Steven Vanni
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View article: Novel mallet/holder manipulation technique for the reduction of anterior slippage in spondylolisthesis: A technical note
Novel mallet/holder manipulation technique for the reduction of anterior slippage in spondylolisthesis: A technical note Open
View article: Cytotoxic effects of Methoxy-substituted Chalcones on glioblastoma stem cells: Computational target prediction and therapeutic insights
Cytotoxic effects of Methoxy-substituted Chalcones on glioblastoma stem cells: Computational target prediction and therapeutic insights Open
The prognosis for patients diagnosed with glioblastoma remains dismal with an average survival of about 15 months. Recently, it has been shown that glioblastoma stem-like cells (GSCs) drive tumor progression and are responsible for tumor r…
View article: Practicing restraint after incidental finding of Pseudotumor deltoideus: A case report
Practicing restraint after incidental finding of Pseudotumor deltoideus: A case report Open
View article: Carbon Dots in Treatment of Pediatric Brain Tumors: Past, Present, and Future Directions
Carbon Dots in Treatment of Pediatric Brain Tumors: Past, Present, and Future Directions Open
Pediatric brain tumors remain a significant source of morbidity and mortality. Though developments have been made in treating these malignancies, the blood–brain barrier, intra- and inter-tumoral heterogeneity, and therapeutic toxicity pos…
View article: DDEL-12. QUADRUPLE CARBON DOT NANO MODEL FOR ENHANCED TUMOR TARGETING AND DUAL DRUG DELIVERY FOR THE TREATMENT OF PEDIATRIC HIGH-GRADE GLIOMAS
DDEL-12. QUADRUPLE CARBON DOT NANO MODEL FOR ENHANCED TUMOR TARGETING AND DUAL DRUG DELIVERY FOR THE TREATMENT OF PEDIATRIC HIGH-GRADE GLIOMAS Open
High-grade gliomas remain among the most lethal neoplasms. Nanotechnology aims to Improve drug targeting and efficacy. Here we developed a quadruple nano-model (QNM) that specifically targets pediatric high-grade glioma cells and delivers …
View article: Chalcones as Anti-Glioblastoma Stem Cell Agent Alone or as Nanoparticle Formulation Using Carbon Dots as Nanocarrier
Chalcones as Anti-Glioblastoma Stem Cell Agent Alone or as Nanoparticle Formulation Using Carbon Dots as Nanocarrier Open
The current prognosis for glioblastoma is dismal. Treatment-resistant glioblastoma stem cells (GSCs) and the failure of most drugs to reach therapeutic levels within the tumor remain formidable obstacles to successful treatment. Chalcones …
View article: NAMPT Inhibition Induces Neuroblastoma Cell Death and Blocks Tumor Growth
NAMPT Inhibition Induces Neuroblastoma Cell Death and Blocks Tumor Growth Open
High-risk neuroblastoma (NB) portends very poor prognoses in children. Targeting tumor metabolism has emerged as a novel therapeutic strategy. High levels of nicotinamide-adenine-dinucleotide (NAD+) are required for rapid cell proliferatio…
View article: Cell-nucleus Targeted Peptide Tethered Quadruple Carbon Dots for Treatment of High-grade Gliomas
Cell-nucleus Targeted Peptide Tethered Quadruple Carbon Dots for Treatment of High-grade Gliomas Open
Ultimate goal of the nanomedicine is built on the idea of robust targeted delivery of complex assemblies that contain sufficient amount of multiple therapeutics and diagnostic agents for highly localized payload release with no adverse sid…
View article: Carbon Dot Nanoarchitectonics: Quadruple Conjugated Nano Model for Superior Cancer Cell-Nucleus Targeting and Multi Drug Delivery
Carbon Dot Nanoarchitectonics: Quadruple Conjugated Nano Model for Superior Cancer Cell-Nucleus Targeting and Multi Drug Delivery Open
View article: Implantable brain–computer interface for neuroprosthetic-enabled volitional hand grasp restoration in spinal cord injury
Implantable brain–computer interface for neuroprosthetic-enabled volitional hand grasp restoration in spinal cord injury Open
Loss of hand function after cervical spinal cord injury severely impairs functional independence. We describe a method for restoring volitional control of hand grasp in one 21-year-old male subject with complete cervical quadriplegia (C5 A…
View article: Incidence and Clinical Outcomes of Hypothyroidism in Patients Undergoing Spinal Fusion
Incidence and Clinical Outcomes of Hypothyroidism in Patients Undergoing Spinal Fusion Open
Background Hypothyroidism has been independently associated with the development of several comorbidities and is known to increase complication rates in non-spinal surgeries. However, there are limited data regarding the effects of hypothy…
View article: Short lever arm, bipedicular handlebar construct for correction of acute angular kyphosis in spondylodiscitis-induced kyphotic deformity: illustrative case
Short lever arm, bipedicular handlebar construct for correction of acute angular kyphosis in spondylodiscitis-induced kyphotic deformity: illustrative case Open
BACKGROUND Pyogenic spondylodiscitis diminishes spinal structural integrity via disruption of the anterior and middle column, sometimes further compounded by iatrogenic violation of the posterior tension band during initial posterior decom…
View article: National Trends and Correlates of Dysphagia After Anterior Cervical Discectomy and Fusion Surgery
National Trends and Correlates of Dysphagia After Anterior Cervical Discectomy and Fusion Surgery Open
Objective Anterior cervical discectomy and fusion (ACDF) is the most common performed surgery in the cervical spine. Dysphagia is one of the most frequent complications following ACDF. Several studies have identified certain demographic an…
View article: UCP2 as a Potential Biomarker for Adjunctive Metabolic Therapies in Tumor Management
UCP2 as a Potential Biomarker for Adjunctive Metabolic Therapies in Tumor Management Open
Glioblastoma (GBM) remains one of the most lethal primary brain tumors in both adult and pediatric patients. Targeting tumor metabolism has emerged as a promising-targeted therapeutic strategy for GBM and characteristically resistant GBM s…
View article: Effects of Body Mass Index on Perioperative Outcomes in Patients Undergoing Anterior Cervical Discectomy and Fusion Surgery
Effects of Body Mass Index on Perioperative Outcomes in Patients Undergoing Anterior Cervical Discectomy and Fusion Surgery Open
Obesity is a well-established modifiable comorbidity that leads to increased perioperative complications in various surgical specialties. We present one of the largest retrospective analyses evaluating the effects of obesity on inpatient c…
View article: The Effects of Lockdown During the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Pandemic on Neurotrauma-Related Hospital Admissions
The Effects of Lockdown During the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Pandemic on Neurotrauma-Related Hospital Admissions Open
View article: THER-35. TARGETED DUAL DRUG DELIVERY USING NON-TOXIC CARBON DOTS AS A NANOCARRIER FOR PEDIATRIC BRAIN TUMORS
THER-35. TARGETED DUAL DRUG DELIVERY USING NON-TOXIC CARBON DOTS AS A NANOCARRIER FOR PEDIATRIC BRAIN TUMORS Open
Notable obstacles to successful treatment of pediatric brain tumor patients include the presence of the blood brain barrier (BBB), tumor heterogeneity and the development of drug resistance. Nanotechnology-based drug delivery systems (DDS)…
View article: Novel Curcumin Inspired Bis-Chalcone Promotes Endoplasmic Reticulum Stress and Glioblastoma Neurosphere Cell Death
Novel Curcumin Inspired Bis-Chalcone Promotes Endoplasmic Reticulum Stress and Glioblastoma Neurosphere Cell Death Open
Glioblastoma (GBM) has a dismal prognosis and successful elimination of GBM stem cells (GSCs) is a high-priority as these cells are responsible for tumor regrowth following therapy and ultimately patient relapse. Natural products and their…
View article: Treatment of posttraumatic lumbar interspinous ligament calcification with partial resection of spinous processes and calcified interspinous ligaments: case report
Treatment of posttraumatic lumbar interspinous ligament calcification with partial resection of spinous processes and calcified interspinous ligaments: case report Open
The authors report on the first surgical treatment for traumatic interspinous ligament calcification, with significant radiographic and symptomatic improvements at long-term follow-up. Heterotopic ossification occurs following traumatic in…
View article: Targeting Glioblastoma Stem Cells with 2-Deoxy-D-Glucose (2-DG) Potentiates Radiation-Induced Unfolded Protein Response (UPR)
Targeting Glioblastoma Stem Cells with 2-Deoxy-D-Glucose (2-DG) Potentiates Radiation-Induced Unfolded Protein Response (UPR) Open
Glioblastoma (GBM) is the most common and aggressive primary brain tumor in adults, and despite optimized treatment options, median survival remains dismal. Contemporary evidence suggests disease recurrence results from expansion of a robu…
View article: Triple conjugated carbon dots as a nano-drug delivery model for glioblastoma brain tumors
Triple conjugated carbon dots as a nano-drug delivery model for glioblastoma brain tumors Open
Most of the dual nano drug delivery systems fail to enter malignant brain tumors due to a lack of proper targeting systems and the size increase of the nanoparticles after drug conjugation. Therefore, a triple conjugated system was develop…
View article: HGG-44. STRESSED TO DEATH: EGFRvIII EXPRESSION RENDERS GLIOBLASTOMA CELLS MORE SENSITIVE TO ER STRESS INDUCING CHEMOTHERAPEUTICS
HGG-44. STRESSED TO DEATH: EGFRvIII EXPRESSION RENDERS GLIOBLASTOMA CELLS MORE SENSITIVE TO ER STRESS INDUCING CHEMOTHERAPEUTICS Open
Epidermal growth factor receptor (EGFR) is often overexpressed and/or mutated cancer. The most common mutation is EGFRvIII and has been found to correlate with tumor aggressiveness and poor outcome. In glioblastoma (GBM) expression of EGFR…
View article: Repair of giant postlaminectomy pseudomeningocele with fast-resorbing polymer mesh: technical report of 2 cases
Repair of giant postlaminectomy pseudomeningocele with fast-resorbing polymer mesh: technical report of 2 cases Open
Pseudomeningocele is a rare but well-known complication of lumbar spine surgery, which arises in 0.068%–0.1% of individuals in large series of patients undergoing laminectomy and in up to 2% of patients with postlaminectomy symptoms. In sy…
View article: Aggressive Resection of Cervical Desmoid Tumor Invading the Paraspinal Muscles without Recurrence at Eight Year Followup: A Case Report and Review of the Literature
Aggressive Resection of Cervical Desmoid Tumor Invading the Paraspinal Muscles without Recurrence at Eight Year Followup: A Case Report and Review of the Literature Open
To provide an overview of head, neck, and spine Desmoid Tumor (DT), to describe the case of a patient who underwent aggressive surgical resection of a large invasive cervical DT, and to analyze the DT literature. We discuss the importance …
View article: Preoperative skin antisepsis with chlorhexidine gluconate versus povidone-iodine: a prospective analysis of 6959 consecutive spinal surgery patients
Preoperative skin antisepsis with chlorhexidine gluconate versus povidone-iodine: a prospective analysis of 6959 consecutive spinal surgery patients Open
OBJECTIVE The aim of this study was to determine the efficacy of 2 common preoperative surgical skin antiseptic agents, ChloraPrep and Betadine, in the reduction of postoperative surgical site infection (SSI) in spinal surgery procedures. …
View article: Resveratrol augments ER stress and the cytotoxic effects of glycolytic inhibition in neuroblastoma by downregulating Akt in a mechanism independent of SIRT1
Resveratrol augments ER stress and the cytotoxic effects of glycolytic inhibition in neuroblastoma by downregulating Akt in a mechanism independent of SIRT1 Open
Cancer cells typically display increased rates of aerobic glycolysis that are correlated with tumor aggressiveness and a poor prognosis. Targeting the glycolytic pathway has emerged as an attractive therapeutic route mainly because it shou…
View article: Disappearing large calcified thoracic disc herniation in a patient with thalassaemia
Disappearing large calcified thoracic disc herniation in a patient with thalassaemia Open
Regression of herniated disc fragments with subsequent improvement in clinical symptoms has been reported in the lumbar and cervical spine. Such regressions in the thoracic spine are extremely rare. We report a case of a 38-year-old patien…
View article: Pooled data analysis on anterior versus posterior approach for rheumatoid arthritis at the craniovertebral junction
Pooled data analysis on anterior versus posterior approach for rheumatoid arthritis at the craniovertebral junction Open
OBJECT Rheumatoid arthritis (RA) is one of the most debilitating autoimmune diseases affecting the craniovertebral junction (CVJ). Patients predominantly present with myelopathic symptoms and intractable neck pain. The surgical approach tr…
View article: Minimally Invasive Versus Open Lumbar Fusion: A Comparison of Blood Loss, Surgical Complications, and Hospital Course.
Minimally Invasive Versus Open Lumbar Fusion: A Comparison of Blood Loss, Surgical Complications, and Hospital Course. Open
Level III, Therapeutic.