Stuart J. Decker
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View article: The yeast AMP-activated protein kinase Snf1 phosphorylates the inositol polyphosphate kinase Kcs1
The yeast AMP-activated protein kinase Snf1 phosphorylates the inositol polyphosphate kinase Kcs1 Open
The yeast Snf1/AMP-activated kinase (AMPK) maintains energy homeostasis, controlling metabolic processes and glucose derepression in response to nutrient levels and environmental cues. Under conditions of nitrogen or glucose limitation, Sn…
View article: An insulin epidermal growth factor-binding protein from Drosophila has insulin-degrading activity.
An insulin epidermal growth factor-binding protein from Drosophila has insulin-degrading activity. Open
We have recently described the purification and characterization of an insulin-degrading enzyme (IDE) from Drosophila melanogaster that can cleave porcine insulin, is highly conserved through evolution and is developmentally regulated. We …
View article: Developmental regulation of an insulin-degrading enzyme from Drosophila melanogaster
Developmental regulation of an insulin-degrading enzyme from Drosophila melanogaster Open
The precise mechanism by which insulin is degraded in mammalian cells is not presently known. Several lines of evidence suggest that degradation is initiated by a specific nonlysosomal insulin-degrading enzyme (IDE). The potential importan…
View article: Characterization of a Drosophila protein that binds both epidermal growth factor and insulin-related growth factors.
Characterization of a Drosophila protein that binds both epidermal growth factor and insulin-related growth factors. Open
The identification of a novel protein from Drosophila melanogaster that binds both mammalian epidermal growth factor (EGF) and insulin has been reported (Thompson, K. L., S. J. Decker, and M. R. Rosner, 1985, Proc. Natl. Acad. Sci. USA., 8…