Stuart B. Goodman
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View article: Management of retro-acetabular osteolysis with a retained shell and injection of demineralized bone matrix using a vinyl urinary catheter and syringe: a simple technique and case series
Management of retro-acetabular osteolysis with a retained shell and injection of demineralized bone matrix using a vinyl urinary catheter and syringe: a simple technique and case series Open
Background The management of retro-acetabular osteolysis in revision hip arthroplasty with acetabular component retention remains controversial and challenging due to limited access to the area. Surgical technique and methods Fourteen pati…
View article: Can alternatives to animal testing yield useful information regarding biological mechanisms and drug discovery?
Can alternatives to animal testing yield useful information regarding biological mechanisms and drug discovery? Open
Establish alternative strategies to standard animal experiments decrease animal utilization and simultaneously enhance the reliability of biological and disease models. This review highlights advancements in three areas: in vitro culture p…
View article: Evidence for using synthetic bone grafts for the treatment of osteonecrosis of the femoral head: a systematic review of the literature and meta-analysis
Evidence for using synthetic bone grafts for the treatment of osteonecrosis of the femoral head: a systematic review of the literature and meta-analysis Open
Synthetic bone grafts (SBGs) potentially add structural stability after core decompression (CD) for osteonecrosis of the femoral head (ONFH). This systematic review assessed the evidence supporting the (i) radiographic efficacy, (ii) revis…
View article: Metformin Modulates Oxidative Stress in Murine Mesenchymal Stem Cells In Vitro and Alleviates Corticosteroid-Induced Inflammation and Impairment of Bone Formation
Metformin Modulates Oxidative Stress in Murine Mesenchymal Stem Cells In Vitro and Alleviates Corticosteroid-Induced Inflammation and Impairment of Bone Formation Open
Background: Long-term use of corticosteroids is a known risk factor for various bone diseases. Corticosteroids disrupt the balance between oxidative and glycolytic energy metabolism, increase oxidative stress and reactive oxygen species (R…
View article: Risk Factors for Corticosteroid-associated Osteonecrosis in Children: A National Database Study
Risk Factors for Corticosteroid-associated Osteonecrosis in Children: A National Database Study Open
Level III: Case-control study or retrospective cohort study.
View article: Pathophysiology of the Effects of Oxidative Stress on the Skeletal System
Pathophysiology of the Effects of Oxidative Stress on the Skeletal System Open
Reactive oxygen species (ROS) are molecules that are generated primarily during energy production in cells. ROS are involved in critical biological functions such as signal transduction; when the production of ROS is imbalanced, excessive …
View article: Human skeletal development and regeneration are shaped by functional diversity of stem cells across skeletal sites
Human skeletal development and regeneration are shaped by functional diversity of stem cells across skeletal sites Open
The skeleton is one of the most structurally and compositionally diverse organ systems in the human body, depending on unique cellular dynamisms. Here, we integrate prospective isolation of human skeletal stem cells (hSSCs; CD45-CD235a-TIE…
View article: Personalized bone organoid using iPSC-derived cells for clinically relevant applications
Personalized bone organoid using iPSC-derived cells for clinically relevant applications Open
Patient-specific induced pluripotent stem cells (iPSCs)-based modeling potentially recapitulates the pathology and mechanisms more faithfully than cell line models and general animal models. Utilizing iPSC-derived cells for personalized bo…
View article: Metformin Modulates Cell Oxidative Stress to Mitigate Corticosteroid-Induced Suppression of Osteogenesis in a 3D Model
Metformin Modulates Cell Oxidative Stress to Mitigate Corticosteroid-Induced Suppression of Osteogenesis in a 3D Model Open
Metformin exhibits promising therapeutic potential beyond its role in diabetes management. The capacity to alleviate oxidative stress highlights the potential of metformin in supporting bone formation in inflammatory environments.
View article: Quantification of Empty Lacunae in Tissue Sections of Osteonecrosis of the Femoral Head Using <scp>YOLOv8</scp> Artificial Intelligence Model
Quantification of Empty Lacunae in Tissue Sections of Osteonecrosis of the Femoral Head Using <span>YOLOv8</span> Artificial Intelligence Model Open
Histomorphometry is an important technique in the evaluation of non‐traumatic osteonecrosis of the femoral head (ONFH). Quantification of empty lacunae and pyknotic cells on histological images is the most reliable measure of ONFH patholog…
View article: 3D Culture of MSCs for Clinical Application
3D Culture of MSCs for Clinical Application Open
Mesenchymal stem cells (MSCs) play an important role in regenerative medicine and drug discovery due to their multipotential differentiation capabilities and immunomodulatory effects. Compared with traditional 2D cultures of MSCs, 3D cultu…
View article: Left ventricular dysfunction, pulmonary congestion, or both and cardiovascular risk after acute myocardial infarction
Left ventricular dysfunction, pulmonary congestion, or both and cardiovascular risk after acute myocardial infarction Open
Background Patients with acute myocardial infarction (AMI) complicated by left ventricular systolic dysfunction (LVSD), pulmonary congestion, or both are at increased risk for adverse cardiovascular events, including long-term heart failur…
View article: The interactions of macrophages, lymphocytes, and mesenchymal stem cells during bone regeneration
The interactions of macrophages, lymphocytes, and mesenchymal stem cells during bone regeneration Open
Bone regeneration and repair are crucial to ambulation and quality of life. Factors such as poor general health, serious medical comorbidities, chronic inflammation, and ageing can lead to delayed healing and nonunion of fractures, and per…
View article: The role of mitochondrial complex I in the proinflammatory response to polylactide implants
The role of mitochondrial complex I in the proinflammatory response to polylactide implants Open
During the foreign body response, immune cells are metabolically rewired after exposure to breakdown products of various biomaterials, including polylactide (PLA) and polyethylene. Particles of polyethylene interact with Toll-like receptor…
View article: T cells and macrophages jointly modulate osteogenesis of mesenchymal stromal cells
T cells and macrophages jointly modulate osteogenesis of mesenchymal stromal cells Open
Approximately 5%–10% of fractures go on to delayed healing and nonunion, posing significant clinical, economic, and social challenges. Current treatment methods involving open bone harvesting and grafting are associated with considerable p…
View article: Insights into Professional Preferences and Rationale for Surgical Sequencing in Managing Hip-Spine Syndrome
Insights into Professional Preferences and Rationale for Surgical Sequencing in Managing Hip-Spine Syndrome Open
Background The optimal sequence of hip and spine surgeries for hip-spine syndrome management remains a contentious issue. This study aimed to investigate the preferences and rationale behind the sequence of surgical treatments across vario…
View article: Correction: Pius et al. Effects of Aging on Osteosynthesis at Bone–Implant Interfaces. Biomolecules 2024, 14, 52
Correction: Pius et al. Effects of Aging on Osteosynthesis at Bone–Implant Interfaces. Biomolecules 2024, 14, 52 Open
Max L. Lee was not included as an author in the original publication [...]
View article: Targeting an inflammation-amplifying cell population can attenuate osteoarthritis-associated pain
Targeting an inflammation-amplifying cell population can attenuate osteoarthritis-associated pain Open
Background Understanding of pain in osteoarthritis, its genesis, and perception is still in its early stages. Identification of precise ligand-receptor pairs that transduce pain and the cells and tissues in which they reside will elucidate…
View article: Sex differences of NF-κB-targeted therapy for mitigating osteoporosis associated with chronic inflammation of bone
Sex differences of NF-κB-targeted therapy for mitigating osteoporosis associated with chronic inflammation of bone Open
Aims Transcription factor nuclear factor kappa B (NF-κB) plays a major role in the pathogenesis of chronic inflammatory diseases in all organ systems. Despite its importance, NF-κB targeted drug therapy to mitigate chronic inflammation has…
View article: Effects of Aging on Osteosynthesis at Bone–Implant Interfaces
Effects of Aging on Osteosynthesis at Bone–Implant Interfaces Open
Joint replacement is a common surgery and is predominantly utilized for treatment of osteoarthritis in the aging population. The longevity of many of these implants depends on bony ingrowth. Here, we provide an overview of current techniqu…