygenase 2C Activity to Suppress Pathological Ocular Angiogenesis
Fenofibrate Inhibits Cytochrome P450 Epoxygenase 2C Activity to Suppress Pathological Ocular Angiogenesis Open
Neovascular eye diseases including retinopathy of prematurity, diabetic retinopathy and age-related-macular-degeneration are major causes of blindness. Fenofibrate treatment in type 2 diabetes patients reduces progression of diabetic retin…
View article: Cytochrome P450 Oxidase 2C Inhibition Adds to ω-3 Long-Chain Polyunsaturated Fatty Acids Protection Against Retinal and Choroidal Neovascularization
Cytochrome P450 Oxidase 2C Inhibition Adds to ω-3 Long-Chain Polyunsaturated Fatty Acids Protection Against Retinal and Choroidal Neovascularization Open
Objective— Pathological ocular neovascularization is a major cause of blindness. Increased dietary intake of ω-3 long-chain polyunsaturated fatty acids (LCPUFA) reduces retinal neovascularization and choroidal neovascularization (CNV), but…