Explanipedia

Personalized medicine in the dish to prevent calcium leak associated with short-coupled polymorphic ventricular tachycardia in patient-derived cardiomyocytes Open

Yvonne Sleiman, Steven Reiken, Azzouz Charrabi, Fabrice Jaffré, Leah Sittenfeld , et al. · 2023

Defective cerebellar ryanodine receptor type 1 and endoplasmic reticulum calcium ‘leak’ in tremor pathophysiology Open

Regina T. Martuscello, Meng‐Ling Chen, Steven Reiken, Leah R. Sittenfeld, D Ruff , et al. · 2023

Zoledronic acid improves bone quality and muscle function in a high bone turnover state Open

Trupti Trivedi, Mohamed Manaa, Sutha K. John, Steven Reiken, Sreemala Murthy , et al. · 2023

SUMMARY Zoledronic acid (ZA) prevents muscle weakness in mice with bone metastases; however, its role in muscle weakness in non-tumor-associated metabolic bone diseases and as an effective treatment modality for the prevention of muscle we…

Molecular mechanisms of cardiac complications associated with COVID-19 Open

Steven Reiken, Haikel Dridi, Leah Sittenfeld, Yang Liu, Andrew R. Marks · 2023

Location of Ryanodine Receptor Type 2 Mutation Predicts Age of Onset of Sudden Death in Catecholaminergic Polymorphic Ventricular Tachycardia Open

Haikel Dridi, Halil Beqaj, Leah Sittenfeld, Marco Miotto, Gloria Willson , et al. · 2023

A drug and ATP binding site in type 1 ryanodine receptor Open

Zephan Melville, Haikel Dridi, Yuan Qi, Steven Reiken, Anetta Wronska , et al. · 2022

The ryanodine receptor (RyR)/calcium release channel on the sarcoplasmic reticulum (SR) is required for excitationcontraction coupling in skeletal and cardiac muscle.Inherited mutations and stress-induced post-translational modifications r…

Role of oxidation of excitation-contraction coupling machinery in age-dependent loss of muscle function in Caenorhabditis elegans Open

Haikel Dridi, Frances M. Forrester, Alisa Umanskaya, Wenjun Xie, Steven Reiken , et al. · 2022

Age-dependent loss of body wall muscle function and impaired locomotion occur within 2 weeks in Caenorhabditis elegans (C. elegans) ; however, the underlying mechanism has not been fully elucidated. In humans, age-dependent loss of muscle …

Author response: Role of oxidation of excitation-contraction coupling machinery in age-dependent loss of muscle function in Caenorhabditis elegans Open

Haikel Dridi, Frances M. Forrester, Alisa Umanskaya, Wenjun Xie, Steven Reiken , et al. · 2022

Acute RyR1 Ca2+ leak enhances NADH-linked mitochondrial respiratory capacity Open

Nadège Zanou, Haikel Dridi, Steven Reiken, Tanes Lima, Chris Donnelly , et al. · 2021

Role of oxidation of excitation-contraction coupling machinery in age-dependent loss of muscle function in <i>C. elegans</i> Open

Haikel Dridi, Frances M. Forrester, Alisa Umanskaya, Wenjun Xie, Steven Reiken , et al. · 2021

Age-dependent loss of body wall muscle function and impaired locomotion occur within 2 weeks in C. elegans ; however, the underlying mechanism has not been fully elucidated. In humans, age-dependent loss of muscle function occurs at about …

RyR1-related myopathy mutations in ATP and calcium binding sites impair channel regulation Open

Qi Yuan, Haikel Dridi, Oliver B. Clarke, Steven Reiken, Zephan Melville , et al. · 2021

Ryanodine receptor remodeling in cardiomyopathy and muscular dystrophy caused by lamin A/C gene mutation Open

Haikel Dridi, Wei Wu, Steven Reiken, Rachel Ofer, Yang Liu , et al. · 2020

Mutations in the lamin A/C gene (LMNA), which encodes A-type lamins, cause several diseases called laminopathies, the most common of which is dilated cardiomyopathy with muscular dystrophy. The role of Ca2+ regulation in these diseases rem…

Late Ventilator-Induced Diaphragmatic Dysfunction After Extubation Open

Haikel Dridi, Boris Jung, Mohamad Yehya, Aurélien Daurat, Steven Reiken , et al. · 2020

Objectives: Mechanical ventilation is associated with primary diaphragmatic dysfunction, also termed ventilator-induced diaphragmatic dysfunction. Studies evaluating diaphragmatic function recovery after extubation are lacking. We evaluate…

Intracellular calcium leak as a therapeutic target for RYR1-related myopathies Open

Alexander Kushnir, Joshua J. Todd, Jessica W. Witherspoon, Qi Yuan, Steven Reiken , et al. · 2020

Mitochondrial oxidative stress induces leaky ryanodine receptor during mechanical ventilation Open

Haikel Dridi, Mohamad Yehya, Robert Barsotti, Steven Reiken, Claire Angebault , et al. · 2019

Ryanodine Receptor Calcium Leak in Circulating B-Lymphocytes as a Biomarker in Heart Failure Open

Alexander Kushnir, Gaetano Santulli, Steven Reiken, Ellie J. Coromilas, Sarah Godfrey , et al. · 2018

Background: Advances in congestive heart failure (CHF) management depend on biomarkers for monitoring disease progression and therapeutic response. During systole, intracellular Ca 2+ is released from the sarcoplasmic reticulum into the cy…

Exploring the Role of Ryanodine Receptors in Huntington's Disease Pathophysiology Open

Panagiota E. Apostolou, Steven Reiken, Qi Yuan, Kaylee Wedderburn-Pugh, Felicia Benoit , et al. · 2018

Osteolytic Breast Cancer Causes Skeletal Muscle Weakness in an Immunocompetent Syngeneic Mouse Model Open

Jenna N. Regan, Carter Mikesell, Steven Reiken, Haifang Xu, Andrew R. Marks , et al. · 2017

Muscle weakness and cachexia are significant paraneoplastic syndromes of many advanced cancers. Osteolytic bone metastases are common in advanced breast cancer and are a major contributor to decreased survival, performance, and quality of …

Post-translational remodeling of ryanodine receptor induces calcium leak leading to Alzheimer’s disease-likepathologies and cognitive deficits Open

Alain Lacampagne, Xiaoping Liu, Steven Reiken, Renaud Bussiere, Albano C. Méli , et al. · 2017

Amyloid β production is regulated by β2-adrenergic signaling-mediated post-translational modifications of the ryanodine receptor Open

Renaud Bussiere, Alain Lacampagne, Steven Reiken, Xiaoping Liu, Valerie Scheuerman , et al. · 2017

The Role of Calcium Leak in Age-Dependent Loss of C. Elegans Muscle Function Open

Frances M. Forrester, Alisa Umanskaya, Wenjun Xie, Steven Reiken, Qi Yuan , et al. · 2017

Mechanistic Role of Type 1 Inositol 1,4,5-Trisphosphate Receptor in the Regulation of Vascular Tone in Heart Failure Open

Gaetano Santulli, Jessica Gambardella, Steven Reiken, Qi Yuan, Ryutaro Nakashima , et al. · 2017

Leaky ryanodine receptors contribute to diaphragmatic weakness during mechanical ventilation Open

Stéfan Matecki, Haikel Dridi, Boris Jung, Nathalie Saint, Steven Reiken , et al. · 2016

Significance Ventilator-induced diaphragmatic dysfunction (VIDD) refers to the diaphragm muscle weakness that follows prolonged controlled mechanical ventilation, impeding recovery from respiratory failure. The mechanisms underlying VIDD a…

Maintenance of normal blood pressure is dependent on IP3R1-mediated regulation of eNOS Open

Qi Yuan, Jingyi Yang, Gaetano Santulli, Steven Reiken, Anetta Wronska , et al. · 2016

Significance In this study, we demonstrate that type 1 inositol 1,4,5-trisphosphate receptor channels are critically involved in the activation of the calcineurin/nuclear factor of activated T cells (NFAT)/endothelial nitric oxide synthase…

Excess TGF-β mediates muscle weakness associated with bone metastases in mice Open

David L. Waning, Khalid S. Mohammad, Steven Reiken, Wenjun Xie, Daniel Andersson , et al. · 2015

Mitochondrial calcium overload is a key determinant in heart failure Open

Gaetano Santulli, Wenjun Xie, Steven Reiken, Andrew R. Marks · 2015

Significance We demonstrate that intracellular Ca 2+ leak causes mitochondrial Ca 2+ overload and dysfunction in postischemic heart failure (HF). In particular, sarcoplasmic reticulum (SR) Ca 2+ leak via type 2 ryanodine receptor (RyR2)—bu…

Mitochondrial oxidative stress promotes atrial fibrillation Open

Wenjun Xie, Gaetano Santulli, Steven Reiken, Qi Yuan, Brent W. Osborne , et al. · 2015

Calcium release channel RyR2 regulates insulin release and glucose homeostasis Open

Gaetano Santulli, Gennaro Pagano, Celestino Sardu, Wenjun Xie, Steven Reiken , et al. · 2015

The type 2 ryanodine receptor (RyR2) is a Ca2+ release channel on the endoplasmic reticulum (ER) of several types of cells, including cardiomyocytes and pancreatic β cells. In cardiomyocytes, RyR2-dependent Ca2+ release is critical for exc…

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