Stuart Bedston
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View article: Creating a Research-Ready Data Asset version of primary care data for Wales and investigating the impact of COVID-19 on utilisation of primary care services
Creating a Research-Ready Data Asset version of primary care data for Wales and investigating the impact of COVID-19 on utilisation of primary care services Open
Objectives We developed an efficient Research-Ready Data Asset (RRDA) for the Welsh Longitudinal General Practice (WLGP) data within the Secure Anonymised Information Linkage Databank to standardise curation, enhance reproducibility, and f…
View article: Children’s early care experiences and their educational attainment: a population data-linkage study in Wales
Children’s early care experiences and their educational attainment: a population data-linkage study in Wales Open
View article: Developing a Research-Ready-Data-Asset (RRDA) for Welsh primary care data within the SAIL Databank: enhancing data quality and reproducible research.
Developing a Research-Ready-Data-Asset (RRDA) for Welsh primary care data within the SAIL Databank: enhancing data quality and reproducible research. Open
ObjectivesWe aimed to develop a high-performance RRDA for the Welsh Longitudinal General Practice (WLGP) data to standardise curation, enhance reproducibility, improve query performance and add additional value/features for research. The R…
View article: Patterns of patient interactions with primary care in Wales: the impact of the COVID-19 pandemic
Patterns of patient interactions with primary care in Wales: the impact of the COVID-19 pandemic Open
ObjectivesWe aim to investigate changes in primary care activities and patient-practice interactions (e.g., face-to-face vs. remote consultations) in Wales during and after the COVID-19 pandemic, compared to pre-pandemic trends. Additional…
View article: Exploring cancer inequalities in Wales through linked health and administrative data
Exploring cancer inequalities in Wales through linked health and administrative data Open
ObjectivesWe aimed to conduct a proof-of-concept study assessing the feasibility of linking population-scale health and administrative data, including the ONS 2021 Census, within the Secure Anonymised Information Linkage (SAIL) Databank. U…
View article: Uptake of COVID-19 vaccinations amongst 3,433,483 children and young people across four nations in the UK
Uptake of COVID-19 vaccinations amongst 3,433,483 children and young people across four nations in the UK Open
Background and ObjectivesSARS-CoV-2 infection in children and young people (CYP) can lead to life threatening conditions including COVID-19, transmission to more vulnerable individuals, or even long COVID. Vaccination against COVID-19 redu…
View article: Wellbeing and retainment of healthcare workers in Wales from 2020 to 2023
Wellbeing and retainment of healthcare workers in Wales from 2020 to 2023 Open
ObjectivesThe COVID-19 pandemic greatly impacted the wellbeing of healthcare workers (HCWs) due to stress, longer hours, and risks of infection during an uncertain time. Post-pandemic, we need to understand the extent of the lasting impact…
View article: Inequalities in severe COVID-19 outcomes in Wales, UK
Inequalities in severe COVID-19 outcomes in Wales, UK Open
ObjectiveResearch evidence shows that COVID-19 has disproportionately affected people from more deprived backgrounds. In Wales (UK), there is strong evidence of a socioeconomic gradient in total hospitalisations, critical care admissions a…
View article: Identifying patterns of Long-COVID diagnosis pathways: a Latent Class Analysis of Welsh clinical data
Identifying patterns of Long-COVID diagnosis pathways: a Latent Class Analysis of Welsh clinical data Open
ObjectivesLong-COVID (LC) diagnosis remains challenging due to its variable, multisystem, episodic symptoms, and lack of uniformity in the critical time points. We aim to classify diagnosis pathways and associated demographic and health de…
View article: COVID-19 and influenza vaccine uptake among pregnant women in national cohorts of England and Wales
COVID-19 and influenza vaccine uptake among pregnant women in national cohorts of England and Wales Open
Vaccines against COVID-19 and influenza can reduce the adverse outcomes caused by infections during pregnancy, but vaccine uptake among pregnant women has been suboptimal. We examined the COVID-19 and influenza vaccine uptake and dispariti…
View article: Exploring ethnicity dynamics in Wales: a longitudinal population-scale linked data study and development of a harmonised ethnicity spine
Exploring ethnicity dynamics in Wales: a longitudinal population-scale linked data study and development of a harmonised ethnicity spine Open
Objective This study aims to create a national ethnicity spine based on all available ethnicity records in linkable anonymised electronic health record and administrative data sources. Design A longitudinal study using anonymised individua…
View article: Uptake of COVID-19 vaccinations amongst 3,433,483 children and young people: meta-analysis of UK prospective cohorts
Uptake of COVID-19 vaccinations amongst 3,433,483 children and young people: meta-analysis of UK prospective cohorts Open
View article: Undervaccination and severe COVID-19 outcomes: meta-analysis of national cohort studies in England, Northern Ireland, Scotland, and Wales
Undervaccination and severe COVID-19 outcomes: meta-analysis of national cohort studies in England, Northern Ireland, Scotland, and Wales Open
View article: Risk of severe COVID-19 outcomes after autumn 2022 COVID-19 booster vaccinations: a pooled analysis of national prospective cohort studies involving 7.4 million adults in England, Northern Ireland, Scotland and Wales
Risk of severe COVID-19 outcomes after autumn 2022 COVID-19 booster vaccinations: a pooled analysis of national prospective cohort studies involving 7.4 million adults in England, Northern Ireland, Scotland and Wales Open
National Core Studies-Immunity, UK Research and Innovation (Medical Research Council and Economic and Social Research Council), Health Data Research UK, the Scottish Government, and the University of Edinburgh.
View article: Impact of socio-economic conditions and perinatal factors on risk of becoming a child looked after: a whole population cohort study using routinely collected data in Wales
Impact of socio-economic conditions and perinatal factors on risk of becoming a child looked after: a whole population cohort study using routinely collected data in Wales Open
View article: Understanding and reporting odds ratios as rate-ratio estimates in case-control studies
Understanding and reporting odds ratios as rate-ratio estimates in case-control studies Open
We recommend that researchers understand and critically evaluate all conditions used to interpret their estimates as consistent for a population parameter in case-control studies.
View article: Clinical coding of long Covid in Wales: A cohort study of 3.5 million people using linked health and demographic data
Clinical coding of long Covid in Wales: A cohort study of 3.5 million people using linked health and demographic data Open
Objectives‘Long COVID’ (LC) is broadly defined as signs and symptoms that continue or develop after the acute phase of COVID-19, and can affect cardiovascular, respiratory and other organ systems. Using electronic health records, we invest…
View article: The impact of the COVID-19 pandemic on community prescription of opioid and antineuropathic analgesics for cancer patients in Wales, UK
The impact of the COVID-19 pandemic on community prescription of opioid and antineuropathic analgesics for cancer patients in Wales, UK Open
Purpose Public health measures instituted at the onset of the COVID-19 pandemic in the UK in 2020 had profound effects on the cancer patient pathway. We hypothesise that this may have affected analgesic prescriptions for cancer patients in…
View article: Maternal Mental Health and Children’s Problem Behaviours: A Bi-directional Relationship?
Maternal Mental Health and Children’s Problem Behaviours: A Bi-directional Relationship? Open
Transactional theory and the coercive family process model have illustrated how the parent-child relationship is reciprocal. Emerging research using advanced statistical methods has examined these theories, but further investigations are n…
View article: ‘When they were taken it is like grieving’: Understanding and responding to the emotional impact of repeat care proceedings on fathers
‘When they were taken it is like grieving’: Understanding and responding to the emotional impact of repeat care proceedings on fathers Open
There is growing recognition, in the UK and internationally, of the huge costs of recurrent appearances of parents in local authority care proceedings. This paper contributes to pressing policy and practice concerns to reduce recurrence. I…
View article: Trends in SARS-CoV-2 infection and vaccination in school staff, students and their household members from 2020 to 2022 in Wales, UK: an electronic cohort study
Trends in SARS-CoV-2 infection and vaccination in school staff, students and their household members from 2020 to 2022 in Wales, UK: an electronic cohort study Open
Objectives We investigated SARS-CoV-2 infection trends, risk of SARS-CoV-2 infection and COVID-19 vaccination uptake among school staff, students and their household members in Wales, UK. Design Seven-day average of SARS-CoV-2 infections a…
View article: An external validation of the QCOVID3 risk prediction algorithm for risk of hospitalisation and death from COVID-19: An observational, prospective cohort study of 1.66m vaccinated adults in Wales, UK
An external validation of the QCOVID3 risk prediction algorithm for risk of hospitalisation and death from COVID-19: An observational, prospective cohort study of 1.66m vaccinated adults in Wales, UK Open
Introduction At the start of the COVID-19 pandemic there was an urgent need to identify individuals at highest risk of severe outcomes, such as hospitalisation and death following infection. The QCOVID risk prediction algorithms emerged as…
View article: Harmonising electronic health records for reproducible research: challenges, solutions and recommendations from a UK-wide COVID-19 research collaboration
Harmonising electronic health records for reproducible research: challenges, solutions and recommendations from a UK-wide COVID-19 research collaboration Open
Background The CVD-COVID-UK consortium was formed to understand the relationship between COVID-19 and cardiovascular diseases through analyses of harmonised electronic health records (EHRs) across the four UK nations. Beyond COVID-19, data…
View article: COVID-19 booster vaccination uptake and infection breakthrough amongst health care workers in Wales: A national prospective cohort study
COVID-19 booster vaccination uptake and infection breakthrough amongst health care workers in Wales: A national prospective cohort study Open
View article: Impact of Socioeconomic Conditions and Perinatal Factors on Risk of Becoming a Child Looked after: A Whole Population Cohort Study Using Routinely Collected Data in Wales
Impact of Socioeconomic Conditions and Perinatal Factors on Risk of Becoming a Child Looked after: A Whole Population Cohort Study Using Routinely Collected Data in Wales Open
View article: Developing a research ready population-scale linked data ethnicity-spine in Wales
Developing a research ready population-scale linked data ethnicity-spine in Wales Open
Introduction Ethnicity information is recorded routinely in electronic health records (EHRs); however, to date, there is no national standard or framework for harmonisation of the existing records. Methods and analysis The national ethnici…
View article: Waning of first- and second-dose ChAdOx1 and BNT162b2 COVID-19 vaccinations: a pooled target trial study of 12.9 million individuals in England, Northern Ireland, Scotland and Wales
Waning of first- and second-dose ChAdOx1 and BNT162b2 COVID-19 vaccinations: a pooled target trial study of 12.9 million individuals in England, Northern Ireland, Scotland and Wales Open
Background Several SARS-CoV-2 vaccines have been shown to provide protection against COVID-19 hospitalization and death. However, some evidence suggests that notable waning in effectiveness against these outcomes occurs within months of va…
View article: Severe COVID-19 outcomes after full vaccination of primary schedule and initial boosters: pooled analysis of national prospective cohort studies of 30 million individuals in England, Northern Ireland, Scotland, and Wales
Severe COVID-19 outcomes after full vaccination of primary schedule and initial boosters: pooled analysis of national prospective cohort studies of 30 million individuals in England, Northern Ireland, Scotland, and Wales Open
View article: Risk of thrombocytopenic, haemorrhagic and thromboembolic disorders following COVID-19 vaccination and positive test: a self-controlled case series analysis in Wales
Risk of thrombocytopenic, haemorrhagic and thromboembolic disorders following COVID-19 vaccination and positive test: a self-controlled case series analysis in Wales Open
View article: Harmonising electronic health records for reproducible research: challenges, solutions and recommendations from a UK-wide COVID-19 research collaboration
Harmonising electronic health records for reproducible research: challenges, solutions and recommendations from a UK-wide COVID-19 research collaboration Open
Background The CVD-COVID-UK consortium was formed to understand the relationship between COVID-19 and cardiovascular diseases through analyses of harmonised electronic health records (EHRs) across the four UK nations. Beyond COVID-19, data…