Stuart Lindsay
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View article: Conducting Atomic Force Microscopy of Protein Wires
Conducting Atomic Force Microscopy of Protein Wires Open
Scanning tunneling microscopy (STM) studies have shown that protein wires based on the consensus tetratricopetide repeat (CTPR) conduct with an electrical resistance proportional to length of the protein, consistent with long‐range hopping…
View article: Mechanisms and Consequences of Plant–Pollinator–Pathogen Interactions
Mechanisms and Consequences of Plant–Pollinator–Pathogen Interactions Open
Infectious disease is a major driver of biodiversity loss, but how disease threatens pollinator communities remains poorly understood. Here, we review the plant–pollinator–pathogen literature to identify mechanisms by which plant and polli…
View article: Scanning Tunneling Microscope Measurement of Proteasome Conductance
Scanning Tunneling Microscope Measurement of Proteasome Conductance Open
The proteasome is an enzyme that sequentially degrades peptides into small fragments, so the ability to make electrical measurements of its conformational fluctuations could lead to an electronic readout of the sequence of single peptide m…
View article: Flora of Singapore precursors 48: Further notes on the genus Piper (Piperaceae) in Singapore
Flora of Singapore precursors 48: Further notes on the genus Piper (Piperaceae) in Singapore Open
Further work on the genus Piper L. in Singapore has led to the need for a number of nomenclatural and taxonomic clarifications. Lectotypes are designated for ten names: Piper flavimarginatum C.DC., P. pachyphyllum Hook.f., P. crassipes Kor…
View article: Nanothermodynamics: There’s Plenty of Room on the Inside
Nanothermodynamics: There’s Plenty of Room on the Inside Open
Nanothermodynamics provides the theoretical foundation for understanding stable distributions of statistically independent subsystems inside larger systems. In this review, it is emphasized that extending ideas from nanothermodynamics to s…
View article: Nanothermodynamics: There’s Plenty of Room on the Inside
Nanothermodynamics: There’s Plenty of Room on the Inside Open
Nanothermodynamics provides the theoretical foundation for understanding stable distributions of statistically independent subsystems inside larger systems. In this review it is emphasized that adapting ideas from nanothermodynamics to sim…
View article: Nanothermodynamics: There's plenty of room on the inside
Nanothermodynamics: There's plenty of room on the inside Open
Nanothermodynamics provides the theoretical foundation for understanding stable distributions of statistically independent subsystems inside larger systems. In this review it is emphasized that adapting ideas from nanothermodynamics to sim…
View article: Coarse-grained modeling of annexin A2-induced microdomain formation on a vesicle
Coarse-grained modeling of annexin A2-induced microdomain formation on a vesicle Open
Annexin A2 (A2)-induced microdomain formation is a key step in biological processes such as Ca2+-mediated exocytosis in neuroendocrine cells. In this work, a total of 15 coarse-grained molecular dynamics simulations were performed on vesic…
View article: A botanical oasis rather than a biological desert: Rediscoveries, new species and new records in a tropical city
A botanical oasis rather than a biological desert: Rediscoveries, new species and new records in a tropical city Open
Societal Impact Statement Cities present a unique challenge for conservation. While overall native biodiversity is reduced, remnant habitats in the urban matrix can be important refugia for native and endemic species. This study reviews th…
View article: Heavy Water Reduces the Electronic Conductance of Protein Wires via Deuteron Interactions with Aromatic Residues
Heavy Water Reduces the Electronic Conductance of Protein Wires via Deuteron Interactions with Aromatic Residues Open
Proteins are versatile, self-assembling nanoelectronic components, but their hopping conductivity is expected to be influenced by solvent fluctuations. The role of the solvent was investigated by measuring the single molecule conductance o…
View article: Long-Range Conductivity in Proteins Mediated by Aromatic Residues
Long-Range Conductivity in Proteins Mediated by Aromatic Residues Open
Single-molecule measurements show that many proteins, lacking any redox cofactors, nonetheless exhibit electrical conductance on the order of a nanosiemen over 10 nm distances, implying that electrons can transit an entire protein in less …
View article: Measuring conductance switching in single proteins using quantum tunneling
Measuring conductance switching in single proteins using quantum tunneling Open
Interpreting the electrical signatures of single proteins in electronic junctions has facilitated a better understanding of the intrinsic properties of proteins that are fundamental to chemical and biological processes. Often, this informa…
View article: Electronic Transport in Molecular Wires of Precisely Controlled Length Built from Modular Proteins
Electronic Transport in Molecular Wires of Precisely Controlled Length Built from Modular Proteins Open
DNA molecular wires have been studied extensively because of the ease with which molecules of controlled length and composition can be synthesized. The same has not been true for proteins. Here, we have synthesized and studied a series of …
View article: Probing Bioelectronic Connections Using Streptavidin Molecules with Modified Valency
Probing Bioelectronic Connections Using Streptavidin Molecules with Modified Valency Open
As molecular electronic components, proteins are distinguished by a remarkably long electronic decay length (∼10 nm) together with high contact resistance and extreme sensitivity to the chemical details of the contact. As a consequence, th…
View article: Flora of Singapore precursors, 21: New records of Euphorbiaceae for Singapore
Flora of Singapore precursors, 21: New records of Euphorbiaceae for Singapore Open
Seven species of Euphorbiaceae are newly recorded for Singapore of which five are presumed native, one is cryptogenic and one is naturalised. One name is lectotypified. The conservation status of the native species is discussed.
View article: The potential and challenges of nanopore sequencing
The potential and challenges of nanopore sequencing Open
A nanopore-based device provides single-molecule detection and analytical capabilities that are achieved by electrophoretically driving molecules in solution through a nano-scale pore. The nanopore provides a highly confined space within w…
View article: Moving Electrons Purposefully through Single Molecules and Nanostructures: A Tribute to the Science of Professor Nongjian Tao (1963–2020)
Moving Electrons Purposefully through Single Molecules and Nanostructures: A Tribute to the Science of Professor Nongjian Tao (1963–2020) Open
Electrochemistry intersected nanoscience 25 years ago when it became possible to control the flow of electrons through single molecules and nanostructures. Many surprises and a wealth of understanding were generated by these experiments. P…
View article: Ubiquitous Electron Transport in Non-Electron Transfer Proteins
Ubiquitous Electron Transport in Non-Electron Transfer Proteins Open
Many proteins that have no known role in electron transfer processes are excellent electronic conductors. This surprising characteristic is not generally evident in bulk aggregates or crystals, or in isolated, solvated peptides, because th…
View article: ElectronicConductance Resonance in Non-Redox-ActiveProteins
ElectronicConductance Resonance in Non-Redox-ActiveProteins Open
Bioelectronics research has mainly\nfocused on redox-active proteins\nbecause of their role in biological charge transport. In these proteins,\nelectronic conductance is a maximum when electrons are injected at\nthe known redox potential o…
View article: Electronic Conductance Resonance in Non-Redox-Active Proteins
Electronic Conductance Resonance in Non-Redox-Active Proteins Open
Bioelectronics research has mainly focused on redox-active proteins because of their role in biological charge transport. In these proteins, electronic conductance is a maximum when electrons are injected at the known redox potential of th…
View article: (2731) Proposal to reject the name <i>Chloranthus elatior</i> (<i>Chloranthaceae</i>)
(2731) Proposal to reject the name <i>Chloranthus elatior</i> (<i>Chloranthaceae</i>) Open
(2731) Chloranthus elatior R. Br. in Bot. Mag.: ad t. 2190. 1 Nov 1820, nom. rej. prop. Typus: non designatus. The genus Chloranthus Sw. (in Philos. Trans. 77: 359. 1787) has about 18 species in East Asia, continental Southeast Asia, and t…
View article: Engineering an Enzyme for Direct Electrical Monitoring of Activity
Engineering an Enzyme for Direct Electrical Monitoring of Activity Open
Proteins have been shown to be electrically conductive if tethered to an electrode by means of a specific binding agent, allowing single molecules to be wired into an electrical sensing circuit. Such circuits allow enzymes to be used as se…
View article: Electronic Decay Length in a Protein Molecule
Electronic Decay Length in a Protein Molecule Open
Antibodies have two identical binding domains and can therefore form a well-defined conducting bridge by binding a pair of electrodes functionalized with an epitope. The conductance measured between these two fixed points on the antibody d…
View article: Role of contacts in long-range protein conductance
Role of contacts in long-range protein conductance Open
Significance The measured electronic properties of proteins are known to depend critically on contacts, although little is known at the single-molecule level. Here, we have measured the conductance of single-protein molecules in their natu…
View article: New records and rediscoveries of plants in Singapore
New records and rediscoveries of plants in Singapore Open
The city-state of Singapore continues to provide many new records and rediscoveries of plant species in its nature reserves, offshore islands and secondary forests. Eleven new records for Singapore and eight rediscoveries of species previo…
View article: Observation of giant conductance fluctuations in a protein
Observation of giant conductance fluctuations in a protein Open
Proteins are insulating molecular solids, yet even those containing easily reduced or oxidized centers can have single-molecule electronic conductances that are too large to account for with conventional transport theories. Here, we report…