Steven Mo
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View article: Exploration of the clinical prognostic model of BRCA based on PCAT7
Exploration of the clinical prognostic model of BRCA based on PCAT7 Open
Purpose Breast cancer (BRCA) is the most common cancer in women. Overexpression of long non-coding RNA Prostate cancer-associated transcript 7 (PCAT7) in BRCA was correlated with an unfavorable prognosis. Consequently, investigating the fu…
View article: Analysis of immune cell activation in patients with diabetes foot ulcer from the perspective of single cell
Analysis of immune cell activation in patients with diabetes foot ulcer from the perspective of single cell Open
This study offers insights into DM and DFU cytology. T cells in DFU are activated, attacking normal tissues and worsening tissue damage. The ATP5E gene may be related to the ecological remodeling of DM, and TPP1, TLR4, and RIPK2 are potent…
View article: Editorial: Single-cell and spatial-omics in delineating immune-related diseases
Editorial: Single-cell and spatial-omics in delineating immune-related diseases Open
EDITORIAL article Front. Cell Dev. Biol., 16 January 2024Sec. Molecular and Cellular Pathology Volume 12 - 2024 | https://doi.org/10.3389/fcell.2024.1365242
View article: A new clinical prognosis model for breast cancer with ADSS as the hub gene
A new clinical prognosis model for breast cancer with ADSS as the hub gene Open
Background: Breast cancer (BRCA) is the most common malignant tumor and the leading cause of cancer death worldwide. Adenylosuccinate synthetase (ADSS) is highly expressed in BRCA and its subtypes malignant tumors and is associated …
View article: Single-cell analysis reveals heterogeneity in the molecular profile of the tumor microenvironment of biliary tract cancers
Single-cell analysis reveals heterogeneity in the molecular profile of the tumor microenvironment of biliary tract cancers Open
Background Biliary tract cancers (BTCs) are heterogeneous malignancies with diverse tumor microenvironment (TME) cells that contribute to tumor progression. However, the characteristics of the TME among different subtypes of BTCs remain un…
View article: Exploration the global single-cell ecological landscape of adenomyosis-related cell clusters by single-cell RNA sequencing
Exploration the global single-cell ecological landscape of adenomyosis-related cell clusters by single-cell RNA sequencing Open
Background: Adenomyosis (AM) is a common benign uterine disease that threatens the normal life of patients. Cells associated with microenvironmental immune ecology are crucial in AM, although they are not as well understood at the cellular…
View article: An N6-Methyladenosine-Related Gene Set Variation Score as a Prognostic Tool for Lung Adenocarcinoma
An N6-Methyladenosine-Related Gene Set Variation Score as a Prognostic Tool for Lung Adenocarcinoma Open
N6-methyladenosine (m6A) is the most prevalent type of RNA modification, and we hypothesized that patterns of m6A-related genes may be useful for estimating risk of lung adenocarcinoma (LUAD). An m6A-related gene set variation score (m6A-G…
View article: Long Non-coding RNA Expression Patterns in Stomach Adenocarcinoma Serve as an Indicator of Tumor Mutation Burden and Are Associated With Tumor-Infiltrating Lymphocytes and Microsatellite Instability
Long Non-coding RNA Expression Patterns in Stomach Adenocarcinoma Serve as an Indicator of Tumor Mutation Burden and Are Associated With Tumor-Infiltrating Lymphocytes and Microsatellite Instability Open
Long non-coding RNAs (lncRNAs) are crucial in controlling important aspects of tumor immunity. However, whether the expression pattern of lncRNAs in stomach adenocarcinoma (STAD) reflects tumor immunity is not fully understood. We screened…
View article: Corrigendum to “Altered Genes and Biological Functions in Response to Severe Burns”
Corrigendum to “Altered Genes and Biological Functions in Response to Severe Burns” Open
[This corrects the article DOI: 10.1155/2021/8836243.].
View article: Altered Genes and Biological Functions in Response to Severe Burns
Altered Genes and Biological Functions in Response to Severe Burns Open
Severe burns are acute wounds caused by local heat exposure, resulting in life‐threatening systemic effects and poor survival. However, the specific molecular mechanisms remain unclear. First, we downloaded gene expression data related to …
View article: Exploring the mechanism of resistance to sorafenib in two hepatocellular carcinoma cell lines
Exploring the mechanism of resistance to sorafenib in two hepatocellular carcinoma cell lines Open
Sorafenib has long been the only approved systemic therapy for advanced hepatocellular carcinoma (HCC), but most patients show primary or acquired drug resistance. In the present study, RNA was extracted from sorafenib-resistant and -sensi…
View article: Landscape of transcription and expression regulated by DNA methylation related to age of donor and cell passage in adipose-derived mesenchymal stem cells
Landscape of transcription and expression regulated by DNA methylation related to age of donor and cell passage in adipose-derived mesenchymal stem cells Open
Adipose-derived mesenchymal stem cells (ADSCs) are pluripotent stromal cells that can differentiate into a variety of cell types, including skin cells. High-throughput sequencing was performed on cells of different ages and cell passage, o…
View article: FGF2-induced PI3K/Akt signaling evokes greater proliferation and adipogenic differentiation of human adipose stem cells from breast than from abdomen or thigh
FGF2-induced PI3K/Akt signaling evokes greater proliferation and adipogenic differentiation of human adipose stem cells from breast than from abdomen or thigh Open
In this study, human adipose stem cells were isolated from subcutaneous fat in the thigh (htASCs), abdomen (haASCs) and breast (hbASCs). Flow cytometry was used to detect cell surface markers, and an enzyme-linked immunosorbent assay was u…
View article: Multiomics global landscape of stemness-related gene clusters in adipose-derived mesenchymal stem cells
Multiomics global landscape of stemness-related gene clusters in adipose-derived mesenchymal stem cells Open
Background Adipose-derived mesenchymal stem cells (AD-MSCs) are a type of stem cell that is abundant and widely used. The molecular characteristics of AD-MSCs from different passages from donors of different ages have not been well elucida…
View article: USP22 promotes development of lung adenocarcinoma through ubiquitination and immunosuppression
USP22 promotes development of lung adenocarcinoma through ubiquitination and immunosuppression Open
Ubiquitin-specific protease 22 (USP22) expresses highly in lung adenocarcinoma (LUAD), which are associated with poor overall survival (OS). Microarray processing was performed to determine gene expression profiling, in which it was found …
View article: Classification of muscle-invasive bladder cancer based on tumor stromal compartment
Classification of muscle-invasive bladder cancer based on tumor stromal compartment Open
Purpose There has been a resurgence of interest in the tumor stroma in recent years. Whether the relative abundance of various stromal cells can be used as a classification system for muscle-invasive bladder cancer (MIBC) remain elusive.Me…
View article: Single-cell RNA-seq reveals the immune escape and drug resistance mechanisms of mantle cell lymphoma
Single-cell RNA-seq reveals the immune escape and drug resistance mechanisms of mantle cell lymphoma Open
Objective: Mantle cell lymphoma (MCL) is a rare subtype of non-Hodgkin lymphoma (NHL) with high heterogeneity and a high recurrence rate. How heterogenous cell populations contribute to relapse remains to be elucidated. Methods:<…
View article: LncRNA-Based Classifier to Predict TMB Levels in Stomach Adenocarcinoma
LncRNA-Based Classifier to Predict TMB Levels in Stomach Adenocarcinoma Open
View article: Increasing the density of nanomedicines improves their ultrasound-mediated delivery to tumours
Increasing the density of nanomedicines improves their ultrasound-mediated delivery to tumours Open
Nanomedicines have provided fresh impetus in the fight against cancer due to their selectivity and power. However, these agents are limited when delivered intravenously due to their rapid clearance from the bloodstream and poor passage fro…