Stuart J. McDonald
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View article: The impact of CGRP monoclonal antibodies on cytokine expression in chronic migraine: a cohort study
The impact of CGRP monoclonal antibodies on cytokine expression in chronic migraine: a cohort study Open
View article: The normative modelling framework for traumatic brain injury
The normative modelling framework for traumatic brain injury Open
This review examines the principles, applications and methodological foundations of normative modelling, emphasizing its potential to assist in mitigating longstanding challenges in traumatic brain injury (TBI) research and management. TBI…
View article: Linear Acceleration Is a Primary Risk Factor for Concussion
Linear Acceleration Is a Primary Risk Factor for Concussion Open
Rotational acceleration of the head has long been posited as the primary cause of concussion due to its ability to generate shear strains that disrupt neuronal structure and function [1,2]. Linear acceleration, by contrast, is considered l…
View article: Factor analysis of multimodal MRI, biofluid, and vascular biomarkers reveals latent constructs of brain health
Factor analysis of multimodal MRI, biofluid, and vascular biomarkers reveals latent constructs of brain health Open
Individual imaging and fluid biomarkers provide insights into specific components of brain health, but integrated multimodal approaches are necessary to capture the complex, interrelated biological systems that contribute to brain homeosta…
View article: The chronic aftermath of recurrent intimate partner violence-related brain injuries: Insights from rat models of traumatic brain injury and non-fatal strangulation
The chronic aftermath of recurrent intimate partner violence-related brain injuries: Insights from rat models of traumatic brain injury and non-fatal strangulation Open
Intimate partner violence (IPV) is a serious global health concern that primarily affects women. Traumatic brain injury (TBI; e.g., concussion) and non-fatal strangulation (NFS) are common forms of IPV-related brain injuries which often oc…
View article: The Acute Effects of Non-concussive Head Impacts on Brain Microstructure, Chemistry and Function in Male Soccer Players: A Pilot Randomised Controlled Trial
The Acute Effects of Non-concussive Head Impacts on Brain Microstructure, Chemistry and Function in Male Soccer Players: A Pilot Randomised Controlled Trial Open
View article: Factor Analysis of Multimodal MRI, Biofluid and Vascular Health Biomarkers Reveals Latent Constructs of Brain Health
Factor Analysis of Multimodal MRI, Biofluid and Vascular Health Biomarkers Reveals Latent Constructs of Brain Health Open
Individual imaging and fluid biomarkers provide insights into specific components of brain health, but integrated multimodal approaches are necessary to capture the complex, interrelated biological systems that contribute to brain homeosta…
View article: 51 (5B) Instrumented mouthguard-measured head kinematics and associations with head injury assessment outcomes in elite men’s and women’s Australian football
51 (5B) Instrumented mouthguard-measured head kinematics and associations with head injury assessment outcomes in elite men’s and women’s Australian football Open
View article: 46 (5A) Exploring the incidence, magnitude and causes of head acceleration events measured by instrumented mouthguards in elite men’s and women’s Australian football
46 (5A) Exploring the incidence, magnitude and causes of head acceleration events measured by instrumented mouthguards in elite men’s and women’s Australian football Open
View article: Plasma pTau-217 Correlates with Brain Atrophy, Cognition, and CSF Biomarkers in a Cognitively Healthy Community Cohort
Plasma pTau-217 Correlates with Brain Atrophy, Cognition, and CSF Biomarkers in a Cognitively Healthy Community Cohort Open
Plasma biomarkers are promising for detecting Alzheimer’s disease (AD) pathology, but their role in cognitively healthy individuals remains unclear. Plasma pTau-217 has high diagnostic accuracy for clinical and prodromal AD, yet its releva…
View article: A pre-existing chronic Toxoplasma gondii infection promotes epileptogenesis and neuropathology in a mouse model of mesial temporal lobe epilepsy
A pre-existing chronic Toxoplasma gondii infection promotes epileptogenesis and neuropathology in a mouse model of mesial temporal lobe epilepsy Open
These findings demonstrate that a chronic T. gondii infection can result in epilepsy, and that a pre-existing T. gondii infection exacerbates epileptogenesis following a brain insult, in mice.
View article: Investigating the role of the brain-derived neurotrophic factor Val66Met polymorphism in repetitive mild traumatic brain injury outcomes in rats
Investigating the role of the brain-derived neurotrophic factor Val66Met polymorphism in repetitive mild traumatic brain injury outcomes in rats Open
View article: A systematic review and meta-analysis of sleep following mild traumatic brain injury: A synthesis of the literature according to age and time-since-injury
A systematic review and meta-analysis of sleep following mild traumatic brain injury: A synthesis of the literature according to age and time-since-injury Open
This systematic review and meta-analysis (PROSPERO: CRD42021287081) compared sleep in individuals with prior mTBI against that of controls. PubMed, Scopus, and EMBASE were searched through to November 2, 2024. Mean differences were calcula…
View article: Plasma phosphorylated tau-217 correlates with brain atrophy, cognition, and cerebrospinal fluid biomarkers in a cognitively healthy community cohort
Plasma phosphorylated tau-217 correlates with brain atrophy, cognition, and cerebrospinal fluid biomarkers in a cognitively healthy community cohort Open
Plasma biomarkers are promising for detecting Alzheimer’s disease (AD) pathology, but their role in cognitively healthy individuals remains unclear. Plasma pTau-217 has high diagnostic accuracy for clinical and prodromal AD, yet its releva…
View article: Investigation of blood‐brain barrier water exchange rate as a novel early indicator of neurovascular dysfunction and Alzheimer’s disease
Investigation of blood‐brain barrier water exchange rate as a novel early indicator of neurovascular dysfunction and Alzheimer’s disease Open
Background Growing evidence shows neurovascular dysfunction occurs early in Alzheimer’s disease (AD) and may be a useful early marker of pathology. Blood‐brain barrier water exchange rate (BBB kw) is a novel measure of fluid transport thro…
View article: Association of Plasma Biomarkers of Amyloid, Neurodegeneration and Neuroinflammation, with Cognitive Performance, Cortical Thickness and Cerebrospinal Fluid Biomarkers
Association of Plasma Biomarkers of Amyloid, Neurodegeneration and Neuroinflammation, with Cognitive Performance, Cortical Thickness and Cerebrospinal Fluid Biomarkers Open
Background Plasma and cerebrospinal (CSF) biomarkers are promising candidates for detecting neuropathology. While CSF biomarkers directly reflect pathophysiological processes within the central nervous system, their requirement for a lumba…
View article: Associations Between Instrumented Mouthguard-Measured Head Acceleration Events and Post-Match Biomarkers of Astroglial and Axonal Injury in Male Amateur Australian Football Players
Associations Between Instrumented Mouthguard-Measured Head Acceleration Events and Post-Match Biomarkers of Astroglial and Axonal Injury in Male Amateur Australian Football Players Open
Background Advances in instrumented mouthguards (iMGs) allow for accurate quantification of single high-acceleration head impacts and cumulative head acceleration exposure in collision sports. However, relationships between these measures …
View article: Linking PI-2620 tau-PET, fluid biomarkers, MRI, and cognition to advance diagnostics for progressive supranuclear palsy
Linking PI-2620 tau-PET, fluid biomarkers, MRI, and cognition to advance diagnostics for progressive supranuclear palsy Open
Importance Identifying biomarkers for primary tauopathies such as progressive supranuclear palsy (PSP) is crucial for improving diagnosis and establishing clinical trial and treatment endpoints. Objective To determine whether brain tau dep…
View article: Pathophysiology, blood biomarkers, and functional deficits after intimate partner violence-related brain injury: Insights from emergency department patients and a new rat model
Pathophysiology, blood biomarkers, and functional deficits after intimate partner violence-related brain injury: Insights from emergency department patients and a new rat model Open
Intimate partner violence is a serious, but underappreciated, issue that predominantly affects women and often results in concussion (i.e., mild traumatic brain injury). However, concussion in intimate partner violence is unique because it…
View article: Plasma biomarkers in chronic single moderate–severe traumatic brain injury
Plasma biomarkers in chronic single moderate–severe traumatic brain injury Open
Blood biomarkers are an emerging diagnostic and prognostic tool that reflect a range of neuropathological processes following traumatic brain injury (TBI). Their effectiveness in identifying long-term neuropathological processes after TBI …
View article: The acute effects of non-concussive head impacts in sport: A randomised control trial.
The acute effects of non-concussive head impacts in sport: A randomised control trial. Open
Background Head impacts, particularly, non-concussive impacts, are common in sport. Yet, their effects on the brain are poorly understood. Here, we investigated the acute effects of non-concussive impacts on brain microstructure, chemistry…
View article: Next-Day Serum Glial Fibrillary Acidic Protein Levels to Aid Diagnosis of Sport-Related Concussion
Next-Day Serum Glial Fibrillary Acidic Protein Levels to Aid Diagnosis of Sport-Related Concussion Open
The diagnostic utility of blood glial fibrillary acidic protein (GFAP) in sport-related concussion (SRC) is unclear. This study measured serum GFAP at either 16-24 hours (h), 24-32h, or 36-52h post-SRC in 156 Australian football players an…
View article: Biomarkers of Neurobiologic Recovery in Adults With Sport-Related Concussion
Biomarkers of Neurobiologic Recovery in Adults With Sport-Related Concussion Open
Importance Sport-related concussion (SRC), a form of mild traumatic brain injury, is a prevalent occurrence in collision sports. There are no well-established approaches for tracking neurobiologic recovery after SRC. Objective To examine t…
View article: Associations of inflammatory cytokines and cortisol with nonmotor features of Huntington's disease
Associations of inflammatory cytokines and cortisol with nonmotor features of Huntington's disease Open
Objective Huntington's disease (HD) is an inherited neurodegenerative disease involving progressive motor abnormalities, cognitive decline, and psychiatric disturbances. Depression and cognitive difficulties are among the most impactful sy…
View article: A pre-existing Toxoplasma gondii infection exacerbates the pathophysiological response and extent of brain damage after traumatic brain injury in mice
A pre-existing Toxoplasma gondii infection exacerbates the pathophysiological response and extent of brain damage after traumatic brain injury in mice Open
Traumatic brain injury (TBI) is a key contributor to global morbidity that lacks effective treatments. Microbial infections are common in TBI patients, and their presence could modify the physiological response to TBI. It is estimated that…
View article: Investigating the Association Between Extended Participation in Collision Sports and Fluid Biomarkers Among Masters Athletes
Investigating the Association Between Extended Participation in Collision Sports and Fluid Biomarkers Among Masters Athletes Open
Traumatic brain injuries (TBIs) and concussions are prevalent in collision sports, and there is evidence that levels of exposure to such sports may increase the risk of neurological abnormalities. Elevated levels of fluid-based biomarkers …
View article: Repetitive mild traumatic brain injury elicits a reactive microglial morphology and elevates serum neurofilament light levels, independent of NLRP3 inflammasome inhibition
Repetitive mild traumatic brain injury elicits a reactive microglial morphology and elevates serum neurofilament light levels, independent of NLRP3 inflammasome inhibition Open
There is growing evidence that a second mild traumatic brain injury (mTBI) sustained prior to cellular and neurological recovery from the first increases risk of cumulative pathological and neurological deficits. Despite this, the pathophy…
View article: Treatment with the vascular endothelial growth factor-A antibody, bevacizumab, has sex-specific effects in a rat model of mild traumatic brain injury
Treatment with the vascular endothelial growth factor-A antibody, bevacizumab, has sex-specific effects in a rat model of mild traumatic brain injury Open
Mild traumatic brain injury (mTBI) involves damage to the cerebrovascular system. Vascular endothelial growth factor-A (VEGF-A) is an important modulator of vascular health and VEGF-A promotes the brain’s ability to recover after more seve…
View article: Utility of Acute and Subacute Blood Biomarkers to Assist Diagnosis in CT-Negative Isolated Mild Traumatic Brain Injury
Utility of Acute and Subacute Blood Biomarkers to Assist Diagnosis in CT-Negative Isolated Mild Traumatic Brain Injury Open
These findings indicate that adding IL-6 to a panel of brain-specific proteins such as GFAP and UCH-L1 might assist in the acute diagnosis of mTBI in adults younger than 50 years. Multiple markers had high classification accuracy in partic…
View article: The Acute Effects Of Soccer Heading On The Brain: A Randomised Controlled Trial
The Acute Effects Of Soccer Heading On The Brain: A Randomised Controlled Trial Open
PURPOSE: To examine the acute effects of soccer heading on brain chemistry and function using advanced neuroimaging techniques.\n\nMETHODS: Fourteen male soccer players (age: 26 ± 5 years [Mean ± SD]) completed two trials at Neuroscience R…