Explanipedia

Geographical variation in the use of glucose‐lowering drugs in type‐2 diabetes in Denmark: A nationwide drug utilization study Open

Lotte Rasmussen, Jacob Harbo Andersen, Peter Bjødstrup Jensen, Gesche Jűrgens, Anton Pottegård , et al. · 2025

Aims To analyse geographical variation in use of glucose‐lowering drugs (GLDs) for type‐2 diabetes (T2DM) in Denmark. Methods We included all adults who filled a prescription for a non‐insulin GLD indicated for T2DM from 2010 to 2023 in De…

Geographical variation in the use of glucose-lowering drugs in type-2 diabetes in Denmark: A nationwide drug utilization study Open

Lotte Rasmussen, Jacob Harbo Andersen, Allan Kofoed‐Enevoldsen, Peter Bjødstrup Jensen, Gitte Krogh Madsen , et al. · 2025

Frontometaphyseal dysplasia associated with the FLNA p.G1576R variant Open

Morten Reiffenstein Huno, Trine Østergaard Nielsen, Michel Bach Hellfritzsch, Sara Markholt, Michael Davidsen , et al. · 2025

This report presents a male patient with frontometaphyseal dysplasia (FMD) caused by a previously reported FLNA variant (NM_001456.4:c.4726G>A (p.Gly1576Arg)) that was maternally inherited. This finding directly contrasts with two previous…

Assessing the Risk of QT Prolongation in a Psychiatric Inpatient Cohort: A Retrospective Cross-Sectional Study Open

Johan Frederik Mebus Meyer Christensen, Jonathan Hugo Jürgens‐Lahnstein, Afrim Iljazi, Stig Ejdrup Andersen, Morten Dahl , et al. · 2024

Background: QT prolongation is a potential serious adverse drug reaction, and assessing the risk of QT-prolonging drugs is routinely included in psychotropic medication reviews. However, the actual clinical benefits of such assessments are…

Medication reviews and the risk of cardiac arrhythmias in psychiatry Open

Jette Christensen, Stig Ejdrup Andersen, Morten Dahl, Jonathan Hugo Jürgens‐Lahnstein, Afrim Iljazi , et al. · 2024

Monotreatment With Conventional Antirheumatic Drugs or Glucocorticoids in Rheumatoid Arthritis Open

Louise Schow Guski, Gesche Jűrgens, Hugo Pedder, Niels K. G. Levinsen, Stig Ejdrup Andersen , et al. · 2023

Importance This is the first network meta-analysis to assess outcomes associated with multiple conventional synthetic disease-modifying antirheumatic drugs and glucocorticoid. Objective To analyze clinical outcomes after treatment with con…

Exploratory pharmacovigilance with machine learning in big patient data: A focused scoping review Open

Benjamin Skov Kaas‐Hansen, Simona Gentile, Alessandro Caioli, Stig Ejdrup Andersen · 2022

Background Machine learning can operationalize the rich and complex data in electronic patient records for exploratory pharmacovigilance endeavours. Objective The objective of this review is to identify applications of machine learning and…

Dihydropyrimidine dehydrogenase (DPD) genotype and phenotype among Danish cancer patients: prevalence and correlation betweenDPYD-genotype variants and P-uracil concentrations Open

Niels Herluf Paulsen, Camilla Qvortrup, Fie Juhl Vojdeman, Peter Plomgaard, Stig Ejdrup Andersen , et al. · 2022

Is the CYP2D6 Genotype Associated with Antipsychotic-Induced Weight Gain? Open

Gesche Jűrgens, Benjamin Skov Kaas‐Hansen, Merete Nordentoft, Thomas Werge, Stig Ejdrup Andersen · 2022

Antipsychotic-induced weight gain (AIWG) is a serious adverse effect. Studies have linked genetically-predicted CYP2D6 metabolic capacity to AIWG. The evidence, however, is ambiguous. We performed multiple regression analyses examining the…

DPYD genotyping and dihydropyrimidine dehydrogenase (DPD) phenotyping in clinical oncology. A clinically focused minireview Open

Niels Herluf Paulsen, Fie Juhl Vojdeman, Stig Ejdrup Andersen, Troels K. Bergmann, Marianne Ewertz , et al. · 2022

Background In clinical oncology, systemic 5‐fluorouracil (5‐FU) and its oral pro‐drugs are used to treat a broad group of solid tumours. Patients with dihydropyrimidine dehydrogenase (DPD) enzyme deficiency are at elevated risk of toxicity…

Language‐agnostic pharmacovigilant text mining to elicit side effects from clinical notes and hospital medication records Open

Benjamin Skov Kaas‐Hansen, Davide Placido, Cristina Leal Rodríguez, Hans‐Christian Thorsen‐Meyer, Simona Gentile , et al. · 2022

We sought to craft a drug safety signalling pipeline associating latent information in clinical free text with exposures to single drugs and drug pairs. Data arose from 12 secondary and tertiary public hospitals in two Danish regions, comp…

Machine Learning to Identify Patients at Risk of Inappropriate Dosing for Renal Risk Medications: A Critical Comment on Kaas-Hansen et al [Response to Letter] Open

Benjamin Skov Kaas‐Hansen, Cristina Leal Rodríguez, Davide Placido, Hans‐Christian Thorsen‐Meyer, Anna Pors Nielsen , et al. · 2022

SO-29 Dihydropyrimidine dehydrogenase (DPD) genotype and phenotype among Danish cancer patients: Prevalence and correlation between DPYD-genotype mutations and P-uracil concentrations Open

Niels Herluf Paulsen, Marianne Ewertz, Troels K. Bergmann, Hanne Spangsberg Holm, Søren Feddersen , et al. · 2022

Drug interactions in hospital prescriptions in Denmark: Prevalence and associations with adverse outcomes Open

Cristina Leal Rodríguez, Benjamin Skov Kaas‐Hansen, Robert Eriksson, Jorge Hernansanz Biel, Kirstine Belling , et al. · 2022

Purpose While the beneficial effects of medications are numerous, drug–drug interactions may lead to adverse drug reactions that are preventable causes of morbidity and mortality. Our goal was to quantify the prevalence of potential drug–d…

CYP2D6 Genetic Variation and Antipsychotic-Induced Weight Gain: A Systematic Review and Meta-Analysis Open

Yanisa Wannasuphoprasit, Stig Ejdrup Andersen, María J. Arranz, Rosa Catalán, Gesche Jűrgens , et al. · 2022

Background Antipsychotic-induced weight gain is a contributing factor in the reduced life expectancy reported amongst people with psychotic disorders. CYP2D6 is a liver enzyme involved in the metabolism of many commonly used antipsychotic …

Language-agnostic pharmacovigilant text mining to elicit side effects from clinical notes and hospital medication records Open

Benjamin Skov Kaas‐Hansen, Davide Placido, Cristina Leal Rodríguez, Hans‐Christian Thorsen‐Meyer, Simona Gentile , et al. · 2022

Aim To create a drug safety signalling pipeline associating latent information in clinical free text with exposure profiles to highlight potential adverse drug reactions to single drugs and drug pairs. Methods All inpatient visits of a 500…

Dihydropyrimidine dehydrogenase (DPD) genotype and phenotype among Danish cancer patients: prevalence and correlation between DPYD-genotype variants and P-uracil concentrations Open

Niels Herluf Paulsen, Camilla Qvortrup, Fie Juhl Vojdeman, Peter Plomgaard, Stig Ejdrup Andersen , et al. · 2022

Dihydropyrimidine dehydrogenase (DPD) genotype and phenotype among Danish cancer patients: prevalence and correlation between DPYD-genotype variants and P-uracil concentrations

Dihydropyrimidine dehydrogenase (DPD) genotype and phenotype among Danish cancer patients: prevalence and correlation between DPYD-genotype variants and P-uracil concentrations Open

Niels Herluf Paulsen, Camilla Qvortrup, Fie Juhl Vojdeman, Peter Plomgaard, Stig Ejdrup Andersen , et al. · 2022

Dihydropyrimidine dehydrogenase (DPD) genotype and phenotype among Danish cancer patients: prevalence and correlation between DPYD-genotype variants and P-uracil concentrations

Identifying patients at high risk of inappropriate drug dosing in periods with renal dysfunction Open

Benjamin Skov Kaas‐Hansen, Cristina Leal Rodríguez, Davide Placido, Hans‐Christian Thorsen‐Meyer, Anna Pors Nielsen , et al. · 2021

Introduction Dosing of renally cleared drugs in patients with kidney failure often deviates from clinical guidelines but little is known about what is predictive of receiving inappropriate doses. Methods and materials We combined data from…

Drug interactions in hospital prescriptions in Denmark: Prevalence and associations with adverse outcomes Open

Cristina Leal Rodríguez, Benjamin Skov Kaas‐Hansen, Robert Eriksson, Jorge Hernansanz Biel, Kirstine Belling , et al. · 2021

Importance While the beneficial effects of medications are numerous, drug-drug interactions may lead to adverse drug reactions that are preventable causes of morbidity and mortality. Objective To quantify the prevalence of potential drug-d…

Effect of Routine Cytochrome P450 2D6 and 2C19 Genotyping on Antipsychotic Drug Persistence in Patients With Schizophrenia Open

Gesche Jűrgens, Stig Ejdrup Andersen, Henrik Berg Rasmussen, Thomas Werge, Heidi Jensen , et al. · 2020

ClinicalTrials.gov Identifier: NCT00707382.

Hyponatraemia and mortality in psychiatric patients: protocol for Bayesian causal inference study Open

Benjamin Skov Kaas‐Hansen, Niels Graudal, Stig Ejdrup Andersen, Lau Caspar Thygesen, Søren Brunak , et al. · 2020

Introduction Hyponatriaemia has been associated with mortality in somatic patients, but little is known about the nature of such an association in psychiatric patients. This manuscript details a study to investigate if hyponatraemia be a d…

OP0310 IMPLEMENTATION OF TNF-BIOSIMILARS (INFLIXIMAB AND ETANERCEPT) IN DANISH DEPARTMENTS OF RHEUMATOLOGY Open

Thomas Bo Jensen, Dorthe Bartels, Eva Aggerholm Sædder, Birgitte Klindt Poulsen, Stig Ejdrup Andersen , et al. · 2019

A systematic review of observational studies of trifluridine/tipiracil (TAS-102) for metastatic colorectal cancer Open

Stig Ejdrup Andersen, Ida Brandt Andersen, Benny Vittrup Jensen, Per Pfeiffer, Takayo Ota , et al. · 2019

Background: The treatment options for patients with therapy refractory metastatic colorectal cancer (mCRC) are sparse. TAS-102 (FTD/TPI) is a new oral anti-tumour agent composed of a nucleoside analogue, trifluridine, and a thymidin…

Adverse Drug Events With Antipsychotics—A Sex Difference Open

Freja Karuna Hemmingsen Sørup, Jesper Hallas, Søren Brunak, Stig Ejdrup Andersen · 2017

Clinical Effects of a Pharmacist Intervention in Acute Wards – A Randomized Controlled Trial Open

Trine Rune Høgh Nielsen, Per Hartvig Honoré, Mette Rasmussen, Stig Ejdrup Andersen · 2017

The purpose of the study was to investigate the clinical effect of a clinical pharmacist (CP) intervention upon admission to hospital on inpatient harm and to assess a potential educational bias. Over 16 months, 593 adult patients taking ≥…

Clinical Pharmacology in Denmark in 2016 – 40 Years with the Danish Society of Clinical Pharmacology and 20 Years as a Medical Speciality Open

Kim Brøsen, Stig Ejdrup Andersen, Jeanett Borregaard, Hanne Rolighed Christensen, Palle Mark Christensen , et al. · 2016

The Danish Society of Clinical Pharmacology was founded in 1976, and mainly thanks to the persistent efforts of the society, clinical pharmacology became an independent medical speciality in Denmark in 1996. Since then, clinical pharmacolo…

Hypoglycaemia when adding sulphonylurea to metformin: a systematic review and network meta‐analysis Open

Stig Ejdrup Andersen, Mikkel Christensen · 2016

Aims The risk of hypoglycaemia may differ among sulphonylureas (SUs), but evidence from head‐to‐head comparisons is sparse. Performing a network meta‐analysis to use indirect evidence from randomized controlled trials (RCTs), we compared t…

Information in medical treatment courses: a steering tool for the quality - a pilot study Open

Marianne Møller, Stig Ejdrup Andersen, Charlotte Bredahl Jacobsen, Erik Hollnagel · 2016

INFORMATION IN MEDICAL TREATMENT COURSES - A STEERING TOOL FOR THE QUALITY – A Pilot Study Marianne Møller1,2 Stig Ejdrup Andersen3 Charlotte Bredahl Jacobsen4 Erik Hollnagel1,2 1: Centre for Quality, Middelfart Region of Southern Denmark …

Antidepressants and the risk of hyponatremia: a Danish register-based population study Open

Katja Leth-Møller, Annette Højmann Hansen, Maia Torstensson, Stig Ejdrup Andersen, Lars Ødum , et al. · 2016

Objective To examine the association between classes of antidepressants and hyponatremia, and between specific antidepressants and hyponatremia. Design Retrospective register-based cohort study using nationwide registers from 1998 to 2012.…

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