Stuart D. Katz
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View article: Platelet Gene Expression in Systemic Lupus Erythematosus and Cardiovascular Health
Platelet Gene Expression in Systemic Lupus Erythematosus and Cardiovascular Health Open
Systemic lupus erythematosus (SLE) is a complex autoimmune disease with an increased risk of vascular dysfunction and cardiovascular disease. We validate our previously developed Systemic Lupus Erythematosus Activity Platelet-Gene Expressi…
View article: Impact of Heart Failure Guideline Publication on Medicare Drug Coverage Policies: A Quasi‐Experimental Analysis
Impact of Heart Failure Guideline Publication on Medicare Drug Coverage Policies: A Quasi‐Experimental Analysis Open
Background Patients with heart failure (HF) often have difficulty obtaining life‐saving medications due to coverage barriers, such as prior authorizations and high out‐of‐pocket costs. To promote better coverage for high value therapies an…
View article: Quality improvement of a community-engaged authorship system: lessons learned from the RECOVER initiative
Quality improvement of a community-engaged authorship system: lessons learned from the RECOVER initiative Open
BACKGROUND: Inclusion of patients, caregivers, and community members in scientific research should be essential for patient-centered care. Patients’ lived experiences can propose new areas of focus that may not have previously been conside…
View article: Characterizing Long COVID Symptoms During Early Childhood
Characterizing Long COVID Symptoms During Early Childhood Open
Importance Recent studies have identified characteristic symptom patterns of long COVID (LC) in adults and children older than 5 years. However, LC remains poorly characterized in early childhood. This knowledge gap limits efforts to ident…
View article: Evaluation of Women with Peripartum or Dilated Cardiomyopathy and Their First-Degree Relatives: The DCM Precision Medicine Study
Evaluation of Women with Peripartum or Dilated Cardiomyopathy and Their First-Degree Relatives: The DCM Precision Medicine Study Open
Background Rare variant genetics have been associated with peripartum cardiomyopathy (PPCM) but the role of genetics remains unsettled. Objective The study sought to compare dilated cardiomyopathy (DCM) genetic risk in first-degree relativ…
View article: 2024 Update of the RECOVER-Adult Long COVID Research Index
2024 Update of the RECOVER-Adult Long COVID Research Index Open
Importance Classification of persons with long COVID (LC) or post–COVID-19 condition must encompass the complexity and heterogeneity of the condition. Iterative refinement of the classification index for research is needed to incorporate n…
View article: Implementing Precision Medicine for Dilated Cardiomyopathy: Insights from The DCM Consortium
Implementing Precision Medicine for Dilated Cardiomyopathy: Insights from The DCM Consortium Open
Background Clinical genetic evaluation of dilated cardiomyopathy (DCM) is implemented variably or not at all. Identifying needs and barriers to genetic evaluations will enable strategies to enhance precision medicine care. Methods An onlin…
View article: Antecedent flu-like illness and onset of idiopathic dilated cardiomyopathy: The DCM Precision Medicine Study
Antecedent flu-like illness and onset of idiopathic dilated cardiomyopathy: The DCM Precision Medicine Study Open
Background Previous studies have speculated that a viral infection may act as a trigger in the development of idiopathic dilated cardiomyopathy (DCM) among individuals genetically at risk. This study aims to describe the frequency of DCM p…
View article: Characterizing Long COVID in Children and Adolescents
Characterizing Long COVID in Children and Adolescents Open
Importance Most research to understand postacute sequelae of SARS-CoV-2 infection (PASC), or long COVID, has focused on adults, with less known about this complex condition in children. Research is needed to characterize pediatric PASC to …
View article: Differentiation of Prior SARS-CoV-2 Infection and Postacute Sequelae by Standard Clinical Laboratory Measurements in the RECOVER Cohort
Differentiation of Prior SARS-CoV-2 Infection and Postacute Sequelae by Standard Clinical Laboratory Measurements in the RECOVER Cohort Open
National Institutes of Health.
View article: REALM-DCM: A Phase 3, Multinational, Randomized, Placebo-Controlled Trial of ARRY-371797 in Patients With Symptomatic <i>LMNA</i> -Related Dilated Cardiomyopathy
REALM-DCM: A Phase 3, Multinational, Randomized, Placebo-Controlled Trial of ARRY-371797 in Patients With Symptomatic <i>LMNA</i> -Related Dilated Cardiomyopathy Open
BACKGROUND: LMNA ( lamin A/C )-related dilated cardiomyopathy is a rare genetic cause of heart failure. In a phase 2 trial and long-term extension, the selective p38α MAPK (mitogen-activated protein kinase) inhibitor, ARRY-371797 (PF-07265…
View article: Risk of post-acute sequelae of SARS-CoV-2 infection associated with pre-coronavirus disease obstructive sleep apnea diagnoses: an electronic health record-based analysis from the RECOVER initiative
Risk of post-acute sequelae of SARS-CoV-2 infection associated with pre-coronavirus disease obstructive sleep apnea diagnoses: an electronic health record-based analysis from the RECOVER initiative Open
Obstructive sleep apnea (OSA) has been associated with more severe acute coronavirus disease-2019 (COVID-19) outcomes. We assessed OSA as a potential risk factor for Post-Acute Sequelae of SARS-CoV-2 (PASC).We assessed the impact of preexi…
View article: Researching COVID to enhance recovery (RECOVER) pediatric study protocol: Rationale, objectives and design
Researching COVID to enhance recovery (RECOVER) pediatric study protocol: Rationale, objectives and design Open
Importance The prevalence, pathophysiology, and long-term outcomes of COVID-19 (post-acute sequelae of SARS-CoV-2 [PASC] or “Long COVID”) in children and young adults remain unknown. Studies must address the urgent need to define PASC, its…
View article: Development and external validation of a dynamic risk score for early prediction of cardiogenic shock in cardiac intensive care units using machine learning
Development and external validation of a dynamic risk score for early prediction of cardiogenic shock in cardiac intensive care units using machine learning Open
Aims Myocardial infarction and heart failure are major cardiovascular diseases that affect millions of people in the USA with morbidity and mortality being highest among patients who develop cardiogenic shock. Early recognition of cardioge…
View article: Implementing a Clinical Decision Support Tool to Improve Physical Activity
Implementing a Clinical Decision Support Tool to Improve Physical Activity Open
Background Currently, only about half of U.S. adults achieve current physical activity guidelines. Routine physical activity is not regularly assessed, nor are patients routinely counseled by their healthcare provider on achieving recommen…
View article: Researching COVID to enhance recovery (RECOVER) tissue pathology study protocol: Rationale, objectives, and design
Researching COVID to enhance recovery (RECOVER) tissue pathology study protocol: Rationale, objectives, and design Open
Importance SARS-CoV-2 infection can result in ongoing, relapsing, or new symptoms or organ dysfunction after the acute phase of infection, termed Post-Acute Sequelae of SARS-CoV-2 (PASC), or long COVID. The characteristics, prevalence, tra…
View article: Researching COVID to enhance recovery (RECOVER) pregnancy study: Rationale, objectives and design
Researching COVID to enhance recovery (RECOVER) pregnancy study: Rationale, objectives and design Open
Importance Pregnancy induces unique physiologic changes to the immune response and hormonal changes leading to plausible differences in the risk of developing post-acute sequelae of SARS-CoV-2 (PASC), or Long COVID. Exposure to SARS-CoV-2 …
View article: Rare Variant Genetics and Dilated Cardiomyopathy Severity: The DCM Precision Medicine Study
Rare Variant Genetics and Dilated Cardiomyopathy Severity: The DCM Precision Medicine Study Open
BACKGROUND: Dilated cardiomyopathy (DCM) can lead to advanced disease, defined herein as necessitating a durable left ventricular assist device or a heart transplant (LVAD/HT). DCM is known to have a genetic basis, but the association of r…
View article: Genetic Architecture of Dilated Cardiomyopathy in Individuals of African and European Ancestry
Genetic Architecture of Dilated Cardiomyopathy in Individuals of African and European Ancestry Open
Importance Black patients with dilated cardiomyopathy (DCM) have increased familial risk and worse outcomes than White patients, but most DCM genetic data are from White patients. Objective To compare the rare variant genetic architecture …
View article: The Impact of an Electronic Best Practice Advisory on Patients' Physical Activity and Cardiovascular Risk Profile
The Impact of an Electronic Best Practice Advisory on Patients' Physical Activity and Cardiovascular Risk Profile Open
Background Regular physical activity (PA) is a component of cardiovascular health and is associated with a lower risk of cardiovascular disease (CVD). However, only about half of US adults achieved the current PA recommendations. Objective…
View article: Researching COVID to Enhance Recovery (RECOVER) adult study protocol: Rationale, objectives, and design
Researching COVID to Enhance Recovery (RECOVER) adult study protocol: Rationale, objectives, and design Open
Importance SARS-CoV-2 infection can result in ongoing, relapsing, or new symptoms or other health effects after the acute phase of infection; termed post-acute sequelae of SARS-CoV-2 infection (PASC), or long COVID. The characteristics, pr…
View article: Researching COVID to enhance recovery (RECOVER) adult study protocol: Rationale, objectives, and design
Researching COVID to enhance recovery (RECOVER) adult study protocol: Rationale, objectives, and design Open
Importance SARS-CoV-2 infection can result in ongoing, relapsing, or new symptoms or other health effects after the acute phase of infection; termed post-acute sequelae of SARS-CoV-2 infection (PASC), or long COVID. The characteristics, pr…
View article: Risk of post-acute sequelae of SARS-CoV-2 infection associated with pre-coronavirus disease obstructive sleep apnea diagnoses: an electronic health record-based analysis from the RECOVER initiative
Risk of post-acute sequelae of SARS-CoV-2 infection associated with pre-coronavirus disease obstructive sleep apnea diagnoses: an electronic health record-based analysis from the RECOVER initiative Open
Study Objectives Obstructive sleep apnea (OSA) has been associated with more severe acute coronavirus disease-2019 (COVID-19) outcomes. We assessed OSA as a potential risk factor for Post-Acute Sequelae of SARS-CoV-2 (PASC). Methods We ass…