Steven P. Nolan
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View article: Transfer Hydrodehalogenation of Aryl Halides Mediated by [Pd(IPr*)(cinnamyl)Cl]
Transfer Hydrodehalogenation of Aryl Halides Mediated by [Pd(IPr*)(cinnamyl)Cl] Open
We report the dehalogenation of aryl halides mediated by a palladium NHC (N-Heterocyclic Carbene) catalyst in alcohol solvents and using potassium phosphate as a mild base. A broad range of substrates, including sterically congested…
View article: Challenges in olefin metathesis: past, present and future
Challenges in olefin metathesis: past, present and future Open
View article: Metal–N-Heterocyclic Carbene Complexes in Buchwald–Hartwig Amination Reactions
Metal–N-Heterocyclic Carbene Complexes in Buchwald–Hartwig Amination Reactions Open
We present a comprehensive overview of the Buchwald-Hartwig amination, one of the most useful methods for C-N bond formation, mediated by NHC-transition-metal-complexes, covering the literature since 1999 (the first report on Buchwald-Hart…
View article: Suzuki–Miyaura Coupling of Pinacolboronic Esters Catalyzed by a Well-Defined Palladium <i>N</i>-Heterocyclic Carbene (NHC) Catalyst
Suzuki–Miyaura Coupling of Pinacolboronic Esters Catalyzed by a Well-Defined Palladium <i>N</i>-Heterocyclic Carbene (NHC) Catalyst Open
We report a versatile synthetic method for coupling heteroaryl chlorides and bromides with (hetero)-aryl pinacolboronic esters of pharmaceutical interest at low catalyst loading of a well-defined palladium-NHC catalyst providing products i…
View article: Expanding the Chemical Space of Allyl Palladates with Anticancer Properties
Expanding the Chemical Space of Allyl Palladates with Anticancer Properties Open
Allyl palladates are emerging as promising anticancer agents due to their unique mechanisms of action, including thioredoxin reductase inhibition and immunogenic cell death activation. However, their lack of selectivity toward cancer cells…
View article: A Well‐Defined Pd‐NHC Pre‐Catalyst for the Borylation of Aryl Chlorides
A Well‐Defined Pd‐NHC Pre‐Catalyst for the Borylation of Aryl Chlorides Open
We report on the design of a new well‐defined Pd‐NHC pre‐catalyst [Pd(IMes Me )(cinnamyl)Cl] as effective catalyst in the Miyaura borylation of a series of aryl chlorides. This complex was designed and developed after a screening of differ…
View article: Facile and green synthesis of [Pd(NHC)(η<sup>3</sup>-R-allyl)Cl] complexes and their anticancer activity
Facile and green synthesis of [Pd(NHC)(η<sup>3</sup>-R-allyl)Cl] complexes and their anticancer activity Open
A facile and environmentally friendly method for synthesizing a range of palladium-N-heterocyclic carbene (NHC) complexes—[Pd(NHC)(η 3 -R-allyl)Cl]—is described. This permits the testing of their anti-cancer activity.
View article: Catalysis meets machine learning: a guide to data-driven discovery and design
Catalysis meets machine learning: a guide to data-driven discovery and design Open
Machine learning (ML) has rapidly become an indispensable tool across the chemical sciences, offering powerful methods to extract patterns from data and make accurate predictions in complex, multidimensional systems.
View article: A straightforward approach to robust thiazolylidene gold complexes: efficient catalysts for propargylamide cycloisomerizations
A straightforward approach to robust thiazolylidene gold complexes: efficient catalysts for propargylamide cycloisomerizations Open
The straightforward synthesis and catalytic activity evaluation of new thiazolylidene gold complexes is described.
View article: A new generation of N-heterocyclic carbene (NHC) gold–selenolato complexes as potent anticancer agents: distinct synthetic routes and evaluation in 2D and 3D cancer models
A new generation of N-heterocyclic carbene (NHC) gold–selenolato complexes as potent anticancer agents: distinct synthetic routes and evaluation in 2D and 3D cancer models Open
Two distinct synthetic pathways are disclosed that lead to new gold–selenolato complexes, stabilized by N-heterocyclic carbenes (NHCs).
View article: Digold photosensitizer for visible light [2 + 2] cycloaddition and <i>E</i> / <i>Z</i> isomerization reactions
Digold photosensitizer for visible light [2 + 2] cycloaddition and <i>E</i> / <i>Z</i> isomerization reactions Open
Energy transfer photocatalysis has emerged as a powerful platform for a variety of transformations, yet advances in this area are often limited by visible-light absorption of catalysts and the high cost of state-of-the-art iridium-based ca…
View article: Palladium-Nhc Mediated Telomerization of Aromatic Alcohols
Palladium-Nhc Mediated Telomerization of Aromatic Alcohols Open
View article: Unlocking the potential of organopalladium complexes for high-grade serous ovarian cancer therapy
Unlocking the potential of organopalladium complexes for high-grade serous ovarian cancer therapy Open
High-Grade Serous Ovarian Cancer (HGSOC) is the most common and lethal subtype of ovarian cancer, known for its high aggressiveness and extensive genomic alterations.
View article: Investigation of the <i>in vitro</i> anticancer potential of bis(imino)acenaphthene–N-heterocyclic carbene transition metal complexes revealed TrxR inhibition and triggering of immunogenic cell death (ICD) for allyl palladates
Investigation of the <i>in vitro</i> anticancer potential of bis(imino)acenaphthene–N-heterocyclic carbene transition metal complexes revealed TrxR inhibition and triggering of immunogenic cell death (ICD) for allyl palladates Open
This study introduces a novel class of palladium-based compounds that uniquely induce immunogenic cell death (ICD) through thioredoxin reductase (TrxR) inhibition, demonstrating robust anticancer potential across various cell lines.
View article: Eliminating creep in vitrimers using temperature-resilient siloxane exchange chemistry and N-heterocyclic carbenes
Eliminating creep in vitrimers using temperature-resilient siloxane exchange chemistry and N-heterocyclic carbenes Open
We explored a novel N-heterocyclic carbene-mediated siloxane exchange mechanism, laying the foundation for designing creep-resistant vitrimers with high temperature stability for the dynamic covalent chemistry.
View article: Cultural Heritage, People and Place (CHerPP) Working Paper Culture's non-use values: towards a spatially informed measurement, understanding and aggregation of value(s)
Cultural Heritage, People and Place (CHerPP) Working Paper Culture's non-use values: towards a spatially informed measurement, understanding and aggregation of value(s) Open
View article: The influential IPr: 25 years after its discovery
The influential IPr: 25 years after its discovery Open
25 Years after the discovery of the most influential NHC ligand, we revisit and highlight studies involving IPr that have shaped the field of NHC-transition metal catalysis.
View article: Impact of the <i>N</i>-Heterocyclic Carbene (NHC) Ligand on the <i>trans</i>-[Pd(NHC)(NH<sub>2</sub><sup><i>n</i></sup>Bu)Cl<sub>2</sub>] Precatalyst Architecture in C–N Bond-Forming Reactions
Impact of the <i>N</i>-Heterocyclic Carbene (NHC) Ligand on the <i>trans</i>-[Pd(NHC)(NH<sub>2</sub><sup><i>n</i></sup>Bu)Cl<sub>2</sub>] Precatalyst Architecture in C–N Bond-Forming Reactions Open
Two straightforward synthetic procedures leading to air- and moisture-stable trans-[Pd(NHC)(NH2nBu)Cl2] precatalysts are presented. These complexes, obtained by adding n-butylamine to [Pd(NHC)(μ-Cl)Cl]2 or trans-[Pd(NHC)(DMS)Cl2] precursor…
View article: [Pd(NHC)(μ-Cl)Cl]<sub>2</sub>: The Highly Reactive Air- and Moisture-Stable, Well-Defined Pd(II)-N-Heterocyclic Carbene (NHC) Complexes for Cross-Coupling Reactions
[Pd(NHC)(μ-Cl)Cl]<sub>2</sub>: The Highly Reactive Air- and Moisture-Stable, Well-Defined Pd(II)-N-Heterocyclic Carbene (NHC) Complexes for Cross-Coupling Reactions Open
ConspectusPalladium-catalyzed cross-coupling reactions owing to their high specificity and superb chemoselectivity represent a powerful tool for the rapid construction of C-C and C-X bonds across various areas of chemical research, includi…
View article: Modular Synthesis of Azines Bearing a Guanidine Core from N‐Heterocyclic Carbene (NHC)‐Derived Selenoureas and Diazo Reagents
Modular Synthesis of Azines Bearing a Guanidine Core from N‐Heterocyclic Carbene (NHC)‐Derived Selenoureas and Diazo Reagents Open
N ‐Heterocyclic carbene (NHC)‐derived selenoureas comprise a fundamentally important class of NHC derivatives, with key applications in coordination chemistry and the determination of NHC electronic properties. Considering the broad reacti…
View article: Unlocking the Potential of Organopalladium Complexes for High-Grade Serous Ovarian Cancer Therapy
Unlocking the Potential of Organopalladium Complexes for High-Grade Serous Ovarian Cancer Therapy Open
High-Grade Serous Ovarian Cancer (HGSOC) is the most common and lethal subtype of ovarian cancer, known for its high aggressiveness and extensive genomic alterations. Typically diagnosed at an advanced stage, HGSOC presents formidable chal…
View article: Continuous Flow Synthesis of Group 11 Metal‐NHC Complexes [M(IPr)(OC(H)(CF<sub>3</sub>)<sub>2</sub>)] (with M=Cu, Ag and Au)
Continuous Flow Synthesis of Group 11 Metal‐NHC Complexes [M(IPr)(OC(H)(CF<sub>3</sub>)<sub>2</sub>)] (with M=Cu, Ag and Au) Open
The weak base method in continuous flow is currently one of the most sustainable and attractive approaches towards the synthesis of transition metal N‐heterocyclic carbene (NHC) complexes. Herein we broaden the scope of this method by usin…
View article: Synthesis of N-heterocyclic carbene (NHC)-Au/Ag/Cu benzotriazolyl complexes and their catalytic activity in propargylamide cycloisomerization and carbonyl hydrosilylation reactions
Synthesis of N-heterocyclic carbene (NHC)-Au/Ag/Cu benzotriazolyl complexes and their catalytic activity in propargylamide cycloisomerization and carbonyl hydrosilylation reactions Open
Facile access to a new family of Au-, Ag- and Cu-based Carbene-Metal-Amide (CMA) complexes is reported. These stable complexes bear the benzotriazolyl anion as the amido fragment, and are evaluated as (pre)catalysts in propargylamide cyclo…
View article: Machine learning directed discovery and optimisation of a platinum-catalysed amide reduction
Machine learning directed discovery and optimisation of a platinum-catalysed amide reduction Open
The discovery and optimisation of reaction conditions leading to the reduction of amides, a fundamental large-scale industrial reaction, is achieved using a machine learning (ML) platform and a platinum catalyst.
View article: Dinuclear NHC–gold(<scp>i</scp>)–thiolato and –alkynyl complexes: synthesis, anticancer activity, and catalytic activity in lactonization reactions
Dinuclear NHC–gold(<span>i</span>)–thiolato and –alkynyl complexes: synthesis, anticancer activity, and catalytic activity in lactonization reactions Open
A series of novel dinuclear NHC–gold–thiolato and –alkynyl complexes bearing aromatic linkers were successfully synthesized by an efficient and simple synthetic route.
View article: Synthesis of cyclohepta[<i>b</i>]indoles <i>via</i> gold mediated energy transfer photocatalysis
Synthesis of cyclohepta[<i>b</i>]indoles <i>via</i> gold mediated energy transfer photocatalysis Open
Gold photocatalyst has been employed as sensitizer for the synthesis of cyclohepta[ b ]indoles. Substrate scope and limitations of the protocol are presented. Mechanistic studies indicate involvement of EnT-HAT mechanism.
View article: Synthesis and reactivity of N-heterocyclic carbene (NHC) gold-fluoroalkoxide complexes
Synthesis and reactivity of N-heterocyclic carbene (NHC) gold-fluoroalkoxide complexes Open
We report a new family of gold-fluoroalkoxide complexes bearing various NHC ligands, and gauge their potential in organometallic synthesis.
View article: The role of the stabilizing/leaving group in palladium catalysed cross-coupling reactions
The role of the stabilizing/leaving group in palladium catalysed cross-coupling reactions Open
Despite the widespread use of well-defined Pd II complexes as pre-catalysts for cross-coupling processes, the role of the throw-away ligand is still underexplored.
View article: Correction: Simple synthetic access to [Au(IBiox)Cl] complexes
Correction: Simple synthetic access to [Au(IBiox)Cl] complexes Open
Correction for ‘Simple synthetic access to [Au(IBiox)Cl] complexes’ by Ekaterina A. Martynova et al. , Dalton Trans. , 2023, 52 , 7558–7563, https://doi.org/10.1039/D3DT01357J.
View article: Synthesis of cyclobutane-fused chromanones <i>via</i> gold-mediated photocatalysis
Synthesis of cyclobutane-fused chromanones <i>via</i> gold-mediated photocatalysis Open
A new general protocol for the synthesis of cyclobutane-fused chromanones via gold-mediated photocatalysis is reported. Gold photocatalyst proved more efficient than widely employed iridium- and organo-photocatalysts.