Stuart A. Nicklin
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View article: Targeting <i>Runx</i> 1 protects against heart failure with preserved ejection fraction
Targeting <i>Runx</i> 1 protects against heart failure with preserved ejection fraction Open
Heart failure with preserved ejection fraction (HFpEF) is a public health problem and an elusive illness for which there are few treatment options. HFpEF is a systemic condition with a broad phenotype including diastolic dysfunction, pulmo…
View article: Unscheduled changes in pre-clinical stroke model housing contributes to variance in physiological and behavioural data outcomes: A post hoc analysis
Unscheduled changes in pre-clinical stroke model housing contributes to variance in physiological and behavioural data outcomes: A post hoc analysis Open
Ischaemic stroke presents a significant problem worldwide with no neuroprotective drugs available. Many of the failures in the search for neuroprotectants are attributed to failure to translate from pre-clinical models to humans, which has…
View article: Ribonucleicacid interference or small molecule inhibition of<i>Runx</i>1 in the border zone prevents cardiac contractile dysfunction following myocardial infarction
Ribonucleicacid interference or small molecule inhibition of<i>Runx</i>1 in the border zone prevents cardiac contractile dysfunction following myocardial infarction Open
Aims Myocardial infarction (MI) is a major cause of death worldwide. Effective treatments are required to improve recovery of cardiac function following MI, with the aim of improving patient outcomes and preventing progression to heart fai…
View article: Agonist-induced phosphorylation of orthologues of the orphan receptor GPR35 functions as an activation sensor
Agonist-induced phosphorylation of orthologues of the orphan receptor GPR35 functions as an activation sensor Open
G protein-coupled receptor 35 (GPR35) is poorly characterized but nevertheless has been revealed to have diverse roles in areas including lower gut inflammation and pain. The development of novel reagents and tools will greatly enhance ana…
View article: In Vitro and In Vivo Evaluation of Human Adenovirus Type 49 as a Vector for Therapeutic Applications
In Vitro and In Vivo Evaluation of Human Adenovirus Type 49 as a Vector for Therapeutic Applications Open
The human adenovirus phylogenetic tree is split across seven species (A–G). Species D adenoviruses offer potential advantages for gene therapy applications, with low rates of pre-existing immunity detected across screened populations. Howe…
View article: In Vitro and In Vivo Evaluation of Human Adenovirus Type 49 as a Vector for Therapeutic Applications
In Vitro and In Vivo Evaluation of Human Adenovirus Type 49 as a Vector for Therapeutic Applications Open
The human adenovirus phylogenetic tree is split across seven species (A-G). Species D adenoviruses offer potential advantages for gene therapy applications, with low rates of preexisting immunity detected across screened populations. Howev…
View article: In Vitro and In Vivo Evaluation of Human Adenovirus Type 49 as a Vector for Therapeutic Applications
In Vitro and In Vivo Evaluation of Human Adenovirus Type 49 as a Vector for Therapeutic Applications Open
The human adenovirus phylogenetic tree is split across seven species (A-G). Species D adenoviruses offer potential advantages for gene therapy applications, with low rates of preexisting immunity detected across screened populations. Howev…
View article: Preclinical models of myocardial infarction: from mechanism to translation
Preclinical models of myocardial infarction: from mechanism to translation Open
Approximately 7 million people are affected by acute myocardial infarction (MI) each year, and despite significant therapeutic and diagnostic advancements, MI remains a leading cause of mortality worldwide. Preclinical animal models have s…
View article: Inhibition of myocardial cathepsin-L release during reperfusion following myocardial infarction improves cardiac function and reduces infarct size
Inhibition of myocardial cathepsin-L release during reperfusion following myocardial infarction improves cardiac function and reduces infarct size Open
Aims Identifying novel mediators of lethal myocardial reperfusion injury that can be targeted during primary percutaneous coronary intervention (PPCI) is key to limiting the progression of patients with ST-elevation myocardial infarction (…
View article: ACE2 and Proinflammatory Signaling by S1 Protein of SARS‐Cov‐2 in Human Endothelial Cells
ACE2 and Proinflammatory Signaling by S1 Protein of SARS‐Cov‐2 in Human Endothelial Cells Open
Introduction COVID‐19 is primarily a respiratory disease associated with cardiovascular risk. SARS‐CoV‐2, the virus causing COVID‐19, uses ACE2, an important enzyme in the cardiovascular system that regulates the conversion of Ang II (dele…
View article: The counter regulatory axis of the renin angiotensin system in the brain and ischaemic stroke: Insight from preclinical stroke studies and therapeutic potential
The counter regulatory axis of the renin angiotensin system in the brain and ischaemic stroke: Insight from preclinical stroke studies and therapeutic potential Open
Stroke is the 2nd leading cause of death worldwide and the leading cause of physical disability and cognitive issues. Although we have made progress in certain aspects of stroke treatment, the consequences remain substantial and new treatm…
View article: Extracellular vesicle signalling in atherosclerosis
Extracellular vesicle signalling in atherosclerosis Open
Atherosclerosis is a major cardiovascular disease and in 2016, the World Health Organisation (WHO) estimated 17.5 million global deaths, corresponding to 31% of all global deaths, were driven by inflammation and deposition of lipids into t…
View article: COVID-19 and the cardiovascular system: implications for risk assessment, diagnosis, and treatment options
COVID-19 and the cardiovascular system: implications for risk assessment, diagnosis, and treatment options Open
The novel coronavirus disease (COVID-19) outbreak, caused by SARS-CoV-2, represents the greatest medical challenge in decades. We provide a comprehensive review of the clinical course of COVID-19, its comorbidities, and mechanistic conside…
View article: RUNX1: an emerging therapeutic target for cardiovascular disease
RUNX1: an emerging therapeutic target for cardiovascular disease Open
Runt-related transcription factor-1 (RUNX1), also known as acute myeloid leukaemia 1 protein (AML1), is a member of the core-binding factor family of transcription factors which modulate cell proliferation, differentiation, and survival in…
View article: Human Adenovirus Serotype 5 Is Sensitive to IgM-Independent Neutralization In Vitro and In Vivo
Human Adenovirus Serotype 5 Is Sensitive to IgM-Independent Neutralization In Vitro and In Vivo Open
Human adenovirus 5 (HAdV-5) is used as a vector in gene therapy clinical trials, hence its interactions with the host immune system have been widely studied. Previous studies have demonstrated that HAdV-5 binds specifically to murine coagu…
View article: Systems biology identifies cytosolic PLA2 as a target in vascular calcification treatment
Systems biology identifies cytosolic PLA2 as a target in vascular calcification treatment Open
Although cardiovascular disease (CVD) is the leading cause of morbimortality worldwide, promising new drug candidates are lacking. We compared the arterial high-resolution proteome of patients with advanced versus early-stage CVD to predic…
View article: BS7 Angiotensin-(1–9) inhibits neointima formation in a murine vein graft model and modulates ERK1/2 phosphorylation and microRNA-132 pathways in human vascular smooth muscle cells
BS7 Angiotensin-(1–9) inhibits neointima formation in a murine vein graft model and modulates ERK1/2 phosphorylation and microRNA-132 pathways in human vascular smooth muscle cells Open
Introduction Vascular smooth muscle cell (VSMC) migration is integral to vascular remodelling in acute vascular injury. The main effector of the renin angiotensin system (RAS), angiotensin II (AngII), is a key mediator of this remodelling.…
View article: What matters in Cardiovascular Research? Scientific discovery driving clinical delivery
What matters in Cardiovascular Research? Scientific discovery driving clinical delivery Open
No abstract available.
View article: Utilizing proteomics to understand and define hypertension: where are we and where do we go?
Utilizing proteomics to understand and define hypertension: where are we and where do we go? Open
Hypertension is a complex and multifactorial cardiovascular disorder. With different mechanisms contributing to a different extent to an individual's blood pressure, the discovery of novel pathogenetic principles of hypertension is challen…
View article: The Orphan Receptor GPR35 Contributes to Angiotensin II–Induced Hypertension and Cardiac Dysfunction in Mice
The Orphan Receptor GPR35 Contributes to Angiotensin II–Induced Hypertension and Cardiac Dysfunction in Mice Open
BACKGROUND The orphan receptor G protein–coupled receptor 35 (GPR35) has been associated with a range of diseases, including cancer, inflammatory bowel disease, diabetes, hypertension, and heart failure. To assess the potential for GPR35 a…
View article: 9 Investigating the counter regulatory renin angiotensin system axis in the stroke prone spontaneously hypertensive rat in ischaemic stroke
9 Investigating the counter regulatory renin angiotensin system axis in the stroke prone spontaneously hypertensive rat in ischaemic stroke Open
Several studies have assessed the potential of targeting the renin angiotensin system (RAS) with therapeutics for ischaemic stroke. The counter regulatory RAS peptide, angiotensin-(1–9) has been shown to act via the angiotensin II type 2 r…
View article: Runx1 Deficiency Protects Against Adverse Cardiac Remodeling After Myocardial Infarction
Runx1 Deficiency Protects Against Adverse Cardiac Remodeling After Myocardial Infarction Open
Background: Myocardial infarction (MI) is a leading cause of heart failure and death worldwide. Preservation of contractile function and protection against adverse changes in ventricular architecture (cardiac remodeling) are key factors to…
View article: Defining a Novel Role for the Coxsackievirus and Adenovirus Receptor in Human Adenovirus Serotype 5 Transduction <i>In Vitro</i> in the Presence of Mouse Serum
Defining a Novel Role for the Coxsackievirus and Adenovirus Receptor in Human Adenovirus Serotype 5 Transduction <i>In Vitro</i> in the Presence of Mouse Serum Open
Human adenoviral serotype 5 (HAdV-5) vectors have predominantly hepatic tropism when delivered intravascularly, resulting in immune activation and toxicity. Coagulation factor X (FX) binding to HAdV-5 mediates liver transduction and provid…
View article: Retargeting FX-binding-ablated HAdV-5 to vascular cells by inclusion of the RGD-4C peptide in hexon hypervariable region 7 and the HI loop
Retargeting FX-binding-ablated HAdV-5 to vascular cells by inclusion of the RGD-4C peptide in hexon hypervariable region 7 and the HI loop Open
Recent studies have generated interest in the function of human adenovirus serotype 5 (HAdV-5) hexon: factor X (FX) binding and subsequent hepatocyte transduction and interaction with the immune system. Here, we retargeted adenovirus serot…