Explanipedia

Infants display reduced NK cell responses in RSV and increased inflammatory responses in SARS-CoV-2 infections Open

Duygu Ucar, Asa Thibodeau, Asunción Mejías, Djamel Nehar-Belaid, Radu Marcheş , et al. · 2025

Semaphorin 4A maintains functional diversity of the hematopoietic stem cell pool Open

Dorsa Toghani, S. Gupte, Sharon Zeng, Elmir Mahammadov, Edie I. Crosse , et al. · 2024

SUMMARY Somatic stem cell pools are comprised of diverse, highly specialized subsets whose individual contribution is critical for the overall regenerative function. In the bone marrow, myeloid-biased HSC (myHSC) are indispensable for repl…

Mechanisms of epigenomic and functional convergence between glucocorticoid- and IL4-driven macrophage programming Open

Dinesh K. Deochand, Marija Dacic, Michael J. Bale, Andrew W. Daman, Vidyanath Chaudhary , et al. · 2024

Broad-spectrum antibiotics disrupt homeostatic efferocytosis Open

Pedro Saavedra, Alissa Trzeciak, Allie Lipshutz, Andrew W. Daman, Anya J. O’Neal , et al. · 2024

Microbial cancer immunotherapy reprograms hematopoiesis to enhance anti-tumor immunity Open

Andrew W. Daman, Anthony C. Antonelli, Gil Redelman‐Sidi, Lucinda Paddock, Jin‐Gyu Cheong , et al. · 2024

Summary Mycobacterium bovis BCG is the vaccine against tuberculosis and an immunotherapy for bladder cancer. When administered intravenously, BCG reprograms bone marrow hematopoietic stem and progenitor cells (HSPCs), leading to heterologo…

Circulating hematopoietic stem/progenitor cell subsets contribute to human hematopoietic homeostasis Open

Pamela Quaranta, Luca Basso‐Ricci, Raisa Jofra Hernández, Guido Pacini, Matteo Maria Naldini , et al. · 2024

In physiological conditions, few circulating hematopoietic stem/progenitor cells (cHSPCs) are present in the peripheral blood, but their contribution to human hematopoiesis remain unsolved. By integrating advanced immunophenotyping, single…

Mechanisms of Epigenomic and Functional Convergence Between Glucocorticoid and IL4-Driven Macrophage Programming Open

Dinesh K. Deochand, Marija Dacic, Michael J. Bale, Andrew W. Daman, Steven Z. Josefowicz , et al. · 2024

Macrophages adopt distinct phenotypes in response to environmental cues, with type-2 cytokine interleukin-4 promoting a tissue-repair homeostatic state (M2IL4). Glucocorticoids, widely used anti-inflammatory therapeutics, reportedly impart…

Fungal microbiota sustains lasting immune activation of neutrophils and their progenitors in severe COVID-19 Open

Takato Kusakabe, Woan-Yu Lin, Jin‐Gyu Cheong, Gagandeep Singh, Arjun Ravishankar , et al. · 2023

Epigenetic memory of coronavirus infection in innate immune cells and their progenitors Open

Jin‐Gyu Cheong, Arjun Ravishankar, Siddhartha Sharma, Christopher N. Parkhurst, Simon Grassmann , et al. · 2023

Low-input chromatin profiling reveals inter- and intra-lineage differences across immune cell types Open

Michael J. Bale, Dughan Ahimovic, Juliana J. Lee, Matthew R. Marunde, Carolina P. Lin , et al. · 2023

Transcriptional regulation in cells is governed by myriad traits that allow specific responses to ever-changing environments. Inclusive of these regulatory factors are the histone proteins that compact the genome while additionally being d…

Transcriptional Activation of Regenerative Hematopoiesis via Vascular Niche Sensing Open

Tomer Itkin, Sean Houghton, Ryan Schreiner, Lin Yang, Chaitanya R. Badwe , et al. · 2023

Transition between activation and quiescence programs in hematopoietic stem and progenitor cells (HSC/HSPCs) is perceived to be governed intrinsically and by microenvironmental co-adaptation. However, HSC programs dictating both transition…

Table of Contents Open

R. Gill, Pavel Solopov, Ruben Manuel Luciano Colunga Biancatelli, John D. Catravas, David Price , et al. · 2022

Angiopoietin 2 Is Associated with Vascular Necroptosis Induction in Coronavirus Disease 2019 Acute Respiratory Distress Syndrome Open

David R. Price, Elisa Benedetti, Eric A. Hoffman, Luis G. Gómez-Escobar, Sergio Alvarez-Mulett , et al. · 2022

Histone variant H3.3 maintains adult haematopoietic stem cell homeostasis by enforcing chromatin adaptability Open

Peipei Guo, Ying Liu, Fuqiang Geng, Andrew W. Daman, Xiaoyu Liu , et al. · 2021

Epigenetic and transcriptional control of interferon-β Open

Andrew W. Daman, Steven Z. Josefowicz · 2021

The three classes of interferons (IFNs) share the ability to inhibit viral replication, activating cell transcriptional programs that regulate both innate and adaptive responses to viral and intracellular bacterial challenge. Due to their …

The maladaptive vascular response in COVID-19 acute respiratory distress syndrome and recovery Open

David R. Price, Elisa Benedetti, Eric A. Hoffman, Luis G. Gómez-Escobar, Sergio Alvarez-Mulett , et al. · 2021

Vascular injury is a menacing element of acute respiratory distress syndrome (ARDS) pathogenesis. To better understand the role of vascular injury in COVID-19 ARDS, we used lung autopsy immunohistochemistry and blood proteomics from COVID-…

Signaling‐to‐chromatin pathways in the immune system Open

Alexia Martínez de Paz, Steven Z. Josefowicz · 2021

Complex organisms are able to respond to diverse environmental cues by rapidly inducing specific transcriptional programs comprising a few dozen genes among thousands. The highly complex environment within the nucleus—a crowded milieu cont…

HDAC inhibition results in widespread alteration of the histone acetylation landscape and BRD4 targeting to gene bodies Open

Mariesa J. Slaughter, Erin K. Shanle, Abid Khan, Katrin F. Chua, Tao Hong , et al. · 2021

Histone acetylation levels are regulated by histone acetyltransferases (HATs) and histone deacetylases (HDACs) that antagonistically control the overall balance of this post-translational modification. HDAC inhibitors (HDACi) are potent ag…

An Interactive Database for the Assessment of Histone Antibody Specificity Open

Scott B. Rothbart, Bradley M. Dickson, Jesse R. Raab, Adrian T. Grzybowski, Krzysztof Krajewski , et al. · 2020

Access to high quality antibodies is a necessity for the study of histones and their posttranslational modifications (PTMs). Here we debut The Histone Antibody Specificity Database (http://www.histoneantibodies.com), an online and expandin…

Histone H3.3 phosphorylation amplifies stimulation-induced transcription Open

Anja Armache, Shuang Yang, Alexia Martínez de Paz, Lexi Robbins, Ceyda Durmaz , et al. · 2020

Gene regulatory networks STARR-ing B cells Open

Alexia Martínez de Paz, Steven Z. Josefowicz · 2019

Phosphorylation of the ancestral histone variant H3.3 amplifies stimulation-induced transcription Open

Anja Armache, Shuang Yang, Lexi Robbins, Ceyda Durmaz, Andrew W. Daman , et al. · 2019

Complex organisms are able to rapidly induce select genes among thousands in response to diverse environmental cues. This occurs in the context of large genomes condensed with histone proteins into chromatin. The macrophage response to pat…

Greater Than the Sum of Parts: Complexity of the Dynamic Epigenome Open

Alexey A. Soshnev, Steven Z. Josefowicz, C. David Allis · 2018

Chromatin Kinases Act on Transcription Factors and Histone Tails in Regulation of Inducible Transcription Open

Steven Z. Josefowicz, Miho Shimada, Anja Armache, Charles H. Li, Rand M. Miller , et al. · 2016

Greater Than the Sum of Parts: Complexity of the Dynamic Epigenome Open

Alexey A. Soshnev, Steven Z. Josefowicz, C. David Allis · 2016

An Interactive Database for the Assessment of Histone Antibody Specificity Open

Scott B. Rothbart, Bradley M. Dickson, Jesse R. Raab, Adrian T. Grzybowski, Krzysztof Krajewski , et al. · 2015

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