Stjepana Kovac
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View article: Risk of Epilepsy and Factors Associated With Time to Seizure Remission in Anti-LGI1 Encephalitis
Risk of Epilepsy and Factors Associated With Time to Seizure Remission in Anti-LGI1 Encephalitis Open
In conclusion, our results demonstrate that AEAE in anti-LGI1 encephalitis is rare and suggest that the diagnosis of epilepsy is inappropriate in patients reaching seizure remission because of a relatively low ROSR. Accordingly, on seizure…
View article: Cytoskeletal disruption-induced calcium dysregulation drives cell death in anti-IgLON5 disease
Cytoskeletal disruption-induced calcium dysregulation drives cell death in anti-IgLON5 disease Open
View article: Occurrence and treatment of depression symptoms and anxiety in patients with epilepsy: Findings from a German multicentre cross-sectional study
Occurrence and treatment of depression symptoms and anxiety in patients with epilepsy: Findings from a German multicentre cross-sectional study Open
Our analysis confirms that a significant proportion of PWE report depression and anxiety symptoms. However, these symptoms frequently go unrecognised in routine clinical practice. In the majority of cases within the study cohort, ASM thera…
View article: Clinical Reasoning: Episodes of Uncontrollable Crying in a 52-Year-Old Man With a Sphenopetroclival Tumor
Clinical Reasoning: Episodes of Uncontrollable Crying in a 52-Year-Old Man With a Sphenopetroclival Tumor Open
A 52-year-old man presented with progressive gait disturbances. MRI demonstrated a large extra-axial tumor in the cerebellopontine angle compressing the brainstem and resulting in hydrocephalus. While taking the patient's history, episodes…
View article: Activated αβ T and reduced mucosa-associated invariant T cells in LGI1- and CASPR2-encephalitis
Activated αβ T and reduced mucosa-associated invariant T cells in LGI1- and CASPR2-encephalitis Open
Anti-leucine-rich glioma inactivated-1 (LGI1) and anti-contactin-associated-protein-2 (CASPR2) autoimmune encephalitis (AIE) are common and characterized by pathogenic antibodies targeting neuronal autoantigens. However, the drivers of the…
View article: Characterization of immune cell profiles in the blood of children and adults with tuberous sclerosis complex disease
Characterization of immune cell profiles in the blood of children and adults with tuberous sclerosis complex disease Open
The overall blood immune cell profile is not changed in patients with epilepsy or TSC. However, analysis of subpopulations (T cells and B cells) has revealed changes in immune cell constitution in patients with epilepsy and those receiving…
View article: CSF and blood signatures support classification of limbic encephalitis subtypes
CSF and blood signatures support classification of limbic encephalitis subtypes Open
Autoimmune limbic encephalitis (ALE) represents a heterogeneous disease associated with antibodies targeting extracellular (ALEextra) epitopes, intracellular (ALEintra) epitopes, anti-glutamic acid decarboxylase65 ALE…
View article: Humoral signatures of Caspr2-antibody spectrum disorder track with clinical phenotypes and outcomes
Humoral signatures of Caspr2-antibody spectrum disorder track with clinical phenotypes and outcomes Open
View article: Retraction Note: Developmental changes in Notch1 and NLE1 expression in a genetic model of absence epilepsy
Retraction Note: Developmental changes in Notch1 and NLE1 expression in a genetic model of absence epilepsy Open
View article: Risk of Seizure Recurrence Due to Autoimmune Encephalitis With NMDAR, LGI1, CASPR2, and GABA <sub>B</sub> R Antibodies
Risk of Seizure Recurrence Due to Autoimmune Encephalitis With NMDAR, LGI1, CASPR2, and GABA <sub>B</sub> R Antibodies Open
Taking a <20% recurrence risk within 12 months as sufficient, patients with NMDAR-AIE and LGI1-AIE could be considered eligible for noncommercial driving after having been seizure-free for 3 months.
View article: A multicenter, matched case–control analysis comparing burden of illness among patients with tuberous sclerosis complex related epilepsy, generalized idiopathic epilepsy, and focal epilepsy in Germany
A multicenter, matched case–control analysis comparing burden of illness among patients with tuberous sclerosis complex related epilepsy, generalized idiopathic epilepsy, and focal epilepsy in Germany Open
Background Depending on the underlying etiology and epilepsy type, the burden of disease for patients with seizures can vary significantly. This analysis aimed to compare direct and indirect costs and quality of life (QoL) among adults wit…
View article: Neuronal Mitochondrial Calcium Uniporter (MCU) Deficiency Is Neuroprotective in Hyperexcitability by Modulation of Metabolic Pathways and ROS Balance
Neuronal Mitochondrial Calcium Uniporter (MCU) Deficiency Is Neuroprotective in Hyperexcitability by Modulation of Metabolic Pathways and ROS Balance Open
View article: Different pain phenotypes are associated with anti-Caspr2 autoantibodies
Different pain phenotypes are associated with anti-Caspr2 autoantibodies Open
View article: Targeted and optimized multi-channel transcranial direct current stimulation for focal epilepsy: An N-of-1 trial
Targeted and optimized multi-channel transcranial direct current stimulation for focal epilepsy: An N-of-1 trial Open
Transcranial direct current stimulation (tDCS) has been used to noninvasively reduce epileptic activity in focal epilepsy. In this proof-of-principle N-of-1 trial in a patient with refractory focal epilepsy in left frontal lobe, we propose…
View article: Targeted and optimized multi-channel transcranial direct current stimulation for focal epilepsy: An N-of-1 trial
Targeted and optimized multi-channel transcranial direct current stimulation for focal epilepsy: An N-of-1 trial Open
Transcranial direct current stimulation (tDCS) has been used to noninvasively reduce epileptic activity in focal epilepsy. In this proof-of-principle N-of-1 trial in a patient with drug-resistant focal epilepsy, we propose distributed cons…
View article: Translational imaging of TSPO reveals pronounced innate inflammation in human and murine CD8 T cell–mediated limbic encephalitis
Translational imaging of TSPO reveals pronounced innate inflammation in human and murine CD8 T cell–mediated limbic encephalitis Open
Autoimmune limbic encephalitis (ALE) presents with new-onset mesial temporal lobe seizures, progressive memory disturbance, and other behavioral and cognitive changes. CD8 T cells are considered to play a key role in those cases where auto…
View article: Adverse Event Profiles of Antiseizure Medications and the Impact of Coadministration on Drug Tolerability in Adults with Epilepsy
Adverse Event Profiles of Antiseizure Medications and the Impact of Coadministration on Drug Tolerability in Adults with Epilepsy Open
View article: NOX4-derived ROS are neuroprotective by balancing intracellular calcium stores
NOX4-derived ROS are neuroprotective by balancing intracellular calcium stores Open
View article: Contactin-associated protein 2 autoantibodies can be associated with multifocal motor-like neuropathy: a case report
Contactin-associated protein 2 autoantibodies can be associated with multifocal motor-like neuropathy: a case report Open
Autoantibodies against contactin-associated protein 2 (CASPR2) are usually associated with autoimmune encephalitis and neuromyotonia. Their association with inflammatory neuropathies has been described in case reports albeit all with dista…
View article: MAPT genotype-dependent mitochondrial aberration and ROS production trigger dysfunction and death in cortical neurons of patients with hereditary FTLD
MAPT genotype-dependent mitochondrial aberration and ROS production trigger dysfunction and death in cortical neurons of patients with hereditary FTLD Open
View article: Review and meta-analysis of neuropsychological findings in autoimmune limbic encephalitis with autoantibodies against LGI1, CASPR2, and GAD65 and their response to immunotherapy
Review and meta-analysis of neuropsychological findings in autoimmune limbic encephalitis with autoantibodies against LGI1, CASPR2, and GAD65 and their response to immunotherapy Open
Currently, there is no definite evidence supporting the notion that different AAB-types of ALE exhibit distinct neuropsychological manifestations and respond differently to immunotherapy. Overall, we could not identify evidence for any eff…
View article: Deterministic programming of human pluripotent stem cells into microglia facilitates studying their role in health and disease
Deterministic programming of human pluripotent stem cells into microglia facilitates studying their role in health and disease Open
Microglia, the resident immune cells of the central nervous system (CNS), are derived from yolk-sac macrophages that populate the developing CNS during early embryonic development. Once established, the microglia population is self-maintai…
View article: Impact of COVID-19 pandemic on physical and mental health status and care of adults with epilepsy in Germany
Impact of COVID-19 pandemic on physical and mental health status and care of adults with epilepsy in Germany Open
View article: Activation of non-classical NMDA receptors by glycine impairs barrier function of brain endothelial cells
Activation of non-classical NMDA receptors by glycine impairs barrier function of brain endothelial cells Open
Blood–brain barrier (BBB) integrity is necessary to maintain homeostasis of the central nervous system (CNS). NMDA receptor (NMDAR) function and expression have been implicated in BBB integrity. However, as evidenced in neuroinflammatory c…
View article: Complement activation contributes to GAD antibody-associated encephalitis
Complement activation contributes to GAD antibody-associated encephalitis Open
View article: Antibody response to herpes simplex virus‐1 is increased in autoimmune encephalitis
Antibody response to herpes simplex virus‐1 is increased in autoimmune encephalitis Open
Autoimmune encephalitides (AE) comprise a group of inflammatory brain diseases characterized by prominent neuropsychiatric symptoms and the detection of serum IgG antibodies specific for antigens expressed by neuronal cells [1]. Aside from…
View article: A genome-wide association study in autoimmune neurological syndromes with anti-GAD65 autoantibodies
A genome-wide association study in autoimmune neurological syndromes with anti-GAD65 autoantibodies Open
Autoimmune neurological syndromes (AINS) with autoantibodies against the 65 kDa isoform of the glutamic acid decarboxylase (GAD65) present with limbic encephalitis, including temporal lobe seizures or epilepsy, cerebellitis with ataxia, an…
View article: Trends in resource utilization and cost of illness in patients with active epilepsy in Germany from 2003 to 2020
Trends in resource utilization and cost of illness in patients with active epilepsy in Germany from 2003 to 2020 Open
Objective This study was undertaken to calculate epilepsy‐related direct, indirect, and total costs in adult patients with active epilepsy (ongoing unprovoked seizures) in Germany and to analyze cost components and dynamics compared to pre…
View article: Multicenter, cross‐sectional study of the costs of illness and cost‐driving factors in adult patients with epilepsy
Multicenter, cross‐sectional study of the costs of illness and cost‐driving factors in adult patients with epilepsy Open
Objective This study was undertaken to quantify epilepsy‐related costs of illness (COI) in Germany and identify cost‐driving factors. Methods COI were calculated among adults with epilepsy of different etiologies and severities. Multiple r…
View article: Neuropsychological Performance in Autoimmune Limbic Encephalitis: Evidence from an Immunotherapy-Naïve Cohort
Neuropsychological Performance in Autoimmune Limbic Encephalitis: Evidence from an Immunotherapy-Naïve Cohort Open
Objective Autoimmune limbic encephalitis (ALE) is characterized by memory impairment, psychiatric symptoms, and epileptic seizures. Though, the neuropsychological profile of ALE is not yet well defined. However, there is some evidence that…