Stuart J Cook
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View article: Minimising the rate of vascular complications in Deep Brain Stimulation surgery for the management of Parkinson’s disease: a single-centre 600-patient case series
Minimising the rate of vascular complications in Deep Brain Stimulation surgery for the management of Parkinson’s disease: a single-centre 600-patient case series Open
Objectives Deep Brain Stimulation (DBS) is an effective, yet underused therapy for people living with Parkinson’s disease (PD) in whom tremor, motor fluctuations and/or dyskinesia are not satisfactorily controlled by oral medical therapy. …
View article: BS03 Interleukin-11: pro-inflammatory, profibrotic and cardiotoxic – a new therapeutic target in heart failure
BS03 Interleukin-11: pro-inflammatory, profibrotic and cardiotoxic – a new therapeutic target in heart failure Open
Introduction Fibrosis and inflammation are key pathophysiological factors in heart failure (HF) however no specific therapies exist which target these pathways. The interleukin-11 (IL11) cytokine was initially described as anti-inflammator…
View article: TCR affinity controls the dynamics but not the functional specification of the Th1 response to mycobacteria
TCR affinity controls the dynamics but not the functional specification of the Th1 response to mycobacteria Open
The quality of T cell responses depends on the lymphocytes’ ability to undergo clonal expansion, acquire effector functions and traffic to the site of infection. Although TCR signal strength is thought to dominantly shape the T cell respon…
View article: Do innate killing mechanisms activated by inflammasomes have a role in treating melanoma?
Do innate killing mechanisms activated by inflammasomes have a role in treating melanoma? Open
Melanoma, as for many other cancers, undergoes a selection process during progression that limits many innate and adaptive tumor control mechanisms. Immunotherapy with immune checkpoint blockade overcomes one of the escape mechanisms but i…