Stuart G. Nicholls
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View article: Efficacy, all-cause discontinuation, and safety of serotonergic psychedelics and MDMA to treat mental disorders: A living systematic review with meta-analysis
Efficacy, all-cause discontinuation, and safety of serotonergic psychedelics and MDMA to treat mental disorders: A living systematic review with meta-analysis Open
Serotonergic psychedelics and 3,4-methylendioxtmethamphetamine (MDMA) are promising treatments for mental disorders with a continuously evolving evidence base. We searched Pubmed/Scopus/clinical trial registries up to 08july2025 for double…
View article: Identifying Challenges and Enablers to Engaging Patients in Preclinical Laboratory Research
Identifying Challenges and Enablers to Engaging Patients in Preclinical Laboratory Research Open
Background Patient engagement in research enriches study design, conduct, and dissemination by integrating lived experiences of patients into the research process. Although patient engagement is increasingly common in clinical research set…
View article: Improving the Reporting on Health Equity in Observational Research (STROBE-Equity)
Improving the Reporting on Health Equity in Observational Research (STROBE-Equity) Open
Importance Observational studies can provide valuable insights to inform decisions on health equity. Existing guidelines for reporting such studies, such as the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) …
View article: Improving the reporting on health equity in observational research (STROBE-Equity): extension checklist and elaboration
Improving the reporting on health equity in observational research (STROBE-Equity): extension checklist and elaboration Open
View article: CAEP Acute Heart Failure Best Practices Checklist
CAEP Acute Heart Failure Best Practices Checklist Open
View article: REaCT-5G: a randomized trial of bone pain with 5-day-filgrastim vs. pegfilgrastim for neutropenia in breast cancer
REaCT-5G: a randomized trial of bone pain with 5-day-filgrastim vs. pegfilgrastim for neutropenia in breast cancer Open
Introduction Granulocyte colony stimulating factors (G-CSF), including filgrastim and pegfilgrastim, are associated with bone pain, potentially impacting treatment adherence. This study hypothesized that a 5-day regimen of filgrastim (5-da…
View article: Gaps in the Ottawa Statement on the Ethical Design and Conduct of Cluster Randomized Trials: a citation analysis reveals a need for updated ethics guidelines
Gaps in the Ottawa Statement on the Ethical Design and Conduct of Cluster Randomized Trials: a citation analysis reveals a need for updated ethics guidelines Open
Identifying 24 gaps reveals a need to update the Ottawa Statement. Alongside additional gaps identified in ongoing empirical work and through engagement with our patient and public partners, the gaps identified through this citation analys…
View article: Recognition, remuneration and reimbursement of patient and public involvement partners in pragmatic randomised controlled trials. A survey of author practices
Recognition, remuneration and reimbursement of patient and public involvement partners in pragmatic randomised controlled trials. A survey of author practices Open
Background: Patient and public involvement (PPI) in the design and conduct of clinical trials has been increasingly encouraged by funders as an essential ingredient in the conduct of research. Recognition of PPI partners through acknowledg…
View article: Calls for Engaging Patient Partners Have Largely Gone Unheard in Cardiovascular Research
Calls for Engaging Patient Partners Have Largely Gone Unheard in Cardiovascular Research Open
View article: Randomization procedures in parallel-arm cluster randomized trials in low- and middle-income countries: a review of 300 trials published between 2017-2022
Randomization procedures in parallel-arm cluster randomized trials in low- and middle-income countries: a review of 300 trials published between 2017-2022 Open
View article: Author response: Preclinical systematic review of CCR5 antagonists as cerebroprotective and stroke recovery enhancing agents
Author response: Preclinical systematic review of CCR5 antagonists as cerebroprotective and stroke recovery enhancing agents Open
View article: Preclinical systematic review of CCR5 antagonists as cerebroprotective and stroke recovery enhancing agents
Preclinical systematic review of CCR5 antagonists as cerebroprotective and stroke recovery enhancing agents Open
C-C chemokine receptor type 5 (CCR5) antagonists may improve both acute stroke outcome and long-term recovery. Despite their evaluation in ongoing clinical trials, gaps remain in the evidence supporting their use. With a panel of patients …
View article: Patient and Healthcare Professional Reflections on Consenting for Extra Bone Marrow Samples to a Biobank for Research—A Qualitative Study
Patient and Healthcare Professional Reflections on Consenting for Extra Bone Marrow Samples to a Biobank for Research—A Qualitative Study Open
Little is known about patient perspectives regarding consent for obtaining extra research-specific bone marrow (BM) samples during the diagnostic procedure for acute leukemia (AL). This study aimed to better understand patient experiences …
View article: Author response: CCR5 antagonists as cerebroprotective and stroke recovery enhancing agents: a preclinical systematic review and meta-analysis
Author response: CCR5 antagonists as cerebroprotective and stroke recovery enhancing agents: a preclinical systematic review and meta-analysis Open
View article: CCR5 antagonists as cerebroprotective and stroke recovery enhancing agents: a preclinical systematic review and meta-analysis
CCR5 antagonists as cerebroprotective and stroke recovery enhancing agents: a preclinical systematic review and meta-analysis Open
Background C-C chemokine receptor type 5 (CCR5) antagonists may improve both acute stroke outcome and long-term recovery. Despite their evaluation in ongoing clinical trials, gaps remain in the evidence supporting their use. Methods With a…
View article: Developing a Model of Advance Consent for Participation in Acute Stroke Trials
Developing a Model of Advance Consent for Participation in Acute Stroke Trials Open
View article: CCR5 antagonists as neuroprotective and stroke recovery enhancing agents: a preclinical systematic review and meta-analysis
CCR5 antagonists as neuroprotective and stroke recovery enhancing agents: a preclinical systematic review and meta-analysis Open
Background C-C chemokine receptor type 5 (CCR5) antagonists may improve both acute stroke outcome and long-term recovery. Despite their evaluation in ongoing clinical trials, gaps remain in the evidence supporting their use. Methods With a…
View article: Preclinical systematic review of CCR5 antagonists as cerebroprotective and stroke recovery enhancing agents
Preclinical systematic review of CCR5 antagonists as cerebroprotective and stroke recovery enhancing agents Open
C-C chemokine receptor type 5 (CCR5) antagonists may improve both acute stroke outcome and long-term recovery. Despite their evaluation in ongoing clinical trials, gaps remain in the evidence supporting their use. With a panel of patients …
View article: Randomization Procedures in Parallel-Arm Cluster Randomized Trials in Low- and Middle-Income Countries: A Review of 300 Trials Published between 2017-2022
Randomization Procedures in Parallel-Arm Cluster Randomized Trials in Low- and Middle-Income Countries: A Review of 300 Trials Published between 2017-2022 Open
View article: Early Detection of Pediatric Permanent Hearing Loss: A Population-Based Retrospective Cohort Study
Early Detection of Pediatric Permanent Hearing Loss: A Population-Based Retrospective Cohort Study Open
View article: Increasing the Use of Newborn Pain Treatment Following the Implementation of a Parent-Targeted Video: An Outcome Evaluation
Increasing the Use of Newborn Pain Treatment Following the Implementation of a Parent-Targeted Video: An Outcome Evaluation Open
Background/Objectives: Despite strong evidence that breastfeeding, skin-to-skin care, and sucrose reduce pain in newborns during minor painful procedures, these interventions remain underutilized in practice. To address this knowledge-to-p…
View article: Advance Consent for Participation in Acute Stroke Trials: A Focus Group Study with People with Lived Experience of Stroke
Advance Consent for Participation in Acute Stroke Trials: A Focus Group Study with People with Lived Experience of Stroke Open
Advance consent could address many of the limitations traditional consenting methods pose to participation in acute stroke trials. We conducted a series of five focus groups with people with lived experience of stroke. Using an inductive t…
View article: Advance Consent for participation in Acute Stroke Trials (ACTION): protocol for a feasibility study
Advance Consent for participation in Acute Stroke Trials (ACTION): protocol for a feasibility study Open
Introduction Obtaining informed consent for research from patients in medical emergencies remains a challenge, particularly in acute stroke care as treatment must be administered quickly and patients often arrive in the hospital in a state…
View article: Preclinical systematic review of CCR5 antagonists as cerebroprotective and stroke recovery enhancing agents
Preclinical systematic review of CCR5 antagonists as cerebroprotective and stroke recovery enhancing agents Open
C-C chemokine receptor type 5 (CCR5) antagonists may improve both acute stroke outcome and long-term recovery. Despite their evaluation in ongoing clinical trials, gaps remain in the evidence supporting their use. With a panel of patients …
View article: Systematic scoping review of cluster randomised trials conducted exclusively in low-income and middle-income countries between 2017 and 2022
Systematic scoping review of cluster randomised trials conducted exclusively in low-income and middle-income countries between 2017 and 2022 Open
Objective Cluster randomised trials (CRTs) are used for evaluating health-related interventions in low-income and middle-income countries (LMICs) but raise complex ethical issues. To inform the development of future ethics guidance, we aim…
View article: Effectiveness of dexmedetomidine on patient-centred outcomes in surgical patients: a systematic review and Bayesian meta-analysis
Effectiveness of dexmedetomidine on patient-centred outcomes in surgical patients: a systematic review and Bayesian meta-analysis Open
PROSPERO (CRD42023439896).
View article: The Ottawa Statement implementation guidance document for cluster randomized trials in the hemodialysis setting
The Ottawa Statement implementation guidance document for cluster randomized trials in the hemodialysis setting Open
View article: Table of Contents
Table of Contents Open
View article: Reporting of equity in observational epidemiology: A methodological review
Reporting of equity in observational epidemiology: A methodological review Open
Despite over 80% of the equity-focused observational studies providing a rationale for a focus on health equity, reporting of study design features relevant to health equity ranged from 0-95%, with over half of the items reported by less t…
View article: Motivations for investigating health inequities in observational epidemiology: a content analysis of 320 studies
Motivations for investigating health inequities in observational epidemiology: a content analysis of 320 studies Open