Steven S. An
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View article: Risk Factors for Serious Hypotension Induced by Intravenous Acetaminophen in Patients With Hematologic Malignancy
Risk Factors for Serious Hypotension Induced by Intravenous Acetaminophen in Patients With Hematologic Malignancy Open
Purpose Owing to their rapid antipyretic effects and predictable pharmacokinetic properties, acetaminophen (AAP) are commonly administered intravenously to severely ill patients. However, the potential development of hypotension as a conse…
View article: A novel high-throughput single-molecule technique DNA curtain: Applications for DNA metabolism
A novel high-throughput single-molecule technique DNA curtain: Applications for DNA metabolism Open
View article: Ovarian Cancer G protein-coupled receptor-1 signaling bias dictates anti-contractile effect of benzodiazepines on airway smooth muscle
Ovarian Cancer G protein-coupled receptor-1 signaling bias dictates anti-contractile effect of benzodiazepines on airway smooth muscle Open
The Gs-biased OGR1 ligand sulazepam relaxed contracted ASM in both tissue- and cell- based models, via inhibition of MLC phosphorylation in a PKA-dependent manner and through inhibition of actin stress fiber formation. The relat…
View article: Serum cAMP levels are increased in patients with asthma
Serum cAMP levels are increased in patients with asthma Open
View article: Corrigendum to “Structure-function studies of the bHLH phosphorylation domain of TWIST1 in prostate cancer cells” [Neoplasia 17 (2014) 85]
Corrigendum to “Structure-function studies of the bHLH phosphorylation domain of TWIST1 in prostate cancer cells” [Neoplasia 17 (2014) 85] Open
View article: Prorelaxant E-type Prostanoid Receptors Functionally Partition to Different Procontractile Receptors in Airway Smooth Muscle
Prorelaxant E-type Prostanoid Receptors Functionally Partition to Different Procontractile Receptors in Airway Smooth Muscle Open
Prostaglandin E2 imparts diverse physiological effects on multiple airway cells through its actions on four distinct E-type prostanoid (EP) receptor subtypes (EP1-EP4). Gs-coupled EP2 and EP4 receptors are expressed on airway smooth muscle…
View article: Identification of a β-arrestin-biased negative allosteric modulator for the β <sub>2</sub> -adrenergic receptor
Identification of a β-arrestin-biased negative allosteric modulator for the β <sub>2</sub> -adrenergic receptor Open
Catecholamine-stimulated β 2 -adrenergic receptor (β 2 AR) signaling via the canonical G s –adenylyl cyclase–cAMP–PKA pathway regulates numerous physiological functions, including the therapeutic effects of exogenous β-agonists in the trea…
View article: Cells in the polyaneuploid cancer cell (PACC) state have increased metastatic potential
Cells in the polyaneuploid cancer cell (PACC) state have increased metastatic potential Open
Although metastasis is the leading cause of cancer deaths, it is quite rare at the cellular level. Only a rare subset of cancer cells (~ 1 in 1.5 billion) can complete the entire metastatic cascade: invasion, intravasation, survival in the…
View article: Adventitial stromal cells and myofibroblasts recruit pro‐ and anti‐inflammatory immune cells in allergic airway inflammation
Adventitial stromal cells and myofibroblasts recruit pro‐ and anti‐inflammatory immune cells in allergic airway inflammation Open
View article: Rhinovirus C15 Attenuates Relaxation and cAMP Production in Human Airways and Smooth Muscle
Rhinovirus C15 Attenuates Relaxation and cAMP Production in Human Airways and Smooth Muscle Open
Rhinoviruses (RVs) evoke as many as 85% of acute asthma exacerbations in children and 50% in adults and can induce airway hyperresponsiveness and decrease efficacy of current therapeutics to provide symptom relief. Using human precision-cu…
View article: Data from The Twist Box Domain Is Required for Twist1-induced Prostate Cancer Metastasis
Data from The Twist Box Domain Is Required for Twist1-induced Prostate Cancer Metastasis Open
Twist1, a basic helix-loop-helix transcription factor, plays a key role during development and is a master regulator of the epithelial–mesenchymal transition (EMT) that promotes cancer metastasis. Structure–function relationships of Twist1…
View article: Supplementary Figures 1 - 11 from The Twist Box Domain Is Required for Twist1-induced Prostate Cancer Metastasis
Supplementary Figures 1 - 11 from The Twist Box Domain Is Required for Twist1-induced Prostate Cancer Metastasis Open
PDF file - 1004K, S1. The Twist box domain is required for full Twist1 transcriptional activity. S2. Quantification of immunofluorescence from isogenic prostate cancer cell lines stably expressing Twist1 and Twist1-F191G. S3. The Twist box…
View article: Supplementary Table 2 from The Twist Box Domain Is Required for Twist1-induced Prostate Cancer Metastasis
Supplementary Table 2 from The Twist Box Domain Is Required for Twist1-induced Prostate Cancer Metastasis Open
PDF file - 116K, Supplemental Table S2 - Myc-CaP + Twist1-F191G versus Myc-CaP + Vector Differentially.
View article: Data from The Twist Box Domain Is Required for Twist1-induced Prostate Cancer Metastasis
Data from The Twist Box Domain Is Required for Twist1-induced Prostate Cancer Metastasis Open
Twist1, a basic helix-loop-helix transcription factor, plays a key role during development and is a master regulator of the epithelial–mesenchymal transition (EMT) that promotes cancer metastasis. Structure–function relationships of Twist1…
View article: Supplementary Table 2 from The Twist Box Domain Is Required for Twist1-induced Prostate Cancer Metastasis
Supplementary Table 2 from The Twist Box Domain Is Required for Twist1-induced Prostate Cancer Metastasis Open
PDF file - 116K, Supplemental Table S2 - Myc-CaP + Twist1-F191G versus Myc-CaP + Vector Differentially.
View article: Supplementary Figures 1 - 11 from The Twist Box Domain Is Required for Twist1-induced Prostate Cancer Metastasis
Supplementary Figures 1 - 11 from The Twist Box Domain Is Required for Twist1-induced Prostate Cancer Metastasis Open
PDF file - 1004K, S1. The Twist box domain is required for full Twist1 transcriptional activity. S2. Quantification of immunofluorescence from isogenic prostate cancer cell lines stably expressing Twist1 and Twist1-F191G. S3. The Twist box…
View article: Supplementary Table 1 from The Twist Box Domain Is Required for Twist1-induced Prostate Cancer Metastasis
Supplementary Table 1 from The Twist Box Domain Is Required for Twist1-induced Prostate Cancer Metastasis Open
PDF file - 384K, Supplemental Table S1 - Myc-CaP + Twist1 versus Myc-CaP + Vector Differentially.
View article: Supplementary Table 1 from The Twist Box Domain Is Required for Twist1-induced Prostate Cancer Metastasis
Supplementary Table 1 from The Twist Box Domain Is Required for Twist1-induced Prostate Cancer Metastasis Open
PDF file - 384K, Supplemental Table S1 - Myc-CaP + Twist1 versus Myc-CaP + Vector Differentially.
View article: Supplementary Tables S6 and S7 from Germline Variants in Asporin Vary by Race, Modulate the Tumor Microenvironment, and Are Differentially Associated with Metastatic Prostate Cancer
Supplementary Tables S6 and S7 from Germline Variants in Asporin Vary by Race, Modulate the Tumor Microenvironment, and Are Differentially Associated with Metastatic Prostate Cancer Open
Supplementary Tables S6 shows bivariate analyses of the most common germline ASPN D genotypes/alleles for adverse pathology. Supplementary Table S7 shows multivariable analyses of ASPN D13/14 and Any 14 with lymph node involvement.
View article: Supplementary Figure S2 from Germline Variants in Asporin Vary by Race, Modulate the Tumor Microenvironment, and Are Differentially Associated with Metastatic Prostate Cancer
Supplementary Figure S2 from Germline Variants in Asporin Vary by Race, Modulate the Tumor Microenvironment, and Are Differentially Associated with Metastatic Prostate Cancer Open
Germline ASPN D-repeat-length is variable among the population.
View article: Supplemental Figures from TWIST1-WDR5-<i>Hottip</i> Regulates <i>Hoxa9</i> Chromatin to Facilitate Prostate Cancer Metastasis
Supplemental Figures from TWIST1-WDR5-<i>Hottip</i> Regulates <i>Hoxa9</i> Chromatin to Facilitate Prostate Cancer Metastasis Open
This document contains supplemental details such as antibodies and primers, list of genes overrepresented in TWIST1 and TWIST1 mutants, IHC staining for TWIST1 in mouse prostate development, IHC staining for TWIST1 and HOXA9 in various mou…
View article: Supplementary Materials and Methods from TWIST1-WDR5-<i>Hottip</i> Regulates <i>Hoxa9</i> Chromatin to Facilitate Prostate Cancer Metastasis
Supplementary Materials and Methods from TWIST1-WDR5-<i>Hottip</i> Regulates <i>Hoxa9</i> Chromatin to Facilitate Prostate Cancer Metastasis Open
This document contains experimental details for microarray data acquisition and analysis, immunohistochemistry, immunofluorescence, western blotting, migration assay, invasion assay, anoikis assay, soft agar colony formation assay, RNA-imm…
View article: Data from TWIST1-WDR5-<i>Hottip</i> Regulates <i>Hoxa9</i> Chromatin to Facilitate Prostate Cancer Metastasis
Data from TWIST1-WDR5-<i>Hottip</i> Regulates <i>Hoxa9</i> Chromatin to Facilitate Prostate Cancer Metastasis Open
TWIST1 is a transcription factor critical for development that can promote prostate cancer metastasis. During embryonic development, TWIST1 and HOXA9 are coexpressed in mouse prostate and then silenced postnatally. Here we report that TWIS…
View article: Supplementary Materials and Methods from Asporin Restricts Mesenchymal Stromal Cell Differentiation, Alters the Tumor Microenvironment, and Drives Metastatic Progression
Supplementary Materials and Methods from Asporin Restricts Mesenchymal Stromal Cell Differentiation, Alters the Tumor Microenvironment, and Drives Metastatic Progression Open
Supplementary Materials and Methods
View article: Supplemental Figures from TWIST1-WDR5-<i>Hottip</i> Regulates <i>Hoxa9</i> Chromatin to Facilitate Prostate Cancer Metastasis
Supplemental Figures from TWIST1-WDR5-<i>Hottip</i> Regulates <i>Hoxa9</i> Chromatin to Facilitate Prostate Cancer Metastasis Open
This document contains supplemental details such as antibodies and primers, list of genes overrepresented in TWIST1 and TWIST1 mutants, IHC staining for TWIST1 in mouse prostate development, IHC staining for TWIST1 and HOXA9 in various mou…
View article: Data from Asporin Restricts Mesenchymal Stromal Cell Differentiation, Alters the Tumor Microenvironment, and Drives Metastatic Progression
Data from Asporin Restricts Mesenchymal Stromal Cell Differentiation, Alters the Tumor Microenvironment, and Drives Metastatic Progression Open
Tumor progression to metastasis is not cancer cell autonomous, but rather involves the interplay of multiple cell types within the tumor microenvironment. Here we identify asporin (ASPN) as a novel, secreted mesenchymal stromal cell (MSC) …
View article: Supplementary Tables S2-4 from Germline Variants in Asporin Vary by Race, Modulate the Tumor Microenvironment, and Are Differentially Associated with Metastatic Prostate Cancer
Supplementary Tables S2-4 from Germline Variants in Asporin Vary by Race, Modulate the Tumor Microenvironment, and Are Differentially Associated with Metastatic Prostate Cancer Open
Supplementary Table S2 shows bivariate and multivariable analyses of germline ASPN D13/14 compared to ASPN D13/13 for lymph node involvement and metastatic recurrence. Supplementary Table S3 show bivariate analyses of ASPN D genotypes/alle…
View article: Data from Germline Variants in Asporin Vary by Race, Modulate the Tumor Microenvironment, and Are Differentially Associated with Metastatic Prostate Cancer
Data from Germline Variants in Asporin Vary by Race, Modulate the Tumor Microenvironment, and Are Differentially Associated with Metastatic Prostate Cancer Open
Purpose: Prostate cancers incite tremendous morbidity upon metastatic growth. We previously identified Asporin (ASPN) as a potential mediator of metastatic progression found within the tumor microenvironment. ASPN contains an…
View article: Supplementary Figure S1 from Germline Variants in Asporin Vary by Race, Modulate the Tumor Microenvironment, and Are Differentially Associated with Metastatic Prostate Cancer
Supplementary Figure S1 from Germline Variants in Asporin Vary by Race, Modulate the Tumor Microenvironment, and Are Differentially Associated with Metastatic Prostate Cancer Open
ASPN antibody validation.
View article: Data from Asporin Restricts Mesenchymal Stromal Cell Differentiation, Alters the Tumor Microenvironment, and Drives Metastatic Progression
Data from Asporin Restricts Mesenchymal Stromal Cell Differentiation, Alters the Tumor Microenvironment, and Drives Metastatic Progression Open
Tumor progression to metastasis is not cancer cell autonomous, but rather involves the interplay of multiple cell types within the tumor microenvironment. Here we identify asporin (ASPN) as a novel, secreted mesenchymal stromal cell (MSC) …