Stina Simonsson
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View article: Differentiation of Human Induced Pluripotent Stem Cells Toward Implantable Chondroprogenitor Cells
Differentiation of Human Induced Pluripotent Stem Cells Toward Implantable Chondroprogenitor Cells Open
Background. Post-traumatic chondral and osteochondral lesions can be treated with autologous chondrocyte implantation (ACI), but the high cost of autologous cell expansion under strict Good Manufacturing Practice (GMP) regulations limits p…
View article: On-chip fabrication of tailored 3D hydrogel scaffolds to model cancer cell invasion and interaction with endothelial cells
On-chip fabrication of tailored 3D hydrogel scaffolds to model cancer cell invasion and interaction with endothelial cells Open
The high mortality associated with certain cancers can be attributed to the invasive nature of the tumor cells. Yet, the complexity of studying invasion hinders our understanding of how the tumor spreads. This work presents a microengineer…
View article: Stem cell therapy for osteoarthritis: Functional cartilage regeneration using 3d bioprinting technology
Stem cell therapy for osteoarthritis: Functional cartilage regeneration using 3d bioprinting technology Open
Stem cell therapy for osteoarthritis: Functional cartilage regeneration using 3d bioprinting technology Osteoarthritis presents a significant societal and economic burden. Stina Simonsson from the University of Gothenburg explains how EU-f…
View article: Mechanical and Biological Characterization of Ionic and Photo-Crosslinking Effects on Gelatin-Based Hydrogel for Cartilage Tissue Engineering Applications
Mechanical and Biological Characterization of Ionic and Photo-Crosslinking Effects on Gelatin-Based Hydrogel for Cartilage Tissue Engineering Applications Open
Articular cartilage degeneration poses a significant public health challenge; techniques such as 3D bioprinting are being explored for its regeneration in vitro. Gelatin-based hydrogels represent one of the most promising biopolymers used …
View article: Injectable In Situ Crosslinking Hydrogel for Autologous Fat Grafting
Injectable In Situ Crosslinking Hydrogel for Autologous Fat Grafting Open
Autologous fat grafting is hampered by unpredictable outcomes due to high tissue resorption. Hydrogels based on enzymatically pretreated tunicate nanocellulose (ETC) and alginate (ALG) are biocompatible, safe, and present physiochemical pr…
View article: Autologous endothelialisation by the stromal vascular fraction on laminin-bioconjugated nanocellulose–alginate scaffolds
Autologous endothelialisation by the stromal vascular fraction on laminin-bioconjugated nanocellulose–alginate scaffolds Open
Establishing a vascular network in biofabricated tissue grafts is essential for ensuring graft survival. Such networks are dependent on the ability of the scaffold material to facilitate endothelial cell adhesion; however, the clinical tra…
View article: Human Pluripotent Stem Cell-Derived Hepatocytes Show Higher Transcriptional Correlation with Adult Liver Tissue than with Fetal Liver Tissue
Human Pluripotent Stem Cell-Derived Hepatocytes Show Higher Transcriptional Correlation with Adult Liver Tissue than with Fetal Liver Tissue Open
Human pluripotent stem cell-derived hepatocytes (hPSC-HEP) display many properties of mature hepatocytes, including expression of important genes of the drug metabolizing machinery, glycogen storage, and production of multiple serum protei…
View article: Collagen 2A Type B Induction after 3D Bioprinting Chondrocytes <i>In Situ</i> into Osteoarthritic Chondral Tibial Lesion
Collagen 2A Type B Induction after 3D Bioprinting Chondrocytes <i>In Situ</i> into Osteoarthritic Chondral Tibial Lesion Open
Objective Large cartilage defects and osteoarthritis (OA) cause cartilage loss and remain a therapeutic challenge. Three-dimensional (3D) bioprinting with autologous cells using a computer-aided design (CAD) model generated from 3D imaging…
View article: Comparative transcriptomics of hepatic differentiation of human pluripotent stem cells and adult human liver tissue
Comparative transcriptomics of hepatic differentiation of human pluripotent stem cells and adult human liver tissue Open
Hepatocytes derived from human pluripotent stem cells (hPSC-HEP) have the potential to replace presently used hepatocyte sources applied in liver disease treatment and models of drug discovery and development. Established hepatocyte differ…
View article: Cartilage Tissue Engineering by the 3D Bioprinting of iPS Cells in a Nanocellulose/Alginate Bioink
Cartilage Tissue Engineering by the 3D Bioprinting of iPS Cells in a Nanocellulose/Alginate Bioink Open
Cartilage lesions can progress into secondary osteoarthritis and cause severe clinical problems in numerous patients. As a prospective treatment of such lesions, human-derived induced pluripotent stem cells (iPSCs) were shown to be 3D biop…
View article: Highly Synchronized Expression of Lineage‐Specific Genes during <i>In Vitro</i> Hepatic Differentiation of Human Pluripotent Stem Cell Lines
Highly Synchronized Expression of Lineage‐Specific Genes during <i>In Vitro</i> Hepatic Differentiation of Human Pluripotent Stem Cell Lines Open
Human pluripotent stem cells‐ (hPSCs‐) derived hepatocytes have the potential to replace many hepatic models in drug discovery and provide a cell source for regenerative medicine applications. However, the generation of fully functional hP…