Explanipedia

Genotype-phenotype correlation and management of Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome: a descriptive cohort study Open

Johannes Hilberath, Ilias Tsiflikas, Anna Sanders, Justus Lieber, Tobias Luithle , et al. · 2025

Minimally invasive surgery in paediatric nephroblastoma Open

Steven W. Warmann, Jörg Fuchs · 2025

[68Ga] labelled Exendin for radioguided surgery of intrapancreatic insulin producing lesions in patients with congenital hyperinsulinism Open

Peter Kühnen, Sonal Prasad, K Rothe, Kai Huang, Kathrin Hauptmann , et al. · 2025

Background Congenital hyperinsulinism (CHI) is a life threatening disease. Localization of affected intrapancreatic beta cells responsible for focal forms during surgery can be challenging. In this study we investigated a new radioguided s…

Renal Autotransplantation for Resection of Bilateral Nephroblastoma and High-Risk Neuroblastoma in Children Open

Benjamin Mayer, Matthias Schunn, Cristian Urla, Lea Weinpert, Ilias Tsiflikas , et al. · 2025

Background/Objectives: In bilateral nephroblastoma and high-risk neuroblastoma in children with extensive tumor involvement of the renal vessels or pedicle, complete tumor resection with preservation of healthy renal tissue is not feasible…

Impact of COVID‐19 on paediatric chronic intestinal failure: A tertiary care children's hospital experience Open

Johannes Hilberath, Anna‐Sophia Mast, Simon Scherer, Jörg Fuchs, Johannes H. Schulte , et al. · 2024

Objectives Paediatric patients with intestinal failure (IF) are at risk for both gastrointestinal (GI) and systemic complications, thus depending on a functioning network of multidisciplinary care. Data on the clinical impact of coronaviru…

How to improve initial diagnostic accuracy of kidney tumours in childhood?—A non‐invasive approach Open

Nils Welter, Gregor Metternich, Rhoikos Furtwängler, Ahmed Bayoumi, Marvin Mergen , et al. · 2024

Non‐invasive differentiation of paediatric kidney tumours is particularly important in the SIOP‐RTSG protocols, which recommend pre‐operative chemotherapy without histological confirmation. The identification of clinical and tumour‐related…

Trap-Door Thoracotomy and Clamshell Thoracotomy as Surgical Approaches for Neuroblastoma and Other Thoracic Tumors in Children Open

Benjamin Mayer, Matthias Schunn, Cristian Urla, Jürgen Schäfer, Frank Fideler , et al. · 2024

Solid tumors of the cervicothoracic junction, the posterior mediastinum, or bilateral dorsal thoracic tumors represent a challenge in pediatric surgical oncology. The aim of this study was to evaluate trap-door thoracotomy and clamshell th…

Local MRI before and after Tumor Resection in Neuroblastoma: Impact of Residual Disease on Event Free Survival Open

Jürgen Schäfer, Sebastian Gassenmaier, Steven W. Warmann, Cristian Urla, Leonie Frauenfeld , et al. · 2023

(1) Background: The study aimed to investigate the influence of MRI-defined residual disease on local tumor control after resection of neuroblastic tumors in patients without routine adjuvant radiotherapy. (2) Methods: Patients, who underw…

TRIM28 inactivation in epithelial nephroblastoma is frequent and often associated with predisposing TRIM28 germline variants Open

Jenny Wegert, Anne Kristin Fischer, Balazs Palhazi, Taryn D. Treger, Cäcilia Hilgers , et al. · 2023

Wilms tumors (WTs) are histologically diverse childhood cancers with variable contributions of blastema, stroma, and epithelia. A variety of cancer genes operate in WTs, including the tripartite‐motif‐containing‐28 gene ( TRIM28 ). Case re…

Solid pseudopapillary neoplasms of the pancreas in childhood and adolescence—an analysis of the German Registry for Rare Pediatric Tumors (STEP) Open

Christian Jentzsch, Jörg Fuchs, Abbas Agaimy, Christian Vokuhl, Gabriele Escherich , et al. · 2023

Solid pseudopapillary neoplasms (SPNs) are the most common entity among pediatric pancreatic tumors. Still, these are rare tumors with an annual incidence of 0.1–0.2/1,000,000, and little is known about their optimal treatment. This analys…

Combined Metabolic and Functional Tumor Volumes on [18F]FDG-PET/MRI in Neuroblastoma Using Voxel-Wise Analysis Open

Maryanna Chaika, Simon Männlin, Sebastian Gassenmaier, Ilias Tsiflikas, Helmut Dittmann , et al. · 2023

Purpose: The purpose of our study was to evaluate the association between the [18F]FDG standard uptake value (SUV) and the apparent diffusion coefficient (ADC) in neuroblastoma (NB) by voxel-wise analysis. Methods: From our prospective obs…

Image‐defined risk factors in localized thoracic neuroblastoma and ganglioneuroma Open

Sarina Butzer, B. Krug, Maike Reisberg, Jörg Fuchs, Steven W. Warmann , et al. · 2023

Background The pretreatment International Neuroblastoma Risk Group Staging System (INRGSS) discriminates localized tumors L1/L2 depending on the absence/presence of image‐defined risk factors (IDRFs) at diagnosis. Referring to this new sta…

The role of surgery in the treatment of neuroblastoma metastases at rare sites Open

Simon Scherer, Benjamin Mayer, Markus Dietzel, Michael Esser, Steven W. Warmann , et al. · 2023

Purpose Treatment of neuroblastoma metastases usually consists of chemotherapy and irradiation. However, in selected cases, surgical treatment is also indicated. In this study, we present three cases of patients with neuroblastoma metastas…

Nephron sparing surgery and surgical management of intravascular extension of Wilms tumor Open

Elisabeth T. Tracy, Sofia Vasconcelos‐Castro, Marcio H. Malogolowkin, Amos Hong Pheng Loh, Meera Kotagal , et al. · 2023

Although general treatment approaches for Wilms tumor differ between Children's Oncology Group and Société Internationale d'Oncologie Pédiatrique‐Renal Tumors Study Group protocols, complex tumors that may be candidates for nephron sparing…

Supplemental Figure legends from Inducing Differentiation of Premalignant Hepatic Cells as a Novel Therapeutic Strategy in Hepatocarcinoma Open